Immunity and clinical efficacy of an inactivated enterovirus 71 vaccine in healthy Chinese children: a report of further observations

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Liu L ¹ , Mo Z ² , Liang Z ³ , Zhang Y ¹ , Li R ² , Ong KC ⁴ Show all authors , Wong KT ⁴ , Yang E ¹ , Che Y ¹ , Wang J ¹ , Dong C ¹ , Feng M ¹ , Pu J ¹ , Wang L ¹ , Liao Y ¹ , Jiang L ¹ , Tan SH ⁴ , David P ⁵ , Huang T ² , Zhou Z ¹ , Wang X ⁶ , Xia J ⁷ , Guo L ¹ , Wang L ⁷ , Xie Z ¹ , Cui W ¹ , Mao Q ³ , Liang Y ¹ , Zhao H ¹ , Na R ¹ , Cui P ¹ , Shi H ¹ , Wang J ⁸ , Li Q ⁹

¹ Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China
² Guangxi Province Centres for Disease Control and Prevention, Nanning, China
³ National Institutes for Food and Drug Control, Beijing, China
⁴ Departments of Biomedical Science and Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
⁵ Institute of Health & Community Medicine, University Malaysia Sarawak, Kuala Lumpur, Malaysia
⁶ Key Laboratory of Medical Molecular Virology, Ministries of Education and Health, Institute of Biological Sciences, Shanghai Medical College, Fudan University, Shanghai, China
⁷ Department of Health Statistics, Fourth Military Medical University, Xi'an, China
⁸ National Institutes for Food and Drug Control, Beijing, China. wangjz@nicpbp.org.cn
⁹ Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. liqihan@imbcams.com.cn

BMC Med, 2015;13:226.

PMID: 26381232 DOI: 10.1186/s12916-015-0448-7

Abstract

To investigate the long-term effects on immunity of an inactivated enterovirus 71 (EV71) vaccine and its protective efficacy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.