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  1. Fulltext Factorial Design and Optimization of Landfill Leachate Treatment Using Tannin-Based Natural Coagulant
    Banch TJH, Hanafiah MM, Alkarkhi AFM, Abu Amr SS
    Polymers (Basel), 2019 Aug 14;11(8).
    PMID: 31416151 DOI: 10.3390/polym11081349
    In this study, tannin-based natural coagulant was used to treat stabilized landfill leachate. Tannin modified with amino group was utilized for the treatment process. Central composite design (CCD) was used to investigate and optimize the effect of tannin dosage and pH on four responses. The treatment efficiency was evaluated based on the removal of four selected (responses) parameters; namely, chemical oxygen demand (COD), color, NH3-N and total suspended solids (TSS). The optimum removal efficiency for COD, TSS, NH3-N and color was obtained using a tannin dosage of 0.73 g at a pH of 6. Moreover, the removal efficiency for selected heavy metals from leachate; namely, iron (Fe2+), zinc (Zn2+), copper (Cu2+), chromium (Cr2+), cadmium (Cd2+), lead (Pb2+), arsenic (As3+), and cobalt (Co2+) was also investigated. The results for removal efficiency for COD, TSS, NH3-N, and color were 53.50%, 60.26%, and 91.39%, respectively. The removal of selected heavy metals from leachate for Fe2+, Zn2+, Cu2+, Cr2+, Cd2+, Pb2+, As3+ and cobalt Co2+ were 89.76%, 94.61%, 94.15%, 89.94%, 17.26%, 93.78%, 86.43% and 84.19%, respectively. The results demonstrate that tannin-based natural coagulant could effectively remove organic compounds and heavy metals from stabilized landfill leachate.
    Matched MeSH terms: Iron
  2. Land suitability analysis for turmeric crop for humid tropical Kerala, India, under current and future climate scenarios using advanced geospatial techniques
    Banu M, Krishnamurthy KS, Srinivasan V, Kandiannan K, Surendran U
    J Sci Food Agric, 2024 May;104(7):4176-4188.
    PMID: 38385763 DOI: 10.1002/jsfa.13299
    BACKGROUND: Turmeric cultivation primarily thrives in India, followed by Bangladesh, Cambodia, Thailand, China, Malaysia, Indonesia and the Philippines. India leads globally in both area and production of turmeric. Despite this, there is a recognized gap in research regarding the impact of climate change on site suitability of turmeric. The primary objective of the present study was to evaluate both the present and future suitability of turmeric cultivation within the humid tropical region of Kerala, India, by employing advanced geospatial techniques. The research utilized meteorological data from the Indian Meteorological Department for the period of 1986-2020 as historical data and projected future data from the Coupled Model Intercomparison Project Phase 6 (CMIP6). Four climatic scenarios of shared socioeconomic pathway (SSP) from the Intergovernmental Panel on Climate Change AR6 model of MIROC6 for the year 2050 (SSP 1-2.6, SSP 2-4.5, SSP 3-7.0 and SSP 5-8.5) were used.

    RESULTS: The results showed that suitable area for turmeric cultivation is declining in future scenario and this decline can be primarily attributed to fluctuations in temperature and an anticipated increase in rainfall in the year 2050. Notable changes in the spatial distribution of suitable areas over time were observed through the application of geographic information system (GIS) techniques. Importantly, as per the suitability criteria provided by ICAR-National Bureau of Soil Survey and Land Use Planning (ICAR-NBSS & LUP), all the districts in Kerala exhibited moderately suitable conditions for turmeric cultivation. With the GIS tools, the study identified highly suitable, moderately suitable, marginally suitable and not suitable areas of turmeric cultivation in Kerala. Presently 28% of area falls under highly suitable, 41% of area falls under moderately suitable and 11% falls under not suitable for turmeric cultivation. However, considering the projected scenarios for 2050 under the SSP framework, there will be a significant decrease in highly suitable area by 19% under SSP 5-8.5. This reduction in area will have an impact on the productivity of the crop as a result of changes in temperature and rainfall patterns.

    CONCLUSION: The outcome of the present research suggests that the state of Kerala needs to implement suitable climate change adaptation and management strategies for sustaining the turmeric cultivation. Additionally, the present study includes a discussion on potential management strategies to address the challenges posed by changing climatic conditions for optimizing turmeric production in the region. © 2024 Society of Chemical Industry.

    Matched MeSH terms: Iron-Dextran Complex*
  3. Effects of ion exchange resins in different mobile ion forms on semi-aerobic landfill leachate treatment
    Bashir MJ, Aziz HA, Yusoff MS, Huqe AA, Mohajeri S
    Water Sci Technol, 2010;61(3):641-9.
    PMID: 20150700 DOI: 10.2166/wst.2010.867
    Landfill leachate is one of the major contamination sources. In this study, the ability of synthetic ion exchange resins which carry different mobile ion for removing color, chemical oxygen demand (COD), and ammonia nitrogen (NH(3)-N) from stabilized leachate was investigated. The synthetic resin INDION 225 Na as a cationic exchanger and INDION FFIP MB as an anionic exchanger were used in this study. INDION 225 Na was used in hydrogen form (H(+)) and in sodium form (Na(+)), while INDION FFIP MB resin was used in hydroxide form (OH(-)) and in calcium form (Cl(-)) form. The results indicated better removal of color, COD and NH(3)-N by using INDION 225 Na in H(+) as compared with Na(+) form, while no performance differences were observed by using INDION FFIP MB in OH(-) or Cl(-) form. Applying cationic resin followed by anionic resin achieved 97, 88 and 94, percent removal of color, COD and NH(3)-N. The residual amounts were 160 Pt-Co, 290 mg/L and 110 mg/L of color, COD and NH(3)-N respectively.
    Matched MeSH terms: Iron/analysis
  4. Fulltext Novel anode catalyst for direct methanol fuel cells
    Basri S, Kamarudin SK, Daud WR, Yaakob Z, Kadhum AA
    ScientificWorldJournal, 2014;2014:547604.
    PMID: 24883406 DOI: 10.1155/2014/547604
    PtRu catalyst is a promising anodic catalyst for direct methanol fuel cells (DMFCs) but the slow reaction kinetics reduce the performance of DMFCs. Therefore, this study attempts to improve the performance of PtRu catalysts by adding nickel (Ni) and iron (Fe). Multiwalled carbon nanotubes (MWCNTs) are used to increase the active area of the catalyst and to improve the catalyst performance. Electrochemical analysis techniques, such as energy dispersive X-ray spectrometry (EDX), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and X-ray photoelectron spectroscopy (XPS), are used to characterize the kinetic parameters of the hybrid catalyst. Cyclic voltammetry (CV) is used to investigate the effects of adding Fe and Ni to the catalyst on the reaction kinetics. Additionally, chronoamperometry (CA) tests were conducted to study the long-term performance of the catalyst for catalyzing the methanol oxidation reaction (MOR). The binding energies of the reactants and products are compared to determine the kinetics and potential surface energy for methanol oxidation. The FESEM analysis results indicate that well-dispersed nanoscale (2-5 nm) PtRu particles are formed on the MWCNTs. Finally, PtRuFeNi/MWCNT improves the reaction kinetics of anode catalysts for DMFCs and obtains a mass current of 31 A g(-1) catalyst.
    Matched MeSH terms: Iron/chemistry
  5. Removal of organochlorine pesticides using zerovalent iron supported on biochar nanocomposite from Nephelium lappaceum (Rambutan) fruit peel waste
    Batool S, Shah AA, Abu Bakar AF, Maah MJ, Abu Bakar NK
    Chemosphere, 2022 Feb;289:133011.
    PMID: 34863732 DOI: 10.1016/j.chemosphere.2021.133011
    Unique zerovalent iron (Fe0) supported on biochar nanocomposite (Fe0-BRtP) was synthesized from Nephelium lappaceum (Rambutan) fruit peel waste and were applied for the simultaneous removal of 6 selected organochlorine pesticides (OCPs) from aqueous medium. During facile synthesis of Fe0-BRtP, Rambutan peel extract was used as the green reducing mediator to reduce Fe2+ to zerovalent iron (Fe0), instead of toxic sodium borohydride which were used for chemical synthesis. For comparison, chemically synthesized Fe0-BChe nanocomposite was also prepared in this work. Characterization study confirmed the successful synthesis and dispersion of Fe0 nanoparticles on biochar surface. Batch experiments revealed that Fe0-BRtP and Fe0-BChe nanocomposites combine the advantage of adsorption and dechlorination of OCPs in aqueous medium and up to 96-99% and 83-91% removal was obtained within 120 and 150 min, respectively at initial pH 4. Nevertheless, the reactivity of Fe0-BChe nanocomposite decreased 2 folds after being aged in air for one month, whilst Fe0-BRtP almost remained the same. Adsorption isotherm of OCPs were fitted well to Langmuir isotherm and then to Freundlich isotherm. The experimental kinetic data were fitted first to pseudo-second-order adsorption kinetic model and then to pseudo-first-order reduction kinetic model. The adsorption mechanism involves π-π electron-donor-acceptor interaction and adsorption is facilitated by the hydrophobic sorption and pore filling. After being reused five times, the removal efficiency of regenerated Fe0-BChe and Fe0-BRtP was 5-13% and 89-92%, respectively. The application of this Fe0-BRtP nanocomposite could represent a green and low-cost potential material for adsorption and subsequent reduction of OCPs in aquatic system.
    Matched MeSH terms: Iron
  6. Flexibility and hardness of dental stainless steel wrought wires used in Thailand
    Benjakul P, Cheunarrom C, Ongthiemsak C
    J Oral Sci, 2001 Mar;43(1):15-9.
    PMID: 11383631
    Stainless steel wrought wires used as clasp arms for removable partial dentures in Thailand were compared with those used in some other countries (in the as-received condition) in terms of flexibility, Vickers microhardness and composition. The results showed that there were significant differences (P< or =0.05) among the wires. A Japanese stainless steel wire (SK) was obviously different from the others. It had the lowest proportional limit and microhardness, but its flexibility was almost the same. The chemical composition of each wire was not greatly different. The wires were about 18-20 wt% chromium and 8-9 wt% nickel, except for the SK wire, which had about 12 wt% nickel.
    Matched MeSH terms: Iron/analysis
  7. Phytoremediation of iron from red soil of tropical region by using Centella asiatica
    Bhat IU, Mauris EN, Khanam Z
    Int J Phytoremediation, 2016 Sep;18(9):918-23.
    PMID: 26940261 DOI: 10.1080/15226514.2016.1156637
    The accumulation and removal efficiency of Fe by Centella asiatica was carried out at various Fe concentrations in soil treatments (0, 50, 100, 150 and 200 mg Fe/kg soil). Iron accumulation in different parts of C. asiatica (leaf, stem and root) was analyzed by atomic absorption spectrophotometer (AAS). Factorial experiment with a completely randomized design and Duncan's test were used for data analyses. The results revealed that C. asiatica have the ability to uptake and accumulate Fe significantly (p 1 and <1, respectively, further supporting its metal hyperaccumulator properties.
    Matched MeSH terms: Biodegradation, Environmental; Iron/metabolism*
  8. On-line preconcentration and determination of trace metals using a flow injection system coupled to ion chromatography
    Bin Abas MR, Takruni IA, Abdullah Z, Tahir NM
    Talanta, 2002 Nov 12;58(5):883-90.
    PMID: 18968820
    A flow injection (FI) method with on-line preconcentration using a mini-column loaded with 8-hydroxyquinoline immobilized on controlled pore glass (CPG-8HQ) is described for the determination of trace metals by ion chromatography (IC) with pyridine-2-6-dicarboxylic acid (PDCA) as the eluent. Copper, cadmium, lead, zinc, nickel and iron were determined at ppb level after post-column derivatization with 4-(2-pyridylazo)-resorcinol (PAR). The detection limits (3sigma) for the FI/IC system were 8.27, 0.89, 0.09, 0.06, 0.09 and 0.07 g l(-1) for Pb(2+), Cd(2+), Cu(2+) Ni(2+), Zn(2+) and Fe(3+), respectively, using 5 ml sample volume. The method was applied to the analysis of Malaysian natural waters.
    Matched MeSH terms: Iron
  9. Free radical scavenging, antidiarrheal and anthelmintic activity of Pistia stratiotes L. extracts and its phytochemical analysis
    Bin Karim MF, Imam H, Sarker MM, Uddin N, Hasan N, Paul N, et al.
    Pak J Pharm Sci, 2015 May;28(3):915-20.
    PMID: 26004725
    In this phyto-pharmacological screening of Pistia stratiotes L leaf and root extracts each separately in two different solvents demonstrated its potential medicinal value. Apparent antioxidant value is demonstrated by DPPH, Nitric oxide scavenging and Ferric ion reducing method. Additionally, total flavonoid and phenolic compounds were measured. The leaf methanolic extract scavenged both nitric oxide (NO) and DPPH radical with a dose dependent manner. But the pet ether fraction of root was found to have highest efficacy in Fe(3±) reducing power assay. Flavonoid was found to contain highest in the pet ether fraction of root (411.35mg/g) in terms of quercetin equivalent, similarly highest amount (34.96mg/g) of total phenolic compounds (assayed as gallic acid equivalents) were found to contain in the same fraction. The methanolic fractions appeared less cytotoxic compared to pet ether extracts. The plant extracts caused a dose dependent decrease in faecal droppings in both castor oil and magnesium sulphate induced diarrhea, where as leaf extracts in each solvent appeared most effective. Also, the plant extracts showed anthelmintic activity in earthworm by inducing paralysis and death in a dose dependent manner. At highest doses (50 mg/ml) all fractions were almost effective as the positive control piperazine citrate (10 mg/ml). Thus, besides this cytotoxic effect it's traditional claim for therapeutic use can never be overlooked.
    Matched MeSH terms: Iron/metabolism
  10. The Role of Public Health Nutrition in Achieving the Sustainable Development Goals in the Asia Pacific Region
    Binns C, Lee MK, Low WY, Zerfas A
    Asia Pac J Public Health, 2017 Oct;29(7):617-624.
    PMID: 29094630 DOI: 10.1177/1010539517736441
    The Sustainable Development Goals (SDGs) replaced the Millennium Development Goals (MDCs) in 2015, which included several goals and targets primarily related to nutrition: to eradicate extreme poverty and hunger and to reduce child mortality and improve maternal health. In the Asia-Pacific Academic Consortium for Public Health (APACPH) member countries as a group, infant and child mortality were reduced by more than 65% between 1990 and 2015, achieving the MDG target of two-thirds reduction, although these goals were not achieved by several smaller countries. The SDGs are broader in focus than the MDGs, but include several goals that relate directly to nutrition: 2 (zero hunger-food), 3 (good health and well-being-healthy life), and 12 (responsible consumption and production-sustainability). Other SDGs that are closely related to nutrition are 4 and 5 (quality education and equality in gender-education and health for girls and mothers, which is very important for infant health) and 13 (climate action). Goal 3 is "good health and well-being," which includes targets for child mortality, maternal mortality, and reducing chronic disease. The Global Burden of Disease Project has confirmed that the majority of risk for these targets can be attributed to nutrition-related targets. Dietary Guidelines were developed to address public health nutrition risk in the Asia Pacific region at the 48th APACPH 2016 conference and they are relevant to the achievement of the SDGs. Iron deficiency increases the risk of maternal death from haemorrhage, a cause of 300000 deaths world-wide each year. Improving diets and iron supplementation are important public health interventions in the APACPH region. Chronic disease and obesity rates in the APACPH region are now a major challenge and healthy life course nutrition is a major public health priority in answering this challenge. This article discusses the role of public health nutrition in achieving the SDGs. It also examines the role of APACPH in education and advocacy and in fulfilling the educational needs of public health students in public health nutrition.
    Matched MeSH terms: Iron
  11. Fulltext Nutritional status and complementary feeding among Penan infants and young children in rural Sarawak, Malaysia
    Bong, M.W., Norimah A. Karim, Ismail Mohd Noor
    Malays J Nutr, 2018;24(4):539-550.
    MyJurnal
    Introduction: The Penan people are largely settled in rural and remote areas of
    Sarawak with high rates of undernutrition among the children. The study aimed to
    determine the nutritional status and infant and young child feeding (IYCF) practices
    of Penan children. Methods: Subjects consisted of 121 children, aged between 0-23
    months, from 15 Penan longhouses in Belaga district. Malnutrition was assessed
    using anthropometric measurements of children and categorised according to the
    World Health Organization (WHO) Growth Standards (2006). Feeding practices were
    assessed using questionnaires based on WHO IYCF Indicators (2008). Results:
    The prevalence of underweight was 29.8%; stunting 43.0% and wasting 5.8%.
    Prevalence of exclusive breastfeeding under 6 months was 44.4%. About 86% of
    infants aged 6-8 months were already given solid, semi-solid and soft foods. The
    proportion of children aged 6-23 months achieving minimum dietary diversity
    (MDD) was 76.6%, while minimum meal frequency (MMF) was 83.0% (breastfed and
    non-breastfed). Among the children who achieved MDD, 64.9% of their meals were
    derived from 4-5 food groups. More than half (55.3%) of all subjects (breastfed and
    non-breastfed) received minimum acceptable diet (MAD). Achievement of iron-rich
    foods (IRF) indicator was 77.7%. There was no significant association between the
    IYCF indicators of MDD, MMF and MAD and underweight, stunting and wasting.
    Conclusion: A high prevalence of poor nutritional status was recorded among
    the Penan children. While the IYCF indicators apparently showed satisfactory
    complementary feeding practices, future studies should assess quantitatively the
    intake of complementary food among Penan infants and young children.
    Matched MeSH terms: Iron
  12. Fulltext Physicochemical characterization and rheological properties of magnetic elastomers containing different shapes of corroded carbonyl iron particles
    Burhannuddin NL, Nordin NA, Mazlan SA, Aziz SAA, Kuwano N, Jamari SKM, et al.
    Sci Rep, 2021 Jan 13;11(1):868.
    PMID: 33441824 DOI: 10.1038/s41598-020-80539-z
    Carbonyl iron particles (CIPs) is one of the key components in magnetic rubber, known as magnetorheological elastomer (MRE). Apart from the influence of their sizes and concentrations, the role of the particle' shape is pronounced worthy of the attention for the MRE performance. However, the usage of CIPs in MRE during long-term applications may lead to corrosion effects on the embedded CIPs, which significantly affects the performance of devices or systems utilizing MRE. Hence, the distinctions between the two types of MRE embedded in different shapes of spherical and plate-like CIPs, at both conditions of non-corroded and corroded CIPs were investigated in terms of the field-dependent rheological properties of MRE. The plate-like shape was produced from spherical CIPs through a milling process using a rotary ball mill. Then, both shapes of CIPs individually subjected to an accelerated corrosion test in diluted hydrochloric (HCl) at different concentrations, particularly at 0.5, 1.0, and 1.5 vol.% for 30 min of immersion time. Eight samples of CIPs, including non-corroded for both CIPs shapes, were characterized in terms of a morphological study by field emission scanning electron microscope (FESEM) and magnetic properties via vibrating sample magnetometer (VSM). The field-dependent rheological properties of MREs were analyzed the change in the dynamic modulus behavior of MREs via rheometer. From the application perspective, this finding may be useful for the system to be considered that provide an idea to prolong the performance MRE by utilizing the different shapes of CIPs even when the material is fading.
    Matched MeSH terms: Iron; Iron Carbonyl Compounds
  13. Exochelin production in Mycobacterium neoaurum
    Chan KG
    Int J Mol Sci, 2009 Jan;10(1):345-53.
    PMID: 19333449
    Mycobacterium neoaurum is a soil saprophyte and obligate aerobic bacterium. This group of mycobacterium is relatively fast-growing. They form colonies on nutrient agar at 37 masculineC within 3 - 4 days. In natural soil habitats, bioavailability of iron is limited. To facilitate iron uptake, most mycobacteria produce siderophores. One example is exochelin, which is extracellular and water-soluble. In this report, the production of exochelin in M. neoaurum was induced in iron-deficiency, but repressed under ironsufficiency growth conditions. It is however not induced under zinc-deficiency growth conditions. The growth of this mycobacterium was correlated with exochelin secretion under iron-deficiency culture conditions. When M. neoaurum was grown in defined medium containing 0.04 microg Fe(III)/mL (final concentration), the production of exochelin reached a maximum and the corresponding cell growth was comparable to that under iron-sufficiency conditions. In this study, exochelin was purified from spent supernatant of M. neoaurum by semi-preparative chromatography. When saturated ferric chloride solution was added into the purified exochelin, a ferri-exochelin complex was formed. It is proposed that iron uptake in M. neoaurum is exochelin-mediated.
    Matched MeSH terms: Iron/deficiency; Iron Chelating Agents/isolation & purification*; Iron Chelating Agents/metabolism
  14. Investigation of trace inorganic elements in street doses of heroin
    Chan KW, Tan GH, Wong RC
    Sci Justice, 2013 Mar;53(1):73-80.
    PMID: 23380066 DOI: 10.1016/j.scijus.2012.08.004
    Sixteen trace elements found in 309 street heroin samples, piped water and contaminated water were determined using inductively coupled plasma-mass spectrometry. All the street heroin samples were found to contain high levels of sodium, a reflection of the use of sodium bicarbonate during heroin synthesis. Additionally, this element was also found to be one of the potential contaminants acquired from the piped water. Calcium could be derived from lime while iron, aluminum and zinc could have come from the metallic container used in the processing/cutting stage. The levels of these elements remained low in the heroin and it could be due to the dilution effects from the addition of adulterants. Statistical validation was performed with six links of related heroin samples using principal component analysis to find the best pretreatment for sample classification. It was obtained that normalization followed by fourth root showed promising results with 8% errors in the sample clustering. The technique was then applied to the case samples. Finally, the result suggested that the case samples could have originated from at least two major groups respectively showing unique elemental profiles at the street level.
    Matched MeSH terms: Iron
  15. Fulltext The prevalence of anemia and iron deficiency is more common in breastfed infants than their mothers in Bhaktapur, Nepal
    Chandyo RK, Henjum S, Ulak M, Thorne-Lyman AL, Ulvik RJ, Shrestha PS, et al.
    Eur J Clin Nutr, 2016 Apr;70(4):456-62.
    PMID: 26626049 DOI: 10.1038/ejcn.2015.199
    INTRODUCTION: Iron deficiency anemia is a widespread public health problem, particularly in low- and middle-income countries. Maternal iron status around and during pregnancy may influence infant iron status. We examined multiple biomarkers to determine the prevalence of iron deficiency and anemia among breastfed infants and explored its relationship with maternal and infant characteristics in Bhaktapur, Nepal.
    SUBJECTS/METHODS: In a cross-sectional survey, we randomly selected 500 mother-infant pairs from Bhaktapur municipality. Blood was analyzed for hemoglobin, ferritin, total iron-binding capacity, transferrin receptors and C-reactive protein.
    RESULTS: The altitude-adjusted prevalence of anemia was 49% among infants 2-6-month-old (hemaglobin (Hb) <10.8 g/dl) and 72% among infants 7-12-month-old (Hb <11.3 g/dl). Iron deficiency anemia, defined as anemia and serum ferritin <20 or <12 μg/l, affected 9 and 26% of infants of these same age groups. Twenty percent of mothers had anemia (Hb <12.3 g/dl), but only one-fifth was explained by depletion of iron stores. Significant predictors of infant iron status and anemia were infant age, sex and duration of exclusive breastfeeding and maternal ferritin concentrations.
    CONCLUSIONS: Our findings suggest that iron supplementation in pregnancy is likely to have resulted in a low prevalence of postpartum anemia. The higher prevalence of anemia and iron deficiency among breastfed infants compared with their mothers suggests calls for intervention targeting newborns and infants.
    Matched MeSH terms: Iron; Anemia, Iron-Deficiency
  16. Improving protein production of indigenous microalga Chlorella vulgaris FSP-E by photobioreactor design and cultivation strategies
    Chen CY, Lee PJ, Tan CH, Lo YC, Huang CC, Show PL, et al.
    Biotechnol J, 2015 Jun;10(6):905-14.
    PMID: 25865941 DOI: 10.1002/biot.201400594
    Fish meal is currently the major protein source for commercial aquaculture feed. Due to its unstable supply and increasing price, fish meal is becoming more expensive and its availability is expected to face significant challenges in the near future. Therefore, feasible alternatives to fish meal are urgently required. Microalgae have been recognized as the most promising candidates to replace fish meal because the protein composition of microalgae is similar to fish meal and the supply of microalgae-based proteins is sustainable. In this study, an indigenous microalga (Chlorella vulgaris FSP-E) with high protein content was selected, and its feasibility as an aquaculture protein source was explored. An innovative photobioreactor (PBR) utilizing cold cathode fluorescent lamps as an internal light source was designed to cultivate the FSP-E strain for protein production. This PBR could achieve a maximum biomass and protein productivity of 699 and 365 mg/L/day, respectively, under an optimum urea and iron concentration of 12.4 mM and 90 μM, respectively. In addition, amino acid analysis of the microalgal protein showed that up to 70% of the proteins in this microalgal strain consist of indispensable amino acids. Thus, C. vulgaris FSP-E appears to be a viable alternative protein source for the aquaculture industry.
    Matched MeSH terms: Iron/metabolism; Iron/chemistry
  17. Ferroptosis as a potential target for cancer therapy
    Chen Z, Wang W, Abdul Razak SR, Han T, Ahmad NH, Li X
    Cell Death Dis, 2023 Jul 24;14(7):460.
    PMID: 37488128 DOI: 10.1038/s41419-023-05930-w
    Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. However, the precise underlying molecular mechanisms and their differential roles in tumorigenesis are unclear. Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers. Moreover, multiple pharmacological ferroptosis activators are summarized, and the prospect of targeting ferroptosis in cancer therapy is further elucidated.
    Matched MeSH terms: Iron Overload*
  18. Fulltext Determination of the presence and levels of heavy metals and other elements in raw and commercial edible bird nests
    Chen, J.X.J., Lim, P.K.C., Wong, S.F., Mak, J.W.
    Malays J Nutr, 2014;20(3):377-391.
    MyJurnal
    Introduction: Heavy metals and other contaminants in food have been a concern to food industries, consumers and governing authorities. The purpose of this study was to determine the levels of heavy metals and other elements in edible bird nests (EBNs). Methods: Raw and processed (commercial) EBNs were used in the study. Raw EBNs were collected directly from five house farms in Peninsular Malaysia - Kuala Sanglang (Kedah), Pantai Remis (Perak), Kluang Gohor), Kota Bharu (Kelantan) and Kajang (Selangor). Processed EBNs were pmchased from five Chinese traditional medicinal shops located in Peninsular Malaysia. The levels of 32 elements were determined by inductively coupled plasma-mass spectrometry and findings of the study were compared to the maximum regulatory limits set by the Standards and Industrial Research Institute of Malaysia (SIRIM) for EBNs. Results: Of the seven elements with maximum regulatory limits (As, Cd, Pb, Hg, Sn, Cu, Fe), one raw EBN was detected with mercury level of 70.180 ppb which was above the SIRIM permissible limit of 50 ppb. All the EBNs had iron levels above the SIRIM permissible limit of 30 ppb. The levels of the other 25 elements with no maximum regulatory limits (Ca, Mg, Na, K, P, Co, Cr, Mn, Mo, Se, Zn, Ag, Ba, Be, Bi, B, Li, Ni, Sb, Sr, Ti, U, V, Al, Zr) were also determined. Conclusion: The data obtained for the 25 elements with no permissible limits can serve as baseline data for further studies to establish their maximum regulatory limits.
    Matched MeSH terms: Iron
  19. Knowledge, attitude and practice towards dietary iron among patients with thalassemia and their caregivers in Peninsular Malaysia
    Chin DM, Kader Maideen SF, Rashid A
    Med J Malaysia, 2019 Oct;74(5):365-371.
    PMID: 31649210
    INTRODUCTION: Thalassemias are the most common human monogenic disorders in the world. Regular blood transfusion and increased intestinal absorption of iron among thalassemia patients will lead to iron overload, which will not only markedly decrease their life expectancy but also pose a heavy burden to the healthcare system. The objective of this study was to evaluate the level of knowledge, attitude and practice towards dietary iron among thalassemia patients and their caregivers.

    METHODS: An analytical cross-sectional study using purposive sampling method was conducted at eight thalassemia societies in Peninsular Malaysia. 260 respondents comprised of patients and caregivers were assessed with two separate sets of questionnaires.

    RESULTS: Knowledge on dietary iron among the respondents was unsatisfactory, despite them having good knowledge on thalassemia disorder. Female patients were found to have better dietary knowledge, attitude and practice compared to males. The percentage of caregivers with good attitude and good practice were significantly higher compared to adult patients. Caregivers with children on iron chelators were noted to have better dietary attitude and practice. Thalassemia knowledge and children on vitamins were found to be the predictors of dietary knowledge among the patients and caregivers respectively.

    CONCLUSION: The level of knowledge on dietary iron among the patients and caregivers was unsatisfactory in spite of their attitude and practice towards dietary iron were good. Effective delivery of dietary information to the patients and caregivers is essential to enable them to choose a healthy diet for their condition.

    Matched MeSH terms: Iron; Iron Chelating Agents; Iron Overload; Iron, Dietary
  20. Fe2+ and Cu2+ increase the production of hyaluronic acid by lactobacilli via affecting different stages of the pentose phosphate pathway
    Choi SB, Lew LC, Hor KC, Liong MT
    Appl Biochem Biotechnol, 2014 May;173(1):129-42.
    PMID: 24648139 DOI: 10.1007/s12010-014-0822-5
    This study aimed at optimizing the production of hyaluronic acid by Lactobacillus acidophilus FTDC 1231 using response surface methodology and evaluating the effects of divalent metal ions along the production pathway using molecular docking. Among different divalent metal ions that were screened, only iron (II) sulphate and copper (II) sulphate significantly (P iron (II) sulphate and 0.16 mol L(-1) of copper (II) sulphate (103 % increase compared to absence of divalent metal ions). Data from molecular docking showed Fe(2+) improved the binding affinity of UDP-pyrophophorylase towards glucose-1-phosphate, while Cu(2+) contributed towards the interaction between UDP-glucose dehydrogenase and UDP-glucose. We have demonstrated that lactobacilli could produce hyaluronic acid at increased concentration upon facilitation by specific divalent metal ions, via specific targets of enzymes and substrates along pentose phosphate pathway.
    Matched MeSH terms: Iron/metabolism*
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