• 1 Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
  • 2 Division of Gastroenterology and Hepatology, University Medicine Cluster, National University Hospital, Singapore
  • 3 Asian Institute of Gastroenterology, Hyderabad, India
  • 4 Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  • 5 Division of Gastroenterology, Cipto Mangunkusumo General Hospital, Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia
  • 6 Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
  • 7 Department of Internal Medicine, Kangnam St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea
  • 8 Division of Gastroenterology, Taipei Veterans General Hospital, National Yang-Ming University Taipei, Taipei, Taiwan
  • 9 GI Motility Research Unit, Division of Gastroenterology, Department of Internal Medicine, Chulalongkorn University, Bangkok, Thailand
  • 10 Gastro Centre Ipoh, Ipoh, Perak, Malaysia
  • 11 Klinic Chong, Slim River, Perak, Malaysia
  • 12 Section of Gastroenterology, Department of Internal Medicine, Medical Center Manila, Manila, Philippines
  • 13 Department of Gastroenterology and Hepatology, Union Hospital of Tongji Medical College, Huazhong University of Science and Techonology, Wuhan, Hubei, China
  • 14 Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
  • 15 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
J Gastroenterol Hepatol, 2017 Aug;32(8):1450-1456.
PMID: 28084664 DOI: 10.1111/jgh.13730


BACKGROUND AND AIM: Information on real world treatment experiences of patients with functional bowel disorders is lacking from Asia. This study aimed to describe the medication exposure and treatment satisfaction of patients presenting to gastroenterology clinics across a sampling of Asian cities.

METHODS: From March 2011 to October 2013, adult patients presenting to hospital-based gastroenterology outpatient clinics in 11 cities across Asia, who fulfilled screening criteria for any functional gastrointestinal disorder, were asked to complete a validated culturally adapted translation of the Rome III diagnostic questionnaire, a checklist of medications received in the preceding 3 months and questions on treatment satisfaction.

RESULTS: A total of 1376 patients (female 755, male 621, 41.36 ± 13.25 years) comprising irritable bowel (621, 45.1%), unspecified functional bowel disorder (372, 27.8%), functional constipation (202, 14.7%), functional bloating (144, 10.5%), and functional diarrhea (56, 4.1%) completed the study. Of 1105 patients with a previous consultation, 509 (46.1%) were dissatisfied with their treatment, with ineffective treatment being the commonest reason. Satisfaction with previous consultation was lowest by diagnosis for functional constipation (29.2%), and the most bothersome symptom was straining (37.5%). Of 1046 patients who had taken medications for their gastrointestinal symptoms in the last 3 months, 793 (75.8%) had received two or more drugs. For irritable bowel syndrome patients, treatment with proton pump inhibitors and antispasmodics was recorded in 57% and 31%, with overlapping epigastric pain and heartburn predicting proton pump inhibitors use.

CONCLUSIONS: More attention should be given to treatment gaps with regards to possible under-treatment with antispasmodics in irritable bowel syndrome and to critically evaluating the efficacy of constipation management.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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