β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo

Syam S 1 , Bustamam A 2 , Abdullah R 3 , Sukari MA 4 , Hashim NM 5 , Mohan S 6 Show all authors , Looi CY 7 , Wong WF 8 , Yahayu MA 9 , Abdelwahab SI 6

Affiliations 

  • 1 UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia; Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: suvithaavs@gmail.com
  • 2 UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia
  • 3 Department of Veterinary Pathology and Microbiology, Faculty of Veterinary, University Putra Malaysia, Serdang, Selangor, Malaysia
  • 4 Department of Chemistry, Faculty of Science, University Putra Malaysia, Serdang, Selangor, Malaysia
  • 5 Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 6 Medical Research Centre, Jazan University, PO Box 114, Jazan, Saudi Arabia
  • 7 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 8 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 9 Institute of Bioproduct Developments, Universiti Teknologi Malaysia, Malaysia
J Ethnopharmacol, 2014 Apr 28;153(2):435-45.
PMID: 24607509 DOI: 10.1016/j.jep.2014.02.051

Abstract

The fruit hull of Garcinia mangostana Linn. has been used in traditional medicine for treatment of various inflammatory diseases. Hence, this study aims to investigate the in vitro and in vivo anti-inflammatory effect of β mangostin (βM), a major compound present in Garcinia mangostana.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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