Displaying publications 1 - 20 of 61 in total

Abstract:
Sort:
  1. Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review
    Che Hassan NKN, Taher M, Susanti D
    Biomed Pharmacother, 2018 Oct;106:1378-1389.
    PMID: 30119210 DOI: 10.1016/j.biopha.2018.07.087
    The purpose of this study was to determine the phytochemical constituents and pharmacological properties of Garcinia xanthochymus which is commonly known as gamboge, yellow mangosteen and false mangosteen. The phytochemicals constituents, pharmacological benefits and their mechanisms were previously presented in a number of studies including in vitro and in vivo studies from published books, journals and articles. The literature used in this review were published between 1970 and 2017 and were available from databases such as Google Scholar, ScienceDirect, Scopus, PubMed, ProQuest and others. The chemical structures in this paper are drawn using ChemBio Ultra 14.0. G. xanthocymus contains many phytochemicals that can be extracted from its constituent parts; the bark, fruits, leaves, roots, twigs and seeds. The predominant extracted phytochemicals are xanthones, benzophenones, flavonoids, depsidones and isocoumarins. These phytochemicals contribute to the pharmacological activities of this plant as an antioxidant, antidiabetic, and for having Nerve Growth Factor-potentiating, antimicrobial and cytotoxic activities. This species contains a broad range of phytochemicals with curative properties that can be greatly beneficial to man. Notably, this review focused on those studies of the pharmacological effects of this plant that were concentrated on by previous researchers. Thus, further study needs to be done on G. xanthocymus in order to unlock additional potential activities and to pinpoint the exact mechanisms of how these activities can be induced, leading to new drug discoveries which have fewer side effects.
  2. Drugs intervention study in COVID-19 management
    Taher M, Tik N, Susanti D
    Drug Metab Pers Ther, 2021 Apr 05.
    PMID: 33818031 DOI: 10.1515/dmdi-2020-0173
    By 9 February 2021, the Coronavirus has killed 2,336,650 people worldwide and it has been predicted that this number continues to increase in year 2021. The study aimed to identify therapeutic approaches and drugs that can potentially be used as interventions in Coronavirus 2019 (COVID-19) management. A systematic scoping review was conducted. Articles reporting clinical evidence of therapeutic management of COVID-19 were selected from three different research databases (Google Scholar, PubMed, and Science Direct). From the database search, 31 articles were selected based on the study inclusion and exclusion criteria. This review paper showed that remdesivir and ivermectin significantly reduced viral ribonucleic acid (RNA) activity. On the other hand, convalescent plasma (CP) significantly improved COVID-19 clinical symptoms. Additionally, the use of corticosteroid increased survival rates in COVID-19 patients with acute respiratory distress syndrome (ARDS). Findings also indicated that both hydroxychloroquine and favipiravir were effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, lopinavir-ritonavir combination was not effective against COVID-19. Finally, ribavirin, galidesivir, and sofosbuvir showed potential therapeutic benefit in treating COVID-19, but there is a lack of clinical evidence on their effectiveness against SARS-CoV-2. Remdesivir, ivermectin, favipiravir, hydroxychloroquine, dexamethasone, methylprednisolone, and CP are the therapeutic agents that can potentially be used in COVID-19 management.
  3. Fulltext Phytochemical screening and larvicidal activity of murraya koenigii leaves ethanolic extract against aedes aegypti
    Norazsida Binti Ramli, Nur Elia Amira Mohd Roslin, Deny Susanti
    International Journal of Allied Health Sciences, 2018;2(1):129-139.
    MyJurnal
    World Health Organization (WHO) estimated over 100 million dengue infections to happen annually worldwide involving more than 2.5 billion people. Temephos or abate is a larvicide that has been used in vector control to eradicate mosquito larvae. Though practically low risk, there had been resistance problem reported with continuous use. This study seeks to find an effective and safer alternative to abate by assessing the use of ethanolic extract of Murraya koenigii leaves as larvicidal agent against Aedes aegypti. M.koenigii leaves were macerated for 3 days with absolute ethanol and evaporated using rotary vapor to produce the crude extract. The crude extract was subjected to phytochemical screening using standard qualitative method. For bioassay, the crude
    extract underwent a serial dilution to produce 3 concentrations of 100 ppm (C1), 50 ppm (C2) and 10 ppm (C3) with abate and absolute ethanol as negative and positive control respectively. Bioassay for larvicidal effect was conducted in accordance to WHO standard method. Phytochemical screening of ethanolic extract of M. koenigii leaves revealed the presence of alkaloid, steroid and saponin. The bioassay shows that after 24 hours, the mortality rate of C1, C2 and C3 larvae were 100%, 38% and 0% and when further extended to 48 hours, the rate increased to 100% and 46% for C2 and C3 respectively. The LC50 and LC99 post 24 hours were 54.489 ppm and 93.961 ppm respectively whilst at post 48 hours, the LC50 and LC99 were 10.263 ppm and 16.176 ppm respectively. The results show that up to 48 hours duration of exposure, the mortality
    rate increase whilst the lethal concentration (LC50 and LC99) decreases. Upon examination on larvae deformities at post 24 and 48 hours, all test concentrations and negative control exhibit normal morphology. Positive control, however, exhibit deformities characterized by twisted and fragmented insides. When statistically analyzed, C1 larvicidal activity was proven comparable with abate at 24 hours while C2 needed 48 hours exposure to be on par. Based on the results, it could be argued that the ethanolic extract of M.koenigii leaves does hold promising value to be further developed as larvicidal.
  4. Fulltext Essential oils from the leaves of ocimum basilicum l., persicaria odorata and coriandrum sativum l. in Malaysia: antiurolithic activity study based on calcium oxalate crystallisation
    Nurul,Elyni,Mat,Shaari,, Deny,Susanti,, Shafida,Abd,Hamid,
    Science Letters, 2021;15(2):14-22.
    MyJurnal
    ABSTRACT
    Calcium oxalate is one of the most common components in urolithiasis. Its treatment includes the
    use of synthetic drugs, ultrasound and surgery. However, cheaper alternative treatment using
    herbal medicine with less adverse side effect is preferred. Essential oils from Thai basil (Ocimum
    bacilicum L.), Vietnamese coriander (Persicaria odorata) and Chinese parsley (Coriandum
    sativum L.) were extracted and investigated for antiurolithic activity based on calcium oxalate
    crystallisation. Most of the crystals formed in control sample were hexagonal calcium oxalate
    monohydrate with sizes ranging between 3 to 4 m. The size of the crystals was found to be slightly
    reduced in O. bacilicum oil (2-4 m) at high concentration with less aggregation of crystals.
    Samples with P. odorata oil gave smaller crystal size (3 m) mainly in dehydrate form and the oil
    was also found to inhibit the aggregation of the crystals at high concentration. C. sativum oil
    enhanced crystallisation (5-6 m) with increased concentration and showed high aggregation of
    the crystals. This preliminary study shows the therapeutic potential of these medicinal plants to be
    used in traditional anti-urolithic therapy.
  5. Fulltext Demographic factors, food security, health-related quality of life and body weight status of adolescents in rural area in Mentakab, Pahang, Malaysia
    Susanti Alie, Norhasmah Sulaiman, Fadilah Mohd Nor, Siti Farhana Mesbah
    Malays J Nutr, 2019;25(3):297-307.
    MyJurnal
    Introduction: Adequate, nutritive and safe foods are crucial for growth and healthy
    living. Adolescents are vulnerable to food insecurity. This study was aimed at
    determining the demographic factors, food security status, health-related quality of
    life (HRQOL) and body weight status of adolescents in Mentakab, Pahang, Malaysia.
    Methods: This study involved 160 households that comprised pairs of mothers and
    children aged 13-17 years. Face-to-face interviews were conducted with the mothers
    to assess their demographic and food security status (Radimer/Cornell Hunger and
    Food Insecurity Instrument). Meanwhile, the children answered a self-administered
    HRQOL questionnaire (Pediatric Quality of Life Inventory, PedsQL). Body weight
    and height were measured to obtain the body mass index (BMI). Results: About
    48.8% of the adolescents were from households with food insecurity. The number
    of school-going siblings, occupation status of mother, occupation status of father,
    household income and house ownership status were predictors of food security
    status (p
  6. Fulltext Isolation of a pigment-producing strain of Staphylococcus kloosii from the respiratory tree of Holothuria (Mertensiothuria) leucospilota (Brandt 1835) from Malaysian waters
    Kamarul Rahim Kamarudin, Nurziana Ngah, Haziyamin Abdul Hamid, Deny Susanti
    Trop Life Sci Res, 2013;24(1):85-100.
    MyJurnal
    Staphylococcus kloosii, an orange pigment-producing bacterium, was isolated from the respiratory tree of Holothuria (Mertensiothuria) leucospilota (Brandt 1835) from Teluk Nipah, Pangkor Island, Perak, Malaysia. This report is the first documentation of this Gram-positive strain, referred to as Strain 68 in Malaysia. A partial 16S ribosomal RNA gene sequence of the mesophilic strain has been registered with GenBank (National Center for Biotechnology Information, US National Library of Medicine) with accession number JX102547. Phylogenetic analysis using the neighbour-joining method further supported the identification of Strain 68 as S. kloosii. The circular strain produced orange pigments on tryptone glucose yeast extract agar (TGYEA) and in nutrient broth (NB) at approximately pH 7. The visible spectra of ethanolic and methanolic pigment extracts of the bacterial strain were considered identical with λmax at 426, 447 and 475 nm and λmax at 426, 445 and 473 nm, respectively. Both visible spectra resemble the visible spectra of lutein, which is a commercial carotenoid; however, further analyses are required to confirm the identity of this pigment. The methanolic extracts of the intracellular pigments comprised at least three pigment compounds: an orange pigment compound (major compound), a yellow pigment compound (the least polar) and a pink pigment compound (the most polar). These findings are the first documentation of the pigment composition of S. kloosii as no such record could be found to date.
  7. Fulltext Effects of Sargassum Oligocystum and Padina Australis extract on Adipogenesis and Adipolysis in 3T3-L1 Cells
    Jaswir, I., Ahmad, H., Susanti, D., Bakhtiar, M.T., Octavianti, F.
    International Food Research Journal, 2017;24(101):0-0.
    MyJurnal
    In recent years, the search for natural, safe and effective therapies for the management of obesity has become important. The present study investigated the potential of brown seaweeds Sargassum oligocystum and Padina australis from Malaysian waters as natural alternatives for the management of obesity. Both seaweeds were macerated using acetone at room temperature for ten hours. The S. oligocystum extracts (SE) and P. australis extracts (PE) were then applied to 3T3-L1 cells during the differentiation stage and during the mature stage of the adipocyte life cycle to assess the effects of extracts on adipogenesis and adipolysis. Application of SE at 12.5 and 50 µg/ml to the cells decreased adipogenesis by 71.7%, and 84.8%, respectively, while cells treated with 12.5 and 50 µg/ml PE showed 85.7%, and 89.0% adipogenesis respectively, compared to control. Application of SE and PE to mature lipid cells stimulated adipolysis and the release of glycerol into the culture media. Application of SE at 12.5 and 50 µg µg/ ml in the cell media induced glycerol release by up to 88.6 and 93.0%, respectively, while PE increased glycerol release up to 92.9 and 95.6% respectively, compared to isoproterenol. This study demonstrates the potential of whole brown seaweed extracts from S. oligocystum and P. australis collected from Malaysian waters as natural anti- obesity agents. Incorporation of the brown seaweed into the diet as a functional food will be useful for prevention and treatment of obesity.
  8. Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes
    Susanti D, Amiroudine MZ, Rezali MF, Taher M
    Nat Prod Res, 2013 Mar;27(4-5):417-24.
    PMID: 22988818 DOI: 10.1080/14786419.2012.725399
    Friedelin and lanosterol have been isolated from twigs of Garcinia prainiana. Their structures were elucidated by spectroscopic methods. The compounds were examined for their effects on 3T3-L1 adipocytes. In the MTT assay, it was found that the compounds had no cytotoxic effects up to 25 µM. Adipocyte differentiation analysis was carried out by Oil Red O staining method. In the presence of adipogenic cocktail (MDI), it was found that friedelin and lanosterol enhanced intracellular fat accumulation by 2.02 and 2.18-fold, respectively, compared with the vehicle-treated cells. Deoxyglucose uptake assay was used to examine the insulin sensitivity of adipocytes in the presence of the compounds. It was found that friedelin was able to stimulate glucose uptake up to 1.8-fold compared with insulin-treated cells. It was suggested that friedelin and lanosterol may be beneficial to mimic insulin action that would be useful in the treatment of diabetes type 2 patients.
  9. Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L
    Sirat HM, Susanti D, Ahmad F, Takayama H, Kitajima M
    J Nat Med, 2010 Oct;64(4):492-5.
    PMID: 20582481 DOI: 10.1007/s11418-010-0431-8
    Successive extraction of the dried leaves of Melastoma malabathricum, followed by purification using repeated chromatographic techniques, yielded six compounds, including two amides, auranamide and patriscabratine, a triterpene, alpha-amyrin, and three flavonoids, quercitrin, quercetin and kaempferol-3-O-(2'',6''-di-O-p-trans-coumaroyl)-beta-glucoside. Their structures were elucidated by spectroscopic means and also by direct comparison of their spectroscopic data with respective published data. These three phenolic constituents were found to be active as free radical scavengers, with quercetin being the strongest radical scavenger, having an IC(50) value of 0.69 microM in the UV method. Quercitrin and kaempferol-3-O-(2'',6''-di-O-p-trans-coumaroyl)-beta-glucoside showed moderate radical scavenging, with IC(50) values of 74.1 and 108.8 microM, respectively.
  10. Fulltext Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats
    Taher M, Tg Zakaria TM, Susanti D, Zakaria ZA
    BMC Complement Altern Med, 2016;16(1):135.
    PMID: 27208974 DOI: 10.1186/s12906-016-1118-9
    Various parts of Garcinia mangostana Linn., including its pericarp, have been traditionally used to treat a variety of ailments. In an attempt to establish its medicinal value, the present study was carried out to determine the hypoglycaemic potential of G. mangostana pericarp ethanolic extract (GME) using the streptozotocin-induced (STZ) diabetic rats.
  11. Fulltext Genus Ophiorrhiza: A Review of Its Distribution, Traditional Uses, Phytochemistry, Biological Activities and Propagation
    Taher M, Shaari SS, Susanti D, Arbain D, Zakaria ZA
    Molecules, 2020 Jun 04;25(11).
    PMID: 32512727 DOI: 10.3390/molecules25112611
    Almost 50 species of Ophiorrhiza plants were reviewed in this work and the main objective is to critically analyse their distribution, phytochemical content, biological activity, and propagation. Moreover, the information would be useful in promoting the relevant uses of the plant, especially in the medicinal fields based on in vitro and in vivo studies. To this end, scientific sources, including theses, PubMed, Google Scholar, International Islamic University Malaysia IIUM EBSCO, PubChem, and Elsevier, were accessed for publications regarding the Ophiorrhiza genus in this review. Scientific literature regarding the Ophiorrhiza plants revealed their wide distribution across Asia and the neighbouring countries, whereby they were utilised as traditional medicine to treat various diseases. In particular, various active compounds, such as alkaloids, flavonoids, and terpenoids, were reported in the plant. Furthermore, the Ophiorrhiza species showed highly diverse biological activities, such as anti-cancer, antiviral, antimicrobial, and more. The genus propagation reported could produce a high quality and quantity of potent anticancer compound, namely camptothecin (CPT). Hence, it is believed that the relevant uses of natural compounds present in the plants can replace the existing crop of synthetic anticancer drugs associated with a multitude of unbearable side effects. Additionally, more future studies on the Ophiorrhiza species should be undertaken to establish the links between its traditional uses, active compounds, and pharmacological activities reported.
  12. Isolation of a Pigment-producing Strain of Staphylococcus kloosii from the Respiratory Tree of Holothuria (Mertensiothuria) leucospilota () from Malaysian Waters
    Kamarudin KR, Ngah N, Hamid TH, Susanti D
    Trop Life Sci Res, 2013 Aug;24(1):85-100.
    PMID: 24575244
    Staphylococcus kloosii, an orange pigment-producing bacterium, was isolated from the respiratory tree of Holothuria (Mertensiothuria) leucospilota (Brandt 1835) from Teluk Nipah, Pangkor Island, Perak, Malaysia. This report is the first documentation of this Gram-positive strain, referred to as Strain 68 in Malaysia. A partial 16S ribosomal RNA gene sequence of the mesophilic strain has been registered with GenBank (National Center for Biotechnology Information, US National Library of Medicine) with accession number JX102547. Phylogenetic analysis using the neighbour-joining method further supported the identification of Strain 68 as S. kloosii. The circular strain produced orange pigments on tryptone glucose yeast extract agar (TGYEA) and in nutrient broth (NB) at approximately pH 7. The visible spectra of ethanolic and methanolic pigment extracts of the bacterial strain were considered identical with λmax at 426, 447 and 475 nm and λmax at 426, 445 and 473 nm, respectively. Both visible spectra resemble the visible spectra of lutein, which is a commercial carotenoid; however, further analyses are required to confirm the identity of this pigment. The methanolic extracts of the intracellular pigments comprised at least three pigment compounds: an orange pigment compound (major compound), a yellow pigment compound (the least polar) and a pink pigment compound (the most polar). These findings are the first documentation of the pigment composition of S. kloosii as no such record could be found to date.
  13. Biotransformation of sesquiterpenoids: a recent insight
    Aminudin NI, Ridzuan M, Susanti D, Zainal Abidin ZA
    J Asian Nat Prod Res, 2022 Feb;24(2):103-145.
    PMID: 33783284 DOI: 10.1080/10286020.2021.1906657
    Sesquiterpenoids have been identified as natural compounds showing remarkable biological activities found in medicinal plants. There is great interest in developing methods to obtain sesquiterpenoids derivatives and biotransformation is one of the alternative methods for structural modification of complex sesquiterpenes structures. Biotransformation is a great drug design tool offering high selectivity and green method. The present review describes a comprehensive summary of biotransformation products of sesquiterpenoids and its structural modification utilizing a variety of biocatalysts including microorganisms, plant tissue culture and enzymes. This review covers recent literatures from 2007 until 2020 and highlights the experimental conditions for each biotransformation process.
  14. Fulltext Clinacanthus nutans L Extracts Reduce the Serum Tumor Necrosis Factor-α, Malondialdehyde, and Interleukin-6 Levels and Improve the Langerhans Islet Area in Diabetic Rat Models
    Mustika A, Fatimah N, Safitri I, Susanti N, Noor NS
    Clin Med Insights Endocrinol Diabetes, 2023;16:11795514231196462.
    PMID: 37694133 DOI: 10.1177/11795514231196462
    BACKGROUND: Diabetes mellitus-induced hyperglycemia increases oxidative stress and inflammatory cytokine production, which play a significant role in the damage and apoptosis of pancreatic β cells. Therefore, the administration of medications that can reduce oxidative stress and inflammation plays an important role in diabetes treatment.

    OBJECTIVE: To probe the Clinacanthus nutans leaf extract effect on oxidative stress and inflammatory markers and the Langerhans islet area in diabetic rat models.

    DESIGN: An experimental laboratory in the animal model.

    METHODS: Twenty-five diabetic rat models were randomly assigned into 5 clusters. Clusters 1, 2, and 3 were administered with C. nutans leaf extract in aqueous suspension with vehicle 1% Na-CMC at 75 mg/kg body weight (BW), 150 mg/kg BW, and 300 mg/kg BW, respectively. Cluster 4 was diabetic control rats administered with metformin at a 21 mg/rat dose. Cluster 5 was a control diabetic rat only administered with 1% Na-CMC suspension. Treatment was administered orally for 14 days. On the 15th day, the rats were sacrificed to obtain blood samples and pancreatic tissues. Serum interleukin (IL)-6, malondialdehyde (MDA), and tumor necrosis factor (TNF-α) were measured using the enzyme-linked immunosorbent assay (ELISA) method. Histopathological examination was performed by counting the Langerhans islet areas.

    RESULTS: The average IL-6, MDA, and TNF-α levels declined in the cluster receiving C. nutans extract and were significantly different from the untreated cluster (P 

  15. Risk factors, logistic model, and vulnerability mapping of lumpy skin disease in livestock at the farm level in Indragiri Hulu District, Riau Province, Indonesia, in 2022
    Susanti T, Susetya H, Widayani P, Fitria Y, Pambudi GT
    Vet World, 2023 Oct;16(10):2071-2079.
    PMID: 38023269 DOI: 10.14202/vetworld.2023.2071-2079
    BACKGROUND AND AIM: Lumpy skin disease (LSD) is an emerging epidemic in livestock in Indonesia. It was first reported in the Indragiri Hulu Regency of Riau Province, which has more cases than the surrounding regencies. This study aimed to identify the risk factors and generate a logistic regression model and vulnerability map of LSD in the Indragiri Hulu Regency.

    MATERIALS AND METHODS: We used a structured questionnaire to interview the case and control farm owners to evaluate the risk factors. We evaluated 244 samples, consisting of 122 case and control farm samples each. At the cattle farm level, the risk factor data related to LSD were analyzed using descriptive statistics, bivariate analysis with Chi-square, and odds ratio, while the logistic model was derived using multivariate logistic regression analysis. Using variables, such as the number of cases and risk factor variables included in the model logistic, and the temperature, humidity, and rainfall data from the Meteorology, Climatology, and Geophysical Agency, we analyzed the vulnerability map of LSD in the regency using scoring, weighting, and overlay methods.

    RESULTS: Ten significant risk factors were associated with LSD occurrence. The LSD model obtained from the logistic regression analysis was LSD (Y) = -3.92095 + 1.13107 (number of cattle >3) + 1.50070 (grazing cattle together with other farmers' cattle) + 1.03500 (poor management of farm waste/dirt) + 2.49242 (presence of livestock collectors/traders near the farm location) + 1.40543 (introduction of new livestock) + 2.15196 (lack of vector control measures on the farm). The LSD vulnerability map indicated that the villages with high vulnerability levels were Rantau Bakung, Kuantan Babu, and Sungai Lala in the Rengat Barat, Rengat, and Sungai Lala subdistricts, respectively.

    CONCLUSION: We found 10 significant risk factors associated with LSD occurrence. The LSD model included the number of cattle (>3), cograzing with other farmers' cattle, poor management of farm waste/dirt, the presence of livestock collectors/traders near the farm, introduction of new livestock, and lack of vector control measures on the farm. The LSD vulnerability map indicated that villages with high vulnerability levels included Rantau Bakung in the Rengat Barat subdistrict, Kuantan Babu in the Rengat subdistrict, and Sungai Lala in the Sungai Lala subdistrict.

  16. Bibliometric insights into microalgae cultivation in wastewater: Trends and future prospects for biolipid production and environmental sustainability
    Purba LDA, Susanti H, Admirasari R, Praharyawan S, Taufikurahman, Iwamoto K
    J Environ Manage, 2024 Feb 14;352:120104.
    PMID: 38242026 DOI: 10.1016/j.jenvman.2024.120104
    Cultivation of microalgae in wastewater stream has been extensively reported, especially for simultaneous production of biolipid and wastewater treatment process. This study aimed to derive the research trend and focus on biolipid production from microalgae cultivated in wastewater by using bibliometric approach. The search strategy used in Scopus database resulted in 1339 research articles from 1990 to November 2023. Majority of publications (46%) were affiliated to China and India, showing their predominance in this field. Keywords related to the center of attention included biodiesel, biofuel, biomass and nutrient removal. Meanwhile, keyword with recent publication year, indicating the emerging research trends, revolved around the cultivation techniques and application of the system. Co-culture involving more than one microalgae species, bacteria and yeast showed promising results, while addition of nanoparticles was also found to be beneficial. Increasing exploration on the application of microalgae for treatment of saline wastewater was also reported and the carbon fixation mechanism by microalgae has been widely investigated to promote less environmental impact. Future research on these topics were suggested based on the findings of the bibliometric analyses.
  17. Fulltext Linum usitatissimum as an antimicrobial agent and a potential natural healer: A review
    Ummu Afifah Fadzir, Deny Susanti Darnis, Basma Ezzat Mustafa, Khairani Idah Mokhtar
    Archives of Orofacial Sciences, 2018;13(2):1-8.
    MyJurnal
    Linum usitatissimum commonly known as flaxseed is one of the oldest crops traditionally cultivated
    mainly for its oil purposes. Flaxseed is widely known for its rich source of nutritive and bioactive compounds. Recently, it has gained considerable interest due to the potential health benefits attributed to its component of metabolites, including its antimicrobial properties. Two main components of flaxseed, the unsaturated fatty acids and lignan, are suggested as the main metabolites that exhibit antimicrobial activities. This paper aims to give an overview on fatty acid and phenolic compound in flaxseed and their possible activities as antimicrobial agents.
  18. Fulltext Correlation between posture of job and musculoskeletal disorders complains among emergency departement nurses in General Hospital Distric of Tangerang City
    Siti Novy Romlah, Dewi Fitriani, Diah Susanti, Suganthi Lokonathan, Nisha Nambiar, Fana Devasa
    Malaysian Journal of Medicine and Health Sciences, 2020;16(110):119-124.
    MyJurnal
    Introduction: Based on World Health Organization (WHO) incidence of musculoskeletal diseases is estimated to reach 60.4% of all occupational illness. Research conducted in the UK and Hongkong on nurses reported lower stage pain of 38% and 39% and some neck pain 34% and 31% respectively. Musculoskeletal disorders are basically complaints of pain in parts of our body that include muscles, joints, ligaments, skeletons, and nerves. Work posture is one of the factors that influence the increase in musculoskeletal disorders. The objective of the research is to identify correlation between posture at job with musculoskeletal disorders complaints in the emergency department among nurses. Methods: The Method of the research was a quantitative research using cross sectional methods with Spear- men Rho correlation statistic test and the sampling method used total sampling. The sample size in this study was 40 nurses in the Emergency Department. Data collection was conducted by using Nordic Body Maps questionnaire to assess Musculoskeletal Disorder and posture of job assessment was carried out by Rapid Entire Body Assessment (REBA). Results: The results from this study showed that half of respondents (50%) were 26-30 years old, more than half (67%) of respondents are male, more than half (60%) have very high risks due to posture of job, and more than half (55%) had heavy complaints. Conclusion: There was a correlation between job posture with musculoskeletal disorders.
  19. Toxic effects of Sapium baccatum (Ludai) extract in rats
    Muhammad Taher, Nur Aizura Mat Alewi, Deny S, Zaitunnatakhin Zamli, Norazsida Ramli, Nurulwahida Saad
    Sains Malaysiana, 2012;41:1423-1429.
    Sapium baccatum is usually used as a timber in Malaysia. Its medicinal values are not well known and very little research has been conducted concerning the plant. Consequently, this study was conducted to observe toxicity effects of hexane extract of stem bark of S. baccatum. The toxicity effects were assessed through observation of physiological changes of the rats as well as through gross and histological examinations of its livers. The doses for the treated groups were given intraperitoneally for T2, T3 and T4 group which were given 100, 250 and 500 mg/kg, respectively. Meanwhile, control group (T1) was administered with 80% PEG 200 only. The observation period was 14 days. If the rat died, it was dissected and the liver was removed and examined. Some physiological effects observed include ataxia and hind-legs paralysis. The gross observations of the livers, growth of abnormal spots and connective tissues attachment to lobes of the livers were observed. The experiment was followed byhistopathological observation, which indicated the presence of abnormal hepatocytes with a distorted shape and undefined cell linings for T2 group. Results also indicated an increase in the distortion of hepatocytes, presence of massive cytoplasm and necrosis of hepatocytes for T3 and T4 groups. The results suggest that non polar extract of the stem bark of S. baccatum may promote toxic effects to the animals.
  20. Fulltext Screening of fatty acid compound of s. Polycystum for anti-cariogenic potential
    Nurul Najwa Zamimi, Noorhazayti Ab.Halim, Widya Lestari, Darnis, Deny Susanti, Wan Mohd Faizal Wan Ishak, Md Muziman Syah Md Mustafa
    International Medical Journal Malaysia, 2017;16(21):53-53.
    MyJurnal
    Dental caries is the most common yet preventable disease. Study found that seaweed
    exhibits anti-cariogenic properties. However, little attention have been given to the study on anticariogenic properties of seaweed and the bioactive compound that responsible for the anticariogenic activities have not adequately investigated. This study was conducted to evaluate the
    best extraction methods for S. polycystum and to determine the fatty acid compounds of S.
    polycystum that have anti-cariogenic potential against oral cariogenic bacteria. (Copied from article).
Related Terms
    Try searching for something
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links