Displaying publications 81 - 100 of 151 in total

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  1. Is gender diversity is diversity washing or good governance for firm sustainable development goal performance: A scoping review
    Asif M, Khan PA, Irfan F, Salim M, Jan A, Khan M
    Environ Sci Pollut Res Int, 2023 Nov;30(53):114690-114705.
    PMID: 37848790 DOI: 10.1007/s11356-023-30211-6
    In Industry 4.0, sustainability is the heart, and governance is the soul of the business, but diversity washing, greenwashing, and SDG washing are skeptical. This is due to the reactive/normative approach in dealing with sustainability and governance, which has created an amounting number of greenhouse gases, waste generation, and several business washing challenges. This study has explored the Scopus and Web of Science databases and searched for the keywords "Sustainable Development Goals" AND "Director," which provided 76 documents. However, when the authors added the third keyword, "ISO 37001-2021," along with the above two keywords, the database provided no study investigating the moderation role of ISO 37001-2021. Therefore, the study advocates the adoption of newly developed ISO 37000:2021 good governance standards for greenwashing, SDG washing, and diversity washing challenges without failing to contribute to the firm sustainable development goal performance and earning management. Secondly, the independent director attribute's role is vital due to the potential, power, position, and evidence to adopt ISO 37000:2021 standards. Thirdly, the scoping review study has proposed a conceptual model to extend the reporting discloser and transparency. It goes beyond mere compliance, contributes towards societal development, and promotes adopting sustainable development goal performance and reporting as a new non-financial parameter for evaluating the firm's performance. Lastly, this will boost firm sustainability and adopt the circular economic model, creating a unique competitive edge and green governance goodwill among the business's external stakeholders and attracting sustainably responsible investors.
  2. Effect of cell density on the biological titer and yield of 146S fraction of foot-and-mouth disease virus O in cell suspension
    Rizvi A, Hussain N, Anjum AA, Ahmed N, Naeem A, Khan M, et al.
    J Virol Methods, 2022 Feb;300:114379.
    PMID: 34826516 DOI: 10.1016/j.jviromet.2021.114379
    Foot-and-mouth disease (FMD) is a highly infectious disease of cattle and other cloven-hoofed animals, causing huge economic losses annually worldwide. This disease is endemic in Pakistan where the serotypes of the foot-and-mouth disease virus (FMDV) are A, O and ASIA-1. At present, trivalent FMDV vaccines are being used to prevent FMD but the current production process is laborious and is unable to fulfill the needs of the meat and dairy industries. To meet the vaccine needs of Pakistan, the conventional method of using adherent cell lines to produce the vaccine could be replaced by suspension cell cultures which produce higher yields in less time and less volume. Therefore, the aim of this study was to investigate and optimize some of the factors that affect viable cell density and subsequent virus yield. The relationship between the yield of the 146S fraction and the TCID50 of the virus preparations obtained was also evaluated as a mean to control and check the quality of the vaccine product. The results provided optimized conditions for vaccine production using cell suspensions and showed that there was a linear relationship between TCID50 and 146S fraction yield. Either TCID50 or the 146S fraction yield, or both could be used as parameters for quality monitoring during vaccine production. Using TCID50 reduced the number of steps involved in virus production while measuring 146S fraction yield was useful for quality control. However, more studies are required to evaluate the relative effectiveness of vaccines produced by virus cultures using either TCID50 or 146S fraction as quality monitoring tools.
  3. Fulltext Intelligent prediction modeling for flexural capacity of FRP-strengthened reinforced concrete beams using machine learning algorithms
    Khan M, Khan A, Khan AU, Shakeel M, Khan K, Alabduljabbar H, et al.
    Heliyon, 2024 Jan 15;10(1):e23375.
    PMID: 38169887 DOI: 10.1016/j.heliyon.2023.e23375
    Fiber-reinforced polymers (FRP) are widely utilized to improve the efficiency and durability of concrete structures, either through external bonding or internal reinforcement. However, the response of FRP-strengthened reinforced concrete (RC) members, both in field applications and experimental settings, often deviates from the estimation based on existing code provisions. This discrepancy can be attributed to the limitations of code provisions in fully capturing the nature of FRP-strengthened RC members. Accordingly, machine learning methods, including gene expression programming (GEP) and multi-expression programming (MEP), were utilized in this study to predict the flexural capacity of the FRP-strengthened RC beam. To develop data-driven estimation models, an extensive collection of experimental data on FRP-strengthened RC beams was compiled from the experimental studies. For the assessment of the accuracy of developed models, various statistical indicators were utilized. The machine learning (ML) based models were compared with empirical and conventional linear regression models to substantiate their superiority, providing evidence of enhanced performance. The GEP model demonstrated outstanding predictive performance with a correlation coefficient (R) of 0.98 for both the training and validation phases, accompanied by minimal mean absolute errors (MAE) of 4.08 and 5.39, respectively. In contrast, the MEP model achieved a slightly lower accuracy, with an R of 0.96 in both the training and validation phases. Moreover, the ML-based models exhibited notably superior performances compared to the empirical models. Hence, the ML-based models presented in this study demonstrated promising prospects for practical implementation in engineering applications. Moreover, the SHapley Additive exPlanation (SHAP) method was used to interpret the feature's importance and influence on the flexural capacity. It was observed that beam width, section effective depth, and the tensile longitudinal bars reinforcement ratio significantly contribute to the prediction of the flexural capacity of the FRP-strengthened reinforced concrete beam.
  4. Fulltext An intelligent decision support system for crop yield prediction using hybrid machine learning algorithms
    Anbananthen KSM, Subbiah S, Chelliah D, Sivakumar P, Somasundaram V, Velshankar KH, et al.
    F1000Res, 2021;10:1143.
    PMID: 34987773 DOI: 10.12688/f1000research.73009.1
    Background: In recent times, digitization is gaining importance in different domains of knowledge such as agriculture, medicine, recommendation platforms, the Internet of Things (IoT), and weather forecasting. In agriculture, crop yield estimation is essential for improving productivity and decision-making processes such as financial market forecasting, and addressing food security issues. The main objective of the article is to predict and improve the accuracy of crop yield forecasting using hybrid machine learning (ML) algorithms. Methods: This article proposes hybrid ML algorithms that use specialized ensembling methods such as stacked generalization, gradient boosting, random forest, and least absolute shrinkage and selection operator (LASSO) regression. Stacked generalization is a new model which learns how to best combine the predictions from two or more models trained on the dataset. To demonstrate the applications of the proposed algorithm, aerial-intel datasets from the github data science repository are used. Results: Based on the experimental results done on the agricultural data, the following observations have been made. The performance of the individual algorithm and hybrid ML algorithms are compared using cross-validation to identify the most promising performers for the agricultural dataset.  The accuracy of random forest regressor, gradient boosted tree regression, and stacked generalization ensemble methods are 87.71%, 86.98%, and 88.89% respectively. Conclusions: The proposed stacked generalization ML algorithm statistically outperforms with an accuracy of 88.89% and hence demonstrates that the proposed approach is an effective algorithm for predicting crop yield. The system also gives fast and accurate responses to the farmers.
  5. Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease
    Khan KM, Rahim F, Khan A, Shabeer M, Hussain S, Rehman W, et al.
    Bioorg Med Chem, 2014 Aug 1;22(15):4119-23.
    PMID: 24986232 DOI: 10.1016/j.bmc.2014.05.057
    A series of thiobarbituric acid derivatives 1-27 were synthesized and evaluated for their urease inhibitory potential. Exciting results were obtained from the screening of these compounds 1-27. Compounds 5, 7, 8, 11, 16, 17, 22, 23 and 24 showed excellent urease inhibition with IC50 values 18.1 ± 0.52, 16.0 ± 0.45, 16.0 ± 0.22, 14.3 ± 0.27, 6.7 ± 0.27, 10.6 ± 0.17, 19.2 ± 0.29, 18.2 ± 0.76 and 1.61 ± 0.18 μM, respectively, much better than the standard urease inhibitor thiourea (IC₅₀=21 ± 0.11 μM). Compound 3, 4, 10, and 26 exhibited comparable activities to the standard with IC₅₀ values 21.4 ± 1.04 and 21.5 ± 0.61 μM, 22.8 ± 0.32, 25.2 ± 0.63, respectively. However the remaining compounds also showed prominent inhibitory potential The structure-activity relationship was established for these compounds. This study identified a novel class of urease inhibitors. The structures of all compounds were confirmed through spectroscopic techniques such as EI-MS and (1)H NMR.
  6. Cytotoxicity and scanning electron microscopy study of gentamycin-coated HA effect on biofilm
    Au LF, Othman F, Mustaffa R, Vidyadaran S, Rahmat A, Besar I, et al.
    Med J Malaysia, 2008 Jul;63 Suppl A:16-7.
    PMID: 19024962
    Biofilms are adherent, multi-layered colonies of bacteria that are typically more resistant to the host immune response and routine antibiotic therapy. HA biomaterial comprises of a single-phased hydroxyapatite scaffold with interconnected pore structure. The device is designed as osteoconductive space filler to be gently packed into bony voids or gaps following tooth extraction or any surgical procedure. Gentamycin-coated biomaterial (locally made hydroxyapatite) was evaluated to reduce or eradicate the biofilm on the implant materials. The results indicated that the HA coated with gentamycin was biocompatible to human osteoblast cell line and the biofilm has been reduced after being treated with different concentrations of gentamycin-coated hydroxyapatite (HA).
  7. Fulltext Cryptanalysis and Improvement of "A Secure Password Authentication Mechanism for Seamless Handover in Proxy Mobile IPv6 Networks"
    Alizadeh M, Zamani M, Baharun S, Abdul Manaf A, Sakurai K, Anada H, et al.
    PLoS One, 2015;10(11):e0142716.
    PMID: 26580963 DOI: 10.1371/journal.pone.0142716
    Proxy Mobile IPv6 is a network-based localized mobility management protocol that supports mobility without mobile nodes' participation in mobility signaling. The details of user authentication procedure are not specified in this standard, hence, many authentication schemes have been proposed for this standard. In 2013, Chuang et al., proposed an authentication method for PMIPv6, called SPAM. However, Chuang et al.'s Scheme protects the network against some security attacks, but it is still vulnerable to impersonation and password guessing attacks. In addition, we discuss other security drawbacks such as lack of revocation procedure in case of loss or stolen device, and anonymity issues of the Chuang et al.'s scheme. We further propose an enhanced authentication method to mitigate the security issues of SPAM method and evaluate our scheme using BAN logic.
  8. Fulltext Tick fauna of Malaysian red jungle fowl (Gallus gallus) in Bangi, Malaysia
    Konto M, Fufa GI, Zakaria A, Tukur SM, Watanabe M, Ola-Fadunsin SD, et al.
    Vet World, 2015 Oct;8(10):1167-71.
    PMID: 27047012 DOI: 10.14202/vetworld.2015.1167-1171
    The red jungle fowl is generally considered as one of the endangered Asian wild Galleopheasants due to man-made encroachment of their habitats, coupled with the effect of disease and disease causing organisms like ticks and tick-borne infections. This study aimed to determine the tick fauna of the red jungle fowl and their predilection sites based on developmental stages.
  9. Mercury in dental amalgam: Are our health care workers at risk?
    Sahani M, Sulaiman NS, Tan BS, Yahya NA, Anual ZF, Mahiyuddin WR, et al.
    J Air Waste Manag Assoc, 2016 Nov;66(11):1077-1083.
    PMID: 27192328 DOI: 10.1080/10962247.2016.1188866
    Dental amalgam in fillings exposes workers to mercury. The exposure to mercury was investigated among 1871 dental health care workers. The aim of the study was to evaluate the risk of mercury exposure among dental compared to nondental health care workers and to determine other risk factors for mercury exposure. Respondents answered questionnaires to obtain demographic, personal, professional, and workplace information and were examined for their own amalgam fillings. Chronic mercury exposure was assessed through urinary mercury levels. In total, 1409 dental and 462 nondental health care workers participated in the study. Median urine mercury levels for dental and nondental health care workers were 2.75 μg/L (interquartile range [IQR] = 3.0175) and 2.66 μg/L (IQR = 3.04) respectively. For mercury exposure, there were no significant risk factor found among the workers involved within the dental care. The Mann-Whitney test showed that urine mercury levels were significantly different between respondents who eat seafood more than 5 times per week compared to those who eat it less frequently or not at all (p = 0.003). The urinary mercury levels indicated significant difference between dental workers in their practice using squeeze cloths (Mann-Whitney test, p = 0.03). Multiple logistic regression showed that only the usage of cosmetic products that might contain mercury was found to be significantly associated with the urinary mercury levels (odds ratio [OR] = 15.237; CI: 3.612-64.276). Therefore, mean urinary mercury levels of health care workers were low. Exposure to dental amalgam is not associated with high mercury exposure. However, usage of cosmetic products containing mercury and high seafood consumption may lead to the increase of exposure to mercury.

    IMPLICATIONS: Exposure to the high levels of mercury from dental amalgam can lead to serious health effects among the dental health care workers. Nationwide chronic mercury exposure among dental personnel was assessed through urinary mercury levels. Findings suggest low urinary mercury levels of these health care workers. Exposure to dental amalgam is not associated with high mercury exposure. However, the usage of cosmetic products containing mercury and high seafood consumption may lead to the increase of exposure to mercury.
  10. Fulltext Pre-grafting histological studies of skin grafts cryopreserved in α helix antarctic yeast oriented antifreeze peptide (Afp1m)
    Khan MS, Ibrahim SM, Adamu AA, Rahman MBA, Bakar MZA, Noordin MM, et al.
    Cryobiology, 2020 02 01;92:26-33.
    PMID: 31580830 DOI: 10.1016/j.cryobiol.2019.09.012
    A number of living creatures in the Antarctic region have developed characteristic adaptation of cold weather by producing antifreeze proteins (AFP). Antifreeze peptide (Afp1m) fragment have been designed in the sequence of strings from native proteins. The objectives of this study were to assess the properties of Afp1m to cryopreserve skin graft at the temperature of -10 °C and -20 °C and to assess sub-zero injuries in Afp1m cryopreserved skin graft using light microscopic techniques. In the present study, a process was developed to cryopreserve Sprague-Dawley (SD) rat skin grafts with antifreeze peptide, Afp1m, α-helix peptide fragment derived from Glaciozyma antractica yeast. Its viability assessed by different microscopic techniques. This study also described the damages caused by subzero temperatures (-10 and -20 °C) on tissue cryopreserved in different concentrations of Afp1m (0.5, 1, 2, 5 and 10 mg/mL) for 72 h. Histological scores of epidermis, dermis and hypodermis of cryopreserved skin grafts showed highly significant difference (p 
  11. Fulltext Effectiveness of the Laser Application in Temporomandibular Joint Disorder: A Systematic Review of 1172 Patients
    Zwiri A, Alrawashdeh MA, Khan M, Ahmad WMAW, Kassim NK, Ahmed Asif J, et al.
    Pain Res Manag, 2020;2020:5971032.
    PMID: 33005278 DOI: 10.1155/2020/5971032
    Objective: The aim of this systematic review was to evaluate the effectiveness of laser application in temporomandibular joint disorder.

    Methods: PubMed, SCOPUS, Science Direct, Web of Science, and Google Scholar electronic databases were searched systematically with restricting the languages to only English and year (January 2001 to March 2020), and studies were selected based on the inclusion criteria. Study quality and publication bias were assessed by using the Robvis, a software package of R statistical software.

    Results: This systematic review included 32 studies (1172 patients) based on the inclusion and exclusion criteria. Most of the studies reported significant reduction of pain by the use of the laser during TMD treatment. Two-thirds of the study (78.13%) found a better outcome comparing with conventional one. According to Robvis, 84.4% of the studies were high methodological studies with low risk of bias.

    Conclusion: TMD patients suffer with continuous pain for long time even after conventional treatment. Laser therapy shows a promising outcome of pain reduction for TMD patients. Therefore, laser therapy can be recommended for the TMD patients' better outcome. This trial is registered with PROSPERO (CRD42020177562).

  12. Fulltext Investigation on Hamburg Wheel-Tracking Device Stripping Performance Properties of Recycled Hot-Mix Asphalt Mixtures
    Rafiq W, Bin Napiah M, Hartadi Sutanto M, Salah Alaloul W, Nadia Binti Zabri Z, Imran Khan M, et al.
    Materials (Basel), 2020 Oct 22;13(21).
    PMID: 33105633 DOI: 10.3390/ma13214704
    Moisture damage in hot mix asphalt pavements is a periodic but persistent problem nowadays, even though laboratory testing is performed to identify different moisture-susceptible mixtures. In this study, a Hamburg Wheel Tracking device (HWTD) was used for rutting tests which were conducted on control and a high percentage of recycled asphalt pavement (RAP), i.e., 30%, 50% and 100% of virgin mixtures, under air dry and water-immersed conditions. Similarly, the extracted bitumen from RAP was tested for binder physical properties. Results showed that the asphalt mixtures containing RAP have less rut depth as compared to the control mix both in air dry and immersion conditions and hence showed better anti-rutting properties and moisture stability. Stripping performance of control and RAP containing mixtures was also checked, concluding that the RAP mixture was greatly dependent on the interaction between the binder (virgin plus aged) and aggregates.
  13. Fulltext Bioflocculants Produced by Bacterial Strains Isolated from Palm Oil Mill Effluent for Application in the Removal of Eriochrome Black T Dye from Water
    Abbas SZ, Yong YC, Ali Khan M, Siddiqui MR, Hakami AAH, Alshareef SA, et al.
    Polymers (Basel), 2020 Jul 13;12(7).
    PMID: 32668712 DOI: 10.3390/polym12071545
    Four strains of bioflocculant-producing bacteria were isolated from a palm oil mill effluent (POME). The four bacterial strains were identified as Pseudomonas alcaliphila (B1), Pseudomonas oleovorans (B2), Pseudomonas chengduensis (B3), and Bacillus nitratireducens (B4) by molecular identification. Among the four bacterial strains, Bacillus nitratireducens (B4) achieved the highest flocculating activity (49.15%) towards kaolin clay suspension after eight hours of cultivation time and was selected for further studies. The optimum conditions for Eriochrome Black T (EBT) flocculation regarding initial pH, type of cation, and B4 dosage were determined to be pH 2, Ca2⁺ cations, and a dosage of 250 mL/L of nutrient broth containing B4. Under these conditions, above 90% of EBT dye removal was attained. Fourier transform infrared spectroscopic (FT-IR) analysis of the bioflocculant revealed the presence of hydroxyl, alkyl, carboxyl, and amino groups. This bioflocculant was demonstrated to possess a good flocculating activity, being a promissory, low-cost, harmless, and environmentally friendly alternative for the treatment of effluents contaminated with dyes.
  14. Evaluation of bisindole as potent β-glucuronidase inhibitors: synthesis and in silico based studies
    Khan KM, Rahim F, Wadood A, Taha M, Khan M, Naureen S, et al.
    Bioorg Med Chem Lett, 2014 Apr 1;24(7):1825-9.
    PMID: 24602903 DOI: 10.1016/j.bmcl.2014.02.015
    Bisindole analogs 1-17 were synthesized and evaluated for their in vitro β-glucuronidase inhibitory potential. Out of seventeen compounds, the analog 1 (IC50=1.62±0.04 μM), 6 (IC50=1.86±0.05 μM), 10 (IC50=2.80±0.29 μM), 9 (IC50=3.10±0.28 μM), 14 (IC50=4.30±0.08 μM), 2 (IC50=18.40±0.09 μM), 19 (IC50=19.90±1.05 μM), 4 (IC50=20.90±0.62 μM), 7 (IC50=21.50±0.77 μM), and 3 (IC50=22.30±0.02 μM) showed superior β-glucuronidase inhibitory activity than the standard (d-saccharic acid 1,4-lactone, IC50=48.40±1.25 μM). In addition, molecular docking studies were performed to investigate the binding interactions of bisindole derivatives with the enzyme. This study has identified a new class of potent β-glucouronidase inhibitors.
  15. Fulltext Determination of Non-Recrystallization Temperature for Niobium Microalloyed Steel
    Akhtar MN, Khan M, Khan SA, Afzal A, Subbiah R, Ahmad SN, et al.
    Materials (Basel), 2021 May 18;14(10).
    PMID: 34070060 DOI: 10.3390/ma14102639
    In the present investigation, the non-recrystallization temperature (TNR) of niobium-microalloyed steel is determined to plan rolling schedules for obtaining the desired properties of steel. The value of TNR is based on both alloying elements and deformation parameters. In the literature, TNR equations have been developed and utilized. However, each equation has certain limitations which constrain its applicability. This study was completed using laboratory-grade low-carbon Nb-microalloyed steels designed to meet the API X-70 specification. Nb- microalloyed steel is processed by the melting and casting process, and the composition is found by optical emission spectroscopy (OES). Multiple-hit deformation tests were carried out on a Gleeble® 3500 system in the standard pocket-jaw configuration to determine TNR. Cuboidal specimens (10 (L) × 20 (W) × 20 (T) mm3) were taken for compression test (multiple-hit deformation tests) in gleeble. Microstructure evolutions were carried out by using OM (optical microscopy) and SEM (scanning electron microscopy). The value of TNR determined for 0.1 wt.% niobium bearing microalloyed steel is ~ 951 °C. Nb- microalloyed steel rolled at TNR produce partially recrystallized grain with ferrite nucleation. Hence, to verify the TNR value, a rolling process is applied with the finishing rolling temperature near TNR (~951 °C). The microstructure is also revealed in the pancake shape, which confirms TNR.
  16. Influence of Incorporated Barium Ion on the Physio-Chemical Properties of Zinc Oxide Nanodisks Synthesized via a Sonochemical Process
    Sagadevan S, Vennila S, Suraiya Begum SN, Wahab YA, Hamizi NAB, Marlinda AR, et al.
    J Nanosci Nanotechnol, 2020 09 01;20(9):5452-5457.
    PMID: 32331117 DOI: 10.1166/jnn.2020.17855
    Nanostructure materials are of interest in last few decades due to their unique size-dependent physio-chemical properties. In this paper, zinc oxide (ZnO) and barium doped ZnO nanodisks (NDs) were synthesized using sonochemical method and characterized by various techniques such as X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM), UV-vis absorption and dielectric measurements. The XRD and FTIR studies confirm the crystalline nature of ZnO NDs, and the average crystallite size was found to be ~25 nm for pure ZnO and ~22 nm for Ba doped ZnO NDs. SEM study confirmed the spherical shaped ZnO NDs with average sizes in the range of 20-30 nm. The maximum absorbance was obtained in the 200-500 nm regions with a prominent peak absorbance were observed by UV-vis spectra. The corresponding band gap for ZnO NDs and Ba doped ZnO NDs were calculated using Tauc's plot and was found to be 3.12 and 3.04, respectively. The conductivity and dielectric measurements as a function of frequency have been studied.
  17. Fulltext Histological and mechanical evaluation of antifreeze peptide (Afp1m) cryopreserved skin grafts post transplantation in a rat model
    Ibrahim SM, Kareem OH, Saffanah KM, Adamu AA, Khan MS, Rahman MBA, et al.
    Cryobiology, 2018 06;82:27-36.
    PMID: 29679551 DOI: 10.1016/j.cryobiol.2018.04.012
    The objective of this study was to evaluate the use of Afp1m as a cryopreservative agent for skin by examining the transplanted skin histological architecture and mechanical properties following subzero cryopreservation. Thirty four (34) rats with an average weight of 208 ± 31 g (mean ± SD), were used. Twenty four (n = 24) rats were equally divided into four groups: (i) immediate non-cryopreserved skin autografts (onto same site), (ii) immediate non-cryopreserved skin autografts (onto different sites), (iii) skin autografts cryopreserved with glycerol for 72 h and (iv) skin autografts cryopreserved with Afp1m for 72 h at -4 °C. Rounded shaped full-thickness 1.5-2.5 cm in diameter skin was excised from backs of rats for the autograft transplantation. Non-cryopreserved or cryopreserved auto skin graft were positioned onto the wound defects and stitched. Non-transplanted cryopreserved and non-cryopreserved skin strips from other ten rats (n = 10) were allowed for comparative biomechanical test. All skin grafts were subjected to histological and mechanical examinations at the end of day 21. Histological results revealed that tissue architecture especially the epidermal integrity and dermal-epidermal junction of the Afp1m cryopreserved skin grafts exhibited better histological appearance, good preservation of tissue architecture and structural integrity than glycerolized skin. However, there was no significant difference among these groups in other histological criteria. There were no significant differences among the 4 groups in skin graft mechanical properties namely maximum load. In conclusion, Afp1m were found to be able to preserve the microstructure as well as the viability and function of the skin destined for skin transplantation when was kept at -4 °C for 72 h.
  18. Giant vesicles (GV) in colloidal system under the optical polarization microscope (OPM)
    Khalid K, Noh MAM, Khan MN, Ishak R, Penney E, Chowdhury ZZ, et al.
    Micron, 2017 Sep;100:30-33.
    PMID: 28477556 DOI: 10.1016/j.micron.2017.04.010
    This paper discusses the unprecedented microscopic findings of micellar growth in colloidal system (CS) of catalyzed piperidinolysis of ionized phenyl salicylate (PS-). The giant vesicles (GV) was observed under the optical polarization microscope (OPM) at [NaX]=0.1M where X=3-isopropC6H4O-. The conditions were rationalized from pseudo-first-order rate constant, kobs of PS- of micellar phase at 31.1×10-3s-1 reported in previous publication. The overall diameter of GV (57.6μm) in CS (CTABr/NaX/H2O)-catalyzed piperidinolysis (where X=3-isopropC6H4O) of ionized phenyl salicylate were found as giant unilamellar vesicles (GUV) and giant multilamellar vesicles (GMV). The findings were also validated by means of rheological analysis.
  19. Flurbiprofen derivatives as novel α-amylase inhibitors: Biology-oriented drug synthesis (BIODS), in vitro, and in silico evaluation
    Khan M, Alam A, Khan KM, Salar U, Chigurupati S, Wadood A, et al.
    Bioorg Chem, 2018 12;81:157-167.
    PMID: 30125730 DOI: 10.1016/j.bioorg.2018.07.038
    Novel derivatives of flurbiprofen 1-18 including flurbiprofen hydrazide 1, substituted aroyl hydrazides 2-9, 2-mercapto oxadiazole derivative 10, phenacyl substituted 2-mercapto oxadiazole derivatives 11-15, and benzyl substituted 2-mercapto oxadiazole derivatives 16-18 were synthesized and characterized by EI-MS, 1H and 13C NMR spectroscopic techniques. All derivatives 1-18 were screened for α-amylase inhibitory activity and demonstrated a varying degree of potential ranging from IC50 = 1.04 ± 0.3 to 2.41 ± 0.09 µM as compared to the standard acarbose (IC50 = 0.9 ± 0.04 µM). Out of eighteen compounds, derivatives 2 (IC50 = 1.69 ± 0.1 µM), 3 (IC50 = 1.04 ± 0.3 µM), 9 (IC50 = 1.25 ± 1.05 µM), and 13 (IC50 = 1.6 ± 0.18 µM) found to be excellent inhibitors while rest of the compounds demonstrated comparable inhibition potential. A limited structure-activity relationship (SAR) was established by looking at the varying structural features of the library. In addition to that, in silico study was conducted to understand the binding interactions of the compounds (ligands) with the active site of α-amylase enzyme.
  20. Fulltext An IoMT-Enabled Smart Healthcare Model to Monitor Elderly People Using Machine Learning Technique
    Khan MF, Ghazal TM, Said RA, Fatima A, Abbas S, Khan MA, et al.
    Comput Intell Neurosci, 2021;2021:2487759.
    PMID: 34868288 DOI: 10.1155/2021/2487759
    The Internet of Medical Things (IoMT) enables digital devices to gather, infer, and broadcast health data via the cloud platform. The phenomenal growth of the IoMT is fueled by many factors, including the widespread and growing availability of wearables and the ever-decreasing cost of sensor-based technology. The cost of related healthcare will rise as the global population of elderly people grows in parallel with an overall life expectancy that demands affordable healthcare services, solutions, and developments. IoMT may bring revolution in the medical sciences in terms of the quality of healthcare of elderly people while entangled with machine learning (ML) algorithms. The effectiveness of the smart healthcare (SHC) model to monitor elderly people was observed by performing tests on IoMT datasets. For evaluation, the precision, recall, fscore, accuracy, and ROC values are computed. The authors also compare the results of the SHC model with different conventional popular ML techniques, e.g., support vector machine (SVM), K-nearest neighbor (KNN), and decision tree (DT), to analyze the effectiveness of the result.
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