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  1. Fulltext Evaluation of the functional properties of mung bean protein isolate for development of textured vegetable protein
    Brishti, F.H., Zarei, M., Muhammad, S.K.S., Ismail-Fitry, M.R., Shukri, R., Saari, N.
    International Food Research Journal, 2017;24(4):1595-1605.
    MyJurnal
    Mung bean is considered a ‘green pearl’ for its relatively high protein content; however, it has limited application as a raw material for industrial food products. As the potential use of mung beans relies on its protein behavior, this study characterized the functional properties of mung bean protein isolates and the results were compared with soy protein isolates. The protein isolates were prepared from mung bean and soy bean flours via extraction with 1 N NaOH, precipitated at pH 4, and subsequently freeze-dried. The amino acid profile as well as the hydrophilic and hydrophobic ratio of mung bean protein isolate, had been comparable with soy protein isolate. The water and oil absorption capacities as well as the denaturation temperature of mung bean protein isolate, were found to be similar with those of soy bean protein isolate. However, foaming capacity (89.66%) of mung bean protein isolate was higher than that of soy protein isolate (68.66%). Besides, least gelation concentration (LGC) of mung bean protein isolate (12%) was also close to LGC of soy protein isolate (14%), while the protein solubility was comparable between both the isolated proteins. The physical features of the textured mung bean were close to the commercial textured soy protein, which showed a heterogeneous and porous network like matrix when the mung bean flour was extruded to measure its potentiality to produce textured vegetable protein.all seaweed extracts. Results showed that extraction parameters had significant effect (p < 0.05) on the antioxidant compounds and antioxidant capacities of seaweed. Sargassum polycystum portrayed the most antioxidant compounds (37.41 ± 0.01 mg GAE/g DW and 4.54 ± 0.02 mg CE/g DW) and capacities (2.00 ± 0.01 μmol TEAC/g DW and 0.84 ± 0.01 μmol TEAC/g DW) amongst four species of seaweed.
  2. Silver nanoparticle conjugation affects antiacanthamoebic activities of amphotericin B, nystatin, and fluconazole
    Anwar A, Siddiqui R, Hussain MA, Ahmed D, Shah MR, Khan NA
    Parasitol Res, 2018 Jan;117(1):265-271.
    PMID: 29218442 DOI: 10.1007/s00436-017-5701-x
    Infectious diseases are the leading cause of morbidity and mortality, killing more than 15 million people worldwide. This is despite our advances in antimicrobial chemotherapy and supportive care. Nanoparticles offer a promising technology to enhance drug efficacy and formation of effective vehicles for drug delivery. Here, we conjugated amphotericin B, nystatin (macrocyclic polyenes), and fluconazole (azole) with silver nanoparticles. Silver-conjugated drugs were synthesized successfully and characterized by ultraviolet-visible spectrophotometry, Fourier transform infrared spectroscopy, and atomic force microscopy. Conjugated and unconjugated drugs were tested against Acanthamoeba castellanii belonging to the T4 genotype using amoebicidal assay and host cell cytotoxicity assay. Viability assays revealed that silver nanoparticles conjugated with amphotericin B (Amp-AgNPs) and nystatin (Nys-AgNPs) exhibited significant antiamoebic properties compared with drugs alone or AgNPs alone (P 
  3. pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation
    Shah SA, Sohail M, Minhas MU, Nisar-Ur-Rehman, Khan S, Hussain Z, et al.
    Drug Deliv Transl Res, 2019 Apr;9(2):555-577.
    PMID: 29450805 DOI: 10.1007/s13346-018-0486-8
    Cellulose acetate phthalate-based pH-responsive hydrogel was synthesized for fabrication of polymeric matrix tablets for gastro-protective delivery of loxoprofen sodium. Cellulose acetate phthalate (CAP) was cross-linked with methacrylic acid (MAA) using free radical polymerization technique. Fourier transform infrared (FTIR) spectra confirmed the formation of cross-linked structure of CAP-co-poly(methacrylic acid). Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the thermal stability of polymeric networks, and scanning electron microscopy (SEM) and energy-dispersive X-ray spectrum (EDS) images unveiled that the prepared formulations were porous in nature and thus the developed formulations had shown better diffusibility. Swelling and in vitro drug release was performed at various pHs and maximum swelling and release was obtained at pH 7.4, while swelling and release rate was very low at pH 1.2 which confirmed the pH-responsive behavior of CAP-co-poly(MAA). CAP-co-poly(MAA) copolymer prevents the release of loxoprofen sodium into the stomach due to reduced swelling at gastric pH while showing significant swelling and drug release in the colon. Cytotoxicity studies revealed higher biocompatibility of fabricated hydrogel. Acute oral toxicity studies were performed for the evaluation and preliminary screening of safety profile of the developed hydrogels. Matrix tablets were evaluated for release behavior at simulated body pH. The investigations performed for analysis of hydrogels and fabricated matrix tablets indicated the controlled drug release and gastro-protective drug delivery of CAP-co-poly(MAA) hydrogels and pH-sensitive matrix tablets for targeted delivery of gastro-sensitive/irritative agents. Graphical abstract.
  4. Evaluating the Potential of Oleaginous Yeasts as Feedstock for Biodiesel Production
    Mukhtar H, Suliman SM, Shabbir A, Mumtaz MW, Rashid U, Rahimuddin SA
    Protein Pept Lett, 2018;25(2):195-201.
    PMID: 29359654 DOI: 10.2174/0929866525666180122112805
    BACKGROUND: Lipid-producing microorganisms, said to be oleaginous have been recognized since several years. We had investigated the effects of medium components and culturing situations on cell growth and lipid accumulation of oleaginous yeasts which were analytically examined so as to enhance lipid yield for biodiesel production.

    OBJECTIVE: The main objective of this study was to explore oleaginous yeast, Yarrowia lipolytica isolated from soil and optimization of culture conditions and medium components to obtained better quality microbial oil for biodiesel production.

    METHODS: Fifty yeast strains were isolated from soil from different regions of Lahore and eleven of them were selected for oil production. The isolated yeast colonies were screened to further check their lipid producing capabilities by the qualitative analysis. Five yeast strains were designated as oleaginous because they produced more than 16% of oil based on their biomass. To estimate the total lipid content of yeast cells, the extraction of lipids was done by performing the procedure proposed by Bligh and Dyer. The transesterification of yeast oils was performed by using different methods. There were three different strategies customized to transesterifying microbial oil using base catalyzed transesterification, acid catalyzed transesterification and enzyme-based transesterification. After completion of transesterification, sample was used for fatty acid methyl esters (FAMEs) were analyzed by gas-chromatograph with ionization detector type MS.

    RESULTS: The isolate IIB-10 identified as Yarrowia lipolytica produced maximum amount of lipids i.e. 22.8%. More amount of biomass was obtained when cane molasses was utilized as carbon source where it produced 29.4 g/L of biomass while sucrose and lactose were not utilized by IIB-10 and no biomass was obtained. Similarly, meat extracts showed best results when it was used as nitrogen source because it resulted in 35.8 g/L biomass of Yarrowia lipolytica IIB-10. The culturing conditions like size of inoculum, effect of pH and time of incubation were also studied. The 10% of inoculum size produced 25.4 g/L biomass at 120 h incubation time, while the pH 7 was the optimum pH at which 24.8 g/L biomass was produced by Yarrowia lipolytica IIB-10. GC-MS analysis showed that biodiesel produced by transesterification contained similar fatty acids as found in vegetable oil for this reason it is widely accepted feedstock for biodiesel production.

    CONCLUSION: The analysis of fatty acids methyl esters showed the similar composition of microbial oil as in vegetable oils and high amount of methyl esters were obtained after transesterification. Therefore, potentially oleaginous yeast could be used to generate a large amount of lipids for biodiesel production that will be the better substitute of petroleum-based diesel and will also control the environmental pollution.

  5. Fulltext Study of Cationic and Nonionic Mixed Micelles with NaBr and 3,5-Cl2C6H3CO2Na by Use of Probe Nucleophilic Reaction of Piperidine with Ionized Phenyl Salicylate
    Fagge II, Khalid K, Noh MAM, Yusof NSM, Zain SM, Khan MN
    J Oleo Sci, 2018 Jan 01;67(1):55-66.
    PMID: 29238023 DOI: 10.5650/jos.ess17033
    Behaviors of cationic and nonionic mixed micelles in the form of hexadecyltrimethylammonium bromide (HDABr) and hexadecyltrimethylammonium bromide-Polyethylene glycol hexadecyl ether (C16E20), in the presence of inert salts (NaBr and 3,5-dichlorosodium benzoate), by the use of reaction probe between Pp and ionized PhSH (Pp = piperidine and PhSH = phenyl salicylate), has been reported in this work. The values of RXBr (RXBr denotes ion exchange constants obtained in the presence of micelles of different structural features) or KXBr (KXBr denotes ion exchange constants obtained in the presence of micelles of the same structural features) for 3,5-Cl2C6H3CO2- were almost the same at three different [HDABr]T (0.006, 0.010 and 0.015 M). The average value of RXBr or KXBr determined, in the presence of pure HDABr micelles, using semi empirical kinetic (SEK) method appeared to be almost 2½-fold larger (RXBr or KXBr = 198) than that in the presence of mixed HDABr-C16E20 micelles (RXBr or KXBr = 78). Rheological measurements indicated the existence of wormlike/twisted micelles and vesicle at 0.015 M pure HDABr, various [3,5-Cl2C6H3CO2Na], and 25 and 35℃ whereas there were evidence of only spherical micelles in the presence of mixed HDABr-C16E20 ([HDABr]T = 0.015 M and [C16E20]T = 0.006 M) at both temperatures.
  6. Fulltext Isolation and characterisation of filamentous fungi from animal agricultural farm soil
    Muhammad Shukri Senwan, Muhd Fauzi Safia, Zainon Mohd Noor, Zaidah Zainal Ariffin
    Pertanika Journal of Science & Technology, 2017;25(104):19-28.
    MyJurnal
    Aspergillus sp. is an extremely resilient species that can be found everywhere in the environment and
    is present abundantly in water and soil. The defining characteristic of Aspergillus sp. is their extensive
    hyphal network which enable them to survive anywhere, even in very harsh conditions. This study was
    carried out to isolate the filamentous fungi from peat soil of animal agricultural farm and characterise
    them based on their morphological and molecular characteristics. Growth rate of each isolated fungi was
    also evaluated in order to determine the period of maturity for each fungi. Soil samples were collected,
    weighed and then dissolved in sterile distilled water. The samples were serially diluted and spread
    onto potato dextrose agar (PDA) for isolation. Different isolated colonies that were morphologically
    different from each plate was purified and sub-cultured onto new media for macroscopic and microscopic
    identifications. For molecular identification, a conventional technique was used in genomic DNA
    extraction of filamentous fungi due to their thick cell wall and presence of surface proteins protecting the
    fungus. These characteristics make it difficult to harvest the genomic DNA. Polymerase chain reaction
    (PCR) was carried out using internal transcribed spacer primers; ITS1 (forward) and ITS4 (reverse).
    The morphological identification and molecular
    technique showed that majority of these isolated
    fungi are Aspergillus sp.
  7. Fulltext Habitat suitability and movement corridors of grey wolf (Canis lupus) in Northern Pakistan
    Kabir M, Hameed S, Ali H, Bosso L, Din JU, Bischof R, et al.
    PLoS One, 2017;12(11):e0187027.
    PMID: 29121089 DOI: 10.1371/journal.pone.0187027
    Habitat suitability models are useful to understand species distribution and to guide management and conservation strategies. The grey wolf (Canis lupus) has been extirpated from most of its historic range in Pakistan primarily due to its impact on livestock and livelihoods. We used non-invasive survey data from camera traps and genetic sampling to develop a habitat suitability model for C. lupus in northern Pakistan and to explore the extent of connectivity among populations. We detected suitable habitat of grey wolf using a maximum entropy approach (Maxent ver. 3.4.0) and identified suitable movement corridors using the Circuitscape 4.0 tool. Our model showed high levels of predictive performances, as seen from the values of area under curve (0.971±0.002) and true skill statistics (0.886±0.021). The main predictors for habitat suitability for C. lupus were distances to road, mean temperature of the wettest quarter and distance to river. The model predicted ca. 23,129 km2 of suitable areas for wolf in Pakistan, with much of suitable habitat in remote and inaccessible areas that appeared to be well connected through vulnerable movement corridors. These movement corridors suggest that potentially the wolf range can expand in Pakistan's Northern Areas. However, managing protected areas with stringent restrictions is challenging in northern Pakistan, in part due to heavy dependence of people on natural resources. The habitat suitability map provided by this study can inform future management strategies by helping authorities to identify key conservation areas.
  8. Fulltext Radiological findings of Pulmonary Tuberculosis in patients with and without HIV infections
    Radhiana Hassan, Haziq Hussaini Fauzi, Kamil Irsyad Yusoff, Muhammad Faizol Mohd Satar, Hafizah Pasi
    International Medical Journal Malaysia, 2017;16(11):49-49.
    MyJurnal
    Radiological manifestation of pulmonary tuberculosis in HIV positive
    patients is different with HIV negative patients. We aim to determine the differences in
    chest radiological findings of Pulmonary Tuberculosis among HIV and non-HIV infected
    patients in HTAA. (Copied from article).
  9. Fulltext Renoprotective role of Tualang honey against high cholestrol diet induced acute kidney diseases in an animal model
    Zenab B. Hamad Mohamed, Hamad Abdulsalam Hamad Alfarisi, Nor Zamzila Abdullah, Naznin Muhammad, Roslan Abdul Rahim
    International Medical Journal Malaysia, 2017;16(11):26-26.
    MyJurnal
    Although there is a growing insight into the causes and mechanisms of
    kidney diseases, preventive and therapeutic measures are still few. The aim of this study
    was therefore to determine the renoprotective effect of tualang honey against high
    cholesterol diet induced acute kidney disease in an animal model. (Copied from article).
  10. Fulltext Tracking-learning-detection using extreme learning machine with Haar-like features
    Melisa Anak Adeh, Mohd Ibrahim Shapiai, Ayman Maliha, Muhammad Hafiz Md Zaini
    Journal of Advanced Research in Applied Sciences and Engineering Technology, 2016;5(2):1-11.
    MyJurnal
    Nowadays, the applications of tracking moving object are commonly used in various
    areas especially in computer vision applications. There are many tracking algorithms
    have been introduced and they are divided into three groups which are generative
    trackers, discriminative trackers and hybrid trackers. One of the methods is TrackingLearning-Detection
    (TLD) framework which is an example of the hybrid trackers where
    combination between the generative trackers and the discriminative trackers occur. In
    TLD, the detector consists of three stages which are patch variance, ensemble classifier
    and KNearest Neighbor classifier. In the second stage, the ensemble classifier depends
    on simple pixel comparison hence, it is likely fail to offer a better generalization of the
    appearances of the target object in the detection process. In this paper, OnlineSequential
    Extreme Learning Machine (OS-ELM) was used to replace the ensemble
    classifier in the TLD framework. Besides that, different types of Haar-like features were
    used for the feature extraction process instead of using raw pixel value as the features.
    The objectives of this study are to improve the classifier in the second stage of detector
    in TLD framework by using Haar-like features as an input to the classifier and to get a
    more generalized detector in TLD framework by using OS-ELM based detector. The
    results showed that the proposed method performs better in Pedestrian 1 in terms of
    F-measure and also offers good performance in terms of Precision in four out of six
    videos.
  11. Fulltext Risk factors of childhood obesity and overweight in young children and adolescents aged between 5 to 15 years in urban Bangladesh: a scoping review
    Faisal Muhammad, Alauddin Chhowdhury, A.B.M., Sifat Rokhsana Hasin, Mustapha Kabir Musa, Moniruddin, Chowdhury
    Malays J Nutr, 2016;22(3):455-459.
    MyJurnal
    Introduction: Childhood obesity is one of the most serious public health challenges of the 21st century. The problem is global and is steadily affecting many low- and middle-income countries, particularly in urban settings. Risk factors for obesity in this context have not been explored. The objective of this study was to identify the risk factors associated with childhood obesity/overweight among young children and adolescents 5-15 years of age in urban Bangladesh.

    Methods: A scoping review based on York methodology was performed. This methodology involves a comprehensive search of published academic articles, conference proceedings and grey literature through PubMed, Bangla JOL, Google and Google scholar, limited to English-written papers.

    Results: Findings revealed that having at least one overweight parent and engaging in sedentary activities for more than 4 h a day were independent risk factors for childhood overweight and/or obesity.Children who spent ≥ 30 min each day in outdoor games at home that involved physical exercise had decreased odds (OR = 0.38, 95% CI: 0.1–0.8) of being overweight or obese compared to children who did not exercise at home.

    Conclusion: Spending much time seated or somewhat inactive were key risk factors for childhood obesity and overweight. More research, prevention and management of childhood obesity/overweight in young children and adolescents in urban Bangladesh should be a policy priority.
  12. Fulltext Construction occupational safety and health from the perspective of Malaysian residential construction industry
    Mohd Hafiidz Jaafar, Kadir Arifin, Kadaruddin Aiyub, Muhammad Rizal Razman, Mark Harris Zuknik
    Journal of Occupational Safety and Health, 2016;13(2):23-34.
    MyJurnal
    Construction industry is one of the major contributors towards Malaysian economy and socio-economy. It is an important
    industry gearing Malaysia towards developed nation status. However, fatalities in this industry are a crucial problem. Number of
    fatalities in this industry is the highest compare to other industries registered in Malaysia. The contributing factors can be separated
    into immediate (human and worksite elements) and underlying (management and external). Occupational safety and health (OSH)
    management is a challenge in the construction industry due to its hazardous nature. A framework of construction OSH management
    consisting of policy, process, personnel and incentive elements were tested. 13 respondents from 13 residential projects comprising of
    high-rise and low-rise in Pulau Pinang were interviewed. It was found that the immediate factors are being more recognized by the
    respondents compare to the underlying factors. Human element is perceived as the most significant contributor, while the external
    element is the least significant. In terms of construction OSH management, process and personnel elements are the most significant in
    developing an effective OSH management programme.
  13. Fulltext Dental treatment need among first-visit patients of dental outpatient clinic at IIUM Kuantan for the year 2016
    Azlini Ismail, Zurainie Abllah, Nur Aishah Muhammad Radhi, Syazalina Musa, Mohd Firdaus Akbar Abdul Halim
    International Medical Journal Malaysia, 2017;16(21):56-56.
    MyJurnal
    Introduction: This cross-sectional study aimed to determine association of age and gender with dental treatment need among first-visit patients at Dental Outpatient Clinic, IIUM Kuantan in 2016.
    Materials and Methods: Ethical approval (IREC 762) was obtained from IIUM Human Ethics Committee. List of first-visit patients who attended clinic from 1st January to 31st December 2016 was retrieved to assess patient's age and gender. Dental treatment need was determined according to the normative need which was professionally defined by dental-officer-in-charge. All first-visit patients were included, except those attended Orthodontic department or with old Malaysian identification card or foreign passport. Included patients were classified into six age groups (≤14, 15-19, 20-34, 35-44, 45-64 and ≥ 65). Pearson's chi square test was used for statistical analysis using SPSS Version 20 software.
    Results: From a total number of 2,713 patients (age range of 2 to 87), 1,210 (44.6%) were males and 1,503 (55.4%) were females. Age (p<0.001) and gender (p<0.001) were significantly associated with dental treatment need. Paediatric patients (≤14) majorly received paedodontic care (97.5%). Young-age patients (15-19, 20-34 and 35-44) mostly required conservative care (39.5%, 31.2% & 30.6%, respectively) while elder-age patients (45-64 and ≥ 65) have major need for prosthodontics (30.0% & 40.2%, respectively). Females outnumbered males in all age groups, except for the age group of ≥ 65 whereby the situation was the opposite. Females also outnumbered males in all types of treatment need, except for periodontics which was predominated by males.
    Conclusion(s): Age and gender have significant associations with treatment need for dental care.
    KEYWORDS: treatment need, dental, association, age, gender
  14. Fulltext Parallelogram linkage leg structure for stabilized walking gaits in humanoid robot
    Firdaus Sukarman, Mohd Ghazali Mohd Hamami, Mazleenda Mazni, Muhammad Amir Mat Shah, Ahmad Faidzal Khodori
    Journal of Advanced Research in Applied Sciences and Engineering Technology, 2017;9(1):22-31.
    MyJurnal
    The utilization of parallelogram structure in a small-sized humanoid robot consists of two parallel platforms that are linked serially in each leg. The thigh and shank of each leg consists of two servomotors as actuator and linked in parallel platform. By using parallel mechanism in leg structure, foot sole surface is always parallel to the walking surface at any point. Even it looks unnatural to human-like walking motion, the expected result is the robot can maintain it posture while walking and at the point foot sole touch the walking surface, unnecessary vibrates can be modulated at the certain level to remain its balance. The effectiveness and the performance of the proposed parallel platforms are experimented by using zero moment point (ZMP) method by taking various scenario data from pressure sensors attached at the footsole. Planned walking gait is introduced to be identical in terms of foot steps length and width of each leg swing. As the results, in terms of load in each actuator, required torque at servomotors can be reduced because two servomotors are used simultaneously in one parallel system. Stable walking gait can be predicted as the quantity of error falls within the error ranges from the published walking gait patterns.
  15. Fulltext An 8-year retrospective review of microbial keratitis in a secondary referral centre in Malaysia
    Nazri Omar, Maimunah Abdul Muna’aim, Rafidah Md. Saleh, Zaidah Mohd. Kasim, Muhammad Mohd. Isa
    Malaysian Journal of Medicine and Health Sciences, 2017;13(2):47-57.
    MyJurnal
    Introduction: Microbial keratitis (MK) is an important cause for corneal blindness and understanding its risk factors enable us to improve management and minimise its complications. Methods: In this retrospective case review, medical records of all patients treated for MK from 2006 to 2013 was analysed to know the socio-demography, preceding risk factors, clinical characteristics, causative organisms and final visual outcome. Results: A total of 174 patients (180 eyes) were included in this study. Identifiable ocular risk factors included contact lens (CL) usage (85, 47.2%), ocular trauma (50, 27.8%), ocular surface disease (21, 11.6%), steroid use (6, 3.3%) and immuno-compromy (19, 10.5%). Association factors for presenting uncorrected visual acuity (UCVA) were age group (p=0.013), size (p
  16. Fulltext Nutritional status of children living in an orphanage in Dhaka City, Bangladesh
    Chowdhury, A.B.M.A., Wasiullah, S., Haque, M.I., Muhammad, F., Hasan, M.M., Ahmed, K.R., et al.
    Malays J Nutr, 2017;23(2):291-298.
    MyJurnal
    Background: Children living in orphanages tend to be neglected and may be malnourished. This study assessed the socio-economic background and nutritional status of children living in an orphanage in Dhaka city, Bangladesh.

    Methods: A cross-sectional study was conducted among the children in Sir Salimullah Muslim Orphanage, Dhaka from January to November 2014. Systematic sampling was adopted to collect data from 232 children using a semi-structured questionnaire. Anthropometric measurements of the children were taken and the WHO reference growth chart was used to determine the children’s nutritional status. Weight-for-age was categorised by mild, moderate and severe malnutrition. The Pearson Chi-square test was performed to determine the association between the extent of malnutrition and socio-demographic characteristics of the children.

    Results: The majority of the children (60.3%) in the orphanage were malnourished, with mild, moderate and severe malnourished being 43.1%, 16.8% and 0.4%, respectively. Malnutrition was higher among the boys than girls in the age group of 15-18 years. The orphans suffered significantly (P
  17. Synthesis of some new 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides as potent antibacterial agents
    Hussain G, Abbasi MA, Rehman A, Siddiqui SZ, Shah SAA, Ahmad I, et al.
    Pak J Pharm Sci, 2018 May;31(3):857-866.
    PMID: 29716866
    In this work, a new series of 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides has been synthesized and evaluated for their antibacterial potential. The synthesis was initiated by the reaction of different aryl/aralkyl amines (1a-u) with 2-bromoacetylbromide (2) to obtain N-aryl/aralkyl-2-bromoacetamides (3a-u). Equimolar quantities of different N-aryl/aralkyl-2-bromoacetamides (3a-u) and 2-furoyl-1-piperazine (4) was allowed to react in acetonitrile and in the presence of K2CO3, to form 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides (5a-u). The structural elucidation was done by EI-MS, IR and 1H-NMR techniques of all the synthesized compounds. All of the synthesized molecules were active against various Gram positive and Gram negative bacterial strains. Among them 5o and 5c showed very excellent MIC values. The cytotoxicity of the molecules was also checked to find their utility as possible therapeutic agents, where 5c (0.51%) and 5g (1.32%) are found to be least toxic in the series.
  18. Fulltext Pyrosequencing-based quantitative evaluation of P16 methylation in diffuse large b-cell lymphoma
    Mohd. Ridah L.J., Ismail A., A. Talib N., Muhammad N., Hussain F.A., Zainuddin N.
    Journal of Biomedical and Clinical Sciences, 2016;1(1):12-17.
    MyJurnal
    Introduction: Methylation of promoter region of p16 leading to gene silencing has been implicated ina wide range of malignancies including lymphomas. In diffuse large B cell lymphoma (DLBCL) particularly, a varying percentage of epigenetic inactivation of p16 promoter region was observed ranging from 16 -54%. However, quantitative analysis of p16 promoter methylation in DLBCL has not been extensively studied in Malaysia. Objective: This study aims to quantitatively analyse p16 methylation in DLBCL samples using pyrosequencing technique. Methods: Genomic DNA was extracted from 16 formalin-fixed paraffin-embedded lymphoma tissue blocks from patients diagnosed with DLBCL. Samples were retrieved from Hospital Tengku Ampuan Afzan, Pahang and Hospital Universiti Sains Malaysia, Kelantan. Primers were designed to amplify bisulfite-treated DNA targeting p16 promoter region. Methylation status of 7 CpG sites was determined by pyrosequencing. Results: All the 16 samples studied showed promoter methylation of p16. The range of mean methylation percentage was between 18 to 81%. Conclusion: The present study has successfully measured the level of methylation of p16 in all 7 CpG sites despite the limitation in sample size. Since p16 methylation is a common event in our series of DLBCL cases, it is worth including a larger sample size in future studies to increase the chance of finding a significant correlation with clinical parameters.
  19. Fulltext Awareness and opinion of dentists towards shortened dental arch (SDA)
    Abdul Hamid Nor Faharina, Ishak Hayati, Salleh Muhammad Firdaus, Ahmad Amirul Qayyum
    Malaysian Dental Journal, 2017;2017(1):1-16.
    MyJurnal
    Aim: The Shortened Dental Arch (SDA) concept, proposed as a strategy to prevent prosthodontics overtreatment, is defined as a specific type of dentition with an intact anterior region and a reduction in the occluding pairs of posterior teeth. While this concept has been accepted worldwide, little is known about such a situation in Malaysia. This study was undertaken to determine the attitudes, awareness and opinion of dentists working at the Faculty of Dentistry, Universiti Teknologi MARA Malaysia (UiTM) towards the SDA concept. Methods and Methods: All dentists (n=71) working at the Faculty of Dentistry, UiTM were invited to participate in a paper-based questionnaire survey to assess their attitudes, awareness and perception towards the SDA concept. Results: The response rate was 59% (n=42). Overall, 85.7% of respondents were aware of the Kayser’s SDA concept. A majority of them (61.1%) learnt about it through undergraduate studies. Only some respondents reported patients’ dissatisfaction in chewing (29.4%), appearance (8.8%) and comfort (6.3%) following application of the concept. Most participants disagreed that missing molar teeth should be replaced in all patients (52.4%), and supported the application of SDA concept in clinical practice (88.1%). However, some would choose to replace missing molars for older patients in order to provide posterior support (90.5%), prevent anterior wear (52.4%) and improve masticatory function (83.3%). Conclusion: Respondents’ awareness and support for the SDA concept suggested its acceptance as a possible strategy in patient care.
  20. Fulltext Retinal redetachment after pneumatic retinopexy – the importance of case selection
    Muhammad Najmi, K., Aida Zairani, M.Z., Mushawiahti, M., Bastion, M.L.C., Amin, A.
    Journal of Surgical Academia, 2017;7(2):18-20.
    MyJurnal
    Pneumatic retinopexy is known as one of the treatment options for a specific type of retinal detachment. It is done in
    an office setting and may be the most cost-effective means of retinal reattachment surgery. Location and size of the
    retinal break remain as the major criteria for a successful outcome. We describe a case that fulfilled all except one
    major criteria for pneumatic retinopexy and underwent multiple procedures but failed. Fluctuation in the resolution
    of the retinal detachment such as in this particular case suggested possibility of early treatment failure.
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