Relation of Doppler ultrasound synovitis versus clinical synovitis with changes in native complement component levels in rheumatoid arthritis patients treated with biologic disease-modifying anti-rheumatic drugs

Montoro Alvarez M 1 , Chong OY 2 , Janta I 1 , González C 1 , López-Longo J 1 , Monteagudo I 1 Show all authors , Valor L 1 , Garrido J 3 , Lau IS 4 , Rosman A 4 , Naredo E 1 , Carreño L 1

Affiliations 

  • 1 Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
  • 2 Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain; and Department of Medicine (Rheumatology Unit), Selayang Hospital, Selangor, Malaysia
  • 3 Department of Social Psychology and Methodology, Faculty of Psychology, Autónoma University, Madrid, Spain
  • 4 Department of Medicine (Rheumatology Unit), Selayang Hospital, Selangor, Malaysia
Clin Exp Rheumatol, 2015 Mar-Apr;33(2):141-5.
PMID: 25665178

Abstract

The complement system plays a fundamental role in mediating the activity of rheumatoid arthritis (RA). Biologic therapy can reduce native complement component levels and its activation. We aimed to study the relation of Doppler ultrasound (US) synovitis versus clinical synovitis with changes in native complement component levels in RA patients on biologic therapy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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