Displaying publications 221 - 240 of 534 in total

Abstract:
Sort:
  1. Fensham's 'Science For All' Vision: A Chemistry Perspective (Visi Fensham 'Sains untuk Semua': Perspektif Kimia)
    Hill JO
    Sains Malaysiana, 2005;34.
    Science has been defined as 'a way of knowing' which is, in certain respects, unlike other ways of knowing. While some forms of knowledge are highly personal and intuitive, the methods of science are designed to be as objective and impersonal as possible. Science has been referred to as 'public knowledge' because of its procedures for verification involve the whole of society. Science is also 'organised knowledge' because it is systematic and because it is supported by a group of social institutions without which it could not exist in its modern form. For many decades, Fensham, an internationally recognised science educator, has been one of the most important and consistent voices for the reform of science education based on his vision of a democratic and socially responsible science education for all, based on the fundamental premise that if society is to understand the world it must be educated in the principles of science upon which a sustainable world is premised. Thus, science has a real place in society and a social responsibility. From a chemistry perspective, this enabling science is perceived by society as irrelevant to the real world and the cause of many of the evils of the world. This paper addresses the pivotal role of chemistry both in science education and in the social responsibility of science campaign and simultaneously shows how chemistry is at the leading edge of sustainable science in both a scientific and social context.
    Sains telah ditakrifkan sebagai 'suatu cara mengetahui'. Dalam ertikata tertentu, takrif ini berlainan dengan cara-cara mengetahui hal-hal lain. Sesetengah bentuk pengetahuan sangatlah tersendiri dan intuitif, namun kaedah sains direkabentuk sedemikian sehingga sejauh mungkin ia berobjektif dan tidak tersendiri. Sains telah dirujukkan sebagai 'pengetahuan awam' kerana prosedur pensahihannya melibatkan seluruh masyarakat. Sains juga merupakan 'pengetahuan yang tersusun' kerana ini bersistem dan kerana ia disokong oleh kumpulan institusi sosial. Tanpa sokongan ini sains tidak boleh wujud dalam bentuk modemnya. Selama beberapa dekad yang lalu, Fensham, seorang ahli pendidikan sains yang diiktiraf antarabangsa, merupakan seorang penggiat yang penting dan konsisten dalam menyuarakan pendapat ke arah perubahan pendidikan sains berdasarkan visinya, iaitu pendidikan sains untuk semua secara demokratik dan bertanggungjawab kepada masyarakat, berlandaskan kepada premis asas bahawa jika masyarakat hendak memahami dunia, maka ia mestilah dididik dalam prinsip-prinsip sains dengan prinsip-prinsip itu sendiri dijadikan premos bagi sebuah dunia mampan. Dengan demikian, sains mempunyai tempatnya yang sebenar dalam masyarakat dan mempunyai tanggungjawab kemasyarakatan. Dari perspektif kimia, masyarakat bertanggapan bahawa sains tersebut tidaklah relevan dalam dunia nyata dan merupakan penyebab kepada banyak keburukan dalam dunia ini. Kertas ini mengupas peranan pengimbangan bidang kimia dalam pendidikan sains dan dalam tanggungjawab sosial kempen sains dan sekali gus menunjukkan bahawa kimia adalah teraju bagi sains mampan dalam kedua-dua konteks sainstifik dan sosial.
    Matched MeSH terms: Social Environment
  2. First discovery of Pleistocene orangutan (Pongo sp.) fossils in Peninsular Malaysia: biogeographic and paleoenvironmental implications
    Ibrahim YKh, Tshen LT, Westaway KE, Cranbrook EO, Humphrey L, Muhammad RF, et al.
    J Hum Evol, 2013 Dec;65(6):770-97.
    PMID: 24210657 DOI: 10.1016/j.jhevol.2013.09.005
    Nine isolated fossil Pongo teeth from two cave sites in Peninsular Malaysia are reported. These are the first fossil Pongo specimens recorded in Peninsular Malaysia and represent significant southward extensions of the ancient Southeast Asian continental range of fossil Pongo during two key periods of the Quaternary. These new records from Peninsular Malaysia show that ancestral Pongo successfully passed the major biogeographical divide between mainland continental Southeast Asia and the Sunda subregion before 500 ka (thousand years ago). If the presence of Pongo remains in fossil assemblages indicates prevailing forest habitat, then the persistence of Pongo at Batu Caves until 60 ka implies that during the Last Glacial Phase sufficient forest cover persisted in the west coast plain of what is now Peninsular Malaysia at least ten millennia after a presumed corridor of desiccation had extended to central and east Java. Ultimately, environmental conditions of the peninsula during the Last Glacial Maximum evidently became inhospitable for Pongo, causing local extinction. Following post-glacial climatic amelioration and reforestation, a renewed sea barrier prevented re-colonization from the rainforest refugium in Sumatra, accounting for the present day absence of Pongo in apparently hospitable lowland evergreen rainforest of Peninsular Malaysia. The new teeth provide further evidence that Pongo did not undergo a consistent trend toward dental size reduction over time.
    Matched MeSH terms: Environment*
  3. Fulltext First report of sylvatic DENV-2-associated dengue hemorrhagic fever in West Africa
    Franco L, Palacios G, Martinez JA, Vázquez A, Savji N, De Ory F, et al.
    PLoS Negl Trop Dis, 2011 Aug;5(8):e1251.
    PMID: 21829739 DOI: 10.1371/journal.pntd.0001251
    Dengue virus (DENV) circulates in human and sylvatic cycles. Sylvatic strains are both ecologically and evolutionarily distinct from endemic viruses. Although sylvatic dengue cycles occur in West African countries and Malaysia, only a few cases of mild human disease caused by sylvatic strains and one single case of dengue hemorrhagic fever in Malaysia have been reported. Here we report a case of dengue hemorrhagic fever (DHF) with thrombocytopenia (13000/µl), a raised hematocrit (32% above baseline) and mucosal bleeding in a 27-year-old male returning to Spain in November 2009 after visiting his home country Guinea Bissau. Sylvatic DENV-2 West African lineage was isolated from blood and sera. This is the first case of DHF associated with sylvatic DENV-2 in Africa and the second case worldwide of DHF caused by a sylvatic strain.
    Matched MeSH terms: Environment
  4. Fulltext Flavonoid and leaf gas exchange responses of Centella asiatica to acute gamma irradiation and carbon dioxide enrichment under controlled environment conditions
    Moghaddam SS, Jaafar HB, Aziz MA, Ibrahim R, Rahmat AB, Philip E
    Molecules, 2011 Oct 25;16(11):8930-44.
    PMID: 22027950 DOI: 10.3390/molecules16118930
    The study was couducted to investigate the effects of gamma irradiation and CO₂ on flavonoid content and leaf gas exchange in C.asiatica. For flavonoid determination, the design was a split split plot based on Randomized Complete Block Design (RCBD). For other parameters, the designs were split plots. Statistical tests revealed significant differences in flavonoid contents of Centella asiatica leaves between different growth stages and various CO₂ treatments. CO₂ 400, G20 (400 = ambient CO₂; G20 = Plants exposed to 20 Gy) showed 82.90% higher total flavonoid content (TFC) in the 5th week than CO₂ 400 as control at its best harvest time (4th week). Increasing the concentration of CO₂ from 400 to 800 μmol/mol had significant effects on TFC and harvesting time. In fact, 800 μmol/mol resulted in 171.1% and 66.62% increases in TFC for control and irradiated plants, respectively. Moreover, increasing CO₂ concentration reduced the harvesting time to three and four weeks for control and irradiated plants, respectively. Enhancing CO₂ to 800 µmol/mol resulted in a 193.30% (CO₂ 800) increase in leaf biomass compared to 400 µmol/mol and 226.34% enhancement in irradiated plants (CO₂ 800, G20) [800 = Ambient CO₂; G20 = Plants exposed to 20 Gy] than CO₂ 400, G20. In addition, the CO₂ 800, G20 had the highest amount of flavonoid*biomass in the 4th week. The results of this study indicated that all elevated CO₂ treatments had higher PN than the ambient ones. The findings showed that when CO₂ level increased from 400 to 800 µmol/mol, stomatal conductance, leaf intercellular CO₂ and transpiration rate had the tendency to decrease. However, water use efficiency increased in response to elevated CO₂ concentration. Returning to the findings of this study, it is now possible to state that the proposed method (combined CO₂ and gamma irradiation) has the potential to increase the product value by reducing the time to harvest, increasing the yield per unit area via boosting photosynthesis capacity, as well as increasing biochemicals (flavonoids) per gram DM.
    Matched MeSH terms: Environment, Controlled
  5. Fulltext Food waste handling in Malaysia and comparison with other Asian countries
    Lim, W. J., Chin, N. L., Yusof, A. Y., Yahya, A., Tee, T. P.
    International Food Research Journal, 2016;23(101):1-6.
    MyJurnal
    The increasing amount of food waste in Malaysia in recent years has brought many environmental
    issues in the country where it affects the nation’s solid waste management framework. At the
    moment, the government is limited to other alternatives of food waste disposal besides the
    conventional landfill and incineration methods. This paper provides information on the current
    status of food waste handling, management, regulations, and policies in Malaysia. It helps
    to draw the problem and challenge to a clearer view in efforts of achieving sustainable and
    integrative food waste handling in the country.
    Matched MeSH terms: Environment
  6. Fulltext Forecasting ozone concentration levels using Box-Jenkins ARIMA modelling and artificial neural networks: a comparative study
    Norhashidah Awang, Ng, Kar Yong, Soo, Yin Hoeng
    MATEMATIKA, 2017;33(2):119-130.
    MyJurnal
    An accurate forecasting of tropospheric ozone (O3) concentration is benefi-
    cial for strategic planning of air quality. In this study, various forecasting techniques are
    used to forecast the daily maximum O3 concentration levels at a monitoring station
    in the Klang Valley, Malaysia. The Box-Jenkins autoregressive integrated movingaverage
    (ARIMA) approach and three types of neural network models, namely, backpropagation
    neural network, Elman recurrent neural network and radial basis function
    neural network are considered. The daily maximum data, spanning from 1 January
    2011 to 7 August 2011, was obtained from the Department of Environment, Malaysia.
    The performance of the four methods in forecasting future values of ozone concentrations
    is evaluated based on three criteria, which are root mean square error (RMSE),
    mean absolute error (MAE) and mean absolute percentage error (MAPE). The findings
    show that the Box-Jenkins approach outperformed the artificial neural network
    methods.
    Matched MeSH terms: Environment
  7. Fulltext Four ways blue foods can help achieve food system ambitions across nations
    Crona BI, Wassénius E, Jonell M, Koehn JZ, Short R, Tigchelaar M, et al.
    Nature, 2023 Apr;616(7955):104-112.
    PMID: 36813964 DOI: 10.1038/s41586-023-05737-x
    Blue foods, sourced in aquatic environments, are important for the economies, livelihoods, nutritional security and cultures of people in many nations. They are often nutrient rich1, generate lower emissions and impacts on land and water than many terrestrial meats2, and contribute to the health3, wellbeing and livelihoods of many rural communities4. The Blue Food Assessment recently evaluated nutritional, environmental, economic and justice dimensions of blue foods globally. Here we integrate these findings and translate them into four policy objectives to help realize the contributions that blue foods can make to national food systems around the world: ensuring supplies of critical nutrients, providing healthy alternatives to terrestrial meat, reducing dietary environmental footprints and safeguarding blue food contributions to nutrition, just economies and livelihoods under a changing climate. To account for how context-specific environmental, socio-economic and cultural aspects affect this contribution, we assess the relevance of each policy objective for individual countries, and examine associated co-benefits and trade-offs at national and international scales. We find that in many African and South American nations, facilitating consumption of culturally relevant blue food, especially among nutritionally vulnerable population segments, could address vitamin B12 and omega-3 deficiencies. Meanwhile, in many global North nations, cardiovascular disease rates and large greenhouse gas footprints from ruminant meat intake could be lowered through moderate consumption of seafood with low environmental impact. The analytical framework we provide also identifies countries with high future risk, for whom climate adaptation of blue food systems will be particularly important. Overall the framework helps decision makers to assess the blue food policy objectives most relevant to their geographies, and to compare and contrast the benefits and trade-offs associated with pursuing these objectives.
    Matched MeSH terms: Environment; Environmental Policy
  8. Fulltext Fuzzy-controlled humidity variation by Silica gel and Nitrogen gas in an atmospheric chamber
    Ali Ghahraei, Nurul Amziah Md Yunus, Izhal Abdul Halin, Nasri Sulaiman
    Pertanika Journal of Science & Technology, 2017;25(102):133-142.
    MyJurnal
    Controlled humidity environment is of significance in many scientific researches and experiments. In most laboratory-scale atmospheric chambers, an electrical temperature-based control system is used to adjust humidity. Since these chambers are not affordable in every laboratory, other low cost chambers using nitrogen gas or silica gel are used to adjust humidity. In this paper, a mechanism was developed to control the relative humidity in closed lab-scale chambers. Humidification is done by spraying water through a blower fan while de-humidification is by pumping air through silica gel as well as nitrogen gas injection. A Mamdani type fuzzy controller was designed to control the components and relative humidity. The results show the proposed system and controller can adjust and maintain relative humidity from 41% to 100% with maximum overshoot of 1% and the maximum range of error of steady state of 1.2 %.
    Matched MeSH terms: Environment, Controlled
  9. Fulltext GIS modeling for selection of a transfer station site for residential solid waste separation and recycling
    Billa, L., Pradhan, B.
    Pertanika Journal of Science & Technology, 2013;21(2):487-498.
    MyJurnal
    In this study a GIS model was developed and spatial analytical techniques performed to identify and select a suitable location for a waste transfer station in the sprawling suburban town of Petaling Jaya. The lack of a transfer station in urban centres of Malaysia has caused many problems and affects the efficiency of waste collection and disposal. With diminishing space for landfills and the increasing cost of solid waste management, the need for urban solid-waste recycling has become very important. However, finding a place for waste to be efficiently sorted before unwanted waste can be carried to disposal landfills has social and physical constraints. This study applies GIS techniques and analysis for site selection and identifies an acceptable area. In the model, environmental, physical and social constraints were taken into account, resulting in the selection of a potential area that is acceptable to the residents of the area because it is out of range of causing public nuisance and within minimum travelling distance for collection vehicles. The results show that the potential location for the transfer station should be in proximity of the industrial area of Petaling Jaya, allowing for the possible sale of recyclable materials to local industries. The location is also sited near a major highway to allow quick transportation of the rest of the unwanted waste to the landfill.
    Matched MeSH terms: Environment
  10. Gender, population and environment in the context of deforestation: a Malaysian case study
    Heyzer N
    IDS Bull, 1995 Jan;26(1):40-6.
    PMID: 12289812
    Matched MeSH terms: Environment*
  11. Fulltext Gene-environment Interaction: The Causes of High Obesity Incidence
    Ellulu MS, Jalambo MO
    Kathmandu Univ Med J (KUMJ), 2018 2 16;15(57):91-93.
    PMID: 29446373
    Urbanization has provided experimental settings for testing the interactive relationship between genetic background and changes in lifestyle and dietary patterns. The concept of gene-environment interaction was described by epidemic of obesity along with urbanization. Genome-wide association has identified several genes such as melanocortin-4 receptor that associates with environmental influences of obesity. Gene environment (GxE) interaction refers to modification by an environmental factor of the effect of a genetic variant on a phenotypic trait. GxE interactions can serve to modulate the adverse effects of a risk allele, or can exacerbate the genotype-phenotype relationship and increase risk.
    Matched MeSH terms: Environment; Gene-Environment Interaction*
  12. Gene-environment interaction in chronic kidney disease among people with type 2 diabetes from The Malaysian Cohort project: a case-control study
    Ahmad N, Shah SA, Abdul Gafor AH, Abdul Murad NA, Kamaruddin MA, Abd Jalal N, et al.
    Diabet Med, 2020 11;37(11):1890-1901.
    PMID: 32012348 DOI: 10.1111/dme.14257
    AIM: To examine the possible gene-environment interactions between 32 single nucleotide polymorphisms and environmental factors that could modify the probability of chronic kidney disease.

    METHODS: A case-control study was conducted involving 600 people with type 2 diabetes (300 chronic kidney disease cases, 300 controls) who participated in The Malaysian Cohort project. Retrospective subanalysis was performed on the chronic kidney disease cases to assess chronic kidney disease progression from the recruitment phase. We genotyped 32 single nucleotide polymorphisms using mass spectrometry. The probability of chronic kidney disease and predicted rate of newly detected chronic kidney disease progression were estimated from the significant gene-environment interaction analyses.

    RESULTS: Four single nucleotide polymorphisms (eNOS rs2070744, PPARGC1A rs8192678, KCNQ1 rs2237895 and KCNQ1 rs2283228) and five environmental factors (age, sex, smoking, waist circumference and HDL) were significantly associated with chronic kidney disease. Gene-environment interaction analyses revealed significant probabilities of chronic kidney disease for sex (PPARGC1A rs8192678), smoking (eNOS rs2070744, PPARGC1A rs8192678 and KCNQ1 rs2237895), waist circumference (eNOS rs2070744, PPARGC1A rs8192678, KCNQ1 rs2237895 and KCNQ1 rs2283228) and HDL (eNOS rs2070744 and PPARGC1A rs8192678). Subanalysis indicated that the rate of newly detected chronic kidney disease progression was 133 cases per 1000 person-years (95% CI: 115, 153), with a mean follow-up period of 4.78 (SD 0.73) years. There was a significant predicted rate of newly detected chronic kidney disease progression in gene-environment interactions between KCNQ1 rs2283228 and two environmental factors (sex and BMI).

    CONCLUSIONS: Our findings suggest that the gene-environment interactions of eNOS rs2070744, PPARGC1A rs8192678, KCNQ1 rs2237895 and KCNQ1 rs2283228 with specific environmental factors could modify the probability for chronic kidney disease.

    Matched MeSH terms: Gene-Environment Interaction
  13. Fulltext Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations
    Williams R, Periasamy M
    Endocrinol Metab (Seoul), 2020 12;35(4):681-695.
    PMID: 33397033 DOI: 10.3803/EnM.2020.772
    Obesity-associated metabolic illnesses are increasing at an alarming rate in Asian countries. A common feature observed in the Asian population is a higher incidence of abdominal obesity-the "skinny-fat" Asian syndrome. In this review, we critically evaluate the relative roles of genetics and environmental factors on fat distribution in Asian populations. While there is an upward trend in obesity among most Asian countries, it appears particularly conspicuous in Malaysia. We propose a novel theory, the Malaysian gene-environment multiplier hypothesis, which explains how ancestral variations in feast-and-famine cycles contribute to inherited genetic predispositions that, when acted on by modern-day stressors-most notably, urbanization, westernization, lifestyle changes, dietary transitions, cultural pressures, and stress-contribute to increased visceral adiposity in Asian populations. At present, the major determinants contributing to visceral adiposity in Asians are far from conclusive, but we seek to highlight critical areas for further research.
    Matched MeSH terms: Gene-Environment Interaction*
  14. Fulltext Genetic and environmental effects on age at menarche, and its relationship with reproductive health in twins
    Jahanfar S, Lye MS, Krishnarajah IS
    Indian J Hum Genet, 2013 Apr;19(2):245-50.
    PMID: 24019629 DOI: 10.4103/0971-6866.116127
    INTRODUCTION: Menarche or first menstrual period is a landmark in reproductive life span and it is the most prominent change of puberty. The timing of menarche can be under the influence of genes as well as individual environmental factors interacting with genetic factors.

    OBJECTIVE: Our study objectives were (a) to investigate the heritability of age of menarche in twins, (b) to obtain the association between age of menarche and childhood factors, and reproductive events/behavior, (c) to examine whether or not having a male co-twin affects early/late menarche.

    METHODOLOGY: A group of female-female identical (n = 108, 54 pairs), non-identical twins (n = 68, 34 pairs) and 17 females from opposite-sex twin sets were identified from twin registries of Malaysia and Iran. Genetic analysis was performed via two methods of Falconers' formula and maximum likelihood.

    RESULTS: Heritability was found to be 66% using Falconers' formula and 15% using univariate twin analysis. Model analysis revealed that shared environmental factors have a major contribution in determining the age of menarche (82%) followed by non-shared environment (18%).

    DISCUSSION: Result of this study is consistent with that of the literature. Timing of menarche could be under the influence of shared and non-shared environmental effects. Hirsutism was found to have a higher frequency among subjects with late menarche. There was no significant difference in age of menarche between females of opposite-sex twins and females of same-sex twins.

    CONCLUSION: It is concluded that twin models provide a powerful means of examining the total genetic contribution to age of menarche. Longitudinal studies of twins may clarify the type of environmental effects that determine the age of menarche.

    Matched MeSH terms: Environment
  15. Fulltext Genetical and comparative genomics of Brassica under altered Ca supply identifies Arabidopsis Ca-transporter orthologs
    Graham NS, Hammond JP, Lysenko A, Mayes S, O Lochlainn S, Blasco B, et al.
    Plant Cell, 2014 Jul;26(7):2818-30.
    PMID: 25082855 DOI: 10.1105/tpc.114.128603
    Although Ca transport in plants is highly complex, the overexpression of vacuolar Ca(2+) transporters in crops is a promising new technology to improve dietary Ca supplies through biofortification. Here, we sought to identify novel targets for increasing plant Ca accumulation using genetical and comparative genomics. Expression quantitative trait locus (eQTL) mapping to 1895 cis- and 8015 trans-loci were identified in shoots of an inbred mapping population of Brassica rapa (IMB211 × R500); 23 cis- and 948 trans-eQTLs responded specifically to altered Ca supply. eQTLs were screened for functional significance using a large database of shoot Ca concentration phenotypes of Arabidopsis thaliana. From 31 Arabidopsis gene identifiers tagged to robust shoot Ca concentration phenotypes, 21 mapped to 27 B. rapa eQTLs, including orthologs of the Ca(2+) transporters At-CAX1 and At-ACA8. Two of three independent missense mutants of BraA.cax1a, isolated previously by targeting induced local lesions in genomes, have allele-specific shoot Ca concentration phenotypes compared with their segregating wild types. BraA.CAX1a is a promising target for altering the Ca composition of Brassica, consistent with prior knowledge from Arabidopsis. We conclude that multiple-environment eQTL analysis of complex crop genomes combined with comparative genomics is a powerful technique for novel gene identification/prioritization.
    Matched MeSH terms: Gene-Environment Interaction
  16. Fulltext Genome-Wide Detection of Genes Under Positive Selection in Worldwide Populations of the Barley Scald Pathogen
    Mohd-Assaad N, McDonald BA, Croll D
    Genome Biol Evol, 2018 Apr 01;10(5):1315-1332.
    PMID: 29722810 DOI: 10.1093/gbe/evy087
    Coevolution between hosts and pathogens generates strong selection pressures to maintain resistance and infectivity, respectively. Genomes of plant pathogens often encode major effect loci for the ability to successfully infect specific host genotypes. Hence, spatial heterogeneity in host genotypes coupled with abiotic factors could lead to locally adapted pathogen populations. However, the genetic basis of local adaptation is poorly understood. Rhynchosporium commune, the pathogen causing barley scald disease, interacts at least partially in a gene-for-gene manner with its host. We analyzed global field populations of 125 R. commune isolates to identify candidate genes for local adaptation. Whole genome sequencing data showed that the pathogen is subdivided into three genetic clusters associated with distinct geographic and climatic regions. Using haplotype-based selection scans applied independently to each genetic cluster, we found strong evidence for selective sweeps throughout the genome. Comparisons of loci under selection among clusters revealed little overlap, suggesting that ecological differences associated with each cluster led to variable selection regimes. The strongest signals of selection were found predominantly in the two clusters composed of isolates from Central Europe and Ethiopia. The strongest selective sweep regions encoded protein functions related to biotic and abiotic stress responses. Selective sweep regions were enriched in genes encoding functions in cellular localization, protein transport activity, and DNA damage responses. In contrast to the prevailing view that a small number of gene-for-gene interactions govern plant pathogen evolution, our analyses suggest that the evolutionary trajectory is largely determined by spatially heterogeneous biotic and abiotic selection pressures.
    Matched MeSH terms: Environment
  17. Fulltext Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
    Coleman JRI, Peyrot WJ, Purves KL, Davis KAS, Rayner C, Choi SW, et al.
    Mol Psychiatry, 2020 Jul;25(7):1430-1446.
    PMID: 31969693 DOI: 10.1038/s41380-019-0546-6
    Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8 × 10-7 versus rg = -0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10-4). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.
    Matched MeSH terms: Gene-Environment Interaction*
  18. Fulltext Genomic Insights of Pectobacterium carotovorum Strain M022 Quorum-Sensing Activity through Whole-Genome Sequencing
    Chan KG, Tan WS
    Genome Announc, 2015;3(1).
    PMID: 25676763 DOI: 10.1128/genomeA.01554-14
    Pectobacterium carotovorum is known to cause serious damage to various major crops worldwide. Here, we report the draft genome of Pectobacterium carotovorum strain M022, a freshwater isolate from a Malaysian waterfall, which has been reported as a plant pathogen and is able to communicate with N-acylhomoserine lactone-mediated quorum sensing.
    Matched MeSH terms: Environment
  19. Fulltext Geographical and social isolation drive the evolution of Austronesian languages
    Padilla-Iglesias C, Gjesfjeld E, Vinicius L
    PLoS One, 2020;15(12):e0243171.
    PMID: 33259529 DOI: 10.1371/journal.pone.0243171
    The origins of linguistic diversity remain controversial. Studies disagree on whether group features such as population size or social structure accelerate or decelerate linguistic differentiation. While some analyses of between-group factors highlight the role of geographical isolation and reduced linguistic exchange in differentiation, others suggest that linguistic divergence is driven primarily by warfare among neighbouring groups and the use of language as marker of group identity. Here we provide the first integrated test of the effects of five historical sociodemographic and geographic variables on three measures of linguistic diversification among 50 Austronesian languages: rates of word gain, loss and overall lexical turnover. We control for their shared evolutionary histories through a time-calibrated phylogenetic sister-pairs approach. Results show that languages spoken in larger communities create new words at a faster pace. Within-group conflict promotes linguistic differentiation by increasing word loss, while warfare hinders linguistic differentiation by decreasing both rates of word gain and loss. Finally, we show that geographical isolation is a strong driver of lexical evolution mainly due to a considerable drift-driven acceleration in rates of word loss. We conclude that the motor of extreme linguistic diversity in Austronesia may have been the dispersal of populations across relatively isolated islands, favouring strong cultural ties amongst societies instead of warfare and cultural group marking.
    Matched MeSH terms: Social Environment
  20. Geologic hazard risk assessment of slopeland villages in southern taiwan using remote sensing techniques
    Yang SR, Yeh YL
    Sains Malaysiana, 2015;44:1677-1683.
    Countering the dangers associated the present extreme climate not only requires continuous improvement of local disaster
    prevention engineering infrastructure but also needs an enhanced understanding of the causes of the disasters. This study
    investigates the geologic hazard risk of 53 slopeland villages in Pingtung county of southern Taiwan. First, remote sensing
    (RS) techniques were utilized to interpret environmental geology and geologic hazard zonation, including dip slope, fault,
    landslide and debris flow. GIS map overlay analysis was used to further identify the extent of the geologic hazard zonation.
    As a final step, field investigation is used to comprehend geologic, topographic conditions and the geologic hazard risk
    specific to each locality. Based on data analysis and field investigation results, this study successfully integrates RS, GIS
    and GPS techniques to construct a geologic hazard risk assessment method of slopeland village. The results of this study
    can be used to promote support for future disaster prevention and disaster mitigation efforts.
    Matched MeSH terms: Environment
Related Terms
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links