MyMedR

Displaying publications 2041 - 2060 of 5752 in total

Abstract:

Sort:

Fulltext Degradability enhancement of poly(lactic acid) by stearate-Zn(3)Al LDH nanolayers

Eili M, Shameli K, Ibrahim NA, Wan Yunus WMZ

Int J Mol Sci, 2012;13(7):7938-7951.
PMID: 22942682 DOI: 10.3390/ijms13077938

Recent environmental problems and societal concerns associated with the disposal of petroleum based plastics throughout the world have triggered renewed efforts to develop new biodegradable products compatible with our environment. This article describes the preparation, characterization and biodegradation study of poly(lactic acid)/layered double hydroxide (PLA/LDH) nanocomposites from PLA and stearate-Zn(3)Al LDH. A solution casting method was used to prepare PLA/stearate-Zn(3)Al LDH nanocomposites. The anionic clay Zn(3)Al LDH was firstly prepared by co-precipitation method from a nitrate salt solution at pH 7.0 and then modified by stearate anions through an ion exchange reaction. This modification increased the basal spacing of the synthetic clay from 8.83 Å to 40.10 Å. The morphology and properties of the prepared PLA/stearate-Zn(3)Al LDH nanocomposites were studied by X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM), thermogravimetric analysis (TGA), tensile tests as well as biodegradation studies. From the XRD analysis and TEM observation, the stearate-Zn(3)Al LDH lost its ordered stacking-structure and was greatly exfoliated in the PLA matrix. Tensile test results of PLA/stearate-Zn(3)Al LDH nanocomposites showed that the presence of around 1.0-3.0 wt % of the stearate-Zn(3)Al LDH in the PLA drastically improved its elongation at break. The biodegradation studies demonstrated a significant biodegradation rate improvement of PLA in the presence of stearate-Zn(3)Al LDH nanolayers. This effect can be caused by the catalytic role of the stearate groups in the biodegradation mechanism leading to much faster disintegration of nanocomposites than pure PLA.
Fulltext Artificial signal peptide prediction by a hidden markov model to improve protein secretion via Lactococcus lactis bacteria

Razmara J, Deris SB, Illias RB, Parvizpour S

Bioinformation, 2013;9(7):345-8.
PMID: 23750078 DOI: 10.6026/97320630009345

A hidden Markov model (HMM) has been utilized to predict and generate artificial secretory signal peptide sequences. The strength of signal peptides of proteins from different subcellular locations via Lactococcus lactis bacteria correlated with their HMM bit scores in the model. The results show that the HMM bit score +12 are determined as the threshold for discriminating secreteory signal sequences from the others. The model is used to generate artificial signal peptides with different bit scores for secretory proteins. The signal peptide with the maximum bit score strongly directs proteins secretion.
The implications of oral health education interventions in providing oral hygiene care for individuals with visual impairment: A systematic review

Khan AJ, Ahmad MS, Sabri BAM

Spec Care Dentist, 2024;44(3):659-675.
PMID: 37964052 DOI: 10.1111/scd.12940

INTRODUCTION: Individuals with visual impairment (VI) are doubly disadvantaged by their lack of vision and poor oral hygiene (OH). Implementing oral health education (OHE) interventions should be set as goals to improve OH status and prevent oral diseases. However, few studies have examined the specific teaching method of OH skills. This study aimed to identify the most influential OHE interventions enabling individuals with VI worldwide, especially those in countries where VI is most frequent, to maintain OH and improve knowledge and practices.
METHODS: An extensive literature review was conducted using the Preferred Reporting Items for Systematic Review and Meta-Analysis method. This study systematically searched electronic databases (PubMed via Medline, Cochrane, Embase, and Google Scholar) using expert-validated keywords, complemented by manual searches, to identify relevant articles published between April 1, 2012, and September 30, 2022.
RESULT: PICOS criteria were formulated for study inclusion. The bibliographical search identified 1485 articles, which were subsequently filtered. Two researchers separately screened the articles for eligibility and to reduce the risk of bias in the included studies. Finally, the most pertinent 21 articles were scrutinized for data synthesis.
CONCLUSION: Most studies identified combination methods, including customized educational demonstrations, as the best at improving OH status, knowledge, and practices. However, long-term, rigorously designed, and effective patient-centered communication trials, including those on innovative methods, are still needed for individuals with VI.
Variation in chemical property of asphalt immersed in varying aqueous solutions and its leachate property

Wu J, Wang H, Liu Q, Huang Z, Yusoff NIM

Sci Total Environ, 2024 Oct 01;945:174138.
PMID: 38906298 DOI: 10.1016/j.scitotenv.2024.174138

The pavement asphalt properties are susceptible to deterioration under environmental factors, and the deterioration product will affect its surrounding aqueous environment. For this reason, the idealized asphalt-aggregate mixture was treated with coupled temperature, ultraviolet and aqueous solutions based on self-made multifactorial coupled simulation device. Subsequently, the deterioration of asphalt chemical properties was analyzed by fourier transform infrared spectroscopy and saturate-aromatic-resin-asphaltene tests. Meanwhile, the effect of environmental factors on leachate properties was explored based on organic matter contents and chemical elements. Based on that, the grey correlation method was adopted to correlate asphalt chemical properties and leachate properties. The results clearly showed that environmental factors increased the sulfoxide and carbonyl group content of asphalt and transformed the chemical components within it into polar substances. The asphalt chemical properties were gradually improved when coupling ultraviolet with sodium carbonate, sodium chloride and distilled water sequentially. Compared to neutral solution, alkaline solution exacerbated the effect of asphalt precipitates on leachate properties. The environmental factors increased the organic matter contents and chemical elements of leachate with time. The interaction mechanism between asphalt and aqueous environment involved the deterioration of asphalt properties caused by the presence of water, as well as the release of precipitates from aged asphalt into surrounding aqueous environment.
Fulltext Molecular epidemiology of giardiasis among Orang Asli in Malaysia: application of the triosephosphate isomerase gene

Anuar TS, Azreen SN, Salleh FM, Moktar N

BMC Infect Dis, 2014 Feb 12;14:78.
PMID: 24520940 DOI: 10.1186/1471-2334-14-78

BACKGROUND: Giardia duodenalis is a flagellate parasite which has been considered the most common protozoa infecting human worldwide. Molecular characterization of G. duodenalis isolates have revealed the existence of eight groups (Assemblage A to H) which differ in their host distribution. Assemblages A and B are found in humans and in many other mammals.
METHODS: This cross-sectional study was conducted to identify assemblage's related risk factors of G. duodenalis among Orang Asli in Malaysia. Stool samples were collected from 611 individuals aged between 2 and 74 years old of whom 266 were males and 345 were females. Socioeconomic data were collected through a pre-tested questionnaire. All stool samples were processed with formalin-ether sedimentation and Wheatley's trichrome staining techniques for the primary identification of G. duodenalis. Molecular identification was carried out by the amplification of a triosephosphate isomerase gene using nested-PCR assay.
RESULTS: Sixty-two samples (10.2%) were identified as assemblage A and 36 (5.9%) were assemblage B. Risk analysis based on the detected assemblages using univariate and logistic regression analyses identified subjects who have close contact with household pets i.e. dogs and cats (OR = 2.60; 95% CI = 1.42, 4.78; P = 0.002) was found to be significant predictor for assemblage A. On the other hand, there were three significant risk factors caused by assemblage B: (i) children ≤15 years old (OR = 2.33; 95% CI = 1.11, 4.87; P = 0.025), (ii) consuming raw vegetables (OR = 2.82; 95% CI = 1.27, 6.26; P = 0.011) and (iii) the presence of other family members infected with giardiasis (OR = 6.31; 95% CI = 2.99, 13.31; P
Sc-CO2 extraction of fish and fish by-products in the production of fish oil and enzyme

Jamalluddin NA, Ismail N, Mutalib SRA, Sikin AM

Bioresour Bioprocess, 2022 Mar 12;9(1):21.
PMID: 38647764 DOI: 10.1186/s40643-022-00509-3

Supercritical carbon dioxide (Sc-CO2) is an alternative tool to extract lipid for the production of fish oil and enzyme from fish by-products (FBPs). In the application of Sc-CO2, this review covers sample preparation, lipid extraction operation, and characterization of fish oil and enzyme as final products. Generally, the fish samples with moisture content less than 20% and particle size less than 5 mm are considered before lipid extraction with Sc-CO2. Sc-CO2 parameters, such as pressure (P), temperature (T), extraction time (text), and flow rate (F), for simultaneous recovery of fish oil, protein, and enzyme were found to be less severe (P: 10.3-25 MPa; T: 25-45 °C, text: 20-150 min; F: 3-50 g/min) than the extraction of fish oil alone (P: 10-40 Mpa; T: 35-80 °C; text: 30-360 min; F: 1-3000 g/min). The enzyme from the Sc-CO2 defatted sample showed higher activity up to 45 U/mg due to lower denaturation of protein as compared to the organic solvent treated sample albeit both samples having similar pH (6-10) and temperature stability (20-60 °C). Overall, mild extraction of lipid from FBPs using Sc-CO2 is effective for the production of enzymes suitable in various industrial applications. Also, fish oil as a result of extraction can be produced as a health product with high polyunsaturated fatty acids (PUFAs) and low contamination of heavy metals.
Fulltext Recent Advances in Biocompatible Ionic Liquids in Drug Formulation and Delivery

Moshikur RM, Carrier RL, Moniruzzaman M, Goto M

Pharmaceutics, 2023 Apr 07;15(4).
PMID: 37111664 DOI: 10.3390/pharmaceutics15041179

The development of effective drug formulations and delivery systems for newly developed or marketed drug molecules remains a significant challenge. These drugs can exhibit polymorphic conversion, poor bioavailability, and systemic toxicity, and can be difficult to formulate with traditional organic solvents due to acute toxicity. Ionic liquids (ILs) are recognized as solvents that can improve the pharmacokinetic and pharmacodynamic properties of drugs. ILs can address the operational/functional challenges associated with traditional organic solvents. However, many ILs are non-biodegradable and inherently toxic, which is the most significant challenge in developing IL-based drug formulations and delivery systems. Biocompatible ILs comprising biocompatible cations and anions mainly derived from bio-renewable sources are considered a green alternative to both conventional ILs and organic/inorganic solvents. This review covers the technologies and strategies developed to design biocompatible ILs, focusing on the design of biocompatible IL-based drug formulations and delivery systems, and discusses the advantages of these ILs in pharmaceutical and biomedical applications. Furthermore, this review will provide guidance on transitioning to biocompatible ILs rather than commonly used toxic ILs and organic solvents in fields ranging from chemical synthesis to pharmaceutics.
Fulltext Critical Factors Influencing Decision to Adopt Human Resource Information System (HRIS) in Hospitals

Alam MG, Masum AK, Beh LS, Hong CS

PLoS One, 2016;11(8):e0160366.
PMID: 27494334 DOI: 10.1371/journal.pone.0160366

The aim of this research is to explore factors influencing the management decisions to adopt human resource information system (HRIS) in the hospital industry of Bangladesh-an emerging developing country. To understand this issue, this paper integrates two prominent adoption theories-Human-Organization-Technology fit (HOT-fit) model and Technology-Organization-Environment (TOE) framework. Thirteen factors under four dimensions were investigated to explore their influence on HRIS adoption decisions in hospitals. Employing non-probability sampling method, a total of 550 copies of structured questionnaires were distributed among HR executives of 92 private hospitals in Bangladesh. Among the respondents, usable questionnaires were 383 that suggesting a valid response rate of 69.63%. We classify the sample into 3 core groups based on the HRIS initial implementation, namely adopters, prospectors, and laggards. The obtained results specify 5 most critical factors i.e. IT infrastructure, top management support, IT capabilities of staff, perceived cost, and competitive pressure. Moreover, the most significant dimension is technological dimension followed by organisational, human, and environmental among the proposed 4 dimensions. Lastly, the study found existence of significant differences in all factors across different adopting groups. The study results also expose constructive proposals to researchers, hospitals, and the government to enhance the likelihood of adopting HRIS. The present study has important implications in understanding HRIS implementation in developing countries.
Case series of children with steroid-Induced glaucoma

Lam CS, Umi Kalthum MN, Norshamsiah MD, Bastion M

Malays Fam Physician, 2018;13(3):32-37.
PMID: 30800232

Steroid-induced glaucoma is the most serious complication of the injudicious use of steroids, particularly among children affected by allergic conjunctivitis. This condition is steroid-dependent, and children are commonly being prescribed topical anti-inflammatories, including topical steroids, by general practitioners. Furthermore, topical steroids are also available over the counter, and this availability contributes to overuse without proper monitoring by an ophthalmologist. We present a series of five cases illustrating the devastating effect of unmonitored, long-term use of steroids among children for vernal keratoconjunctivitis. The medications were prescribed initially by general ophthalmologists and were continually bought over the counter by parents. At the presentation to our center, these patients were already compromised visually, exhibiting glaucomatous optic disc changes and high intraocular pressure. The series highlights the optic nerve damage resulting in irreversible visual compromises among children on long-term, topical steroids and the importance of regular monitoring with a low threshold for ophthalmologist referral.
Multi-spectral and docking assessments to explore the combination of an antiviral drug, entecavir with bovine serum albumin

Murathan Z, Zahirul Kabir M, Seng J, Mohamad SB, Uslu B

Spectrochim Acta A Mol Biomol Spectrosc, 2024 Jul 06;322:124792.
PMID: 38981287 DOI: 10.1016/j.saa.2024.124792

Molecular interaction of entecavir (ETV) with the transport protein, albumin from bovine serum (BSA) was explored through multispectral and molecular docking approaches. The BSA fluorescence was appreciably quenched upon ETV binding and the quenching nature was static. The ETV-BSA complexation and the static quenching process were further reiterated using UV-visible absorption spectra. The binding constant (Ka) values of the complex were found as 1.47 × 104-4.0 × 103 M-1, which depicting a modarate binding strength in the ETV-BSA complexation. The experimental outcomes verified that the stable complexation was primarily influenced by hydrophobic interactions, hydrogen bonds and van der Waals forces. Synchronous and 3-D fluorescence spectral results demonstrated that ETV had significant impact on the hydrophobicity and polarity of the molecular environment near Tyr and Trp residues. Competitive site-markers displacement (with warfarin and ketoprofen) results discovered the suitable binding locus of ETV at site I in BSA. The molecular docking assessments also revealed that ETV formed hydrogen bonds and hydrophobic interactions with BSA, predominantly binding to site I (sub-domain IIA) of BSA.
Fulltext Agarwood Induction: Current Developments and Future Perspectives

Tan CS, Isa NM, Ismail I, Zainal Z

Front Plant Sci, 2019;10:122.
PMID: 30792732 DOI: 10.3389/fpls.2019.00122

Agarwood is a resinous part of the non-timber Aquilaria tree, which is a highly valuable product for medicine and fragrance purposes. To protect the endangered Aquilaria species, mass plantation of Aquilaria trees has become a sustainable way in Asian countries to obtain the highly valuable agarwood. As only physiologically triggered Aquilaria tree can produce agarwood, effective induction methods are long sought in the agarwood industry. In this paper, we attempt to provide an overview for the past efforts toward the understanding of agarwood formation, the evolvement of induction methods and their further development prospects by integrating it with high-throughput omics approaches.
Fulltext Fire risk assessments and fire protection measures for wind turbines: A review

You F, Shaik S, Rokonuzzaman M, Rahman KS, Tan WS

Heliyon, 2023 Sep;9(9):e19664.
PMID: 37809655 DOI: 10.1016/j.heliyon.2023.e19664

Wind turbine fires pose a significant global problem, leading to substantial financial losses. However, due to limited open discussions and lax regulations in the wind power industry, progress in addressing this issue has been hindered. This study aims to shed light on the fire risks associated with wind turbine nacelles and blades, while also exploring preventive measures and the latest fire detection and extinguishing technologies. The research conducted in this study involves a comprehensive investigation of various case studies, utilizing causal examination to identify common failure forms and their roles in fire incidents. Additionally, typical hazards, with a focus on fire incidents, in wind turbines are diagnosed. The primary causes of these fires were determined to be lightning strikes and hydraulic faults, often exacerbated by the presence of combustible materials. To conclude, the study includes a survey that encompasses education, knowledge analysis, and real-life accident experiences to assess fire risks and prevention measures in wind turbines. The participation of experts from wind farms, including those from the People's Republic of Bangladesh and other countries, adds valuable insights. The findings from this study serve as a crucial resource for enhancing safety standards and mitigating fire incidents within the wind power industry.
Fulltext Global economic crisis, energy use, CO2 emissions, and policy roadmap amid COVID-19

Aktar MA, Alam MM, Al-Amin AQ

Sustain Prod Consum, 2021 Apr;26:770-781.
PMID: 33786357 DOI: 10.1016/j.spc.2020.12.029

The COVID-19 pandemic has emerged as one of the deadliest infectious diseases on the planet. Millions of people and businesses have been placed in lockdown where the main aim is to stop the spread of the virus. As an extreme phenomenon, the lockdown has triggered a global economic shock at an alarming pace, conveying sharp recessions for many countries. In the meantime, the lockdowns caused by the COVID-19 pandemic have drastically changed energy consumption patterns and reduced CO2 emissions throughout the world. Recent data released by the International Monetary Fund and International Energy Agency for 2020 further forecast that emissions will rebound in 2021. Still, the full impact of COVID-19 in terms of how long the crisis will be and how the consumption pattern of energy and the associated levels of CO2 emissions will be affected are unclear. This review aims to steer policymakers and governments of nations toward a better direction by providing a broad and convincing overview on the observed and likely impacts of the pandemic of COVID-19 on the world economy, world energy demand, and world energy-related CO2 emissions that may well emerge in the next few years. Indeed, given that immediate policy responses are required with equal urgency to address three things-pandemic, economic downturn, and climate crisis. This study outlines policy suggestions that can be used during these uncertain times as a guide.
Migration of foreign body from postcricoid region to the subcutaneous tissue of the neck

Shaariyah MM, Salina H, Dipak B, Majid MN

Ann Saudi Med, 2010 9 25;30(6):475-7.
PMID: 20864791

Migration of a foreign body from the hypopharynx to the subcutaneous tissue of the neck is a rare event. We report a case of a 48-year-old male who accidentally swallowed a fish bone which was not identified intraoperatively. The patient then presented with migration of the bone to the soft tissue of the neck. We conclude that careful assessment of the patient with a foreign body in the throat is crucial to avoid fatal complications.
Fulltext A prospective, randomized clinical trial comparing bipolar plasma kinetic resection of the prostate versus conventional monopolar transurethral resection of the prostate in the treatment of benign prostatic hyperplasia

Kong CH, Ibrahim MF, Zainuddin ZM

Ann Saudi Med, 2009;29(6):429-32.
PMID: 19847078 DOI: 10.4103/0256-4947.57163

BACKGROUND AND OBJECTIVE: For treatment of benign prostatic hyperplasia (BPH), Plasma Kinetic loop Resection of the Prostate (PKRP) is an alternative to conventional monopolar transurethral resection of prostate (TURP). We compared outcomes with the two treatments in a randomized trial.
PATIENTS AND METHODS: Over a one-year period, we randomly assigned patients with an indication for surgery for BPH and who met inclusion criteria to treatment with either PKRP or TURP. We measured prostate volume by transrectal ultrasound, relief of bladder outlet obstruction, operative time, decline in serum sodium and hemoglobin, weight of resected prostatic chips, duration of catheterization and hospital stay. Patients were evaluated one month after discharge for obstructive symptoms. Complications were also recorded.
RESULTS: Of 102 patients enrolled, 51 underwent PKRP and 51 underwent TURP. Relief of obstructive symptoms and mean operative time showed no statistically significant difference. The PKRP group had a smaller decline in hemoglobin than the TURP group (0.6 g/dL vs 1.8 g/dL, P=.01), a lower reduction in serum sodium levels (1.03 mmol/L vs 5.01 mmol/L, P=.01), a shorter catheterization time (37.2 hours versus 57.7 hours, P=.03) and a shorter hospital stay (1.5 days versus 2.6 days, P=.02). One patient in the bipolar PKRP group needed recatheterization versus four patients in the TURP group.
CONCLUSION: PKRP reduces morbidity with an outcome similar to conventional monopolar TURP in the treatment of BPH.
Fulltext Standardized ethanol extract, essential oil and zerumbone of Zingiber zerumbet rhizome suppress phagocytic activity of human neutrophils

Akhtar NMY, Jantan I, Arshad L, Haque MA

BMC Complement Altern Med, 2019 Nov 21;19(1):331.
PMID: 31752812 DOI: 10.1186/s12906-019-2748-5

BACKGROUND: Zingiber zerumbet rhizome and its bioactive metabolites have previously been reported to exhibit innumerable pharmacological properties particularly anti-inflammatory activities. In the present study, the 80% ethanol extract, essential oil and zerumbone of Z. zerumbet rhizomes were explored for their in vitro immunosuppressive properties on chemotaxis, CD11b/CD18 expression, phagocytosis and chemiluminescence of isolated human polymorphonuclear neutrophils (PMNs).
METHODS: The extract was analyzed quantitatively by performing a validated reversed phase high performance liquid chromatography (RP-HPLC). Zerumbone was isolated by chromatographic technique while the essential oil was acquired through hydro-distillation of the rhizomes and further analyzed by gas chromatography (GC) and GC-MS. Chemotaxis assay was assessed by using a 24-well cell migration assay kit, while CD18 integrin expression and phagocytic engulfment were measured using flow cytometry. The reactive oxygen species (ROS) production was evaluated by applying lucigenin- and luminol-enhanced chemiluminescence assays.
RESULTS: Zerumbone was found to be the most abundant compound in the extract (242.73 mg/g) and the oil (58.44%). Among the samples tested, the oil revealed the highest inhibition on cell migration with an IC50 value of 3.24 μg/mL. The extract, oil and zerumbone showed moderate inhibition of CD18 integrin expression in a dose-dependent trend. Z. zerumbet extract showed the highest inhibitory effect on phagocytic engulfment with percentage of phagocytizing cells of 55.43% for PMN. Zerumbone exhibited strong inhibitory activity on oxidative burst of zymosan- and PMA-stimulated neutrophils. Zerumbone remarkably inhibited extracellular ROS production in PMNs with an IC50 value of 17.36 μM which was comparable to that of aspirin.
CONCLUSION: The strong inhibition on the phagocytosis of neutrophils by Z. zerumbet extract and its essential oil might be due the presence of its chemical components particularly zerumbone which was capable of impeding phagocytosis at different stages.
Fulltext Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects

Kamarudin MNA, Sarker MMR, Zhou JR, Parhar I

J Exp Clin Cancer Res, 2019 Dec 12;38(1):491.
PMID: 31831021 DOI: 10.1186/s13046-019-1495-2

Growing evidence showed the increased prevalence of cancer incidents, particularly colorectal cancer, among type 2 diabetic mellitus patients. Antidiabetic medications such as, insulin, sulfonylureas, dipeptyl peptidase (DPP) 4 inhibitors and glucose-dependent insulinotropic peptide (GLP-1) analogues increased the additional risk of different cancers to diabetic patients. Conversely, metformin has drawn attention among physicians and researchers since its use as antidiabetic drug exhibited beneficial effect in the prevention and treatment of cancer in diabetic patients as well as an independent anticancer drug. This review aims to provide the comprehensive information on the use of metformin at preclinical and clinical stages among colorectal cancer patients. We highlight the efficacy of metformin as an anti-proliferative, chemopreventive, apoptosis inducing agent, adjuvant, and radio-chemosensitizer in various colorectal cancer models. This multifarious effects of metformin is largely attributed to its capability in modulating upstream and downstream molecular targets involved in apoptosis, autophagy, cell cycle, oxidative stress, inflammation, metabolic homeostasis, and epigenetic regulation. Moreover, the review highlights metformin intake and colorectal cancer risk based on different clinical and epidemiologic results from different gender and specific population background among diabetic and non-diabetic patients. The improved understanding of metformin as a potential chemotherapeutic drug or as neo-adjuvant will provide better information for it to be used globally as an affordable, well-tolerated, and effective anticancer agent for colorectal cancer.
Fulltext Metasurface Loaded High Gain Antenna based Microwave Imaging using Iteratively Corrected Delay Multiply and Sum Algorithm

Islam MT, Samsuzzaman M, Kibria S, Misran N, Islam MT

Sci Rep, 2019 Nov 21;9(1):17317.
PMID: 31754189 DOI: 10.1038/s41598-019-53857-0

In this paper, the design consideration is investigated for a cylindrical system with low-cost and low-loss dielectric materials for the detection of breast tumor using iteratively corrected delay multiply and sum (IC- DMAS) algorithm. Anomaly in breast tissue is one of the most crucial health issues for women all over the world today. Emergency medical imaging diagnosis can be harmlessly managed by microwave-based analysis technology. Microwave Imaging (MI) has been proved to be a reliable health monitoring approach that can play a fundamental role in diagnosing anomaly in breast tissue. An array of 16 high gain microstrip antennas loaded by Index Near-Zero (INZ) metasurfaces (MS), having the impedance bandwidth of 8.5 GHz (2.70-11.20 GHz) are used as transceivers for the system. The MS is used to increase the electrical length of the signal that results in the gain enhancements. The antennas are mounted in a cylindrical arrangement on a mechanical rotating table along with a phantom mounting podium. A non-reflective positive control switching matrix is used for transmitting and receiving microwave signals. A set of lab-made realistic heterogeneous breast phantoms containing skin, fat, glandular, and tumor tissue dielectric properties in individual layers are used to verify the performance of the proposed technique. The control of the mechanical unit, data collection, and post-processing is conducted via MATLAB. The system can detect multiple tumor objects. The imaging results and numerical Signal to Mean Ratio (SMR) values of the experiment validate the system efficiency and performance that can be a viable solution for tumor detections.
Dietary supplementation of Polygonum chinense improves the immunity of Asian seabass, Lates calcarifer (Bloch, 1790) against Vibrio harveyi infection

Rashidah AR, Shariff M, Yusoff FM, Ismail IS

Fish Shellfish Immunol Rep, 2023 Dec 15;5:100118.
PMID: 37822351 DOI: 10.1016/j.fsirep.2023.100118

Aquaculture plays a significant role in the overall fish production in Malaysia, contributing a substantial quantity of food-fish amounting to roughly 573,683 tonnes with an estimated economic value of US$860 million in 2022. However, diseases have become a significant limitation for aquaculture production. Therefore, herbal immunostimulant has been considered a natural and practical approach of preventing disease infection in fish. The ability of Polygonum chinense extract (PCE) on haemato-biochemistry parameters, immunomodulatory properties, and disease resistance of Lates calcarifer (Asian seabass) under Vibrio harveyi challenge was evaluated in this study, with a focus on dose-response associations and variability over various exposure durations (0-, 7- and 14-day post-infection). A total of 480 Asian seabass (9.5 ± 0.2 g) were distributed in 12 aquaria and fed four diets supplemented with 0 (control), 2, 5 and 10 g/kg diet for 60 days before being challenged with V. harveyi. Dietary PCE significantly improved (P < 0.05) survival, with the dose of 10 g/kg showing the highest survival rate (90 %) when compared to the control (60 %). Additionally, hematological (red and white blood cell counts, hemoglobulin, packed cell volume, and mean corpuscular volume) and immunological (activities of lysozyme, phagocytic activity and respiratory burst, and serum total immunoglobulin) properties were significantly increased (P < 0.05) in comparison to the control group. In contrast, serum aspartate aminotransferase and alanine aminotransferase levels, as well as glucose level were significantly reduced (P < 0.05) in PCE-fed fish compared to the control group. Conclusively, the current study discovered that supplementing fish feed with P. chinense extract improves fish haemato-biochemical profile, immunocompetence and disease resistance to V. harveyi infection.
Fulltext Effect of Nigella sativa and its bioactive compound on type 2 epithelial to mesenchymal transition: a systematic review

Nordin A, Kamal H, Yazid MD, Saim A, Idrus R

BMC Complement Altern Med, 2019 Oct 30;19(1):290.
PMID: 31666058 DOI: 10.1186/s12906-019-2706-2

BACKGROUND: Nigella sativa or commonly known as black seed or black cumin is one of the most ubiquitous complementary medicine. Epithelial to mesenchymal transition (EMT) of type 2 is defined by the balance between wound healing and tissue fibrosis, which is dependent to the state of inflammation. This systematic review is conducted to provide an overview regarding the reported effect of Nigella sativa and its bioactive compound on the type 2 EMT.
METHODS: A search was done in EBSCOHOST, OVID and SCOPUS database to obtain potentially relevant articles that were published between 1823 and August 2019. This review includes studies that focus on the effect of Nigella sativa and its bioactive compound on the events related to type 2 EMT.
RESULTS: A total of 1393 research articles were found to be potentially related to the effect of Nigella sativa and its bioactive compound, thymoquinone on Type 2 EMT. After screening was done, 22 research articles met inclusion criteria and were included in this review. Majority of the studies, reported better wound healing rate or significant prevention of tissue inflammation and organ fibrosis following Nigella sativa or thymoquinone treatments. In terms of wound healing, studies included reported progression of EMT related pathological changes after treatment with Nigella sativa or thymoquinone. Alternatively, in terms of fibrosis and inflammation, studies included reported reversal of pathological changes related to EMT after treatment with Nigella sativa or thymoquinone.
CONCLUSION: Through this review, Nigella sativa and thymoquinone have been associated with events in Type 2 EMT. They have been shown to promote wound healing, attenuate tissue inflammation, and prevent organ fibrosis via regulation of the EMT process.

Filters

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links