Expanding arsenal against diabetes mellitus through nanoformulations loaded with glimepiride and simvastatin: A comparative study

Pandey NK 1 , Singh SK 2 , Kumar B 1 , Gulati M 1 , Vishwas S 1 , Khursheed R 1 Show all authors , Dureja H 3 , Chellappan DK 4 , Jha NK 5 , Sharma A 5 , Jha SK 5 , Gupta PK 6 , Gupta S 7 , Gupta G 8 , Prasher P 9 , Dua K 10

Affiliations 

  • 1 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India
  • 2 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India. singhsachin23@gmail.com
  • 3 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, Haryana, India
  • 4 School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia
  • 5 Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No.32-34 Knowledge Park III Greater Noida, Greater Noida, Uttar Pradesh, 201310, India
  • 6 Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Plot no. 32 - 34, Knowledge Park III, Greater Noida, 201310, Greater Noida, Uttar Pradesh, India
  • 7 Chitkara College of Pharmacy, Chitkara University, Punjab, 140401, India
  • 8 School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, 302017, Jaipur, India
  • 9 Department of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun, 248007, India
  • 10 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, Australia
Environ Sci Pollut Res Int, 2022 Jul;29(34):51976-51988.
PMID: 35254621 DOI: 10.1007/s11356-022-19371-z

Abstract

Type 2 diabetes mellitus is one of the most common and life-threatening diseases found across the globe. It occurs due to insulin resistance (IR). Major causes of IR include obesity, sedentary life style and hyperlipidemia. Glimepiride (GLM) is one of the most common oral sulphonyl ureas that is being used to treat diabetes and Simvastatin (SIM) is one of the most common statins that is used to treat hyperlipidaemia. However, both the drugs suffer from dissolution rate limited oral bioavailability. Hence, the aim of present study was to develop two different nanoformulations viz. nanosuspension and self-nanoemulsifying drug delivery systems (SNEDDS) and evaluate their potential in treating type 2 diabetes mellitus on streptozotocin (STZ) induced rats. In the present study two such drugs, GLM and SIM were co-formulated into nanosuspension (NS) as well as self-nanoemulsifying drug delivery systems (L-SNEDDS). Both formulations were spray dried for solidification and evaluated for their antidiabetic potential against high fat diet and streptozotocin induced rat model. The study showed significant (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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