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Chemopreventive efficacy of ginger (Zingiber officinale) in ethionine induced rat hepatocarcinogenesis

Yusof YA, Ahmad N, Das S, Sulaiman S, Murad NA

Afr J Tradit Complement Altern Med, 2008 Oct 25;6(1):87-93.
PMID: 20162046

Ginger (Zingiber officinale Rosco) is widely used in foods as a spice all around the world. It has been reported to have antioxidant and anticarcinogenic properties. We investigated the effect of ginger in ethionine induced rat hepatocarcinogenesis. Male Wistar rats were divided into 5 groups: group 1 and 2 served as controls and they received normal rat chow and olive oil respectively. Group 3 was fed with ginger oleoresin dissolved in olive oil at 100 mg/kg body wt. Group 4 was fed with choline deficient diet and 0.1% ethionine in drinking water (CDE diet), and group 5 received ginger with CDE diet. Blood samples were taken from the orbital sinus at 0 and 8 weeks of experiment for the determination of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase and lipid peroxidation end product, malondialdehyde (MDA). Rats were also killed at 8 weeks for the observation of liver tumor formation. CDE diet induced the formation of liver nodules in rats and increased SOD activity. However, it had no effect on catalase, GPx and MDA levels when compared to both controls at 8 weeks of experiment. When CDE rats were treated with ginger, the formation of liver tumour, SOD activity and MDA level reduced, catalase activity was increased but no change was observed for GPx activity when compared to CDE group. In conclusion, ginger supplementation suppressed liver carcinogenesis by scavenging the free radical formation, and by reducing lipid peroxidation.
Fulltext I Have Had Enough: When and How Customer Mistreatment Leads to Coworker Undermining

Huilian Z, Waqas M, Yahya F, Ahmad Qadri U, Zahid F

Front Psychol, 2022;13:629901.
PMID: 35615183 DOI: 10.3389/fpsyg.2022.629901

Service workers are more prone to experience customer mistreatment because of their frequent interactions with them. Hence, it compels them to the level where their performance is compromised. Employees who face customer mistreatment feel ill-treated and develop the desire for revenge. Based on the social exchange and displaced revenge perspective, this study examined the relationship between customer mistreatment and coworker undermining, and individual-level resource-based moderator service rule commitment (SRC) for this relationship. An analysis of time-lagged, dyadic data (81 supervisors and 410 subordinates) from the Chinese service industry confirmed that customer mistreatment significantly predicted coworker undermining. In addition, in support of the resource perspective, employees' SRC effectively restricts an effect of customer mistreatment on coworker undermining. Finally, this study contributes to the customer mistreatment and coworker undermining literature by highlighting their relationship. This study also shows the importance of SRC in restraining the adverse effects of customer mistreatment.
Fulltext Not by the light of the moon: Investigating circadian rhythms and environmental predictors of calling in Bornean great argus

Clink DJ, Groves T, Ahmad AH, Klinck H

PLoS One, 2021;16(2):e0246564.
PMID: 33592004 DOI: 10.1371/journal.pone.0246564

Great argus pheasants are known for their elaborate visual mating displays, but relatively little is known about their general ecology. The use of passive acoustic monitoring-which relies on long-term autonomous recorders-can provide insight into the behavior of visually cryptic, yet vocal species such as the great argus. Here we report the results of an analysis of vocal behavior of the Bornean great argus (Argusianus argus grayi) in Sabah, Malaysia, using data collected with 11 autonomous recording units. Great argus regularly emitted two call types, the long call and the short call, and we found that although both call types were emitted throughout the day, the short calls were more likely to occur during the morning hours (06:00-12:00LT). Great argus were less likely to call if there was rain, irrespective of the time of day. A substantial portion of calls at our site (~20%) were emitted between the hours of 18:00-06:00LT. We found that for nighttime calls, calling activity increased during new moon periods and decreased during periods of rain. We attribute the negative influence of rain on calling to increased energetic costs of thermoregulation during wet periods, and propose that the influence of the lunar cycle may be related to increased predation risk during periods with high levels of moonlight. Little is known about the behavioral ecology of great argus on Borneo, so it is difficult to know if the results we report are typical, or if we would see differences in calling activity patterns depending on breeding season or changes in food availability. We advocate for future studies of great argus pheasant populations using paired camera and acoustic recorders, which can provide further insight into the behavior of this cryptic species.
Fulltext Enhancing drilling mud performance through CMITS-modified formulations: rheological insights and performance optimization

Ali I, Ahmad M, Ridha S, Iferobia CC, Lashari N

RSC Adv, 2023 Nov 07;13(47):32904-32917.
PMID: 38025871 DOI: 10.1039/d3ra06008j

In the context of deep well drilling, the addition of functionalized additives into mud systems becomes imperative due to the adverse impact of elevated borehole temperatures and salts on conventional additives, causing them to compromise their intrinsic functionalities. Numerous biomaterials have undergone modifications and have been evaluated in drilling muds. However, the addition of dually modified tapioca starch in bentonite-free mud systems remains a notable gap within the existing literature. This study aims to examine the performance of dually modified carboxymethyl irradiated tapioca starch (CMITS) under high temperature and salt-containing conditions employing central composite design approach; the study evaluates the modified starch's impact on mud rheology, thermal stability, and salt resistance. The findings indicated that higher DS (0.66) and CMITS concentrations (8 ppb) improved plastic viscosity (PV), yield point (YP) and gel strength (GS), while increased salt and temperature decreased it, demonstrating the complex interplay of these factors on mud rheology. The developed empirical models suggested that DS 0.66 starch addition enhanced rheology, especially at elevated temperatures, demonstrating improved borehole cleaning potential, supported by quadratic model performance indicators in line with American Petroleum Institute (API) ranges. The optimized samples showed a non-Newtonian behavior, and Power-law model fitting yields promising results for improved cuttings transportation with starch additives.
Fulltext Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease

Shaikh A, Ahmad F, Teoh SL, Kumar J, Yahaya MF

Front Cell Neurosci, 2023;17:1292858.
PMID: 38026688 DOI: 10.3389/fncel.2023.1292858

Alzheimer's disease (AD) is characterized by the pathologic deposition of amyloid and neurofibrillary tangles in the brain, leading to neuronal damage and defective synapses. These changes manifest as abnormalities in cognition and behavior. The functional deficits are also attributed to abnormalities in multiple neurotransmitter systems contributing to neuronal dysfunction. One such important system is the dopaminergic system. It plays a crucial role in modulating movement, cognition, and behavior while connecting various brain areas and influencing other neurotransmitter systems, making it relevant in neurodegenerative disorders like AD and Parkinson's disease (PD). Considering its significance, the dopaminergic system has emerged as a promising target for alleviating movement and cognitive deficits in PD and AD, respectively. Extensive research has been conducted on dopaminergic neurons, receptors, and dopamine levels as critical factors in cognition and memory in AD. However, the exact nature of movement abnormalities and other features of extrapyramidal symptoms are not fully understood yet in AD. Recently, a previously overlooked element of the dopaminergic system, the dopamine transporter, has shown significant promise as a more effective target for enhancing cognition while addressing dopaminergic system dysfunction in AD.
Nutritional value and therapeutic potential of Moringa oleifera: a short overview of current research

Bibi N, Rahman N, Ali MQ, Ahmad N, Sarwar F

Nat Prod Res, 2023 Dec 03.
PMID: 38043118 DOI: 10.1080/14786419.2023.2284862

A member of the Moringaceae family, Moringa Oleifera Lam is a perennial deciduous tropical tree known as the 'Miracle Tree' for its medicinal and nutritional benefits. Food and nutrition are crucial aspects of the development and maintenance of healthy health. Moringa oleifera is a multi-purpose herbal bush that is used as both human food and a medical alternative all over the world. Various parts of the tree are used to treat chronic diseases such as hypertension, heart disease, inflammation, oxidative stress, diabetes, and cancer. Moringa is an excellent source of essential nutrients and has been found to have a significant impact on improving nutritional deficiencies in populations with limited access to food. Moringa oleifera contains essential amino acids, carotenoids, minerals, fats, carbohydrates, proteins, phytochemicals, vitamins, and fibre. Moringa offers nutritional and economic advantages, medicinal and therapeutic uses, and future biological potential for human well-being.
Fulltext Green biosynthesis and characterization of magnetic iron oxide (Fe₃O₄) nanoparticles using seaweed (Sargassum muticum) aqueous extract

Mahdavi M, Namvar F, Ahmad MB, Mohamad R

Molecules, 2013 May 21;18(5):5954-64.
PMID: 23698048 DOI: 10.3390/molecules18055954

The synthesis of nanoparticles has become a matter of great interest in recent times due to their various advantageous properties and applications in a variety of fields. The exploitation of different plant materials for the biosynthesis of nanoparticles is considered a green technology because it does not involve any harmful chemicals. In this study, iron oxide nanoparticles (Fe3O4-NPs) were synthesized using a rapid, single step and completely green biosynthetic method by reduction of ferric chloride solution with brown seaweed (BS, Sargassum muticum) water extract containing sulphated polysaccharides as a main factor which acts as reducing agent and efficient stabilizer. The structural and properties of the Fe3O4-NPs were investigated by X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray fluorescence spectrometry (EDXRF), vibrating sample magnetometry (VSM) and transmission electron microscopy. The average particle diameter as determined by TEM was found to be 18 ± 4 nm. X-ray diffraction showed that the nanoparticles are crystalline in nature, with a cubic shape. The nanoparticles synthesized through this biosynthesis method can potentially useful in various applications.
Fulltext Constipation: A Pristine Universal Pediatric Health Delinquent

Chowdhury K, Sinha S, Kumar S, Haque M, Ahmad R

Cureus, 2024 Jan;16(1):e52551.
PMID: 38249647 DOI: 10.7759/cureus.52551

Constipation suffered by children is a global public health problem. Functional constipation (FC) brings about deteriorating effects in the children's lives who suffer from it. The risk factors for the development of constipation include the consumption of a diet low in fiber and high in calories (such as the consumption of fast food), a sedentary lifestyle with a lack of exercise, a family history of constipation, and emotional and psychological stress endured by children in their families. It is one of the most common causes of stomachaches in children. FC may lead to fecal incontinence (FI), anal fissures, recurrent urinary tract infections (RUTI), and enuresis in children. Severe constipation may result in stool becoming rock-hard and inflexible in the rectum, which is clinically identified as fecal impaction. It is imperative to perform clinical evaluation and treatment, including pharmacological (the use of stimulant and osmotic laxatives) and non-pharmacological (education, changes in diet, intervention to promote positive behavior and address any emotional issues, toilet training, and physiotherapy for the pelvic floor) interventions. In the case of refractory patients, neuromodulation, the irrigation of the anal canal, and surgical management may be needed. It is essential to lead a healthy, stress-free lifestyle with plenty of exercise and a balanced diet rich in fiber (such as fruits and vegetables) so children can have regular bowel habits and thrive.
Bicornuate bicollis uterus with right cervical stenosis and ipsilateral renal agenesis

Nik Mhd Nor NS, Ahmad Khairuddin SND, Ramli R

BMJ Case Rep, 2024 Jan 09;17(1).
PMID: 38199665 DOI: 10.1136/bcr-2023-259175
Fulltext Run! This road has no ending! A systematic review of PLS-SEM application in strategic management research among developing nations

Shela V, Ramayah T, Aravindan KL, Ahmad NH, Alzahrani AI

Heliyon, 2023 Dec;9(12):e22476.
PMID: 38125546 DOI: 10.1016/j.heliyon.2023.e22476

Partial least squares structural equation modelling (PLS-SEM) is emerging as a prominent methodological tool in strategic management research. Although it offers various advancements to stay relevant with growing research needs, the pace of PLS-SEM adoption may differ in different parts of the world. In this paper, we conducted a systematic review using the PRISMA framework and extracted from the top-ranking strategic management journals 120 articles published between 2011 and 2022 that presented a microscopic view on developing nations. Our findings reveal that despite the astounding methodological solutions offered by PLS-SEM, the studies from developing nations are still trailing behind developed nations in terms of fully exploiting the advancements of PLS-SEM to provide substantial insights to strategic management literature. This review identifies discrepancies in the current application of the method, discusses the most recent advancements and provides the best practices, standard guidelines and recommendations for the best use of PLS-SEM in strategic management research.
Modulating of microencapsulated virgin coconut oil-based creamer

Mohammed NK, Ahmad NH, Muhialdin BJ, Meor Hussin AS

J Food Sci Technol, 2024 Mar;61(3):528-538.
PMID: 38327854 DOI: 10.1007/s13197-023-05860-7

This work aims to produce a virgin coconut oil (VCO) creamer through two drying stages; spray drying followed by fluidised bed drying, and to examine its antioxidant properties and oxidative stability during different storage conditions. Evaluation of the physicochemical properties of spray dry VCO and oxidative stability of the VCO creamer were performed using peroxide value (PV), antioxidant activity (DPPH), and total phenolic content (TPC) at 25, 4, and 25 °C, respectively, for 8 weeks. Agglomeration process has improved the agglomerated VCO creamer's properties in terms of moisture content (4.34%), solubility (85.2%), water activity (0.32%), and bulk density (0.36 g/cm3). The morphology of agglomerated VCO creamer showed cluster and irregular shapes with enlargement in the particle size, (d32) 395 µm and (d43) 426 µm. The overall oxidative results showed stability for the agglomerated VCO creamer stored at 4 °C in terms of TPC, DPPH and PV over 8 weeks followed by creamer stored at 25 °C which had similar stability with slight differences. The creamer stored at 38 °C showed rapid degradation for all oxidation tests from week 2 onwards. Agglomeration technology has indicated to be effective in the stabilization of virgin coconut oil against lipid oxidation and prolonging its shelf-life.
Fulltext Virulence gene profiles and antimicrobial susceptibility of Salmonella Brancaster from chicken

Khoo E, Roslee R, Zakaria Z, Ahmad NI

J Vet Sci, 2023 Nov;24(6):e82.
PMID: 38031519 DOI: 10.4142/jvs.23053

BACKGROUND: The current conventional serotyping based on antigen-antisera agglutination could not provide a better understanding of the potential pathogenicity of Salmonella enterica subsp. enterica serovar Brancaster. Surveillance data from Malaysian poultry farms indicated an increase in its presence over the years.
OBJECTIVE: This study aims to investigate the virulence determinants and antimicrobial resistance in S. Brancaster isolated from chickens in Malaysia.
METHODS: One hundred strains of archived S. Brancaster isolated from chicken cloacal swabs and raw chicken meat from 2017 to 2022 were studied. Two sets of multiplex polymerase chain reaction (PCR) were conducted to identify eight virulence genes associated with pathogenicity in Salmonella (invasion protein gene [invA], Salmonella invasion protein gene [sipB], Salmonella-induced filament gene [sifA], cytolethal-distending toxin B gene [cdtB], Salmonella iron transporter gene [sitC], Salmonella pathogenicity islands gene [spiA], Salmonella plasmid virulence gene [spvB], and inositol phosphate phosphatase gene [sopB]). Antimicrobial susceptibility assessment was conducted by disc diffusion method on nine selected antibiotics for the S. Brancaster isolates. S. Brancaster, with the phenotypic ACSSuT-resistance pattern (ampicillin, chloramphenicol, streptomycin, sulphonamides, and tetracycline), was subjected to PCR to detect the corresponding resistance gene(s).
RESULTS: Virulence genes detected in S. Brancaster in this study were invA, sitC, spiA, sipB, sopB, sifA, cdtB, and spvB. A total of 36 antibiogram patterns of S. Brancaster with a high level of multidrug resistance were observed, with ampicillin exhibiting the highest resistance. Over a third of the isolates displayed ACSSuT-resistance, and seven resistance genes (β-lactamase temoneira [blaTEM], florfenicol/chloramphenicol resistance gene [floR], streptomycin resistance gene [strA], aminoglycoside nucleotidyltransferase gene [ant(3″)-Ia], sulfonamides resistance gene [sul-1, sul-2], and tetracycline resistance gene [tetA]) were detected.
CONCLUSION: Multidrug-resistant S. Brancaster from chickens harbored an array of virulence-associated genes similar to other clinically significant and invasive non-typhoidal Salmonella serovars, placing it as another significant foodborne zoonosis.
Solutions of a three-dimensional multi-term fractional anomalous solute transport model for contamination in groundwater

Ahmad I, Ali I, Jan R, Idris SA, Mousa M

PLoS One, 2023;18(12):e0294348.
PMID: 38064451 DOI: 10.1371/journal.pone.0294348

The study presents a meshless computational approach for simulating the three-dimensional multi-term time-fractional mobile-immobile diffusion equation in the Caputo sense. The methodology combines a stable Crank-Nicolson time-integration scheme with the definition of the Caputo derivative to discretize the problem in the temporal direction. The spatial function derivative is approximated using the inverse multiquadric radial basis function. The solution is approximated on a set of scattered or uniform nodes, resulting in a sparse and well-conditioned coefficient matrix. The study highlights the advantages of meshless method, particularly their simplicity of implementation in higher dimensions. To validate the accuracy and efficacy of the proposed method, we performed numerical simulations and compared them with analytical solutions for various test problems. These simulations were carried out on computational domains of both rectangular and non-rectangular shapes. The research highlights the potential of meshless techniques in solving complex diffusion problems and its successful applications in groundwater contamination and other relevant fields.
Identification of copy neutral loss of heterozygosity on chromosomes 1p, 1q, and 6p among nonsyndromic cleft lip and/or without cleft palate with hypodontia

Ghazali N, Rahman NA, Kannan TP, Ahmad A, Sulong S

BMC Oral Health, 2023 Nov 29;23(1):945.
PMID: 38031027 DOI: 10.1186/s12903-023-03464-3

BACKGROUND: Nonsyndromic cleft lip and/or without cleft palate (NSCL/P) with or without hypodontia is a common developmental aberration in humans and animals. This study aimed to identify the loss of heterozygosity (LOH) involved in hypodontia and NSCL/P pathogenesis.
METHODS: This is a cross-sectional study that conducted genome-wide copy number analysis using CytoScan 750K array on salivary samples from Malay subjects with NSCL/P with or without hypodontia aged 7-13 years. To confirm the significant results, simple logistic regression was employed to conduct statistical data analysis using SPSS software.
RESULTS: The results indicated the most common recurrent copy neutral LOH (cnLOH) observed at 1p33-1p32.3, 1q32.2-1q42.13 and 6p12.1-6p11.1 loci in 8 (13%), 4 (7%), and 3 (5%) of the NSCL/P subjects, respectively. The cnLOHs at 1p33-1p32.3 (D1S197), 1q32.2-1q42.13 (D1S160), and 6p12.1-6p11.1 (D1S1661) were identified observed in NSCL/P and noncleft children using microsatellite analysis markers as a validation analysis. The regions affected by the cnLOHs at 1p33-1p32.3, 1q32.2-1q42.13, and 6p12.1-6p11.1 loci contained selected genes, namely FAF1, WNT3A and BMP5, respectively. There was a significant association between the D1S197 (1p33-32.3) markers containing the FAF1 gene among NSCL/P subjects with or without hypodontia compared with the noncleft subjects (p-value = 0.023).
CONCLUSION: The results supported the finding that the genetic aberration on 1p33-32.3 significantly contributed to the development of NSCL/P with or without hypodontia. These results have an exciting prospect in the promising field of individualized preventive oral health care.
A mini review of recent progress in the removal of emerging contaminants from pharmaceutical waste using various adsorbents

Ahammad NA, Ahmad MA, Hameed BH, Mohd Din AT

Environ Sci Pollut Res Int, 2023 Dec;30(60):124459-124473.
PMID: 35314938 DOI: 10.1007/s11356-022-19829-0

The presence of emerging contaminants (ECs) originating from pharmaceutical waste in water, wastewater, and marine ecosystems at various geographical locations has been clearly publicised. This review paper presents an overview of current monitoring data on the occurrences and distributions of ECs in coastal ecosystem, tap water, surface water, ground water, treated sewage effluents, and other sources. Technological advancements for EC removal are also presented, which include physical, chemical, biological, and hybrid treatments. Adsorption remains the most effective method to remove ECs from water bodies. Various types of adsorbents, such as activated carbons, biochars, nanoadsorbents (carbon nanotubes and graphene), ordered mesoporous carbons, molecular imprinting polymers, clays, zeolites, and metal-organic frameworks have been extensively used for removing ECs from water sources and wastewater. Extensive findings on adsorptive performances, process efficiency, reusability properties, and other related information are thoroughly discussed in this mini review.
Determinants of Caesarean Risk Factor in Northern Region of Bangladesh: A Multivariate Analysis

Rahman M, Ahmad Shariff A, Shafie A, Saaid R, Md Tahir R

Iran J Public Health, 2014 Jan;43(1):16-27.
PMID: 26060675

Caesarean section (c-section) rates have been increasing dramatically in the past decades around the world. This increase has been attributed to multiple factors such as maternal, socio-demographic and institutional fac-tors. Therefore, this study examines the impact of maternal, socio-demographic and relevant characteristics on caesar-ean delivery in the northern region of Bangladesh.
Fulltext The Alchemy of Coaching: Psychological Capital as HERO within Coaches' Selves

Burhanuddin NAN, Ahmad NA, Said RR, Asimiran S

Int J Environ Res Public Health, 2022 Sep 23;19(19).
PMID: 36231322 DOI: 10.3390/ijerph191912020

The complex nature of coaching challenges instructional coaches (ICs) professionally as it requires them to deal with not only teachers' resistance, acceptance and expectation but also adhere to the complex and multifaceted roles that they are bearing. Psychological capital (PsyCap) has been upheld as an effective construct for defending against stress, negative emotions and burnout among educators. This phenomenological study explores ways in which PsyCap was experienced by Malaysian instructional coaches (ICs). Data were gathered from face-to-face interviews with seven instructional coaches purposefully selected from six different District Education Offices (DEOs) throughout Malaysia. Extracted from participants' own words and through the exploration performed, PsyCap was experienced by the participants through a sense of responsibility, positive resources and work commitment. This study highlights the importance of PsyCap as inner positive psychological resources that aided instructional coaches in their practice of coaching. In addition, this study suggests future research recommendations towards implementing PsyCap developmental training with another group of instructional coaches.
Fulltext A systematic review on risk factors for khat chewing among adolescents in the African continent and Arabian Peninsula

Fiidow OA, Minhat HS, Zulkefli NAM, Ahmad N

PLoS One, 2022;17(2):e0263372.
PMID: 35113927 DOI: 10.1371/journal.pone.0263372

INTRODUCTION: Khat is a flowering plant with stimulant effect on the nervous system and produce psychological dependence. Despite its harmful effects, the ingestion of khat has been part of cultural norms and the legality of khat varies by region.
OBJECTIVE: This systematic review aimed at critically evaluating the available evidence on the risk factors of khat chewing among adolescents.
METHODS: A systematic review was conducted on published research studies from five databases Scopus, PubMed, Science-direct, Ovid and google scholar using keywords khat chewing OR qat chewing AND associated factors OR risk factors OR contributing factors AND adolescents OR teenagers. Articles included were either cross-sectional, cohort, case-control or qualitative studies which were published between the year 1990 till present. Excluded articles were the non-English written articles, descriptive studies and irrelevant topics being studied.
RESULTS: Out of 2617 records identified and screened, six were included for the analysis and interpretation of the data. All included studies were cross-sectional study design. All six studies reported having family members who chewed khat significantly predict khat chewing among adolescents, followed by five articles for friends or peers who also chewed khat and four articles for male gender. Smoking was also found to have the highest odds (OR = 18.2; 95% CI: 12.95-25.72) for khat chewing among adolescents.
CONCLUSION: The review highlights the crucial role of family members, friends or peers and male gender to predict khat chewing among adolescents. Effectiveness of health promotion programs to educate and reduce khat chewing among adolescents will require active participation of family members and friends.
The need for mandatory autopsy teaching in Forensic Medicine for medical students

Abdullah NK, Ahmad NA, Ramli SB, Razak NA

Autops Case Rep, 2024;14:e2024509.
PMID: 39176103 DOI: 10.4322/acr.2024.509

The effectiveness of the autopsy as an educational tool in forensic medicine courses has been widely acknowledged, and medical students were expected to attend regularly. Nevertheless, the use of autopsies for teaching has dramatically declined in recent years and worldwide despite their high-value benefits. This study aims to understand the importance and relevance of attending autopsies during forensic teaching sessions and identify any challenges that may impede attendance. A self-administered online questionnaire that assesses the knowledge, attitudes, and practices related to autopsies attendance was distributed to fourth-year medical students at the National Defence University of Malaysia and Universiti Sains Islam Malaysia. A total of 99 respondents were involved in this study. Our findings indicate that most respondents (over 85%) demonstrated good knowledge of forensic medicine. Pearson's statistical test revealed a significant correlation between the knowledge and students' attitudes toward autopsy. This study demonstrates the need to strategically integrate autopsy attendance into medical curricula to encourage constructive attitudes and practices among medical students. Students gain the most benefits from frequently attending autopsies. Passionate educators can conduct preparatory sessions to set expectations and address concerns, encourage students to process their experiences, and reinforce learning outcomes in the mortuary setting. Mandatory autopsy teaching should be integrated into the curriculum to ensure medical students have the necessary skills and knowledge to become competent doctors.
HIV Stigma, Sexual Identity Stigma and Online Coping Strategy of Gay, Bisexual and Queer People Living with HIV: A Moderated Mediation Study

Ahmad MA, Nor AM, Abd Hamid HS

Curr HIV Res, 2024;22(3):181-194.
PMID: 38867529 DOI: 10.2174/011570162X300696240530095046

INTRODUCTION: Living with HIV/AIDS is more difficult for gay, bisexual, and queer (GBQ) people as they face stigma on both the disease and sexuality, which puts significant stress on coping with stressors, and online platforms have become an alternative coping channel.
METHODS: This study investigated the use of online coping strategies in moderating the HIV stigma mediated by sexual identity stigma on mental health in Malaysia. 123 GBQ people living with HIV between the ages of 20 and 39 participated in the study, responding to the HIV Stigma - Short Form Scale, adapted China MSM Stigma Scale, Online Coping Inventory, and DASS-21.
RESULT: Results were analyzed using OLS, and logistic regression path modeling showed a statistically significant indirect effect of sexual identity stigma mediating HIV stigma on depressive (ab = 0.1362), anxiety (ab = 0.1259), and stress (ab = 0.1636) levels. Problem-focused online coping strategy was found to moderate the indirect association between HIV stigma and depression levels via sexual identity stigma at low (β = 0.2110, SE = 0.0741, p

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