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Psychosocial stressors at work and well-being of male employees

Noor Dalila IZA, Rosnah I, Ismail NH

Med J Malaysia, 2019 04;74(2):160-167.
PMID: 31079128

INTRODUCTION: Psychosocial stressors appear to alter the state of mind and adoption of overeating behaviour, resulting in high body mass index. This study was conducted to determine the magnitude of psychosocial stressors on male employees' well-being.
METHOD: This study used secondary data retrieved from a cross-sectional study involving 492 male employees' completed data. Eligible participants completed validated questionnaires of the Psychosocial Safety Climate (PSC-12) scale, short version Demand Induced Strain Compensation (DISQ 2.1), Oldenburg Burnout Inventory - Emotional Exhaustion domain and the Three Eating Factor Questionnaire (TEFQ) -Uncontrolled Eating domain; assessing psychosocial safety climate, job demands and job resources, emotional exhaustion, and uncontrolled eating behaviour, respectively. Body mass index (BMI) was calculated based on weight and height. The research statistical model was tested by two-steps of assessment replicating partial least squares structural equation modelling (PLS-SEM).
RESULT: The results show that psychosocial stressors (psychosocial safety climate, job demands and job resources) had significant effects on emotional exhaustion (β= -0.149, p=0.004; β= 0.223, p<0.001; β= -0.127, p=0.013). Emotional exhaustion predicted by work stressors may act as a chain reaction which could result in uncontrolled eating (β=0.138, p=0.005) and high BMI (β=0.185, p<0.001). Emotional exhaustion does mediate the relationship between PSC and uncontrolled eating behaviour (β= -0.021 [95% boot CI bias corrected: -0.048, -0.002]).
CONCLUSION: The psychosocial stressors at work are significant factors for emotional exhaustion, which further signifies the positive effect on uncontrolled eating behaviour and BMI among Malaysian male employees.
Fulltext Particulate Matter-Induced Acute Coronary Syndrome: MicroRNAs as Microregulators for Inflammatory Factors

Razak NIA, Ezani NE, Ismail N

Mediators Inflamm, 2021;2021:6609143.
PMID: 34931116 DOI: 10.1155/2021/6609143

The most prevalent cause of mortality and morbidity worldwide is acute coronary syndrome (ACS) and its consequences. Exposure to particulate matter (PM) from air pollution has been shown to impair both. Various plausible pathogenic mechanisms have been identified, including microRNAs (miRNAs), an epigenetic regulator for gene expression. Endogenous miRNAs, average 22-nucleotide RNAs (ribonucleic acid), regulate gene expression through mRNA cleavage or translation repression and can influence proinflammatory gene expression posttranscriptionally. However, little is known about miRNA responses to fine PM (PM2.5, PM10, ultrafine particles, black carbon, and polycyclic aromatic hydrocarbon) from air pollution and their potential contribution to cardiovascular consequences, including systemic inflammation regulation. For the past decades, microRNAs (miRNAs) have emerged as novel, prospective diagnostic and prognostic biomarkers in various illnesses, including ACS. We wanted to outline some of the most important studies in the field and address the possible utility of miRNAs in regulating particulate matter-induced ACS (PMIA) on inflammatory factors in this review.
Normalisation of human chorionic gonadotrophin (hCG) levels in a patient with partial molar pregnancy with a uterine mass without chemotherapy: impact of using herbal remedies

Ismail N, Zainudin AM, Hua GS

J Complement Integr Med, 2021 Apr 02;18(4):859-863.
PMID: 33818024 DOI: 10.1515/jcim-2019-0091

OBJECTIVES: Level of βhCG and the presence of any uterine mass of hydatidiform mole need a careful review or monitoring in order to prevent metastasis, provide an early treatment and avoid unnecessary chemotherapy.
CASE PRESENTATION: A 36-year old fifth gravida patient who had a missed abortion was diagnosed as having a molar pregnancy with beta human chorionic gonadotrophin (βhCG) level of 509,921 IU/L. Her lung field was clear and she underwent suction and curettage (S & C) procedure. However, after six weeks, AA presented to the emergency department with a massive bleeding, although her βhCG level had decreased to 65,770 IU/L. A trans-abdominal ultrasound indicated the presence of an intra-uterine mass (3.0 × 4.4 cm). Nevertheless, her βhCG continued to show a declining trend (8,426 IU/L). AA was advised to undergo a chemotherapy but she refused, citing preference for alternative medicine like herbs instead. She opted for an "at own risk" (AOR) discharge with scheduled follow up. Subsequently, her condition improved with her βhCG showing a downward trend. Surprisingly, at six months post S & C, her βhCG ameliorated to 0 IU/L with no mass detected by ultrasound.
CONCLUSIONS: Brucea javanica fruits, Pereskia bleo and Annona muricata leaves can potentially be useful alternatives to chemotherapy and need further studies.
Fulltext A Randomised Crossover Trial of Behaviour Guidance Techniques on Children with Special Health Care Needs during Dental Treatment: The Physiological Variations

Ismail N, Isa KAM, Wan Mokhtar I

Children (Basel), 2022 Oct 05;9(10).
PMID: 36291461 DOI: 10.3390/children9101526

Passive immobilisation is regarded as able to potentially cause physical distress and intense anxiety manifestations. The study aims to investigate the physiological variations of children with special health care needs while using a Papoose board and a combination of basic behaviour guidance during dental treatment. This is a randomised crossover trial involving 90 children with special health care needs receiving standard dental care with two methods of behaviour guidance sequentially. Exposure A is a combination of tell-show-do, distraction, and positive reinforcement, while exposure B is passive immobilisation with a Papoose board. The subject child’s blood pressure, heart rate, and oxygen saturation level were measured at four different times during dental treatment. In total, 74 children’s physiological data were successfully collected with a mean age of 9.85 years (SD = 2.71). Further, 64.9% of the children were diagnosed with autism spectrum disorder, 12.2% with attention deficit hyperactivity disorder, 9.5% with intellectual disability, 8.1% with Down syndrome, 2.2% with global developmental delay, and 1.1% with dyslexia and cerebral palsy, respectively. The measurement of children’s blood pressure, heart rate, and oxygen saturation level with the application of a Papoose board or a combination of the basic behaviour guidance revealed no significant changes (p > 0.05). The use of a Papoose board is safe and has no discernible influence on the child’s physiological responses.
Dataset for five recent years (2019 - 2023) agarwood essential oil research trends: A bibliometric analysis

Yusoff ZM, Ismail N, Nordin SA

Data Brief, 2024 Jun;54:110310.
PMID: 38544913 DOI: 10.1016/j.dib.2024.110310

Research on Agarwood Essential Oils (AEO) has undergone dynamic evolution, propelled by its diverse applications in industries such as perfumery, pharmaceuticals, and alternative medicine. The aromatic richness and therapeutic potential of these essential oils have sparked a surge in research interest. Despite extensive exploration, there is a need for a comprehensive analysis of trends, patterns, and the impact of AEO research to provide insights for future studies and applications.This work presents a meticulously curated dataset encompassing the last five years of Agarwood Essential Oil (AEO) research trends. Sourced from two reputable scholarly databases, namely Web of Science and Scopus, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, analyzing the data using Biblioshiny, and spanning the period from 2019 to 2023, the dataset is designed to facilitate a comprehensive understanding of the evolving landscape of AEO studies. It covers a wide array of parameters, including authorship, subject areas, citations, source titles, wordcloud, and keywords. This dataset is made available to researchers, institutions, and decision-makers to provide insights into the academic debates on agarwood oil studies, allowing for a nuanced understanding of the progression of scholarly endeavors within the field. The dataset aims to serve as a valuable resource for researchers, policymakers, and industry stakeholders interested in the multifaceted applications of essential oils. The structured and comprehensive nature of the dataset makes it a valuable asset for exploring historical trends, identifying key contributors, and fostering collaborative initiatives within the AEO research domain.
Fulltext Knowledge, practices and attitudes towards adverse drug reaction reporting by private practitioners from klang valley in malaysia

Agarwal R, Daher AM, Mohd Ismail N

Malays J Med Sci, 2013 Mar;20(2):52-61.
PMID: 23983578 MyJurnal

The study aimed to determine current status of knowledge, practices, and attitudes towards adverse drug reaction (ADR) reporting among private practitioners in Klang region of Malaysia.
Fulltext Effect of polydextrose on physicochemical properties of threadfin bream (Nemipterus spp) surimi during frozen storage

Nopianti R, Huda N, Ismail N, Ariffin F, Easa AM

J Food Sci Technol, 2013 Aug;50(4):739-46.
PMID: 24425976 DOI: 10.1007/s13197-011-0394-0

Physicochemical properties of threadfin bream surimi with different levels of polydextrose (3%, 6%, 9% and 12%), raw surimi, raw surimi with addition sodium tripolyphosphate and commercial surimi (sucrose) during 6 months of frozen storage were investigated. The analyses included the measurement of Ca(2+)-ATPase, sulfhydryl contents, protein solubility, sodium dodecyl sulfate polyacrylamide gel electrophoresis, differential scanning calorimetry and scanning electron microscopy. The Ca(2+)-ATPase, sulfhydryl content and protein solubility levels added with 3%, 6%, 9% and 12% polydextrose can be maintained until the 6 months of storage by 47.33%, 41.60% and 51.41%, respectively. Differential scanning calorimetry showed decreases in thermal stabilization of myosin with regard to transition termperature. Analysis by scanning electron microscopy demonstrated that the number of pores formed was increased after storage. This study suggested that surimi stored with the polydextrose as a cryoprotectant was able to maintain physicochemical of surimi better compared to raw surimi with no additives or raw surimi with sodium tripolyphosphate.
A systematic review of statistical methods used to test for reliability of medical instruments measuring continuous variables

Zaki R, Bulgiba A, Nordin N, Azina Ismail N

Iran J Basic Med Sci, 2013 Jun;16(6):803-7.
PMID: 23997908

Reliability measures precision or the extent to which test results can be replicated. This is the first ever systematic review to identify statistical methods used to measure reliability of equipment measuring continuous variables. This studyalso aims to highlight the inappropriate statistical method used in the reliability analysis and its implication in the medical practice.
Fulltext Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: role of anti-apoptotic, pro-survival and antioxidant genes

Azmi NH, Ismail N, Imam MU, Ismail M

BMC Complement Altern Med, 2013;13:177.
PMID: 23866310 DOI: 10.1186/1472-6882-13-177

There are reports of improved metabolic outcomes due to consumption of germinated brown rice (GBR). Many of the functional effects of GBR can be linked to its high amounts of antioxidants. Interestingly, dietary components with high antioxidants have shown promise in the prevention of neurodegenerative diseases like Alzheimer's disease (AD). This effect of dietary components is mostly based on their ability to prevent apoptosis, which is believed to link oxidative damage to pathological changes in AD. In view of the rich antioxidant content of GBR, we studied its potential to modulate processes leading up to AD.
Treatment of landfill leachate by using lateritic soil as a natural coagulant

Syafalni, Lim HK, Ismail N, Abustan I, Murshed MF, Ahmad A

J Environ Manage, 2012 Dec 15;112:353-9.
PMID: 22964042 DOI: 10.1016/j.jenvman.2012.08.001

In this research, the capability of lateritic soil used as coagulant for the treatment of stabilized leachate from the Penang-Malaysia Landfill Site was investigated. The evaluation of lateritic soil coagulant in comparison with commercialized chemical coagulants, such as alum, was performed using conventional jar test experiments. The optimum pH and coagulant dosage were identified for the lateritic soil coagulant and the comparative alum coagulant. It was found that the application of lateritic soil coagulant was quite efficient in the removal of COD, color and ammoniacal-nitrogen content from the landfill leachate. The optimal pH value was 2.0, while 14 g/L of lateritic soil coagulant was sufficient in removing 65.7% COD, 81.8% color and 41.2% ammoniacal-nitrogen. Conversely, the optimal pH and coagulant dosage for the alum were pH 4.8 and 10 g/L respectively, where 85.4% COD, 96.4% color and 47.6% ammoniacal-nitrogen were removed from the same leachate sample. Additionally, the Sludge Volume Index (SVI) ratio of alum and lateritic soil coagulant was 53:1, which indicated that less sludge was produced and was an environmentally friendly product. Therefore, lateritic soil coagulant can be considered a viable alternative in the treatment of landfill leachate.
Fulltext Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress

Mohd Fahami NA, Ibrahim IA, Kamisah Y, Mohd Ismail N

BMC Gastroenterol, 2012;12:54.
PMID: 22639913 DOI: 10.1186/1471-230X-12-54

This study examined the effects of Palm vitamin E (PVE) and α-tocopherol (α-TF) supplementations on adrenalin, noradrenalin, xanthine oxidase plus dehydrogenase (XO + XD) activities and gastric lesions in rats exposed to water-immersion restraint stress (WIRS).
Selection of design parameters and optimization of operating parameters of soybean oil-based bulk liquid membrane for Cu(II) removal and recovery from aqueous solutions

Chang SH, Teng TT, Ismail N, Alkarkhi AF

J Hazard Mater, 2011 Jun 15;190(1-3):197-204.
PMID: 21493005 DOI: 10.1016/j.jhazmat.2011.03.025

The objectives of this work were to select suitable design parameters and optimize the operating parameters of a soybean oil-based bulk liquid membrane (BLM) for Cu(II) removal and recovery from aqueous solutions. The soybean oil-based BLM consists of an aqueous feed phase (Cu(II) source), an organic membrane phase (soybean oil (diluent), di-2-ethylhexylphosphoric acid (D2EHPA) (carrier) and tributylphosphate (phase modifier)) and an aqueous stripping phase (sulfuric acid solution (H(2)SO(4))). Effects of design parameters (stirring condition and stripping/membrane to feed/membrane interface area ratio) of soybean oil-based BLM on the Cu(II) removal and recovery from aqueous solutions were investigated and the suitable parameters were selected for further studies. Optimization of the operating parameters (D2EHPA concentration, H(2)SO(4) concentration, stirring speed, temperature and operating time) of soybean oil-based BLM for maximum percentage (%) recovery of Cu(II) was then conducted using Response Surface Methodology and the optimum parameters were determined. A regression model for % recovery was developed and its adequacy was evaluated. The experimental % recovery obtained under the optimum operating conditions was compared with the predicted one and they were found to agree satisfactorily with each other.
A preliminary study on Jatropha curcas as coagulant in wastewater treatment

Abidin ZZ, Ismail N, Yunus R, Ahamad IS, Idris A

Environ Technol, 2011 Jul;32(9-10):971-7.
PMID: 21882550

Many coagulants, mainly inorganic, are widely used in conventional water and wastewater treatment. Recent studies reported the occurrence of some chronic diseases associated with residual coagulant in treated wastewater. The use of alternative coagulants which are biodegradable and environmentally friendly could alleviate the problem associated with these diseases. This work investigates the capability of Jatropha curcas seed and presscake (the residue left after oil extraction) to reduce the turbidity of wastewater through coagulation. The coagulant was prepared by dissolving Jatropha curcas seed and presscake powder into solution. Then jar tests were conducted on kaolin solution as the model wastewater. The Jatropha seed was found to be an effective coagulant with more than 96% of turbidity removal at pH 1-3 and pH 11-12. The highest turbidity removal was recorded at pH 3 using a dosage of 120 mg/L. The flocs formed using Jatropha were observed to be bigger and to sediment faster when compared with flocs formed using alum. The turbidity removal was high (>98%) at all turbidities (100 NTU to 8000 NTU), suggesting its suitability for a wide range of industrial wastewater. The performance of Jatropha presscake after extraction of oil was also comparable to the fresh seed and alum at highly acidic and highly alkaline conditions. The addition of Jatropha did not significantly affect the pH of the kaolin samples after treatment and the sludge volume produced was less in comparison to alum. These results strongly support the use of Jatropha curcas seed and presscake as a potential coagulant agent.
Fulltext Knowledge, attitude and practice of oral health promoting factors among caretakers of children attending day-care centers in Kubang Kerian, Malaysia: a preliminary study

Mani SA, Aziz AA, John J, Ismail NM

J Indian Soc Pedod Prev Dent, 2010 Apr-Jun;28(2):78-83.
PMID: 20660972 DOI: 10.4103/0970-4388.66741

The role of caretakers at day-care centers has become more imperative in promoting oral health care in children since many new mothers opt to work outside their homes, leaving their children at day-care centers. The aim of this study is to assess the knowledge, attitude and practice of oral health promoting factors among secondary caretakers of children attending day-care centers.
Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin

Ho K, Yazan LS, Ismail N, Ismail M

Cancer Epidemiol, 2009 Aug;33(2):155-60.
PMID: 19679064 DOI: 10.1016/j.canep.2009.06.003

Vanillin is responsible for the flavor and smell of vanilla, a widely used flavoring agent. Previous studies showed that vanillin could enhance the repair of mutations and thus function as an anti-mutagen. However, its role in cancer, a disease that is closely related to mutation has not yet been fully elucidated.
Treatment of Terasil Red R dye wastewater using H2O2/pyridine/Cu(II) system

Lim CL, Morad N, Teng TT, Ismail N

J Hazard Mater, 2009 Aug 30;168(1):383-9.
PMID: 19303709 DOI: 10.1016/j.jhazmat.2009.02.061

The H(2)O(2)/pyridine/Cu(II) advanced oxidation system was used to assess the efficiency of the treatment of a 1 g L(-1) Terasil Red R dye solution. This system was found to be capable in reducing the concentration of chemical oxygen demand (COD) of the dye solution up to 90%, and achieving 99% in decolorization at the optimal concentration of 5.5mM H(2)O(2), 38 mM pyridine and 1.68 mM Cu(II). The final concentration of COD was recorded at 117 mg L(-1) and color point at 320 PtCo. Full 2(4) factorial design and the response surface methodology using central composite design (CCD) were utilized in the screening and optimization of this study. Treatment efficiency was found to be pH independent. The amount of sludge generation was in the range of 100-175 mg L(-1) and the sludge produced at the optimal concentration was 170 mg L(-1).
The prevalence of enamel opacities in permanent teeth of 11-12 year-old school children in Kuala Lumpur, Malaysia

Yusoff N, Jaafar N, Razak IA, Chew YY, Ismail N, Bulgiba AM

Community Dent Health, 2008 Mar;25(1):55-8.
PMID: 18435236

To determine the prevalence, distribution, severity and treatment need of enamel opacities among 11-12 year-old school children in a fluoridated urban community.
Analysis of heavy metal concentrations in sediments of selected estuaries of Malaysia--a statistical assessment

Alkarkhi AF, Ismail N, Ahmed A, Easa Am

Environ Monit Assess, 2009 Jun;153(1-4):179-85.
PMID: 18504644 DOI: 10.1007/s10661-008-0347-x

Statistical analysis of heavy metal concentrations in sediment was studied to understand the interrelationship between different parameters and also to identify probable source component in order to explain the pollution status of selected estuaries. Concentrations of heavy metals (Cu, Zn, Cd, Fe, Pb, Cr, Hg and Mn) were analyzed in sediments from Juru and Jejawi Estuaries in Malaysia with ten sampling points of each estuary. The results of multivariate statistical techniques showed that the two regions have different characteristics in terms of heavy metals selected and indicates that each region receives pollution from different sources. The results also showed that Fe, Mn, Cd, Hg, and Cu are responsible for large spatial variations explaining 51.15% of the total variance, whilst Zn and Pb explain only 18.93 of the total variance. This study illustrates the usefulness of multivariate statistical techniques for evaluation and interpretation of large complex data sets to get better information about the heavy metal concentrations and design of monitoring network.
Xanthones from Garcinia mangostana (Guttiferae)

Ee GC, Daud S, Taufiq-Yap YH, Ismail NH, Rahmani M

Nat Prod Res, 2006 Oct;20(12):1067-73.
PMID: 17127660

Studies on the stem of Garcinia mangostana have led to the isolation of one new xanthone mangosharin (1) (2,6-dihydroxy-8-methoxy-5-(3-methylbut-2-enyl)-xanthone) and six other prenylated xanthones, alpha-mangostin (2), beta-mangostin (3), garcinone D (4), 1,6-dihydroxy-3,7-dimethoxy-2-(3-methylbut-2-enyl)-xanthone (5), mangostanol (6) and 5,9-dihydroxy-8- methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-2H,6H-pyrano-[3,2-b]-xanthene-6-one (7). The structures of these compounds were determined by spectroscopic methods such as 1H NMR, 13C NMR, mass spectrometry (MS) and by comparison with previous studies. All the crude extracts when screened for their larvicidal activities indicated very good toxicity against the larvae of Aedes aegypti. This article reports the isolation and identification of the above compounds as well as bioassay data for the crude extracts. These bioassay data have not been reported before.
Multivariate analysis of heavy metals concentrations in river estuary

Alkarkhi AF, Ahmad A, Ismail N, Easa AM

Environ Monit Assess, 2008 Aug;143(1-3):179-86.
PMID: 17899414

Multivariate statistical techniques such as multivariate analysis of variance (MANOVA) and discriminant analysis (DA) were applied for analyzing the data obtained from two rivers in the Penang State of Malaysia for the concentration of heavy metal ions (As, Cr, Cd, Zn, Cu, Pb, and Hg) using a flame atomic absorption spectrometry (F-AAS) for Cr, Cd, Zn, Cu, Pb, As and cold vapor atomic absorption spectrometry (CV-AAS) for Hg. The two locations of interest with 20 sampling points of each location were Kuala Juru (Juru River) and Bukit Tambun (Jejawi River). MANOVA showed a strong significant difference between the two rivers in terms of heavy metal concentrations in water samples. DA gave the best result to identify the relative contribution for all parameters in discriminating (distinguishing) the two rivers. It provided an important data reduction as it used four parameters (Zn, Pb, Cd and Cr) affording 100% correct assignations. Results indicated that the two rivers were different in terms of heavy metals concentrations in water, and the major difference was due to the contribution of Zn. A negative correlation was found between discriminate functions (DF) and Cr and As, whereas positive correlation was exhibited with other heavy metals. Therefore, DA allowed a reduction in the dimensionality of the data set, delineating a few indicator parameters responsible for large variations in heavy metal concentrations. Correlation matrix between the parameters exhibited a strong evidence of mutual dependence of these metals.

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