MyMedR

Fulltext (+)-Kunstlerone, a new antioxidant neolignan from the Leaves of Beilschmiedia kunstleri gamble

Mollataghi A, Hadi AH, Awang K, Mohamad J, Litaudon M, Mukhtar MR

Molecules, 2011 Aug 04;16(8):6582-90.

PMID: 21818061 DOI: 10.3390/molecules16086582

A new neolignan, 3,4-dimethoxy-3',4'-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC(50) of 20.0 µg/mL.

Matched MeSH terms: Malaysia

Fulltext (GTG)5-PCR analysis and 16S rRNA sequencing of bacteria from Sarawak aquaculture environment

Kathleen, M.M., Samuel, L., Felecia, C., Ng K. H., Lesley, M.B., Kasing, A.

International Food Research Journal, 2014;21(3):915-920.

MyJurnal

(GTG)5 PCR is a type of repetitive extragenic palindromic (rep)-PCR which amplifies the (GTG)5 repetitive element that lays throughout the bacterial genome. In this study, fifty, thirty-nine and forty-nine unknown bacteria were isolated from aquaculture farms in Miri, Limbang and Lundu, respectively. (GTG)5 PCR was used to screen for clonal diversity among the isolates according to sampling sites. Banding profiles obtained from electrophoresed (GTG)5 PCR products were analyzed by RAPDistance Software to generate a dendrogram of neighbor joining tree (NJT) format. Based on the constructed dendrogram, representative isolates were selected for further identification. Conserved 16S rRNA region of the selected bacteria isolates were amplified and purified DNA products were sequenced. (GTG)5 PCR is useful in differentiation of unknown bacterial isolates and 16S rRNA analysis species identity of the bacteria in Sarawak aquaculture environment. The high diversity of bacteria in aquaculture environment may be caused by contamination from various sources.

Matched MeSH terms: Malaysia

Fulltext 10-Year Cardiovascular Disease Risk Estimation Based on Lipid Profile-Based and BMI-Based Framingham Risk Scores across Multiple Sociodemographic Characteristics: The Malaysian Cohort Project

Borhanuddin B, Mohd Nawi A, Shah SA, Abdullah N, Syed Zakaria SZ, Kamaruddin MA, et al.

ScientificWorldJournal, 2018;2018:2979206.

PMID: 30111990 DOI: 10.1155/2018/2979206

Cardiovascular disease (CVD) leads to high morbidity and mortality rate worldwide. Therefore, it is important to determine the risk of CVD across the sociodemographic factors to strategize preventive measures. The current study consisted of 53,122 adults between the ages of 35 and 65 years from The Malaysian Cohort project during recruitment phase from year 2006 to year 2012. Sociodemographic profile and physical activity level were assessed via self-reported questionnaire, whereas relevant CVD-related biomarkers and biophysical variables were measured to determine the Framingham Risk Score (FRS). The main outcome was the 10-year risk of CVD via FRS calculated based on lipid profile and body mass index (BMI) associated formulae. The BMI-based formula yielded a higher estimation of 10-year CVD risk than the lipid profile-based formula in the study for both males (median = 13.2% and 12.7%, respectively) and females (median = 4.3% and 4.2%, respectively). The subgroup with the highest risk for 10-year CVD events (based on both FRS formulae) was the Malay males who have lower education level and low physical activity level. Future strategies for the reduction of CVD risk should focus on screening via BMI-based FRS in this at-risk subpopulation to increase the cost-effectiveness of the prevention initiatives.
Study name: The Malaysian Cohort (TMC) project

Matched MeSH terms: Malaysia/epidemiology

10th Kuwait Dermatology Update and Laser Symposium, April 23-25, 2019, Kuwait City

Schwartz RA

Dermatol Ther, 2019 Jun 07.

PMID: 31172646 DOI: 10.1111/dth.12990

The tenth edition of this extraordinary dermatologic congress was held in the Crowne Plaza Hotel in the magnificent Kuwait City on April 23-25, 2019, thanks to the patronage of His Excellency, the Honorable Dr. Basel H Al-Sabah, Minister of Health, Kuwait. It was organized and shepherded by the renowned Chairman of the Dermatology Council in Kuwait, Professor Nawaf Al-Mutairi, FRCP Edin This article is protected by copyright. All rights reserved.

Matched MeSH terms: Malaysia

12-Epi-9-deacetoxyxenicin, new cytotoxic diterpenoid from a Bornean soft coral, Xenia sp

Phan CS, Kamada T, Ishii T, Hamada T, Vairappan CS

Nat Prod Res, 2019 Mar;33(6):808-813.

PMID: 29202596 DOI: 10.1080/14786419.2017.1410812

One new compound, 12-epi-9-deacetoxyxenicin (1) along with a hydroperoxide product, 12-epi-9-deacetoxy-8-hydroperoxyxenicin (2) and two known sesquiterpenoids (3-4) were isolated from a population of Bornean soft coral Xenia sp. The structures of these secondary metabolites were elucidated based on their spectroscopic data. Compounds 1 and 2 showed cytotoxic activity against ATL cell line, S1T. In addition, compound 3 exhibited hyphal inhibition of Lagenidium thermophilum.

Matched MeSH terms: Malaysia

137Cs and 40K in the flesh of fish of the Indian Ocean and the Straits of Malacca

Lowe BG

Health Phys, 1979 Jun;36(6):723-4.

PMID: 468543

Matched MeSH terms: Malaysia

137Cs and 40K levels in marine species caught in Malaysian waters

Dougherty G, Ng CE

Health Phys, 1982 Dec;43(6):915-9.

PMID: 7152953

Matched MeSH terms: Malaysia

Fulltext 16 cases of acute renal failure due to leptospirosis

Tan DSK, Suleiman AB, Jeyaindran S

Med J Malaysia, 1986 Jun;41(2):152-5.

PMID: 3821611

A study was carried out on 16 cases of leptospirosis with acute renal failure (ARF) detected in adult patients admitted into the Medical and Nephrology wards of the General Hospital, Kuala Lumpur, over a four-year period from 1980 to 1983. Most of the cases were male, Malays and older adults. The predominant infecting serovars were L. celledoni (of the serogroup L. javanica and L. pomona (of the L. pomona serogroup]. All the cases survived, including those who required peritoneal dialysis. The sensitised erythrocyte lysis (SEL) antibody prevalence rate of the chronic renal failure cases (10.4%) was found to be similar to that of the healthy population in West Malaysia (12. 7%), confirming the observation by other workers that leptospirosis is not an important cause of chronic renal failure.

Matched MeSH terms: Malaysia

16-Hydroxycembra-1,3,7,11-tetraene, a new Cembrane Diterpene from Malaysian Soft Coral Genus Sarcophyton

Kamada T, Phan CS, Tin HS, Vairappan CS, Muhammad TST

Nat Prod Commun, 2016 Aug;11(8):1077-1078.

PMID: 30725560

One new cembrane diterpene, 16-hydroxycembra-1,3,7,11-tetraene (1), along with three known compounds, 15-hydroxycembra-1,3,7,11-tetraene (2), sarcophine (3) and sarcophytoxide (4) were isolated from Sarcophyton sp. collected from Karah Island, Terengganu, West Malaysia. Their structures were elucidated based on spectroscopic data. Activities of these compounds against antibacterial resistant clinical bacteria are reported. Only 1 exhibited inhibition against Staphylococcus aureus.

Matched MeSH terms: Malaysia

18F-FDG PET/CT for the pre-surgical localization of epileptogenic focus among paediatric patients with drug resistant epilepsy in Malaysia: perspective of a nuclear medicine physician

Abdul Aziz AF, Mohamed AR, Murugesu S, Siti Zarina AH, Lee BN

Med J Malaysia, 2021 07;76(4):502-509.

PMID: 34305111

BACKGROUND: Scalp video electroencephalography monitoring (VEM) and brain MRI sometime fail to identify the epileptogenic focus (EF) in patients with drug resistant epilepsy (DRE). 18F-FDG PET/CT has been shown to improve the detection of EF in patients but is not widely used in Malaysia. Thus, the objective of this study was to identify whether 18F-FDG PET/CT conferred an added benefit in the pre-surgical evaluation of DRE.

METHODS: Retrospective review of 119 consecutive paediatric patients referred for 18F-FDG-PET/CT at the Department of Nuclear Medicine of the National Cancer Institute, Putrajaya. All had DRE and underwent evaluation at the Paediatric Institute, Hospital Kuala Lumpur. Visually detected areas of 18F-FDG-PET/CT hypometabolism were correlated with clinical, MRI and VEM findings.

RESULTS: Hypometabolism was detected in 102/119 (86%) 18FFDG- PET/CT scans. The pattern of hypometabolism in 73 patients with normal MRI was focal unilobar in 16/73 (22%), multilobar unilateral in 8/73 (11%), bilateral in 27/73 (37%) and global in 5/73 (7%) of patients; whilst 17/73 (23%) showed normal metabolism. In 46 patients with lesions on MRI, 18F-FDG-PET/CT showed concordant localisation and lateralization of the EF in 30/46 (65%) patients, and bilateral or widespread hypometabolism in the rest. Addition of 18FFDG PET/CT impacted decision making in 66/119 (55%) of patients; 24/73 with non-lesional and 30/46 patients with lesional epilepsies were recommended for surgery or further surgical work up, whilst surgery was not recommended in 11/46 patients with lesional epilepsy due to bilateral or widespread hypometabolism. 25 patients subsequently underwent epilepsy surgery, with 16/25 becoming seizure free following surgery.

CONCLUSION: 18F-FDG-PET/CT has an added benefit for the localization and lateralization of EF, particularly in patients with normal or inconclusive MRI.

Matched MeSH terms: Malaysia

1982 Galloway Memorial Lecture. Citation on Professor R Sinniah

Chow KW

Ann Acad Med Singap, 1983 Jan;12(1):133-4.

PMID: 6344739

Matched MeSH terms: Malaysia

1998 National Conference on Quality in Health, Kuala Lumpur, Malaysia

Hussein RH

Int J Qual Health Care, 1998 Jun;10(3):284-5.

PMID: 9661068

Matched MeSH terms: Malaysia

Fulltext 2013 dengue outbreaks in Singapore and Malaysia caused by different viral strains

Ng LC, Chem YK, Koo C, Mudin RNB, Amin FM, Lee KS, et al.

Am J Trop Med Hyg, 2015 Jun;92(6):1150-1155.

PMID: 25846296 DOI: 10.4269/ajtmh.14-0588

Characterization of 14,079 circulating dengue viruses in a cross-border surveillance program, UNITEDengue, revealed that the 2013 outbreaks in Singapore and Malaysia were associated with replacement of predominant serotype. While the predominant virus in Singapore switched from DENV2 to DENV1, DENV2 became predominant in neighboring Malaysia. Dominance of DENV2 was most evident on the southern states where higher fatality rates were observed.

Matched MeSH terms: Malaysia/epidemiology

2018 Kidney Disease: Improving Global Outcomes (KDIGO) Hepatitis C in Chronic Kidney Disease Guideline Implementation: Asia Summit Conference Report

Li PK, Bavanandan S, Mohamed R, Szeto CC, Wong VW, Chow KM, et al.

Kidney Int Rep, 2020 Aug;5(8):1129-1138.

PMID: 32775812 DOI: 10.1016/j.ekir.2020.05.001

In 2018, Kidney Disease: Improving Global Outcomes (KDIGO) published a clinical practice guideline on the prevention, diagnosis, evaluation, and treatment of hepatitis C virus (HCV) infection in chronic kidney disease (CKD). The guideline synthesized recent advances, especially in HCV therapeutics and diagnostics, and provided clinical recommendations and suggestions to aid healthcare providers and improve care for CKD patients with HCV. To gain insight into the extent that the 2018 guideline has been adopted in Asia, KDIGO convened an HCV Implementation Summit in Hong Kong. Participants included nephrologists, hepatologists, and nurse consultants from 8 Southeast Asian countries or regions with comparable high-to-middle economic ranking by the World Bank: mainland China, Hong Kong, Japan, Malaysia, Singapore, South Korea, Taiwan, and Thailand. Through presentations and discussions, meeting participants described regional practice patterns related to the KDIGO HCV in CKD guideline, identified barriers to implementing the guideline, and developed strategies for overcoming the barriers in Asia and around the world.

Matched MeSH terms: Malaysia

Fulltext 210Po and 210Pb in cockle tissues in west coast of Peninsula Malaysia

Che Abd Rahim Mohamed, Tee, Lee Theng, Zaharuddin Ahmad

Journal of Nuclear and Related Technologies, 2006;2006(1):69-75.

MyJurnal

Natural radionuclides such as 210 Po and 210 Pb were analyzed in soft part of cockle (Anadara granosa) obtained from Kuala Selangor in the west coast Peninsular of Malaysia. The activity levels of both nuclides fluctuated within the size of cockles from 41.3 ± 2.5 Bq/kg to 114 ± 7 Bq/kg and 12.9 ± 1.7 Bq/kg to 96.8 ± 5.3 Bq/kg in dry weight (dwt) for 210 Po and 210 Pb, respectively. The level activity in wet weight (wwt) also varied from 8.60 ± 0.52 Bq/kg to 25.70 ± 1.63 Bq/kg and 2.47 ± 0.40 Bq/kg to 19.27 ± 1.05 Bq/kg for 210 Po and 210 Pb, respectively, probably related to the different of metabolic rate and growth of cockles. Activity ratio of 210 Po/ 210 Pb in dry weight also fluctuated from 0.93 to 6.41 with not related to the decay of 210 Pb.

Matched MeSH terms: Malaysia

Fulltext 21st century medical education in University of Malaya

Tan, Christina Phoay Lay, Blitz, Julia J.

JUMMEC, 2008;11(1):1-2.

MyJurnal

What does this term medical education conjure up? Does it refer to the teaching and learning of medicine and therefore relates to students and the curriculum? Does it refer to the process of teaching and therefore relates to teachers? Perhaps it is both, since teaching and learning go hand in hand.(Copied from article).

Matched MeSH terms: Malaysia

Fulltext 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population

Ng ZX, Kuppusamy UR, Tajunisah I, Fong KC, Koay AC, Chua KH

Br J Ophthalmol, 2012 Feb;96(2):289-92.

PMID: 22116960 DOI: 10.1136/bjophthalmol-2011-300658

The receptor for advanced glycation end-products (RAGE) has been implicated in the pathogenesis of diabetic microvascular complications. The aim of this study was to investigate the association between 2245G/A gene polymorphism of the RAGE gene and retinopathy in Malaysian type 2 diabetic patients.

Matched MeSH terms: Malaysia

Fulltext 226Ra and 228Ra in water column of Peninsular Malaysia: southern South China Sea

Nioo, Siew Yew, Zaharuddin Ahmad, Masni Mohd Ali, Che Abd Rahim Mohamed

Journal of Nuclear and Related Technologies, 2005;2005(2):31-40.

MyJurnal

Analyses activities of 226 Ra and 228 Ra were conducted at ten stations of Pulau Redang, Malaysia. Dissolved radium isotopes such as 226 Ra and 228 Ra had shown enrichment at coastal area stations. Meanwhile, activities of both nuclides in the suspended particle matters were slightly in equilibrium with the activity ratio ranging from 0.88 – 1.86. The calculated distribution coefficient values (Kd) of 226 Ra and 228 Ra were in the range of 0.78 x 10 5 L g -1 to 5.56 x 10 5 L g -1 and 0.21 x 10 5 L g -1 to 1.86 x 10 5 L g -1 , respectively, indicate that most of the radium nuclides in the study area are strongly absorbed into the particulate phases. Therefore, low concentrations of suspended particles matter in the water column (< 10 mg L -1 ) have insignificant effects on the Kd values.

Matched MeSH terms: Malaysia

238U and 232Th in cassiterites samples and amang by-products

Hu SJ, Chong CS, Subas S

Health Phys, 1981 Feb;40(2):248-50.

PMID: 7216807

Matched MeSH terms: Malaysia

Fulltext 25-hydroxy-vitamin D demography and the risk of vitamin D insufficiency in the South East Asian Nutrition Surveys (SEANUTS)

Poh BK, Rojroongwasinkul N, Nguyen BK, Sandjaja, Ruzita AT, Yamborisut U, et al.

Asia Pac J Clin Nutr, 2016;25(3):538-48.

PMID: 27440689 DOI: 10.6133/apjcn.092015.02

The South East Asian Nutrition Surveys (SEANUTS) were conducted in 2010/2011 in Indonesia, Malaysia, Thailand and Vietnam in country representative samples totalling 16,744 children aged 0.5 to 12 years. Information on socio-demographic and behavioural variables was collected using questionnaires and anthropometric variables were measured. In a sub-sample of 2016 children, serum 25-hydroxy-vitamin D (25(OH)D) was determined. Data were analysed using SPSS complex sample with weight factors to report population representative data. Children were categorized as deficient (<25 nmol/L), insufficient (<50 nmol/L), inadequate (<75 nmol/L) or desirable (>=75 nmol/L). In Malaysia and Thailand, urban children had lower 25(OH)D than rural children. In all countries, except Vietnam, boys had higher 25(OH)D levels and older children had lower 25(OH)D. Regional differences after correcting for age, sex and area of residence were seen in all countries. In Thailand and Malaysia, 25(OH)D status was associated with religion. The percentage of children with adequate 25(OH)D (>=75 nmol/L) ranged from as low as 5% (Indonesia) to 20% (Vietnam). Vitamin D insufficiency (<50 nmol/L) was noted in 40 to 50% of children in all countries. Logistic regression showed that girls, urban area, region within the country and religion significantly increased the odds for being vitamin D insufficient. The high prevalence of vitamin D insufficiency in the (sub) tropical SEANUTS countries suggests a need for tailored approach to successfully combat this problem. Promoting active outdoor livestyle with safe sunlight exposure along with food-based strategies to improve vitamin D intake can be feasible options.

Matched MeSH terms: Malaysia/epidemiology

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