Affiliations 

  • 1 Head and Neck Pathology, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom. zuraiza@um.edu.my
  • 2 Department of Oral Medicine, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, SE1 9RT, United Kingdom
  • 3 School of Cancer and Pharmaceutical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom
  • 4 Head and Neck Pathology, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom
Sci Rep, 2018 10 26;8(1):15874.
PMID: 30367100 DOI: 10.1038/s41598-018-34165-5

Abstract

The value of image cytometry DNA ploidy analysis and dysplasia grading to predict malignant transformation has been determined in oral lesions considered to be at 'high' risk on the basis of clinical information and biopsy result. 10-year follow up data for 259 sequential patients with oral lesions clinically at 'high' risk of malignant transformation were matched to cancer registry and local pathology database records of malignant outcomes, ploidy result and histological dysplasia grade. In multivariate analysis (n = 228 patients), 24 developed carcinoma and of these, 14 prior biopsy samples were aneuploid. Aneuploidy was a significant predictor (hazard ratio 7.92; 95% CI 3.45, 18.17) compared with diploidy (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.