Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria

Seddiki LS 1 , Belboukhari N 2 , Ould El Hadj-Khelil A 3 , Sulaiman MR 4 , Sekkoum K 2 , Cheriti A 5

Affiliations 

  • 1 Bioactives Molecules & Chiral Separation Laboratory, University Tahri Mohamed, Bechar, 08000, Algeria; Inflammatory and Pain Group.Faculty of Bioscience and Health.University Putra Malaysia, 43400, Serdang, Selangore Darul Elhsan, Malaysia; Faculty of Science of Nature and Life, University of Kasdi Merbah, Ouargla, 30000, Algeria. Electronic address: seddiki.lamia@univ-bechar.dz
  • 2 Bioactives Molecules & Chiral Separation Laboratory, University Tahri Mohamed, Bechar, 08000, Algeria
  • 3 Bioactives Molecules & Chiral Separation Laboratory, University Tahri Mohamed, Bechar, 08000, Algeria; Faculty of Science of Nature and Life, University of Kasdi Merbah, Ouargla, 30000, Algeria
  • 4 Inflammatory and Pain Group.Faculty of Bioscience and Health.University Putra Malaysia, 43400, Serdang, Selangore Darul Elhsan, Malaysia
  • 5 Phytochemistry and Organic Synthesis Laboratory, University Tahri Mohamed, Bechar, 08000, Algeria
J Ethnopharmacol, 2021 Jul 15;275:114137.
PMID: 33915133 DOI: 10.1016/j.jep.2021.114137

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Launaea arborescens, its vernacular name is Mol-albina belonging to asteracaea family origin of the southwest of Algeria. This plant is used in folk medicines to treat gastroenteritis, diabetes, child aliment and other diseases; it is taken macerated or boiled.

AIM: This study aims to evaluate the anti-inflammation an analgesic activity of the aqueous extract of Launaea arborescens (AqELA) and its pathway of action.

METHODS: the investigation of anti-inflammatory and analgesic effects were done using formalin test, acetic acid test. For mechanism investigation, it was used hot plate test to induce opioid receptors, a histamine and serotonin test to induce edema paw, finally, for the TRPV1 receptor, it was used the capsaicin test.

RESULTS: The aqueous extract of Launaea arborescens showed a significant inhibition of abdominal writhing test 95% and 100% inhibition of licking paw using acid acetic test and formalin test respectively (EC: 47 mg/kg and 104 mg/kg). The analgesic effect of the aqueous extract of Launaea arborescens showed inhibition of sensation of pain after 120 min compared to morphine effect. The aqueous extract of Launaea arborescens reduced paw volume after 180 min and 120 min for histamine and serotonin respectively with dose-dependent. Concerning of TRPV1 receptors, the inhibition was showed at doses 100 mg and 300 mg.

CONCLUSION: Our results contribute towards validation of the traditional use of Launaea arborescens for inflammation ailment.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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