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Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Zamora-Ros R 1 , Alghamdi MA 2 , Cayssials V 2 , Franceschi S 3 , Almquist M 4 , Hennings J 5 Show all authors , Sandström M 6 , Tsilidis KK 7 , Weiderpass E 8 , Boutron-Ruault MC 9 , Hammer Bech B 10 , Overvad K 10 , Tjønneland A 11 , Petersen KEN 11 , Mancini FR 9 , Mahamat-Saleh Y 9 , Bonnet F 9 , Kühn T 12 , Fortner RT 12 , Boeing H 13 , Trichopoulou A 14 , Bamia C 14 , Martimianaki G 14 , Masala G 15 , Grioni S 16 , Panico S 17 , Tumino R 18 , Fasanelli F 19 , Skeie G 8 , Braaten T 8 , Lasheras C 20 , Salamanca-Fernández E 21 , Amiano P 22 , Chirlaque MD 22 , Barricarte A 22 , Manjer J 4 , Wallström P 23 , Bueno-de-Mesquita HB 24 , Peeters PH 25 , Khaw KT 26 , Wareham NJ 27 , Schmidt JA 28 , Aune D 24 , Byrnes G 29 , Scalbert A 29 , Agudo A 2 , Rinaldi S 29

Affiliations 

  • 1 Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Av Gran Via 199-203, 08908, L'Hospitalet de Llobregat, Spain. rzamora@idibell.cat
  • 2 Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Av Gran Via 199-203, 08908, L'Hospitalet de Llobregat, Spain
  • 3 Epidemiology Unit, Aviano Cancer Center, Milan, Italy
  • 4 Department of Surgery, Skåne University Hospital Malmö, Lund University, Lund, Sweden
  • 5 Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden
  • 6 Department for Radiation Sciences, Umeå University, Umeå, Sweden
  • 7 Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
  • 8 Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Tromsø, Tromsö, Norway
  • 9 CESP, Université Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France
  • 10 Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
  • 11 Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
  • 12 Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
  • 13 Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  • 14 Hellenic Health Foundation, Athens, Greece
  • 15 Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy
  • 16 Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • 17 Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
  • 18 Cancer Registry and Histopathology Unit, "Civic M.P. Arezzo" Hospital, ASP Ragusa, Ragusa, Italy
  • 19 Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and University of Turin, Turin, Italy
  • 20 Department of Functional Biology, Faculty of Medicine, University of Oviedo, Asturias, Spain
  • 21 Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.Granada, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain
  • 22 CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
  • 23 Nutrition Epidemiology Research Group, Department of Clinical Sciences, Lund University, Malmö, Sweden
  • 24 School of Public Health, Imperial College London, London, UK
  • 25 Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
  • 26 Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  • 27 MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK
  • 28 Cancer Epidemiology Unit, University of Oxford, Oxford, UK
  • 29 International Agency for Research on Cancer (IARC), Lyon, France
Eur J Nutr, 2019 Dec;58(8):3303-3312.
PMID: 30535794 DOI: 10.1007/s00394-018-1874-z

Abstract

PURPOSE: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study.

METHODS: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires.

RESULTS: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97-1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95-1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95-1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81-0.99), but this association was based on a sub-analysis with a small number of cancer cases.

CONCLUSIONS: In this large prospective study, coffee and tea consumptions were not associated with TC risk.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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