Dengue fever is endemic in Malaysia and poses a significant problem to the national health system. Because of its nonspecific clinical features, it creates clinical and administrative uncertainties. We evaluated the role of an emergency department short-stay ward (EDSSW) in the management of dengue fever in the Universiti Kebangsaan Malaysia Medical Centre (UKMMC).
Aflatoxin B1 (AFB1) was detected in 57% of the nuts and nut products marketed in Penang, Malaysia using the liquid chromatography tandem mass spectrometry. The contamination levels ranged from 0.40 to 222 μg/kg and 17 out of 128 samples (13.3%) contained AFB1 above the European Commission permitted level (2 μg/kg). Estimated dietary exposure of AFB1 in nuts and nut products were 0.36 ng per kg body weight and day and 8.89 ng per kg body weight and day, representing the low and high-level of exposure, respectively. Dose-response modelling resulted in benchmark dose lower confidence limit (BMDL10) values of 0.305 ng per kg body weight and day, with the best fitted from the log-logistic model. The derived margin of exposure (MoE) values ranged from 34 to 847 suggested that AFB1 would be of public health concern and might reasonably be considered as a high priority for risk management actions.
We have calculated the vibrational frequencies of clusters of atoms from the first principles by using the density-functional theory in the local density approximation (LDA). We are also able to calculate the electronic binding energy for all of the clusters of atoms from the optimized structure. We have made clusters of BanOm (n, m=1-6) and have determined the bond lengths, vibrational frequencies as well as intensities in each case. We find that the peroxide cluster BaO2 occurs with the O-O vibrational frequency of 836.3 cm(-1). We also find that a glass network occurs in the material which explains the vibrational frequency of 67 cm(-1). The calculated values agree with those measured from the Raman spectra of barium peroxide and Ba-B-oxide glass. We have calculated the vibrational frequencies of BaO4, GeO4 and SiO4 each in tetrahedral configuration and find that the vibrational frequencies in these systems depend on the inverse square root of the atomic mass.
This audit report assessed the structure, processes and outcome of the pulmonary tuberculosis (PTB) management in adults conducted at eight government health clinics within the high TB burden Gombak district. All newly diagnosed PTB patients from November 2012 to November 2013 were identified from the tuberculosis registry. Patients less than 18 years old, were transferred out or extrapulmonary tuberculosis was excluded from the study. The assessment criteria for PTB were defined according to the latest Malaysian TB clinical practice guidelines (TB CPG) 2012. A total of 117 patients were included in this report and data were extracted and analysed using SPSS version 20.0. The mean age of patients was 40.4 ± 14.4 SD. Majority was men (63.2%). Out of 117 patients, 82.1% were Malaysian citizens and 17.9% were foreigners. Malays were the majority (65%) followed by 7.7% Chinese, 10.3% Indian and 17.1% others. The most common clinical feature was cough (88.0%) followed by loss of weight (58.1%), loss of appetite (57.3%), fever (56.4%), night sweat (30.8%) and haemoptysis (32.5%). Acid-fast bacilli (AFB) smear was positive in 94% of cases. Chest X-ray and human immunodeficiency virus (HIV) screening results were available for 89.1 and 82.1% cases respectively. The results for the sputum culture were available in 27.4% of patients and 54.7% were documented as done but pending results. The clinics have a successful directly observed therapy (DOT) program with 94.0% patients documented under DOT. Out of 53 patients on maintenance phase, 47.2% were identified as cured. Cure rate for those completed treatment was 100%. The defaulter rate was 17.1%. This audit demonstrated the attempt made by the clinics to adhere to the recommended guidelines. However, improvements are to be made in the documentation of medical records, tracing of investigation results and reduction of the number of defaulters.
The inexorable exposure of plants to the combinations of abiotic stresses has affected the worldwide food supply. The crop improvement against these abiotic stresses has been captivating approach to increase the yield and enhance the stress tolerance. By using traditional and modern breeding methods, the characters that confer tolerance to these stresses were accomplished. No doubt genetic engineering and molecular breeding have helped in comprehending the intricate nature of stress response. Understanding of abiotic stress-involved cellular pathways provides vital information on such responses. On the other hand, genomic research for crop improvement has raised new assessments in breeding new varieties against abiotic stresses. Interpretation of responses of the crop plants under stress is of great significance by studying the main role of crops in food and biofuel production. This review presents genomic-based approaches revealing the complex networks controlling the mechanisms of abiotic stress tolerance, and the possible modes of assimilating information attained by genomic-based approaches due to the advancement in isolation and functional analysis of genes controlling the yield and abiotic stress tolerance are discussed.
Fire emergencies are threat to the occupants of a residential college. Some of the Malaysian residential colleges were built in the 1970s. Back then, the compliancy to Uniform Building By-law 1984 was not entirely practiced. This study aims to evaluate fire safety measures in selected residential colleges of a Malaysian University, which were built before 1984. This includes occupants’ level of awareness and knowledge of the occupants regarding fire safety measures. This study was conducted in selected residential colleges, built before 1984, which were named as A, B, C, and D Colleges. One new college building was selected to be the control variable, the E College. Survey questionnaires were given to 401 respondents to obtain information regarding the fire safety awareness and knowledge. Fire safety inspections were conducted to determine the level of fire safety protection systems in colleges and the documentation of emergency response plan were reviewed. From the study, the level of fire safety awareness among the occupants were higher compared to their fire safety knowledge. Fire safety inspection result indicated that overall buildings inspected complies with the local regulation while safety documentation reviews were satisfactorily adequate. Overall, the score for fire safety measures in all selected colleges were sufficient and in good condition. This study is significant for those in the field of safety and health practice pertaining to fire safety engineering and regulations, to plan for better and more efficient fire hazard and risk assessment.
Introduction:Lymphatic filariasis (LF) is a neglected tropical disease that can cause significant morbidity. In Malay-sia, National Programme for the Elimination of Lymphatic Filariasis started in 2001 with the initial target of achiev-ing Lymphatic Filariasis elimination status by 2018 but it has been revised to year 2020. Mass Drug Administration (MDA) Programme was performed from 2004 to 2008 in all endemic areas (Red Implementation Unit, IU) in Malay-sia including Terengganu state to stop disease transmission. Transmission Assessment Surveys (TAS) were conducted later on and for Terengganu, they were done in 2011 (TAS 1), 2015 (TAS 2) and 2017 (TAS 3) and had passed all the surveys based on critical cut off (CCO) point given. Methods: A cross sectional analysis of 10-year Terengganu filariasis records (2009-2018) was initiated in June 2019 using data source from eVekpro and filariasis cases line-list-ing. Results: Majority of filariasis cases in Terengganu were among males (n=147, 76.6%) with the highest number among 30-39 year-old age group (n=35, 18.2%). Majority of cases were Malaysian citizens (n=162, 84.4%) with main filariasis species identified were Brugia Malayi (n=149, 77.6%). The number of cases diagnosed was slightly higher from Green Implementation Unit area (n=102, 53.1%) compared to Red Implementation Unit area. Conclu-sion: The number of lymphatic filariasis cases among Terengganu citizens was below critical cut off point after the accomplishment of MDA programme and in accordance with the aim of lymphatic filariasis elimination status in Malaysia by 2020.
Introduction: Adolescent aggression has become a serious public health problem with the escalating juvenile cases and violence among secondary school students by inflicting harm to others. The objective of this study was to deter-mine the biopsychosocial predictors of adolescent aggression among Form Four students in Hulu Langat. Methods: Cross-sectional study was conducted by proportionate population sampling method among Form Four students from all public secondary schools in Hulu Langat. Pre-tested questionnaires distributed to measure students’ ag-gression, demographic (ethnicity, family income), biological (sex, head injury, nutritional deficiency, breakfast skip-ping), psychological (attitude towards aggression, normative beliefs to aggression, personality trait, and emotional intelligence), and social factors (family environment, single parent status, domestic violence, peer deviant affiliation, alcohol, smoking, and substance abuse). Data was analysed using multivariate analysis to determine the significant predictors. Results: 480 students from four randomly selected schools participated in the study with response rate of 96.5%. The median aggression score was low, which was 23.00 (IQR=12.00). From simple linear regression, 15 factors had significant relationship with adolescent aggression. The predictors of adolescent aggression were lower family income, Malay ethnicity, nutritional deficiency, attitude towards aggression, and peer deviant affiliation (F [8, 244] =15.980, p-value
The present work deals with the production of paper materials from onion peels (Allium Cepa) fibers
as an alternative potential non-wood fiber. The onion peels were obtained from a local small and
medium food industry. The onion peels were cooked at 120, 150 and 180 minutes. The peels were
grinded and poured in a set of mould and deckle for the formation of a thin sheet of paper. The
physical, mechanical, morphological characteristics and water rise capillary values (KLEMM
Method) were evaluated to determine its suitability for a paper material. The results show that the
increase in cooking time from 120 to 180 minutes resulted in an increase in the tensile index from
32.28N*m/g to 42.13N*m/g and tear index from 9.80mN*m2
/g to 15.62mN*m2
/g. The bonding
strength increased due to higher number of fibers, finer fiber size, and increase in the fiber contact
area and fiber distribution. The high porosity area affects the performance of water rise capillary
values of the paper sheets. The onion peels fiber gave impressive handsheets characteristics when
compared with other sources of non-wood fibers.
Demand for milk has increased in Malaysia due to the increased in awareness of healthy foods consumption.
Hence, research of milk is crucial to ensure that it is not contaminated with Escherichia coli. This study
evaluated the survival of Escherichia coli at different temperature and haemolysin activity of Escherichia
coli on blood agar. A total of 8 samples of raw fresh and pasteurized milk were collected from nearby farm
and market in Negeri Sembilan, Malaysia. After an overnight exposure to four different temperatures of
0
0C, 280C, 350C and 450C, the bacteriological test of milk was evaluated for the presence of Escherichia
coli. Overall, all raw fresh milk sampled exceeded the acceptable limit of bacterial count of 1 x 105 CFU/ml.
Raw fresh milk recorded the highest count at 35oC with 4.4 x 107 CFU/ml and the lowest at 0oC with 8.3 x
104 CFU/ml. The presence of Escherichia coli was detected in 7/20(35%) of the total raw fresh milk
samples. All pasteurized milk showed no presence of Escherichia coli due to the effectiveness of heat
treatment. Haemolysin test showed no haemolytic activity. Milk contaminated with Escherichia coli can
cause diarrheal, gastrointestinal diseases and urinary infection. Hence, it is important to study the survival
rate of Escherichia coli and its pathogenicity in milk to ensure public safety.
Students nowadays in Malaysia and globally, prefer to consume caffeinated energy drink to stay up late to finish their daily task especially during exams or finishing their coursework. Despite the rising trends and aggressive marketing strategies aimed toward college students, there has been little research done on college students’ intake of caffeinated energy drinks and their impact on sleep quality such as the daytime sleepiness. Bad sleep quality is also significantly found more commonly in those with psychological distress which will then consequently affect students’ academic performances. This research studies about universities student pattern of consumption of caffeinated energy drink and how it affects their level of daytime sleepiness and level of psychological distress. In this research, The Epworth Sleepiness Scale (ESS) was used to evaluate general level of daytime sleepiness and the capability to stay alert and awake during crucial moments of the day. While the level of psychological distress were measured using the 12-item General Health Questionnaire (GHQ-12), a self-administered screening instrument designed to detect current diagnosable mental disturbances and disorders. Research findings showed that there are generally higher usage of caffeinated energy drink in male, between 20 to 22 years old and active in any physical activity, among participants whom does not consume caffeinated energy drink, majority score CGPA between 3.00 to 3.50. Also, there are significance between the psychological distress and consumption of caffeinated energy drink, 86.3% whom does not consume caffeinated energy drink does not have psychological distress and between daytime sleepiness and psychological distress, about 71.8% daytime sleepers have psychological distress (p
The use of honey as a therapeutic agent dates back at 8000 years and has markedly increased interest into its potential
health benefits. The by-products of the flower nectar have a complex chemical composition which promotes benefits in
underlying mechanism of human diseases. Malaysian Tualang Honey (MTH) is a multifloral jungle honey produced by
the rock bee (Apis dorsata). This review consolidates the results of carious studies involving biochemical assays of tissue
culture and animal trials of anti-cancer properties of MTH. Often studied in the context of breast cancer cell lines, MTH
has promising data for possible mechanisms in anti-cancer activity. These include apoptosis via depolarization of the
mitochondrial membrane, caspase-dependent apoptosis, reduction of angiogenesis and the promotion of cell cycle arrest
without posing cytotoxic effect on normal cell lines. Despite positive outcomes in tissue cultures, the oral administration
of MTH in breast cancer animal models showed slower tumour progression, reduction in tumour size and better grading
of histological features. The alleviation of breast carcinogenesis via modulation of hematologic, estrogenic and apoptotic
activities promotes MTH as a promising anticancer agent. With confidence in a conclusion that MTH is a useful treatment
for cancer, further experimental and clinical studies should be conducted.
In this paper, we develop algebraic order conditions for two-point block hybrid method up to order five using the approach
of B-series. Based on the order conditions, we derive fifth order two-point block explicit hybrid method for solving
special second order ordinary differential equations (ODEs), where the existing explicit hybrid method of order five is
used to be the method at the first point. The method is then trigonometrically fitted so that it can be suitable for solving
highly oscillatory problems arising from special second order ODEs. The new trigonometrically-fitted block method is
tested using a set of oscillatory problems over a very large interval. Numerical results clearly showed the superiority
of the method in terms of accuracy and execution time compared to other existing methods in the scientific literature.
Despite being effective in promoting healthy dietary behaviour, smartphone apps are scarcely available for our local communities and the majority of nutritional-related information is based on western food selections. Our new innovation aims to provide specific educational advice about recommended food intake, types, nutritional qualities and weight issues for cancer patients and survivors who suffer appetite problems and nutritional deficits. The Cancer Dietary (CanDiTM) app was developed as a convenient, flexible and attractively engaging smartphone app containing healthy tips which are uniquely tailored to the local food choices, preferences and ingredients. This helps customise users’ dietary needs besides permitting constant information up-dating. Features are broadly categorised into Healthy Eating Guide (advice from healthy eating to eating problems, weight loss prevention and increasing proteins and calories intake) and Malaysian Recipes For Cancer Patients (focusing on common Malaysian dishes, ingredients, treatment-based recipes and special diets). An additional Symptom Diary allows user’s personal profile to be recorded and stored virtually online. Its feasibility and acceptability were further tested among 30 cancer patients, family caregivers and dieticians recruited from a public hospital in Terengganu, Malaysia. Very good feasibility (> 80%) and excellent acceptability (> 90%) were reported regarding its ease of operation, suitability of language used, attractiveness, knowledge enhancement and perceived usefulness. With this scientific yet creative innovation, routine dietary habits related to cancer conditions could be easily facilitated for both patients/survivors as well as family caregivers for their independent and healthy living.
In vivo stability of biomaterial-based bone scaffolds often present a significant drawback in the development of materials
for tissue engineering purpose. Previously developed nanobiocomposite bone scaffold using alginate and nano cockle shell
powder has shown ideal characteristics. However, it showed high degradation rate and reduced stability in an in vivo
setting. In this study, we aim to observe the effect of cross-linking glutaraldehyde (GA) in three different concentrations
of 0.5%, 1% and 2% during the fabrication process as a potential factor in increasing scaffold stability. Microstructure
observations of scaffolds using scanning electron microscope (SEM) showed all scaffolds crossed linked with GA and
control had an ideal pore size ranging from 166.8-203.5 µm. Increase in porosity compared to the control scaffolds
was observed in scaffolds cross-linked with 2% GA which also presented better structural integrity as scored through
semi-quantitative methods. Tested pH values during the degradation period showed that scaffolds from all groups
remained within the range of 7.73-8.76. In vitro studies using osteoblast showed no significant changes in cell viability
but a significant increase in ALP enzyme levels in scaffold cross-linked with 2% GA. The calcium content released from
all scaffold showed significant differences within and between the groups. It can be concluded that the use of GA in the
preparation stage of the scaffold did not affect the growth and proliferation of osteoblast and use of 2% GA showed
improved scaffold structural integrity and porosity.
In this day and age, with the ever-growing population and energy demand, we should take the renewable option route in our energy source. We should also keep in mind that said energy should not cause any lasting environmental damage, one of the perfect example being solar energy. A country that is hot and sunny all year long is the perfect contributor to solar energy, case in point, Malaysia. With that in mind Solar Tree is designed and developed to facilitate consumers who need electric power at any place, anytime, anywhere. The objective of this study is to assess a mini project in the likes of Solar Tree that can generate electricity without harming the environment, despite the weather. Intended specifically to be a mini project, it is understandable that electricity generated is limited, with only up to 500W in total. As a trial, two electronic devices were tested, specifically a mobile phone and a laptop, as both devices are used almost every day. The data collected is then tabulated and analysed. It was concluded the solar tree developed proved efficient in charging both devices and will continue to do so given enough sunlight.
Nanosilver particles (NSPs) were produced by the reduction of silver nitrate using glucose as reducer, poly (vinyl pyrrolidone) as stabilizer and sodium hydroxide as reaction enhancer. Two parameters were investigated which are silver nitrate concentration (0.1 M, 0.5 M and 1.0 M) and reaction temperature (60°C and 80°C). Through spectral analysis using ultraviolet-visible spectrophotometer (UV-vis), all the samples recorded the maximum peak in the range of 384-411 nm which verified the formation of NSPs. TEM images showed the nanoparticles have spherical shape with the size range of 25-39 nm. Particle size and zeta potential analysis recorded the hydrodynamic size of nanoparticles in the range of 85-105 nm and the zeta potential ranging from -25 to -30 mV, under the pH value of 8. X-ray diffraction analysis showed that the NSPs have face center cubic (FCC) structure. All the produced NSPs surprisingly showed ferromagnetic-like behaviour based on the magnetization curves. FTIR result confirmed the presence of poly (vinyl pyrrolidone) on the NSPs surface. Furthermore, at the reaction temperature 60°C, the crystallite size, physical size as well as hydrodynamic size increased as the precursor concentration increased from 0.1 M to 0.5 M. However, as the precursor concentration further increases to 1.0 M, the size become smaller due to incomplete reduction process. In contrast, at 80°C, the sizes was gradually increased as the precursor concentration increases up to 1.0 M. In terms of controlled precursor concentration, the crystallite size and physical size become smaller as the temperature increases.
Introduction: Providing adequate and equal access to healthcare is a key goal towards achieving universal health coverage. However, social and demographic inequalities in accessing health care services exist in both developed and developing countries. This study examined the demographic and socio-economic factors associated with the lack of access to public clinics in the Greater Kuala Lumpur area.
Materials and Methods: The study employed a survey involving 1032 participants. Data were collected using self- administered questionnaires distributed between October and December 2015 in the Greater Kuala Lumpur area.
Results: Of the 1032 participants, 535 were public clinic users. A quarter (25.8%) of the users stated that they did not have access to public clinics in their residential area. A multiple logistic analysis showed that the elderly, the women, those from ethnic minority groups, those of lower family income, and the private sector workers were more likely not to have access to public clinics than their counterparts.
Conclusions: The existing level of accessibility to public clinics could be improved by increasing the number of clinics. Clinics should be established to focus more on reaching the elderly, the women, the ethnic minority groups, the poorer families, and the private sector employees.
Pressurized water reactor (PWR) type AP1000 is a third generation of a nuclear
power plant. The primary system of PWR using uranium dioxide to generate heat energy
via fission process. The process influences temperature, pressure and pH value of water
chemistry of the PWR. The aim of this paper is to transform the primary system of PWR
using fuzzy autocatalytic set (FACS). In this work, the background of primary system
of PWR and the properties of the model are provided. The simulation result, namely
dynamic concentration of PWR is verified against published data.