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2'-Aryl and 4'-arylidene substituted pyrazolones: As potential α-amylase inhibitors

Yousuf S, Khan KM, Salar U, Chigurupati S, Muhammad MT, Wadood A, et al.

Eur J Med Chem, 2018 Nov 05;159:47-58.
PMID: 30268823 DOI: 10.1016/j.ejmech.2018.09.052

Acarbose and voglibose are well-known α-amylase inhibitors used for the management of type-II diabetes mellitus. Unfortunately, these well-known and clinically used inhibitors are also associated with several adverse effects. Therefore, there is still need to develop the safer therapy. Despite of a broad spectrum of biological significances of pyrazolone, it is infrequently evaluated for α-amylase inhibition. Current study deals with the synthesis and biological screening of aryl and arylidene substituted pyrazolones 1-18 for their potential α-amylase inhibitory activity. Structures of synthetic derivatives 1-18 were identified by different spectroscopic techniques. All compounds 1-18 (IC50 = 1.61 ± 0.16 μM to 2.38 ± 0.09 μM) exhibited significant to moderate inhibitory potential when compared to standard acarbose (IC50 = 1.46 ± 0.26 μM). A number of derivatives including 8-12 (IC50 = 1.68 ± 0.1 μM to 1.97 ± 0.07 μM) and 14-16 (IC50 = 1.61 ± 0.16 μM to 1.93 ± 0.07 μM) were found to be significantly active. Limited SAR suggested that different substitutions on compounds do not have any significant effect on the inhibitory potential. Compounds were found to be mixed-type inhibitors revealed by kinetic studies. However, in silico study was identified a number of key features participating in the interaction with the binding site of α-amylase enzyme.
Fulltext Factors associated with awareness, knowledge and attitude towards prostate cancer among Malay men in traditional Malay Villages, Negeri Sembilan, Malaysia

Suriani Ismail, Huda Zainuddin, Titi Rahmawati Hamedon, Muhammad Hanafiah Juni, Nor Afiah Mohd. Zulkefli, Suhainizam bin Muhamad Saliluddin

Malaysian Journal of Medicine and Health Sciences, 2018;14(2):31-38.
MyJurnal

Background: Lack of awareness, poor knowledge and attitude regarding cancer have been identified as possible reasons accounting for the late presentation which lead to the poor survival of cancer patients in Malaysia. Method: A cross sectional study was conducted in three traditional Malay villages in Negeri Sembilan among adult males. Those who were already diagnosed with prostate cancer or Non malaysians were excluded from the study. Data was collected using self-administered questionnaires which consist of several sections namely socio-demographic, awareness about prostate cancer, sources of information, family history of prostate cancer, lifestyle associated with risk of cancer, knowledge and attitude towards prostate cancer. Data was analysed using SPSS version 22.0. Chisquare test was used to determine associations. Level of significance was set at p
Fulltext The use and addiction to smart phones among medical students and staffs in a public university in Malaysia

Azlina Wati Nikmat, Nurul Azreen Hashim, Muhammad Farid Saidi, Nur Suhailah Mohd Zaki, Nur Nabihah Hasan Shukri, Nur Basyariah Abdulla

ASEAN Journal of Psychiatry, 2018;19(1):0-0.
MyJurnal

Objective: Smart phones have become an important part of human’s life, including the healthcare population and medical students. However, pathological use of smart phones could lead to smart phones addiction. The aim of this study is to observe a pattern of usage of smart phones among the medical students and staffs in the Faculty of Medicine Universiti Teknologi MARA (UiTM) and screen for smart phone addiction among the respondents.

Methods: A cross sectional, quasi-experimental study design involving medical students and staffs in the Faculty of Medicine Universiti Teknologi MARA (UiTM) was employed. A total of 598 respondents was approached to participate, and all consented to this study. Measurements used in the study include a self-developed questionnaire to measure pattern of smart phone usage and Smart phone addiction scale (Malay version).

Result: We found that 65.9% of the respondents were heavy users of the smart phone (more than 3 hours daily) and majority of them were using it for social networking. More than half of the respondents (52.2%) were at risk of developing smart phone addiction based on Smart phone Addiction Scale (Malay Version).

Conclusion: This study revealed that medical students, and the faculty staffs were heavy users of smart phones, and they were at risk to develop smart phone addiction.
Fulltext A rare case of Subglottic Ectopic Thyroid tissue causing upper airway obstruction: detection by CECT and MRI neck

Ngah, N.A., Siti Jusna Muhammad, Suraini, M.S., Mohd Noh, M.S.F., Ab Hamid, S., Salleh, H., et al.

Pertanika Journal of Science & Technology, 2018;26(2):887-892.
MyJurnal

Internal obstruction of the upper airways can be due to infection, anaphylactic reaction, congenital anomaly, foreign body inhalation or mass. This case report is of a lady who presented with upper airway obstruction due to subglottic ectopic thyroid tissue. She had a history of noisy breathing and progressive neck swelling since childhood. Biochemical results showed hypothyroid features while flexible scope showed tracheal stenosis. Computed Tomography (CT) detected a goitre and a posterior laryngeal mass at subglottic region causing laryngeal stenosis. The MRI helped to better delineate the soft tissue details of this mass. while elective direct laryngoscope showed a firm mass arising from the trachea. Debulking of the mass was done and histopathological diagnosis was nodular thyroid hyperplasia. Treatment with L-thyroxine was instituted with good clinical improvement. An ectopic thyroid gland can develop if its normal migration is halted along this tract during embryogenesis. Subglottic location of ectopic thyroid is extremely rare. However, ectopic thyroid tissue in the larynx should be considered as a possible diagnosis causing upper airway obstruction, especially in a patient that is clinically hypothyroid and having a concurrent goitre.
Fabrication and performance evaluation of blood compatible hemodialysis membrane using carboxylic multiwall carbon nanotubes and low molecular weight polyvinylpyrrolidone based nanocomposites

Irfan M, Irfan M, Idris A, Baig N, Saleh TA, Nasiri R, et al.

J Biomed Mater Res A, 2019 03;107(3):513-525.
PMID: 30484939 DOI: 10.1002/jbm.a.36566

This study focused to optimize the performance of polyethersulfone (PES) hemodialysis (HD) membrane using carboxylic functionalized multiwall carbon nanotubes (c-MWCNT) and lower molecular weight grade of polyvinylpyrrolidone (PVP-k30). Initially, MWCNT were chemically functionalized by acid treatment and nanocomposites (NCs) of PVP-k30 and c-MWCNT were formed and subsequently blended with PES polymer. The spectra of FTIR of the HD membranes revealed that NCs has strong hydrogen bonding and their addition to PES polymer improved the capillary system of membranes as confirmed by Field Emission Scanning Electron Microscope (FESEM) and leaching of the additive decreased to 2% and hydrophilicity improved to 22%. The pore size and porosity of NCs were also enhanced and rejection rate was achieved in the establish dialysis range (<60 kDa). The antifouling studies had shown that NCs membrane exhibited 30% less adhesion of protein with 80% flux recovery ratio. The blood compatibility assessment disclosed that NCs based membranes showed prolonged thrombin and prothrombin clotting times, lessened production of fibrinogen cluster, and greatly suppressed adhesion of blood plasma than a pristine PES membrane. The results also unveiled that PVP-k30/NCs improved the surface properties of the membrane and the urea and creatinine removal increased to 72% and 75% than pure PES membranes. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 513-525, 2019.
Fulltext A new strategy for taste masking of azithromycin antibiotic: development, characterization, and evaluation of azithromycin titanium nanohybrid for masking of bitter taste using physisorption and panel testing studies

Amin F, Khan S, Shah SMH, Rahim H, Hussain Z, Sohail M, et al.

Drug Des Devel Ther, 2018;12:3855-3866.
PMID: 30510401 DOI: 10.2147/DDDT.S183534

Background: The obnoxious bitter taste of orally taken antibiotics is one of the biggest problems in the treatment of children. The pediatric population cannot tolerate the bitter taste of drugs and vomit out which ultimately leads to suboptimal therapeutic value, grimace and mental stress so it is the challenging task for the formulation scientists to formulate a palatable formulation particularly to overcome address the issue.
Purpose of study: The study aimed to mask and evaluate the unpleasant bitter taste of azithro-mycin (AZ) in the dry suspension dosage form by physisorption technique.
Materials and methods: AZ was selected as an adsorbent and titanium dioxide nanoparticles as adsorbate. The AZ nanohybrids (AZN) were prepared by treating fixed amount of adsorbent with a varied amount of adsorbate, prepared separately by dispersing it in an aqueous medium. The mixture was sonicated, stirred followed by filtration and drying. The AZN produced were characterized by various techniques including scanning electron microscopy (SEM), energy dispersive X-rays (EDX), powder X-ray diffraction (PXRD), HPLC and Fourier-transformed infrared (FTIR). The optimized nanohybrid was blended with other excipients to get stable and taste masked dry suspension dosage form.
Results: The results confirmed the adsorption of titanium dioxide nanoparticles on the surface of AZ. The fabricated optimized formulation was subjected for taste masking by panel testing and accelerated stability studies. The results showed a remarkable improvement in bitter taste masking, inhibiting throat bite without affecting the dissolution rate. The product showed an excellent stability both in dry and reconstituted suspension. The optimized formulation of AZN and was found stable when subjected to physical and chemical stability studies, this is because of short and single step process which interns limits the exposure of the product to various environmental factors that could potentially affect the stability of the product. The dissolution rate of the optimized formulation of AZN was compared with its marketed counterpart, showing the same dissolution rate compared to its marketed formulation.
Conclusion: The current study concludes that, by fabricating AZ-titanium nanohybrids using physisorption can effectively mask the bitter taste of the drug. The palatability and stability of azithromycin formulation was potentially enhanced without affecting its dissolution rate.
Fulltext Dose enhancement effects by different size of gold nanoparticles under irradiation of megavoltage photon beam

Wan Nordiana W Abd Rahman, Raizulnasuha Ab Rashid, Mahfuzah Muhammad, Khairunisak Abdul Razak, Norhayati Dollah, Moshi Geso

Jurnal Sains Nuklear Malaysia, 2018;30(2):23-29.
MyJurnal

Gold nanoparticles (AuNPs) have been extensively investigated as dose enhancement agent to increase the lethal dose to the tumours while minimizing dose to the normal tissue. Their intriguing properties and characteristics such as small size and shape provide favorable option in increasing radiotherapy therapeutic efficiency. In this study, the effects of AuNPs size on the dose enhancement effects irradiated under megavoltage photon beams were investigated. The study was conducted in-vitro on HeLa cells using AuNPs of 5 nm and 15 nm sizes. The cells samples were incubated with AuNPs and irradiated with photon beam of energy 6 MV and 10 MV at 100 cm SSD and 10 cm x 10 cm field size. Clonogenic assay were performed to observe the dose enhancement effects on cell survival. Dose enhancement factor (DEF) were extrapolated and evaluated from the cell survival curves. The results show that both sizes of AuNPs produce dose enhancement with the larger size AuNPs of 15 nm produce more dose enhancement compare to 5 nm AuNPs for 6 MV photon beam. Dose enhancements were observed for 10 MV photon beams but DEF for both sizes AuNPs shows no differences. In conclusion, larger size AuNPs produce higher dose enhancement compare to small size of AuNPs which conclude that nanoparticles size is important factor that need to be taken into account for AuNPs to be applied in radiotherapy.
Fulltext Social media as an e-health communication channel: the use of (@MedTweetMYHQ) among students of UiTM Melaka

Wan Azfarozza Wan Athmar, Nur Azmina Ghazali, Muhammad Saiful Adli Mohd Nasir, Anis Athirah Zuhaizar, Farahani Mohd Asli

Journal of Academia Universiti Teknologi MARA Negeri Sembilan, 2018;6(1):129-138.
MyJurnal

Social media are now acknowledged as one of the platforms for engaging e-health that contributing to serious discussion and information regarding on medical and health issues. However, there are challenges and risks associated with social media in medical and health care which is misinformation. Misinformation can spread quickly on Twitter and each retweet is exposing to wider audiences. The aim of this paper is to identify the use of @MedTweetMYHQ among its’ users sepcifically among UiTM Melaka students. The researchers used in-depth interviews to five informants based on purposive sampling. The data was analysed using thematic analysis. Four themes emerged from the analysis which are the use of @MedTweetMYHQ to receive updated useful information on health, to share information on healthy lifestyle, to debunk health myths and as a platform for health discussions.
Fulltext Consumers' understanding and awareness of food irradiation in UiTM Penang

Nor Azureen Rozekhi, Shahril Hussin, Ashraf Siddik Khan Abdul Rahim Siddiqe, Muhammad 'Arif Aizat Bashir, Hairul Nizwan Abd Majid

Journal of Academia Universiti Teknologi MARA Negeri Sembilan, 2018;6(1):97-104.
MyJurnal

It has been remarked that food irradiation is an emerging technology with many advantages to
consumers. Among the benefits of food irradiation include the destruction of insects, fungi and bacteria
that cause food to spoil and causes food borne illnesses in humans. However, there appears to be a
lacking in widespread public awareness and understanding of food radiation for human consumption.
Therefore, this study is attempting to investigate consumer awareness, attitude, trust and understanding
toward food irradiation. A total of 237 respondents participated in the study via self-administered
questionnaires. Findings revealed that consumers’ level of awareness towards food irradiation was
surprisingly high. On the other hand, level of positive attitude and trust towards irradiated food were
accepted. The findings of this study could contribute to the body of knowledge regarding the
awareness, knowledge, attitude and trust towards food irradiation among consumers. In addition, it
provides information and suggestions for the authorities in governing and imposing rules and
regulations on food and beverage operators and handlers in Malaysia.
Fulltext Henneguya (Cnidaria: Myxosporea: Myxobolidae) infections of cultured barramundi, Lates calcarifer (Perciformes: Latidae) in an estuarine wetlands system of Malaysia: description of Henneguya setiuensis n. sp., Henneguya voronini n. sp. and Henneguya calcarifer n. sp

Borkhanuddin MH, Cech G, Molnár K, Shaharom-Harrison F, Khoa TND, Samshuri MA, et al.

Parasitol Res, 2020 Jan;119(1):85-96.
PMID: 31768684 DOI: 10.1007/s00436-019-06541-1

Examination of 35 barramundi (Lates calcarifer) from aquaculture cages in Setiu Wetland, Malaysia, revealed a single fish infected with three Henneguya spp. (Cnidaria: Myxosporea). Characterization of the infections using tissue tropism, myxospore morphology and morphometry and 18S rDNA sequencing supported description of three new species: Henneguya setiuensis n. sp., Henneguya voronini n. sp. and H. calcarifer n. sp. Myxospores of all three species had typical Henneguya morphology, with two polar capsules in the plane of the suture, an oval spore body, smooth valve cell surfaces, and two caudal appendages. Spores were morphometrically similar, and many dimensions overlapped, but H. voronini n. sp. had shorter caudal appendages compared with H. calcarifer n. sp. and H. setiuensis n. sp. Gross tissue tropism distinguished the muscle parasite H. calcarifer n. sp. from gill parasites H. setiuensis n. sp. and H. voronini n. sp.; and these latter two species were further separable by fine-scale location of developing plasmodia, which were intra-lamellar for H. setiuensis n. sp. and basal to the filaments for H. voronini n. sp. small subunit ribosomal DNA sequences distinguished all three species: the two gill species H. setiuensis n. sp. and H voronini n. sp. were only 88% similar (over 1708 bp), whereas the muscle species H. calcarifer n. sp. was most similar to H. voronini n. sp. (98% over 1696 bp). None of the three novel species was more than 90% similar to any known myxosporean sequence in GenBank. Low infection prevalence of these myxosporeans and lack of obvious tissue pathology from developing plasmodia suggested none of these parasites are currently a problem for barramundi culture in Setiu Wetland; however additional surveys of fish, particularly at different times of the year, would be informative for better risk assessment.
Connotations of psychological and physiological health in the psychosocial work environment: An industrial context

Javaid MU, Bano S, Mirza MZ, Isha ASN, Nadeem S, Jawaid A, et al.

Work, 2019;64(3):551-561.
PMID: 31658088 DOI: 10.3233/WOR-193016

BACKGROUND: Psychological conditions are experiences of the conscious and unconscious elements of the work context, which revolve around workers' perceptions of feeling either engaged or disengaged with the assigned tasks. In the psychosocial work environment of hazardous industries like petrochemicals where production lasts twenty-four hours a day and continues seven-days-a-week, a psychologically available worker is extremely important. Psychological availability refers to when workers who are physically, emotionally and psychologically engaged at the moment of performing tasks.
OBJECTIVE: The broad objective of this study was to investigate the direct and indirect effects of behavioral factors on the psychological and physiological health of workers.
METHODS: The latest, second generation technique, which is structural equation modeling, is used to identify the relationships between behavioral antecedents and health outcomes. A total of 277 technical workers participated, aged between 20 and 49 and were healthy in all aspects.
RESULTS: The study results showed quantitative demands, emotional demands, work-family conflict, and job insecurity were significantly associated with both psychological (stress) and physiological (Body Mass Index) factors. The social support of colleagues produced mixed findings with direct and indirect paths. Stress also significantly mediates the psychosocial factors and burnout of the workers.
CONCLUSION: The study concluded that workers were physically available, but they experienced distractions as members of social systems, affecting their physiological and psychological health.
Fulltext QoSRP: A Cross-layer QoS Channel-Aware Routing Protocol for the Internet of Underwater Acoustic Sensor Networks

Faheem M, Butt RA, Raza B, Alquhayz H, Ashraf MW, Shah SB, et al.

Sensors (Basel), 2019 Nov 02;19(21).
PMID: 31684014 DOI: 10.3390/s19214762

Quality of service (QoS)-aware data gathering in static-channel based underwater wireless sensor networks (UWSNs) is severely limited due to location and time-dependent acoustic channel communication characteristics. This paper proposes a novel cross-layer QoS-aware multichannel routing protocol called QoSRP for the internet of UWSNs-based time-critical marine monitoring applications. The proposed QoSRP scheme considers the unique characteristics of the acoustic communication in highly dynamic network topology during gathering and relaying events data towards the sink. The proposed QoSRP scheme during the time-critical events data-gathering process employs three basic mechanisms, namely underwater channel detection (UWCD), underwater channel assignment (UWCA) and underwater packets forwarding (UWPF). The UWCD mechanism finds the vacant channels with a high probability of detection and low probability of missed detection and false alarms. The UWCA scheme assigns high data rates channels to acoustic sensor nodes (ASNs) with longer idle probability in a robust manner. Lastly, the UWPF mechanism during conveying information avoids congestion, data path loops and balances the data traffic load in UWSNs. The QoSRP scheme is validated through extensive simulations conducted by NS2 and AquaSim 2.0 in underwater environments (UWEs). The simulation results reveal that the QoSRP protocol performs better compared to existing routing schemes in UWSNs.
Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches

Raza H, Abbasi MA, Aziz-Ur-Rehman, Siddiqui SZ, Hassan M, Abbas Q, et al.

Bioorg Chem, 2020 01;94:103445.
PMID: 31826809 DOI: 10.1016/j.bioorg.2019.103445

In the current research work, different N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides have been synthesized according to the protocol described in scheme 1. The synthesis was initiated by reacting various substituted anilines (1a-e) with 4-chlorobutanoyl chloride (2) in aqueous basic medium to give various electrophiles, 4-chloro-N-(substituted-phenyl)butanamides (3a-e). These electrophiles were then coupled with 1-[(E)-3-phenyl-2-propenyl]piperazine (4) in polar aprotic medium to attain the targeted N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides (5a-e). The structures of all derivatives were identified and characterized by proton-nuclear magnetic resonance (1H NMR), carbon-nuclear magnetic resonance (13C NMR) and Infra-Red (IR) spectral data along with CHN analysis. The in vitro inhibitory potential of these butanamides was evaluated against Mushroom tyrosinase, whereby all compounds were found to be biologically active. Among them, 5b exhibited highest inhibitory potential with IC50 value of 0.013 ± 0.001 µM. The same compound 5b was also assayed through in vivo approach, and it was explored that it significantly reduced the pigments in zebrafish. The in silico studies were also in agreement with aforesaid results. Moreover, these molecules were profiled for their cytotoxicity through hemolytic activity, and it was found that except 5e, all other compounds showed minimal toxicity. The compound 5a also exhibited comparable results. Hence, some of these compounds might be worthy candidates for the formulation and development of depigmentation drugs with minimum side effects.
Enhancing the three-dimensional visualization of a foreign object using Mimics software

Asif MK, Nambiar P, Khan IM, Aziz ZABCA, Noor NSBM, Shanmuhasuntharam P, et al.

Radiol Case Rep, 2019 Dec;14(12):1545-1549.
PMID: 31719943 DOI: 10.1016/j.radcr.2019.10.001

A patient was referred to the Oral and Maxillofacial Imaging Division and the attending dental specialist suspected a foreign object at the anterior region of the maxilla. The region was scanned using Kodak 9000 3D cone-beam computed tomography (CBCT) extraoral imaging system (Carestream Health, Inc.) to determine the type and morphometric characteristic of foreign object. The CBCT images failed to determine the identity and nature of the foreign object. CBCT images were then exported to the Materialise Interactive Medical Image Control System (Mimics) software to evaluate whether this software can help in enhancing the visualization of the foreign object in the maxillofacial region. The findings showed that there was an improved visualization of the foreign body and the type of the object could be determined with certainty. The object was identified as an endodontic file and was clearly visible when visualized as a reconstructed 3D model in Mimics software. Although the identification of abnormalities has been dramatically improved using 3D scans, the visualization can be further enhanced using image processing software like Mimics.
Prestasi penyahikatan pelarut dengan menggunakan kaedah reka bentuk eksperimen

Khairul Rijal Jamaludin, Norhamidi Muhammad, Mohd Nizam Ab. Rahman, Murtadhahadi, Sri Yulis M. Amin, Sufizar Ahmad, et al.

Sains Malaysiana, 2009;38.

Proses penyahikatan pelarut telah diterima dengan meluas dalam proses pengacuanan suntikan logam (MIM) berdasarkan kemampuannya meningkatkan proses penyahikatan. Bahan pengikat boleh larut yang dikeluarkan dari jasad anum akan menghasilkan liang-liang yang akan membantu meningkatkan kadar penyahikatan terma. Kertas ini membentangkan pengoptimuman proses penyahikatan pelarut dengan menggunakan kaedah Taguchi. Pengaruh pembolehubah penyahikatan pelarut seperti suhu pelarut, taburan saiz partikel, beban serbuk dan tekanan penyuntikan juga dibincangkan. Dua jenis serbuk SS316L digunakan dalam kajian ini iaitu serbuk pengatoman gas dan pengatoman air. Kajian ini mendapati bahawa suhu pelarut memainkan peranan yang sangat penting dalam proses penyahikatan
pelarut dan menyumbang sebanyak 91.602% (bagi serbuk pengatoman gas) dan 84.978% (bagi serbuk pengatoman air) terhadap kadar pengeluaran bahan pengikat. Bagaimanapun, taburan saiz partikel serbuk hanya menyumbangkan sebanyak 6.638% dan 12.228% bagi serbuk pengatoman gas dan pengatoman air masing-masing terhadap kadar pengeluaran bahan pengikat. Suhu pelarut menunjukkan tahap signifikan yang sangat tinggi iaitu α = 0.005 bagi kedua-dua jenis serbuk tersebut. Walau bagaimanapun, taburan saiz partikel serbuk SS316L menunjukkan tahap signifikan yang sederhana iaitu α = 0.025 dan α = 0.01 bagi kedua-dua padatan serbuk tersebut.
Haid daripada perspektif sains dan Maqasid Syariah

Nur Asmadayana Hasim, Mohd Izhar Ariff Mohd Kashim, Mohammad Zaini Yahaya, Muhammad Adib Samsudin, Rozida Khalid, Rizafizah Othaman

Sains Malaysiana, 2016;45:1879-1885.

Setiap kejadian semula jadi merupakan rahmat dan memberi kemaslahatan kepada manusia termasuklah pendarahan haid dalam kalangan wanita. Haid merupakan suatu proses yang unik dan terancang yang melibatkan tiga fasa utama iaitu fasa haid, fasa folikel dan fasa luteal. Objektif penyelidikan ini ialah untuk mengkaji dan menghubungkaitkan kebaikan haid daripada perspektif sains dan maqasid syariah. Kajian ini dijalankan dengan menggunakan ulasan literatur secara deskriptif. Kajian mendapati bahawa perubahan hormon, warna darah dan faktor fiziokimia lain memberi kesan terhadap kenormalan kitaran haid. Darah haid juga dikenal pasti mempunyai agen antimikrob terutamanya terhadap bakteria E. coli dan bakteria Gram-negatif lain. Hal ini bertepatan dengan maqasid syariah memelihara jiwa kerana haid mampu juga memelihara kesihatan wanita. Selain itu, kajian lepas menemukan bahawa darah haid terdiri daripada sel stem yang boleh digunakan dalam aktiviti klinikal pada masa akan datang. Maqasid syariah melindungi keturunan juga dapat dilihat dengan kehadiran haid yang sering digunakan bagi menjangkakan waktu subur bagi merancang kehamilan. Hikmah Islam melarang mendekatkan diri (bersetubuh) dengan wanita yang sedang haid adalah satu rahmat yang besar, kerana wanita yang sedang haid biasanya mempunyai kelaziman gejala prahaid (PMS) yang melibatkan isu kesihatan. Oleh itu, haid daripada perspektif sains adalah bertepatan dengan maqasid syariah.
Cloning and analysis of pyrG gene encoding orotidine 5-monophosphate decarboxylase of Aspergillus Oryzae strain S1

Oh SSL, Leong JM, Abdul Munir Abdul Murad, Farah Diba Abu Bakar, Nor Muhammad Mahadi

Sains Malaysiana, 2011;40.

In this study, the pyrG gene which encodes for orotidine 5-monophosphate decarboxylase (OMP decarboxylase) of Aspergillus oryzae strain S1 was cloned and analysed. This 1.8kb A. oryzae pyrG encompasses the 5’-regulatory flanking region (465 bp), open reading frame (899 bp) and 3’-regulatory region (475 bp). The pyrG contained one intron at position 623-687 bp based on the AUGUSTUS and FGENESH (SoftBerry) analysis corresponding to the intron present in the pyrG of A. oryzae (Accession Number: Y13811). In silico analysis showed that the enzyme encoded by the A. oryzae S1 pyrG gene has a theoretical molecular weight of 30.28 kDa and theoretical pI value of 5.92. This enzyme is hydrophilic, located in a region outside of the transmembrane and it functions in the cytoplasm. Five motives such as N-glycosylation site, protein kinase C (PKC) phosphorylation site, casein kinase II (CK-2) phosphorylation site, N-myristolation site and orotidine 5-monophoshate decarboxylase active site have been identified in the pyrG amino acid sequence. The three dimensional structure of this enzyme generated via protein homology modeling using the bioinformatic software, Swiss Model, shows that OMP decarboxylase is a protein with an α/ß barrel structure possessing 8 ß-strands surrounded by 9 α-helices. The amino acid residues involved in the active site have been identified and it is located on one of the ß-strands. The pyrG DNA sequence will be used for the complementation of a pyrG auxotroph mutant of A. oryzae.
Effect of ZnO addition on structural properties of ZnO-PANi/carbon black thin films

Siti Fariza Mat Tahir, Mohammad Hafizuddin Haji Jumali, Norhashimah Ramli, Izura Izzuddin, Muhammad Yahaya, Muhamad Mat Salleh, et al.

Sains Malaysiana, 2012;41:1001-1004.

The aim of this project was to investigate the effect of ZnO addition on the structural properties of ZnO-PANi/carbon black thin films. The sol gel method was employed for the preparation of ZnO sol. The sol was dried for 24 h at 100°C and then annealed at 600°C for 5 h. XRD characterization of the ZnO powder showed the formation of wurtzite type ZnO
crystals. The ZnO powder were mixed into PANi/carbon black solution which was dissolved into M-Pyrol, N-Methyl-2-Pyrrolidinone (NMP) to produce a composite solution of ZnO-PANi/carbon black. The weight ratio of ZnO were 4 wt%, 6 wt% and 8 wt%. The composite solutions were deposited onto glass substrates using a spin-coating technique to fabricate
ZnO-PANi/carbon black thin films. AFM characterization showed the decreasing of average roughness from 7.98 nm to 2.23 nm with the increment of ZnO addition in PANi/carbon black films. The thickness of the films also decreased from 59.5 nm to 28.3 nm. FESEM image revealed that ZnO-PANi/carbon black thin films have changed into agglomerated
surface morphology resulting in the increment of porosity of the films.
Microwave-induced zinc chloride activated palm kernel shell for dye removal

Muhammad Abbas Ahmad Zaini, Tan Wee Meng, Mohd. Johari Kamaruddin, Siti Hamidah Mohd Setapar, Mohd. Azizi Che Yunus

Sains Malaysiana, 2014;43:1421-1428.

This work is aimed to determine the characteristics of activated carbons derived from palm kernel shell (PKS) by microwave-induced zinc chloride activation for dye removal. Activation was performed in a microwave oven at power intensity of 70% for 10 min. The same procedures were repeated for activation using recycled ZnCl2 solution from the first activation. The activated carbons were characterized according to surface area, morphology, functional groups and batch adsorption. The yield for the first activation was 70.7% with surface area of 858m2/g. It was found that the activated carbon prepared using the recycled ZnCl2 still possesses good surface area for methylene blue removal. The adsorption behaviour of the continuous system was well fitted to and could be satisfactorily described by the Yoon and Nelson model.
Sel Stem dalam Perkembangan Darah(Stem Cell in Blood Development)

Shahrul Hisham Zainal Ariffin, Intan Zarina Zainal Abidin, Sahidan Senafi, Nor Muhammad Mahadi, Rohaya Megat Abdul Wahab, Zaidah Zainal Ariffin

Sains Malaysiana, 2005;34.

Stem cells, also known as mother cells are capable of undergoing both cell division and differentiation. The most primitive stem cells are totipotent cells which are capable of producing a complete organism from one cell. There are two types of haemopoietic stem cells depending on their developmental stages known as embryo and adult haemopoietic stem cells. Studies showed that only 0.01-0.05% of total bone marrow cell population consists of haemopoietic stem cells. This small population of stem cells exists in three different sizes with different characteristics. In addition, the microenvironment which contains various regulatory molecules plays an important role in the differentiation of stem cells into specific adult cells.
[Sel stem juga dikenali sebagai sel induk berupaya untuk menjalani kedua-dua proses pembahagian dan pembezaan sel. Sel stem yang paling primitif iaitu sel totipoten berupaya untuk membentuk satu organisma lengkap daripada satu sel. Sel stem hemopoietik terdiri daripada dua jenis bergantung kepada peringkat perkembangan individu iaitu sel stem hemopoietik embrio dan dewasa. Kajian mendapati hanya 0.01-0.05% daripada keseluruhan populasi sel sumsum tulang berupaya bertindak sebagai sel stem hemopoietik. Daripada julat yang kecil ini sel stem hemopoietik wujud dalam tiga saiz yang mempunyai ciri yang berbeza. Selain daripada itu mikrosekitaran yang mempunyai molekul-molekul regulatori yang berbeza-beza juga memainkan peranan yang penting dalam pembezaan sel stem kepada sel-sel matang yang spesifik].

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