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Synthesis, characterization, and efficacy of antituberculosis isoniazid zinc aluminum-layered double hydroxide based nanocomposites

Saifullah B 1 , El Zowalaty ME 2 , Arulselvan P 3 , Fakurazi S 4 , Webster TJ 5 , Geilich BM 6 Show all authors , Hussein MZ 1

Affiliations 

  • 1 Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, (ITMA), Universiti Putra Malaysia, Serdang, Selangor, Malaysia
  • 2 School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, South Africa; Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience
  • 3 Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience
  • 4 Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience; Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
  • 5 Department of Chemical Engineering; Department of Bioengineering, Northeastern University, Boston, MA, USA; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia
  • 6 Department of Chemical Engineering; Department of Bioengineering, Northeastern University, Boston, MA, USA
Int J Nanomedicine, 2016;11:3225-37.
PMID: 27486322 DOI: 10.2147/IJN.S102406

Abstract

The chemotherapy for tuberculosis (TB) is complicated by its long-term treatment, its frequent drug dosing, and the adverse effects of anti-TB drugs. In this study, we have developed two nanocomposites (A and B) by intercalating the anti-TB drug isoniazid (INH) into Zn/Al-layered double hydroxides. The average size of the nanocomposites was found to bê164 nm. The efficacy of the Zn/Al-layered double hydroxides intercalated INH against Mycobacterium tuberculosis was increased by approximately three times more than free INH. The nanocomposites were also found to be active against Gram-positive and -negative bacteria. Compared to the free INH, the nanodelivery formulation was determined to be three times more biocompatible with human normal lung fibroblast MRC-5 cells and 3T3 fibroblast cells at a very high concentration of 50 µg/mL for up to 72 hours. The in vitro release of INH from the Zn/Al-layered double hydroxides was found to be sustained in human body-simulated buffer solutions of pH 4.8 and 7.4. This research is a step forward in making the TB chemotherapy patient friendly.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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