Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014

Huang L 1 , Luo X 1 , Shao J 1 , Yan H 1 , Qiu Y 2 , Ke P 3 Show all authors , Zheng W 4 , Xu B 5 , Li W 6 , Sun D 2 , Cao D 7 , Chen C 8 , Zhuo F 9 , Lin X 10 , Tang F 11 , Bao B 12 , Zhou Y 13 , Zhang X 14 , Li H 15 , Li J 16 , Wan D 17 , Yang L 18 , Chen Y 19 , Zhong Q 20 , Gu X 21 , Liu J 22 , Huang L 23 , Xie R 24 , Li X 25 , Xu Y 1 , Luo Z 1 , Liao M 1 , Wang H 1 , Sun L 1 , Li H 1 , Lau GW 26 , Duan C 27

Affiliations 

  • 1 Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, People's Republic of China
  • 2 Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China
  • 3 Department of Clinical Laboratory, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, 510120, People's Republic of China
  • 4 Department of Clinical Laboratory, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China
  • 5 Department of Laboratory Medicine, Guangzhou First Municipal People's Hospital, Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong, 510180, People's Republic of China
  • 6 Department of Clinical Laboratory, The First People's Hospital of Foshan, Foshan, Guangdong, 528000, People's Republic of China
  • 7 Department of Laboratory Medicine, Guangdong No.2 Provincial People's Hospital, Guangzhou, Guangdong, 510317, People's Republic of China
  • 8 Department of Clinical Laboratory, Zhanjiang Center People's Hospital, Zhanjiang, Guangdong, 524037, People's Republic of China
  • 9 Luohu District Center for Disease Control and Prevention, Shenzhen, Guangdong, 518020, People's Republic of China
  • 10 Department of Clinical Laboratory, Shantou Central Hospital, Shantou, Guangdong, 515021, People's Republic of China
  • 11 Department of Clinical Laboratory, Zhuhai People's Hospital, Zhuhai Hospital of Jinan University, Zhuhai, Guangdong, 522000, China
  • 12 Department of Clinical Laboratory, 12th Guangzhou People's Hospital, Guangzhou, Guangdong, 510420, People's Republic of China
  • 13 Department of Clinical Laboratory, Guangzhou Xinhai Hospital, Guangzhou, Guangdong, 510300, People's Republic of China
  • 14 Department of Laboratory Diagnosis, Sun Yat-sen University Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, Guangdong, 528403, China
  • 15 Department of Clinical Laboratory, Zhaoqing People's Hospital, Zhaoqing, Guangdong, 526040, China
  • 16 Department of Clinical Laboratory, Qingyuan People's Hospital, Qingyuan, Guangdong, 511518, China
  • 17 Department of Clinical Laboratory, Dongguan People's Hospital, Dongguan, Guangdong, 523059, China
  • 18 Department of Clinical Laboratory, Chaozhou Central Hospital, Chaozhou, Guangdong, 521021, China
  • 19 Department of Clinical Laboratory, Maoming People's Hospital, Maoming, Guangdong, 525000, China
  • 20 Department of Clinical Laboratory, Jieyang People's Hospital, Jieyang, Guangdong, 522000, China
  • 21 Department of Clinical Laboratory, Heyuan People's Hospital, Heyuan, Guangdong, 517000, China
  • 22 Department of Clinical Laboratory, Huizhou First Municipal People's Hospital, Huizhou, Guangdong, 516003, China
  • 23 Department of Clinical Laboratory, Shaoguan People's Hospital, Shaoguan, Guangdong, 512000, China
  • 24 Department of Clinical Laboratory, Yunfu People's Hospital, Yunfu, Guangdong, 527300, China
  • 25 Department of Clinical Laboratory, Shanwei Yihui Foundation Hospital, Shanwei, Guangdong, 516600, China
  • 26 Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA
  • 27 Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, People's Republic of China. 1725012289@qq.com
Eur J Clin Microbiol Infect Dis, 2016 Feb;35(2):269-77.
PMID: 26700953 DOI: 10.1007/s10096-015-2540-5

Abstract

Dengue is a rapidly spreading mosquito-borne disease caused by the dengue virus (DENV) and has emerged as a severe public health problem around the world. Guangdong, one of the southern Chinese provinces, experienced a serious outbreak of dengue in 2014, which was believed to be the worst dengue epidemic in China over the last 20 years. To better understand the epidemic, we collected the epidemiological data of the outbreak and analyzed 14,594 clinically suspected dengue patients from 25 hospitals in Guangdong. Dengue cases were then laboratory-confirmed by the detection of DENV non-structural protein 1 (NS1) antigen and/or DENV RNA. Afterwards, clinical manifestations of dengue patients were analyzed and 93 laboratory-positive serum specimens were chosen for the DENV serotyping and molecular analysis. Our data showed that the 2014 dengue outbreak in Guangdong had spread to 20 cities and more than 45 thousand people suffered from dengue fever. Of 14,594 participants, 11,387 were definitively diagnosed. Most manifested with a typical non-severe clinical course, and 1.96 % developed to severe dengue. The strains isolated successfully from the serum samples were identified as DENV-1. Genetic analyses revealed that the strains were classified into genotypes I and V of DENV-1, and the dengue epidemic of Guangdong in 2014 was caused by indigenous cases and imported cases from the neighboring Southeast Asian countries of Malaysia and Singapore. Overall, our study is informative and significant to the 2014 dengue outbreak in Guangdong and will provide crucial implications for dengue prevention and control in China and elsewhere.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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