Displaying publications 101 - 120 of 1034 in total

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  1. Edwin N
    Med J Malaysia, 1978 Dec;33(2):184-5.
    PMID: 755173
    Matched MeSH terms: Kidney Glomerulus/ultrastructure*
  2. Dutt AK
    Med J Malaya, 1969 Dec;24(2):161-3.
    PMID: 4244145
    Matched MeSH terms: Kidney Neoplasms*
  3. Jaddi NS, Abdullah S
    PLoS One, 2019;14(1):e0208308.
    PMID: 30608936 DOI: 10.1371/journal.pone.0208308
    Optimization of an artificial neural network model through the use of optimization algorithms is the common method employed to search for an optimum solution for a broad variety of real-world problems. One such optimization algorithm is the kidney-inspired algorithm (KA) which has recently been proposed in the literature. The algorithm mimics the four processes performed by the kidneys: filtration, reabsorption, secretion, and excretion. However, a human with reduced kidney function needs to undergo additional treatment to improve kidney performance. In the medical field, the glomerular filtration rate (GFR) test is used to check the health of kidneys. The test estimates the amount of blood that passes through the glomeruli each minute. In this paper, we mimic this kidney function test and the GFR result is used to select a suitable step to add to the basic KA process. This novel imitation is designed for both minimization and maximization problems. In the proposed method, depends on GFR test result which is less than 15 or falls between 15 and 60 or is more than 60 a particular action is performed. These additional processes are applied as required with the aim of improving exploration of the search space and increasing the likelihood of the KA finding the optimum solution. The proposed method is tested on test functions and its results are compared with those of the basic KA. Its performance on benchmark classification and time series prediction problems is also examined and compared with that of other available methods in the literature. In addition, the proposed method is applied to a real-world water quality prediction problem. The statistical analysis of all these applications showed that the proposed method had a ability to improve the optimization outcome.
    Matched MeSH terms: Kidney/physiology*
  4. Cheong I
    Family Practitioner, 1988;11:92-93.
    5% of hospital admissions in Malaysia each year consist of patients suffering from renal diseases; from these 600 new cases of chronic renal failure will be diagnosed. The common causes of chronic renal failure in Malaysia in order of frequency are chronic glomerulonephritis, diabetic nephropathy, obstructive uropathy, malignant hypertension, chronic pyelonephritis, SLE nephritis and gouty nephropathy. Prevention of renal diseases require good control of the underlying conditions.
    Matched MeSH terms: Kidney; Kidney Diseases
  5. Teh GC
    Urol Oncol, 2010 Nov-Dec;28(6):682-5.
    PMID: 21062652 DOI: 10.1016/j.urolonc.2010.03.017
    With maturing functional and oncologic outcomes data, open partial nephrectomy (OPN) has become the standard of care for T1a renal tumor. Laparoscopic approach can provide a speedier recovery with less blood loss and postoperative pain. Presuming adequate laparoscopic expertise, laparoscopic partial nephrectomy can provide equivalent oncologic outcome as for OPN albeit with higher urologic complications rate and longer warm ischemia time. With refinement of technique and use of robotic assistant, the shortcomings of laparoscopic approach can be further reduced. This article is a mini-review on the current status of laparoscopic approach to partial nephrectomy in the management of small renal mass.
    Matched MeSH terms: Kidney Neoplasms/surgery*
  6. Karmila AB, Yap YC, Appadurai M, Oh L, Fazarina M, Abd Ghani F, et al.
    Fetal Pediatr Pathol, 2021 Apr;40(2):113-120.
    PMID: 31707902 DOI: 10.1080/15513815.2019.1686788
    Introduction: Denys-Drash Syndrome (DDS) consists of a triad of pseudohermaphroditism, Wilms'tumor and nephropathy. This condition may manifest as a complete triad or in an incomplete form; with either one or a combination of the above features. The characteristic glomerular abnormality in DDS is diffuse mesangial sclerosis (DMS).Case report: We report two cases of DDS with focal membranoproliferative glomerulonephritis (MPGN). Both of our cases were males with ambiguous genitalia. They had a similar heterozygous germline mutation in exon 9 of WT1, c.1180C>T, p.R394W; a known mutation hotspot for DDS. Case 1 had nephropathy at the age of 4 years and Case 2 at 2.5 years with different rates of progression to end-stage renal failure. Conclusion: Our findings, in combination with other reports, illustrate the clinicopathological heterogeneity of DDS. There are no universal recommendations for optimal management of patients with DDS due to the inability to accurately predict affected individuals' progress.
    Matched MeSH terms: Kidney Diseases*
  7. Peter Gan Kim Soon, Sanjay Rampal, Lim Soo Kun, Tin Tin Su
    MyJurnal
    Introduction: Kidney transplantation (KT) is the preferred end-stage renal disease (ESRD) treatment because it pro-vides a better survival rate, quality of life as well as a cheaper alternative. However, Malaysia’s KT rates is consis-tently low considering that ESRD rates have been increasing exponentially. With only four hospitals performing KT, there’s a gap to indicate a lack of evaluation in KT system of Malaysia. Qualitative study was undertaken to explore and describe the barriers and solutions improve the rates and service of KT in Malaysia. Methods: Semi-structured interviews adopted as qualitative methodological approach to explore current KT policy and service in Malaysia be-tween March – May 2018 in Kuala Lumpur. Eight key-informants selected using stakeholder analysis and informed consent were obtained. Interviews were digitally audio-recorded, transcribed verbatim and analysed using thematic analysis. Results: Barriers and solutions of Malaysia’s KT are the results of complex interplay of personal, cultural, and environmental factors that can be categorized and described using the five levels of influence conceptualized by the socio-ecological model (SEM). Guidance for developing culturally appropriate and sensitive interventional strategies was elicited from the key informants’ experiences to improve KT rate and services in Malaysia. Conclusion:Malaysia is experiencing very low rate of KT compared to other countries. The use of SEM provided a framework to foster a better understanding of current practice, barriers and solutions to KT in Malaysia. Implications of these find-ings could prompt policy change for better KT service delivery model. Further stakeholder engagement and evalua-tion is required to align best practices to improve KT rates and service in Malaysia that is comparable to high-income countries.
    Matched MeSH terms: Kidney Failure, Chronic; Kidney Transplantation
  8. Lee KT, Kammal WSWA, Kong BH
    Saudi J Kidney Dis Transpl, 2021 2 11;31(6):1403-1406.
    PMID: 33565454 DOI: 10.4103/1319-2442.308356
    Anticoagulant-related nephropathy (ARN) is a recently described disease entity which is an underdiagnosed complication of anticoagulation. Despite widespread usage of anticoagulants, ARN is not commonly reported. We report a case of a 64-year old man with biopsy-proven ARN who presented with over anticoagulation and acute chronic kidney injury while on warfarin therapy for his left lower limb deep-vein thrombosis. Various investigations were performed and renal biopsy confirmed the diagnosis of anticoagulant-related nephropathy.
    Matched MeSH terms: Kidney; Acute Kidney Injury
  9. MUIR CS
    Med J Malaya, 1957 Mar;11(3):242-6.
    PMID: 13477002
    Matched MeSH terms: Kidney/blood supply*
  10. HUTTER FH
    Med J Malaya, 1953 Dec;8(2):186-91.
    PMID: 13164689
    Matched MeSH terms: Kidney/injuries*
  11. Nor Hanipah Z, Punchai S, Augustin T, Brethauer SA, Schauer PR, Aminian A
    Obes Surg, 2018 11;28(11):3580-3585.
    PMID: 30043143 DOI: 10.1007/s11695-018-3398-2
    BACKGROUND: Bariatric surgery can improve renal dysfunction associated with obesity and diabetes. However, acute kidney injury (AKI) can complicate the early postoperative course after bariatric surgery. The long-term consequences of early postoperative AKI on renal function are unknown.

    METHODS: Patient undergoing bariatric surgery from 2008 to 2015 who developed AKI within 60 days after surgery were studied. Patients on dialysis before surgery were excluded.

    RESULTS: Out of 4722 patients, 42 patients (0.9%) developed early postoperative AKI after bariatric surgery of whom five had chronic kidney disease (CKD) preoperatively including CKD stage 3 (n = 2), stage 4 (n = 2), and stage 5 (n = 1). Etiologies of AKI included prerenal in 37 and renal in 5 patients. Nine patients (21%) underwent hemodialysis in early postoperative period for AKI. The median duration of follow-up was 28 months (interquartile range, 4-59). Of the 40 patients eligible for follow-up, 36 patients (90%) returned to their baseline renal function. However, four patients (10%) had worsening of renal function at follow-up.

    CONCLUSIONS: The incidence of early postoperative AKI after bariatric surgery is about 1%. The most common causes of AKI after bariatric surgery are dehydration and infectious complications. In our series, 10% of patients who developed AKI in early postoperative period had worsening of renal function in long-term follow-up. In the absence of severe sepsis and severe underlying kidney dysfunction (CKD stages 4 and 5), full recovery is expected after postoperative AKI.

    Matched MeSH terms: Kidney/physiopathology
  12. Mac Guad, R., Zaharan, N.L., Wan Md Adnan, W.A.H., Gan, S.H., Chik, Z.,
    JUMMEC, 2019;22(1):20-26.
    MyJurnal
    Aim: A once-daily formulation of tacrolimus, Advagraf®, is increasingly being used in place of twice-daily
    tacrolimus, Prograf®, as a standard immunosuppressive agent for transplant patients. In this study, the
    clinical safety and efficacy of Advagraf® were compared with Prograf®, among multi-ethnic Malaysian renal
    transplanted population.

    Method: This retrospective study identified renal transplant patients who were converted from Prograf® to
    Advagraf® at the University Malaya Medical Centre (UMMC) (n=69). Clinical notes and laboratory records,
    including tacrolimus daily dose and trough levels, were obtained for one-year, pre-and post-conversion. Causality
    assessment of suspected adverse events were based on the WHO-Uppsala Monitoring Center criteria. Renal
    biopsy records were re-evaluated based on the updated Banff 2007 classification for biopsy-confirmed acute
    rejection (BPAR).

    Results: Following conversion to Advagraf®, the mean tacrolimus trough level and daily dose decreased
    significantly (p
    Matched MeSH terms: Kidney; Kidney Transplantation
  13. Onn LV, Bickle I, Chua HB, Telisinghe PU, Chong CF, Chong VH
    Malays Fam Physician, 2017;12(3):33-36.
    PMID: 29527279
    Urinary tract infection (UTI) is one of the most common presentations in general practice and, in most instances, occurs in a single episode and is easily treated with a course of anti-microbial therapy. In the case of recurrent urinary tract infections, it is important to consider evaluation for any underlying causes. We report the case of a 32 year old female who had recurrent UTIs; this was a case of recurrent UTI secondary to xanthogranulomatous pyelonephritis from renal stones with resultant reno-colic fistula formation.
    Matched MeSH terms: Kidney; Kidney Calculi
  14. Philip N, Lung Than LT, Shah AM, Yuhana MY, Sekawi Z, Neela VK
    BMC Infect Dis, 2021 Oct 19;21(1):1081.
    PMID: 34666707 DOI: 10.1186/s12879-021-06766-5
    BACKGROUND: Leptospirosis is a re-emerging disease with vast clinical presentations, that ranges from subclinical or mild to severe and fatal outcomes. Leptospirosis can be managed well if diagnosed earlier, however, similar clinical presentations by several other febrile illnesses or co-infections, and laboratory diagnostic challenges due to the biphasic nature of the illness, often result in mis- or underdiagnosis, thereby lead to severe illness. Identification of clinical predictors for the severe form of the disease plays a crucial role in reducing disease complication and mortality. Therefore, we aimed to determine the clinical predictors associated with severe illness among leptospirosis patients from Central Malaysia through a prospective multicenter observational study.

    METHODS: A prospective multicenter observational study was performed on patients admitted for clinically suspected leptospirosis. Three hospitals namely Hospital Serdang, Hospital Tengku Ampuan Rahimah and Hospital Teluk Intan were included in the study. Among a total of 165 clinically suspected leptospirosis patients, 83 confirmed cases were investigated for clinical predictors for severe illness. Qualitative variables were performed using χ2 and the relationship between mild and severe cases was evaluated using logistic regression. Multivariable logistic regression was used to predict the independent variable for severity.

    RESULTS: Among the 83 patients, 50 showed mild disease and 33 developed severe illness. The mean age of the patients was 41.92 ± 17.99 and most were males (n = 54, 65.06%). We identified mechanical ventilation, acute kidney injury, septic shock, creatinine level of > 1.13 mg/dL, urea > 7 mmol/L, alanine aminotransferase > 50 IU, aspartate aminotransferase > 50 IU, and platelet  50 IU and platelet 

    Matched MeSH terms: Acute Kidney Injury*
  15. Snelson M, R Muralitharan R, Dinakis E, Nakai M, Jama HA, Shihata WA, et al.
    Hypertension, 2021 06;77(6):e53-e55.
    PMID: 33866801 DOI: 10.1161/HYPERTENSIONAHA.121.17039
    Matched MeSH terms: Kidney/metabolism*
  16. Azrina Md Ralib, Mohd Basri Mat Nor
    MyJurnal
    Urine output provides a rapid estimate for kidney function, and its use has been incorporated in the diagnosis of acute kidney injury. However, not many studies had validated its use compared to the plasma creatinine. It has been showed that the ideal urine output threshold for prediction of death or the need for dialysis was 0.3 ml/kg/h. We aim to assess this threshold in our local ICU population.
    Matched MeSH terms: Kidney Function Tests; Acute Kidney Injury
  17. Cheng JY, Samudram H, Lee Lai Ling C, Nadarajan VS
    Transfus Med, 2022 Dec;32(6):484-491.
    PMID: 36239101 DOI: 10.1111/tme.12924
    OBJECTIVES: To evaluate the performance and utility of a time-temperature indicator (TTI) to determine the cumulative exposure time (CET) of red cell components (RCC) to temperatures above 10°C occurring within and outside the transfusion laboratory.

    BACKGROUND AND OBJECTIVES: Blood centres often use the '30 or 60-min rule' for accepting RCC exposed to room temperature (RT) back into inventory. Effective monitoring of these temperature deviations is however lacking.

    MATERIALS AND METHODS: A Timestrip PLUS® TP153 10°C (TS + 10) TTI was attached to RCC units after preparation of the unit in the blood bank or on issue to the ward, to track the CET > 10°C during laboratory processing and outside the transfusion laboratory.

    RESULTS: The mean CET of 153 RCC tracked within the laboratory was 56 min. Sixty-four (41.8%) and 34 (22.2%) of RCC had core temperature (CT) >10°C for more than 30 and 60 min, respectively. Among the 69 RCC that were returned unused, 27 (39.1%), 17 (24.6%) and 5 (7.2%) RCC units had CT >10°C for more than 30, 60 and 120 min respectively.

    CONCLUSION: A large proportion of RCC have CT >10°C exceeding 30 min during handling within the transfusion laboratory, as well as when RCC are returned unused from transfusion locations. Corrective measures should be implemented to better manage the cold chain to avoid undesirable consequences to blood transfusion. A temperature sensitive device that can also indicate CET can be employed to objectively monitor the period that RCC remained at a CT that exceeds 10°C.

    Matched MeSH terms: Kidney Neoplasms*
  18. Aizat Sabri I, Yusof MR, Jagwani AV, Fahmy O, Lee CK, Mg-Khairul Asri MA, et al.
    Urologiia, 2022 Dec.
    PMID: 36625624
    We present a rare case of leiomyoma of the urinary bladder that was diagnosed during pregnancy. The case of a 29-year-old woman primigravida at 13 weeks of pregnancy who presented with 6 months history of abdominal swelling which was gradually increasing in size. Computed tomography done revealed a large heterogenous mass(enhancing) with an area of non-enhancing (necrosis) suggestive of malignant ovarian tumor. The histological findings of the surgical specimen confirmed a leiomyoma of the urinary bladder. The clinical presentation, imaging findings, and management of this relatively rare benign tumor are discussed in this case report.
    Matched MeSH terms: Kidney Neoplasms*
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