Fulltext

Geographical distribution and risk association of human papillomavirus genotype 52-variant lineages

Zhang C 1 , Park JS 2 , Grce M 3 , Hibbitts S 4 , Palefsky JM 5 , Konno R 6 Show all authors , Smith-McCune KK 7 , Giovannelli L 8 , Chu TY 9 , Picconi MA 10 , Piña-Sánchez P 11 , Settheetham-Ishida W 12 , Coutlée F 13 , De Marco F 14 , Woo YL 15 , Ho WC 1 , Wong MC 16 , Chirenje MZ 17 , Magure T 17 , Moscicki AB 18 , Sabol I 3 , Fiander AN 4 , Chen Z 19 , Chan MC 1 , Cheung TH 20 , Burk RD 19 , Chan PK 1

Affiliations 

  • 1 Department of Microbiology
  • 2 Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea
  • 3 Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia
  • 4 HPV Research Group, Cancer and Genetics Research Institute, School of Medicine, Cardiff University, United Kingdom
  • 5 Department of Medicine
  • 6 Department of Obstetrics and Gynecology, Jichi Medical University, Saitama Medical Center, Japan
  • 7 Department of Obstetrics, Gynecology, and Reproductive Sciences Helen Diller Family Comprehensive Cancer Center
  • 8 Sezione di Microbiologia, Dipartimento di Scienze per la Promozione della Salute, Azienda Ospedaliera Universitaria Policlinico P. Giaccone, Palermo
  • 9 Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
  • 10 Servicio Virus Oncogénicos, Departamento Virología, Instituto Nacional de Enfermedades Infecciosas, ANLIS Carlos G. Malbrán, Buenos Aires, Argentina
  • 11 Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología, CMN Siglo XXI, México DF
  • 12 Department of Physiology, Faculty of Medicine, Khon Kaen University, Thailand
  • 13 Département de Microbiologie et Infectiologie, Centre Hospitalier de l'Université de Montréal, Canada
  • 14 Laboratory of Virology, Regina Elena National Cancer Institute, Rome, Italy
  • 15 Department of Obstetrics and Gynecology, Faculty of Medicine UM Cancer Research Institute, University of Malaya, Malaysia
  • 16 School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong
  • 17 Department of Obstetrics and Gynecology, University of Zimbabwe, Harare
  • 18 Helen Diller Family Comprehensive Cancer Center Department of Pediatrics, University of California-San Francisco
  • 19 Albert Einstein College of Medicine, Bronx, New York
  • 20 Department of Obstetrics and Gynecology, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
J Infect Dis, 2014 Nov 15;210(10):1600-4.
PMID: 24879800 DOI: 10.1093/infdis/jiu310

Abstract

Human papillomavirus (HPV) genotype 52 is commonly found in Asian cases of cervical cancer but is rare elsewhere. Analysis of 611 isolates collected worldwide revealed a remarkable geographical distribution, with lineage B predominating in Asia (89.0% vs 0%-5.5%; P(corrected) < .001), whereas lineage A predominated in Africa, the Americas, and Europe. We propose that the name "Asian lineage" be used to denote lineage B, to signify this feature. Preliminary analysis suggested a higher disease risk for lineage B, although ethnogeographical confounders could not be excluded. Further studies are warranted to verify whether the reported high attribution of disease to HPV52 in Asia is due to the high prevalence of lineage B.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications