Consumption of Solanum lycopersicum or known as tomato has been associated
with the decreased risk of some cancer types. Epidemiological findings confirmed
the observed health effects due to the presence of varied antioxidants in tomato.
This is due to variations of antioxidants presence in tomatoes. Therefore, it is
important to know which types of tomatoes species contain the highest number
of antioxidants and antioxidant activity. In this study, antioxidant content and
antioxidant activity of four tomato variants was studied. The objectives of this
research was to screen for metabolites and to compare number of metabolites by
using two different extraction method. A comparison of the antioxidant activity
and total phenolic content between four tomato variants was conducted based on
the results. Tomatoes that are used in this study includes tomato, truss tomato,
yellow cherry tomato and red cherry tomato. These tomatoes were subjected to
metabolite extraction using two different solvents which is methanol and
methanol-chloroform. Following that, screening of metabolites were performed
using Gas Chromatography-Mass Spectrometry (GCMS) and metabolites were
detected and analysed. The total antioxidant activity of the tomatoes was
measured using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing
power (FRAP) assays. The Total Phenolic Content (TPC) was determined
spectrophotometrically according to the Folin-Ciocalteau procedure. The number
of metabolites detected using GCMS are higher in methanol-chloroform extract
as compared to methanol extract. Methanolic extracts of all four tomatoes were
shown to have free radical scavenging activity. However, red cherry tomato
showed to have the highest antioxidant activity with IC50 value of 1.7 mg/ml,
followed by truss tomato with IC50 2.1 mg/ml, yellow cherry tomato with IC50 4.0
mg/ml and finally tomato with IC50 5.6 mg/ml. The highest value of FRAP in
Gallic Acid Equivalent was 4.3 mg/g in red cherry tomato, followed by 3.8 mg/g
in truss tomato, 2.9 mg/g in yellow cherry tomato and 2.4 mg/g in tomato. The
total phenolic content ranges from 0.44 to 3.73 mg/ml. In conclusion, red cherry
tomato shown to have the highest total phenolic content and antioxidant activity
compared to the other three variants. The findings of this research provide some
valuable information to consumers when choosing the best type of tomatoes for
good wellbeing and as well to set the basis of future research.
Modern-day Malacca is a vibrant old city with a unique historical and cultural background from being the capital of a powerful Malay kingdom before the colonial era, as well as subsequent Portuguese, Dutch and British rule. The city centre was listed by UNESCO as a World Heritage Site in July 2008, many tourists come to Malacca to visit historical sites and tourism, so homestay facilities need to be available to their families Homestay a stay at a residence by a traveller and especially by a visiting foreign student who is hosted by a local family. In this study, propose a smart digital door lock system for homestay system. A digital door lock system is equipment that uses the digital information such as a secret code, semi-conductors, smart card, and finger prints as the method for authentication instead of the legacy key system. In proposed system, a ZigBee module is embedded in digital door lock and the door lock acts as a central main controller of the overall homestay system. A door lock system proposed here consists of RFID reader for user authentication, touch LCD, motor module for opening and closing of the door, sensor modules for detecting the condition inside the house, communication module, and control module for controlling other modules. Status of individual ZigBee module can be monitored and controlled by the centralized controller, digital door lock. As the door lock is the first and last thing people come across in entering and leaving the homestay respectively, the homestay automation function in digital door lock system enables user to conveniently control and monitor homestay environment and condition all at once before entering or leaving the house stay. Furthermore, it also allows users to remotely monitor the condition inside the house through Internet or any other public network.
The purpose of this study was to observe the effects of wearing compression socks on postural balance in university netball players. Fourteen advanced learner netball players performed three trials of 20 seconds each of dynamic postural balance test on Biodex Stability System, while wearing two socks, (a) Normal Socks and (b) Compression Socks. Data on overall, anterior/posterior and medial/lateral stability indexes were analyzed using Paired Sample T-tests. The results revealed that wearing compression materials significantly enhanced static and dynamic postural balance among the university netball players. The improvements in these key variables are likely due to enhanced somatosensory feedback information
which allowed the lower limbs to better regulate postural stability. It is suggested that compression socks can be used by university netball players to improve their postural stability.
Transdermal delivery of drugs is more challenging for drugs that are insoluble or sparingly soluble in water and most organic solvents. To overcome this problem, ionic liquid (IL)-mediated ternary systems have been suggested as potential drug carriers. Here, we report potent ternary (IL-EtOH-IPM) systems consisting of biocompatible ILs, ethanol (EtOH), and isopropyl myristate (IPM) that can dissolve a significant amount of the sparingly soluble drug acyclovir (ACV). The ternary systems were optically transparent and thermodynamically stable with a wide range of IL pertinence. An in vitro drug permeation study showed that the ILs in the ternary systems dramatically enhanced ACV permeation into and across the skin. Fourier Transform Infrared spectroscopy of the stratum corneum (sc) after treatment with ternary systems showed that the skin barrier function was reduced by disturbance of the regularly ordered arrangement of corneocytes and modification of the surface properties of the sc during permeation. Histological analysis, and skin irritation studies using a reconstructed human epidermis model showed the safety profile of the ternary system, and there were no significant changes in the structures of the sc, epidermis, and dermis. Therefore, ternary systems containing biocompatible ILs are promising for transdermal delivery of insoluble or sparingly soluble drugs.
In order to prevent common hypersensitivity reactions to paclitaxel injections (Taxol), we previously reported an ionic liquid-mediated paclitaxel (IL-PTX) formulation with small particle size and narrow size distribution. The preliminary work showed high PTX solubility in the IL, and the formulation demonstrated similar antitumor activity to Taxol, while inducing a smaller hypersensitivity effect in in vitro cell experiments. In this study, the stability of the IL-PTX formulation was monitored by quantitative HPLC analysis, which showed that IL-PTX was more stable at 4 °C than at room temperature. The in vivo study showed that the IL-PTX formulation could be used in a therapeutic application as a biocompatible component of a drug delivery system. To assess the in-vivo biocompatibility, IL or IL-mediated formulations were administered intravenously by maintaining physiological buffered conditions (neutral pH and isotonic salt concentration). From in vivo pharmacokinetics data, the IL-PTX formulation was found to have a similar systemic circulation time and slower elimination rate compared to cremophor EL mediated paclitaxel (CrEL-PTX). Furthermore, in vivo antitumor and hypersensitivity experiments in C57BL/6 mice revealed that IL-PTX had similar antitumor activity to CrEL-PTX, but a significantly smaller hypersensitivity effect compared with CrEL-PTX. Therefore, the IL-mediated formulation has potential to be an effective and safe drug delivery system for PTX.
The technological utility of active pharmaceutical ingredients (APIs) is greatly enhanced when they are transformed into ionic liquids (ILs). API-ILs have better solubility, thermal stability, and the efficacy in topical delivery than solid or crystalline drugs. However, toxicological issue of API-ILs is the main challenge for their application in drug delivery. To address this issue, 11 amino acid esters (AAEs) were synthesized and investigated as biocompatible counter cations for the poorly water-soluble drug salicylic acid (Sal) to form Sal-ILs. The AAEs were characterized using 1H and 13C NMR, FTIR, elemental, and thermogravimetric analyses. The cytotoxicities of the AAE cations, Sal-ILs, and free Sal were investigated using mammalian cell lines (L929 and HeLa). The toxicities of the AAE cations greatly increased with inclusion of long alkyl chains, sulfur, and aromatic rings in the side groups of the cations. Ethyl esters of alanine, aspartic acid, and proline were selected as a low cytotoxic AAE. The cytotoxicities of the Sal-ILs drastically increased compared with the AAEs on incorporation of Sal into the cations, and were comparable to that of free Sal. Interestingly, the water miscibilities of the Sal-ILs were higher than that of free Sal, and the Sal-ILs were miscible with water at any ratio. A skin permeation study showed that the Sal-ILs penetrated through skin faster than the Sal sodium salt. These results suggest that AAEs could be used in biomedical applications to eliminate the use of traditional toxic solvents for transdermal delivery of poorly water-soluble drugs.
The novel coronavirus disease (COVID-19) has spread over 219 countries of the globe as a pandemic, creating alarming impacts on health care, socioeconomic environments, and international relationships. The principal objective of the study is to provide the current technological aspects of artificial intelligence (AI) and other relevant technologies and their implications for confronting COVID-19 and preventing the pandemic's dreadful effects. This article presents AI approaches that have significant contributions in the fields of health care, then highlights and categorizes their applications in confronting COVID-19, such as detection and diagnosis, data analysis and treatment procedures, research and drug development, social control and services, and the prediction of outbreaks. The study addresses the link between the technologies and the epidemics as well as the potential impacts of technology in health care with the introduction of machine learning and natural language processing tools. It is expected that this comprehensive study will support researchers in modeling health care systems and drive further studies in advanced technologies. Finally, we propose future directions in research and conclude that persuasive AI strategies, probabilistic models, and supervised learning are required to tackle future pandemic challenges.
Purpose – Evidences have shown that participation in a cardiac rehabilitation programme improves outcomes and quality of life for cardiac patients. Hospital Serdang has conducted this programme since 2007 and it is the first to be run by the Rehabilitation Medicine Department. The purpose of this survey is to find out whether the programme is suitable, informative and useful from the patient’s perspective as well as to determine whether the 6 weeks duration is sufficient.
Design/ methodology/approach - A patient feedback survey using a self-administered questionnaire on the programme was conducted from January 2008 to December 2010 in Hospital Serdang.
Findings - A total of 323 patients were invited to join the programme but only 182 completed the programme and took part in this survey. 30% of the patients thought that the six weeks programme was not enough for them. 100% of the respondents agreed that the programme was beneficial, well suited to their problems and were willing to promote the programme to their friends. Therefore, it is recommended that this programme be extended to the community level.
Conclusion - In conclusion, this programme is beneficial, suitable, informative and adequate from the patient’s point of view. Extension of this programme into the community as a continuation of the hospital-based programme is likely to improve the outcome further.
Introduction : The purpose of this study was to determine the quality of life (QOL) of breast cancer survivors based on socio-demographic and clinical characteristics.
Methods : A cross-sectional study was performed on 125 breast cancer survivors from the outpatient clinics. FACT-B (Functional Assessment of Cancer Therapy-Breast) questionnaire was used to assess survivors’ QOL.
Results : Survivors with low body mass index (BMI) (underweight) were found to have the lowest overall QOL. Those who were overweight had a higher overall QOL, and those who were normal-weight had the highest QOL. Low educational level, being underweight and low monthly household income were significantly associated with lower overall QOL Tamoxifen use and employment status were significantly associated with QOL in some domains. Time since diagnosis to QOL interview was significantly associated with greater scores in emotional well-being (EWB). Multiple linear regression indicated that age, marital status, monthly household income, surgery and histological grade were indicative of the patients QOL.
Conclusion : The four primary factors related to better QOL were high educational level, high income, normal body weight and greater duration from the time of diagnosis to the time of interview. Age, marital status, income, lumpectomy and histological grade were indicative of the patient QOL.
Study site: Oncology and Surgical clinics; Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia
Tuberkulosis merupakan penyakit yang masih meigadi masalah kesihatan di seluruh dunia amnya dan di Malaysia khasnya. Kajian telah dilakukan ali Cheras, Kuala Lumpur menggunakan aplikasi GIS untuk mengenalpasti taburan geografi dan tren tuberkulosis daripada tahun 1996 sehingga tahun 2000. Kajian ini juga dilakukan untuk melihat kebolehan GIS sebagai alat surveilan penyakit beyangkit. Hasil kajian dengan menggunakan aplikasi GIS mendapati tren peningkatan tuberkulosis di kawasan·kawasan yang tertentu di Cheras. Penumpuan kes-kes tuberkulosis dapat dilihat di kawasan taburan penduduk yang kepadatan tinggi dan sederhana tinggi terutama di kawasan Kampung Pandan, kawasan penempatan Jalan Cheras dan Bandar Tun Razak. Kes—kes tersebut juga kebanyakannya adalah dalam lingkungan 100 meter ke 200 meter di antara satu sama lain. Kesimpulannya secara am, aplikasi GIS memberikan dimensi baru dalam kawalan penyakit dan ia pasti dapat digunakan dalam membantu aktiviti surveilan penyakit tuberkulosis.
Objective: This case report highlights the abuse and dependence potential of Zolpidem and the risk of life-threatening withdrawal symptoms upon abrupt discontinuation. Method: We report a case of Zolpidem dependence which presented with withdrawal symptoms upon abrupt discontinuation. Results: A 32 year old male, who had abused non-benzodiazepine Zolpidem for 6 years presented to the accident and emergency unit with generalized seizures upon stopping Zolpidem ‘cold turkey’. He required admission to the neurology high dependency unit for stabilization of the seizures and was later managed by the addiction team where a tapering dose of benzodiazepine was prescribed. Conclusion: This case demonstrates that non-benzodiazepine agents can cause tolerance and dependence, and thus produce withdrawal symptoms upon discontinuation.
Ceramic foams are a class of high porosity materials that are used or being considered for a wide range of technological applications. Ceramic foam was produce by polymer replication method. In this process, commercial polymeric sponge was use as template, dipping with ceramic particles slurry, drying and then sintered to yield a replica of the original foams. The study was focus on the fabrication of different density of ceramic foams by varying the density of ceramic slurries (1.1876, 1.2687, 1.3653 and 1.5295 g/cm3). Properties of ceramic foam produced such as density was characterized accordingly to ASTM C 271-94 and porosity were characterized using Archimedes methods. Compressive and bending strength was performed accordingly to ASTM C1161-94 and C773-88 (1999), respectively. The morphological study was performed using Scanning Electron Microscopy (SEM) and EDX. Density of ceramic foams produced was about 0.5588 and 1.1852 g/cm3, where as porosity was around 26.28 and 70.59 %. Compressive and bending strength was increase from strength also increases from 2.60 to 23.07 MPa and 1.20 to 11.10 MPa, respectively, with increasing of slurries density from 1.1876 to 1.3653 g/cm3. The SEM micrographs show that the cells structure become denser as the slurries density increased. EDX proved that the ceramic used is porcelain. As a conclusion, increasing in slurries density produced ceramic foams with good mechanical properties such as compressive and bending strength and denser body.
Many attempts have been focused in the past on preparing of synthetic E-tricalcium (E-TCP), which being employed as bone substitute due to its biocompatibility and resorbability. Low temperature synthesize such as sol-gel method become popular due to the high product purity and homogenous composition. Sol-gel method is less economical towards commercialization because the cost of raw materials and the yield of the product that can be achieved. This paper describes the synthesis of ETCP via mixing of CaCO3 and H3PO4 followed by calcinations process at 750qC – 1050qC. X-ray diffraction (XRD), scanning electron microscopy (SEM), differential scanning calorimeter (DSC), fourier transformation infra-red (FTIR) were used for characterization and evaluation of the phase composition, morphology, particle size and thermal behavior of the product. E-TCP phase start to occur after calcinations at 750qC.
Environmental factors such as temperature, lighting and noise have very significant impact to workers’ health, safety, comfort, performance and productivity. In an ergonomically design industrial work environment, these factors need to be control at their optimum levels. The main objective of this study is to find the effect of temperature, illuminance and sound pressure level on workers’ productivity in automotive industry. To perform this study a workstation in an automotive component manufacturing was selected as the location of the study. Results of data analysis showed there were relationships between temperature, illuminance and noise on workers’ productivity. Later, the authors’ developed multiple linear equation models to represent the relationships between temperature, illuminance and noise on the workers’ productivity. These multiple linear equation models could be used to predict the production rate for the workstation by referring to the value of temperature, illuminance and noise level.
Similarity measurement is a critical component in any case-based reasoning (CBR) system. CBR is
a superior technique for solving new problems based on previous experiences. Main assumption in
CBR relies on the hypothesis that states similar problems should have similar solutions. This paper
describes a comparative analysis on several commonly used similarity measures (Canberra, Clark, and Normalized Euclidean distance) in retrieving phase of the case-based reasoning approach to facilitate supplier selection. In addition, the proposed agent-based supplier selection framework was designed to use customer’s defined weights to evaluate the price, volume, quality grade, and delivery date of supply materials, and also provide them with alternative products which are closest to their first order if it was out of stock. Finally, based on the proposed framework, a numerical example of the used approach is illustrated.
Assessment of source and sediment quality was carried out on marine sediments collected from the Tuanku Abdul Rahman National Park. Enrichment factors (EF), pollution load index (PLI) and geo-accumulation index (Igeo) were used to identify the sources of pollution, degree of contamination and sediment quality, respectively. Elemental analyses of marine sediment samples were performed by using the Instrumental Neutron Activation Analysis (INAA). Results from the Tunku Abdul Rahman National Park of Sabah indicated that most of the elements are considered to be from lithological or natural origin with EF values of less than 2 except for As (10 stations), Cr (3 stations), Lu (5 stations), Mg (2 stations), Sb (6 stations) and U (3 stations). For the sediment quality, most of the study area can be categorised as unpolluted for most of the elements (Igeo value < 2) except for As, Cr, Lu, Mg, Sb and U. A few study areas were slightly low contaminated with As, Cr, Lu, Mg, Sb and U. The contamination of As, Cr, Lu, Mg, Sb and U in the study area can be categorised as moderate with Igeo values ranged from 1 to 2. Meanwhile, the results of PLI value for sediment were ranged from 0.93 to 1.47 (PLI < 50) indicating there are not required to perform drastic rectification measures for the screening of the elements in the Tunku Abdul Rahman Park. Overall, assessment of the sediment quality at the Tunku Abdul Rahman National Park showed a few elements such as As, Cr, Lu, Mg, Sb and U were slightly enriched while most of the elements were similar to background values.
In industrial plants such as electricity generating, petroleum, chemical and petrochemical plants, pipelines are used extensively to transport liquid from one location to another. In radiation vulcanization of natural rubber latex (RVNRL) plants, pipelines are also used to transport latex to storage tank. During one of its maintenance activities, a pipeline intelligent gauge (PIG) that was used to monitor pipe integrity jammed inside the pipe causing interruption to its operation or loading activities. Sealed source technology was utilized to determine the location of jammed PIG in the pipeline. Fast neutrons from a 50 mCi Americium Beryllium (AmBe241), with energy range between 0.5 to11 MeV, were used for the study. Helium 3 (He3) detector was used to detect slow neutrons having a range of energy of 30 eV- 0.5 MeV. The investigation was carried out using neutron backscatter technique scanner. By adopting back-scattered technique, the location of jammed PIG in the pipeline has been successfully determined.
Poly(lactic acid) (PLA)-based nanocomposites filled with graphene nanoplatelets (xGnP) that contains epoxidized palm oil (EPO) as plasticizer were prepared by melt blending method. PLA was first plasticized by EPO to improve its flexibility and thereby overcome its problem of brittleness. Then, xGnP was incoporated into plasticized PLA to enhance its mechanical properties. Plasticized and nanofilled PLA nanocomposites (PLA/EPO/xGnP) showed improvement in the elongation at break by 3322% and 61% compared to pristine PLA and PLA/EPO, respectively. The use of EPO and xGnP increases the mobility of the polymeric chains, thereby improving the flexibility and plastic deformation of PLA. The nanocomposites also resulted in an increase of up to 26.5% in the tensile strength compared with PLA/EPO blend. XRD pattern showed the presence of peak around 26.5° in PLA/EPO/xGnP nanocomposites which corresponds to characteristic peak of graphene nanoplatelets. Plasticized PLA reinforced with xGnP showed that increasing the xGnP content triggers a substantial increase in thermal stability. Crystallinity of the nanocomposites as well as cold crystallization and melting temperature did not show any significant changes upon addition of xGnP. However, there was a significant decrease of glass transition temperature up to 0.3wt% of xGnP incorporation. The TEM micrograph of PLA/EPO/xGnP shows that the xGnP was uniformly dispersed in the PLA matrix and no obvious aggregation was observed.
Radiation processing of food materials by gamma-radiation is a well-established method for
microbial decontamination and insect disinfestation. Irradiation of spices at doses ranging from
10 to 30 kGy has been reported to result in complete elimination of microorganisms with
negligible changes in the flavour quality. The effect of gamma-radiation on microflora and
vanillin content of cured vanilla beans in the dose range of 5 - 50 kGy has been investigated, but
its effect on other major aroma compounds and vanillin glucoside (vanillin aroma precursor)
remaining after curing have not been studied so far. Vanillin (4-hydroxy-3-methoxybenzaldehyde)
is one such compound used as a flavouring agent and as a dietary component. It is the major
component of natural vanilla, which is one of the most widely used and important flavouring
materials throughout the world. Vanillin is an antioxidant capable of protecting membrane
against lipid peroxidation and DNA against strand breaks induced by reactive oxygen species.
The present work was aimed to study the effect of gamma-radiation processing on the major
aroma compounds of cured vanilla beans and also to investigate possible enhancement in vanillin
content by the radiolytic breakdown of vanillin glucoside present already. Cured vanilla beans
were irradiated (5, 10, 15, 20 and 30 kGy) and the vanillin content of control and irradiated
samples were analysed, respectively for possible enhancement of vanillin content by radiolysis of
vanillin glucoside. Radiolytic breakdown of glycosidic precursors of aroma constituents and
consequent release of free aroma was shown to result in the enhancement of aroma quality of
these products. Since a considerable amount of vanillin exists as its glycosidic precursor in cured
vanilla pods, a possible enhancement in yield of vanillin by radiation processing is thus expected.
Hence the highly stable oxygen–carbon linkage between vanillin and glucose limits the possible
enhancement of aroma quality of irradiated beans.