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Myxobolus acanthogobii Hoshina, 1952 and Myxobolus selari n. sp. (Myxosporea: Myxobolidae) infecting brain of commercial fishes in Terengganu, Malaysia

Samshuri MÁ, Borkhanuddin MH

Syst Parasitol, 2024 May 11;101(3):39.
PMID: 38733439 DOI: 10.1007/s11230-024-10162-3

Myxosporean infection in marine water fishes has drawn less attention than in freshwater fishes, which resulted in a higher taxonomic variety in freshwater in Malaysia. This study aimed to address the gap by conducting a myxosporean survey on two commercially significant marine fish species, Nemipterus furcosus (Valenciennes) (Eupercaria incertae sedis: Nemipteridae) and Selar crumenophthalmus (Bloch) (Carangiformes: Carangidae), collected from the northeastern part of peninsular Malaysia. During the examination of the organs, two distinct Myxobolus Bütschli, 1882 species were discovered in the brain tissue of these fishes, despite the absence of any observable pathological signs. The two Myxobolus species were characterized through morphometry, morphology, and analysis of partial small subunit ribosomal RNA (18S rDNA) gene. As a result, Myxobolus acanthogobii Hoshina, 1952, which infects 2.3% of N. furcosus, is synonymous with a myxobolid species commonly found in Japanese waters, based on its morphological traits, tissue tropism, and molecular diagnostics. Furthermore, a novel species, Myxobolus selari n. sp., was described, infecting the brain of one (11%) individual S. crumenophthalmus. This unique species displayed distinctive features, placing it within a well-supported subclade primarily comprising brain-infecting myxobolids. Maximum likelihood analysis further revealed the close relationships among these brain-infecting myxobolids, underscoring the significance of tissue tropism and host taxonomy for myxobolids. This study represents the initial documentation of Myxobolus species within the southern South China Sea, shedding light on the potential diversity of marine myxosporean in this region. This article was registered in the Official Register of Zoological Nomenclature (ZooBank) as urn:lsid:zoobank.org:pub:7C400E35-7CB8-4DEE-92B7-F75FF3926441.
Fulltext A rare case of massive systemic embolisation secondary to atrial myxoma- case report

Muhammad Amin AU

Med J Malaysia, 2013 Dec;68(6):471-2.
PMID: 24632916

We report a case of a 21 year old girl who presented with sudden onset of abdominal, back and bilateral leg pain, paralysis with unexpected collapse at home. Physical examination was suggestive of acute aortic occlusion. CTangiogram revealed multi-system thrombo-embolic shower. She proceeded to urgent aortic thrombectomy and fasciotomy of the bilateral lower limb. Further investigation revealed atrial myxoma and we report the patient's postoperative progress and eventual transfer to rehabilitation facility.
Potent microbial and tyrosinase inhibitors from stem bark of Bauhinia rufescens (Fabaceae)

Muhammad A, Sirat HM

Nat Prod Commun, 2013 Oct;8(10):1435-7.
PMID: 24354195

The stem bark extracts of Bauhinia rufescens Lam. (Fabaceae) yielded 6-methoxy-7-methyl-8-hydroxydibenz[b,f]oxepin, alpha-amyrin acetate, beta-sitosterol 3-O-beta-D-xylopyranoside, 4-(2'-Hydroxyphenethyl)-5-methoxy-2-methylphenol, menisdaurin and sequoyitol. Their structures were determined using spectroscopic methods and comparisons with the literature data. For the antimicrobial assay Gram-positive and Gram-negative bacterial and fungal strains were tested, while the tyrosinase inhibition assay utilized L-DOPA as a substrate for the tyrosinase enzyme. 6-Methoxy-7-methyl-8-hydroxydibenz[b,f]oxepin, a-amyrin acetate, beta-sitosterol 3-O-D-xylopyranoside, menisdaurin and sequoyitol showed weak to moderate activities with minimum inhibition concentration (MIC) values in the range of 112.5-900 microg/mL against all bacterial strains, while the MIC values for the fungal strains were in the range of 28.1-450 microg/mL. In the tyrosinase inhibition assay, a-amyrin acetate was found to be moderately active against tyrosinase with an inhibition of 62% at 0.1 mg/mL. This activity was lower than that of the positive control, kojic acid (85%).
The need for enhancement of research, development, and commercialization of natural medicinal products in Nigeria: lessons from the Malaysian experience

Muhammad BY, Awaisu A

Afr J Tradit Complement Altern Med, 2008 Jan 22;5(2):120-30.
PMID: 20161927

The use of natural medicinal products in modern medicine as complementary and alternative therapies is of the increase globally. More so in developing and third world countries where the cost of research and development of synthetic drugs is prohibitive and technological facilities as well as expertise are lacking. These, coupled with the crumbling health care management systems in many of such countries make herbal medicines attractive alternatives. The potential medicinal values of these plant products are not being properly harnessed and research and development (R&D) in this area are lagging behind. R&D and consultancy services span from phytochemical analysis, standardization and quality control of herbs, and dosage forms design to preclinical and clinical trials. This paper tries to highlight all the necessary steps needed to conduct research and development in this area and proposes the nitty-gritty needed to impose statutory regulations on ensuring the quality, safety, efficacy, and commercial distribution of such products. The paper examines these important issues and highlights by way of examples, some of the steps taken and the positive achievements of the people and government of Malaysia towards self reliance in the area of natural medicinal plant research. It is primarily intended to map out strategies on how Nigeria in conjunction with research and academic institutions can be actively involved in natural products R&D, taking the Malaysian experience as a prototype. It is also aimed at urging government's efforts to encourage research in this area and impose regulations for commercial production and distribution of such products.
COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)

Muhammad A, Sirat HM

EXCLI J, 2013;12:824-30.
PMID: 26600739

Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 µM (IC50 0.46 µM) compared to the positive control, indomethacin (79.20 %, IC50 0.24 µM).
China's seaborne oil import and shipping emissions: The prospect of belt and road initiative

Muhammad S, Long X

Mar Pollut Bull, 2020 Sep;158:111422.
PMID: 32753206 DOI: 10.1016/j.marpolbul.2020.111422

China's seaborne foreign oil supply through the Malacca Strait is facing security challenges due to territorial disputes, pirate attacks, and geopolitics. To overcome these challenges, China plans to import oil through one of the corridors of the Belt and Road Initiative (BRI)-the China-Pakistan Economic Corridor (CPEC). This study estimated and compared ship emissions and their externalities associated with seaborne oil supply from the top five oil suppliers to China through the existing shipping route via the Malacca Strait and proposed route via CEPC. Ship activity-based methodology is applied to estimate the emissions of air pollutants (CO2, NOx, SO2, PM10, and CO) during cruising, maneuvering, and hoteling periods. The results show that the total ship emissions of China's seaborne oil supply can be significantly reduced from 6.2 million tons to 2.1 million tons via the CPEC route. While external cost can be reduced up to 65.9% via the CPEC route.
Fulltext Fabrication and characterization of Mg-Zn alloys reinforced with carbon nanofiber for orthopaedics implant application: a study on the different compositions

Muhammad Al Kahfi Edrus, Muhammad Sallehuddin Mohd Azman, Herman Tuminoh, Ahmad Kafrawi Nasution, Muhammad Hanif Ramlee

Malaysian Journal of Medicine and Health Sciences, 2020;16(4):252-258.
MyJurnal

Introduction: Biodegradable materials, such as Mg-based, Fe-based, and Zn-based, bring as much attention as bone-implant materials due to its biocompatibility and biodegradability characteristics. Among them, the Mg is the most abundant elements in human body and primarily found in the bones. However, the Mg has a lower mechanical properties and resistances to fracture compared to the other biodegradable and non-biodegradable metals. Therefore, the aim of this study was to develop a possible biodegradable material made of Mg-Zn alloys reinforced with carbon nano fiber (CNF) and later tested with several testing procedures. Methods: The powder metallurgy method (PM) was utilized to fabricate a total of 24 samples of Mg-Zn alloys reinforced with 1.0%wt, 1.2%wt, 1.4%wt, 1.6%wt, 1.8%wt and 2.0%wt of CNF. The PM method was involved with the process of grinding using ball milling, compaction under 400MPa pressure and sintered under 400 °C. Compression testing was done to measure the mechanical strength meanwhile scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDS) was used to identify the microstructural of samples. Results: From this study, it was found that Mg-Zn alloys with 1.6 wt% of CNF produce the highest Young's modulus (2687.91MPa) with acceptable yield strength (84.91MPa). For microstructural analysis, the results showed a compact surface for 1.2, 1.4 and 1.6 wt% of CNF and non-homogeneous structure of all the samples. Conclusion: In conclusion, this study has successfully shown the promising use of Mg-Zn-CNF composite as new materials for implant in terms of suitable strength and structure.
The first use of combination of Intrapleural Fibrinolytics (Alteplase & DNAse) for pleural infection in Malaysia

Muhammad Redzwan SRA

Med J Malaysia, 2019 04;74(2):176-178.
PMID: 31079131

The use of a combination of intrapleural fibrinolytics or tissue plasminogen activator(tPA) Alteplase and deoxyribonuclease (Dnase) has been increasing for cases of complicated pleural infection/parapneumonic effusion worldwide. Its efficacy and success rate in selected cases of complicated parapneumonic effusion unresponsive to antibiotics and chest drainage are well documented. This case report demonstrates the first use of combination intrapleural fibrinolytic (Alteplase) and DNAse (Pulmozyme) in Malaysia for a case of pleural infection/parapneumonic effusion.
Preventing Childhood Neurodisability

Muhammad Ismail HI

Malays J Med Sci, 2024 Apr;31(2):1-5.
PMID: 38694588 DOI: 10.21315/mjms2024.31.2.1

Globally 8.4% of children under 5 years old have a neurodisability. The important factors contributing to this are infection and inflammation, nutrition and quality of care especially during pregnancy and in the first 2 years of life. In an attempt to reduce neurodisability arising from these factors, WHO launched the 1,000 days initiative in 2014. Recent data from the National Health and Morbidity, and Malaysian National Neonatal Registry is a cause for concern. The rate of low weight babies has shown a significant increase during this period. The percentage of pregnant mothers with diabetes has doubled over the last 6 years. In addition, 20% of children under 5 years old are stunted and 46% have anaemia. All of these impact on neurological development, potentially increasing the incidence of developmental disorders and motor deficits.
Fulltext Review of cyber security applications in nuclear power plants

Muhammad Adil Khattak, Muhammad Khairy Harmaini Shaharuddin, Muhammad Saiful Islam Haris, Muhammad Zuhaili Mohammad Aminuddin, Nik Mohamad Amirul Nik Azhar, Nik Muhammad Hakimi Nik Ahmad

Journal of Advanced Research in Applied Sciences and Engineering Technology, 2017;7(1):43-54.
MyJurnal

It is essential to ensure the nuclear power plant system are not compromise and avoid
failure that can result in significant economic loss and physical damage to the public.
However, a very little attention was given to software and cybersecurity hazard. This
review paper discusses about the cybersecurity in nuclear power plant, history of
accident, implementation and future plan on cybersecurity deeply. About 51 published
studies (2006-2017) are reviewed in this paper. It is marked from the literature survey
articles that it is important for the cybersecurity of a nuclear power plant to be at par
with the evolution of hardware and software and to counter the increasing risk on
cyber vulnerabilities. Moreover, it should be addressed as a concern and major priority
for researches and policy-makers.
Fulltext A Case of Traumatic Distal End Radius Fracture With a Hemorrhagic Volar Wrist Ganglion Cyst

Firdaus M, Aslam F, Muhammad Nawawi RF

Cureus, 2024 Jun;16(6):e61923.
PMID: 38978947 DOI: 10.7759/cureus.61923

Wrist ganglion cysts are the most common benign soft tissue swelling in the hand and wrist. They may arise from flexor and extensor tendon sheaths, interphalangeal joints, wrist joints, and even the neural tissues around the hand and wrist. Some volar wrist ganglion cysts arise from the radiocarpal joint and scaphotrapezial joint. It is uncommonly encountered as an incidental finding during the fixation of a distal radius fracture. In our case, a volar wrist hemorrhagic ganglion cyst was incidentally found during the fixation of the fracture. Prior to the injury, the patient had no complaints of swelling over her right wrist. The cyst was removed using microscopic magnification.
Fulltext Dataset on the safety behavior among Pakistani healthcare workers during COVID-19

Awais-E-Yazdan M, Ilyas MA, Aziz MQ, Waqas M

Data Brief, 2022 Apr;41:107831.
PMID: 35071698 DOI: 10.1016/j.dib.2022.107831

The dataset includes the particulars of 515 respondents on safety behavior during COVID-19. The questionnaires were adapted using Social Learning Theory and Social Exchange Theory. The variables included in dataset are Transactional Leadership (TSL), Transformational Leadership (TFL), Employee Well-Being (EWB) and Safety behavior (SB). Moreover, the dataset also contains the demographic profile of the respondents. Data was collected with the help of self-administered questionnaire from eight public hospitals in Punjab, Pakistan, namely Services Hospital Lahore, Sir Ganga Ram Hospital Lahore, Government General Hospital Faisalabad, DHQ Hospital Chiniot, Municipal General Hospital Sargodha, DHQ Hospital Jhang, DHQ Hospital Multan and Sulehri Children & General Hospital Sialkot. This dataset could provide a significant insight for future research in employee safety behavior.
Fulltext Cydonia oblonga M., A Medicinal Plant Rich in Phytonutrients for Pharmaceuticals

Ashraf MU, Muhammad G, Hussain MA, Bukhari SN

Front Pharmacol, 2016;7:163.
PMID: 27445806 DOI: 10.3389/fphar.2016.00163

Cydonia oblonga M. is a medicinal plant of family Rosaceae which is used to prevent or treat several ailments such as cancer, diabetes, hepatitis, ulcer, respiratory, and urinary infections, etc. Cydonia oblonga commonly known as Quince is rich in useful secondary metabolites such as phenolics, steroids, flavonoids, terpenoids, tannins, sugars, organic acids, and glycosides. A wide range of pharmacological activities like antioxidant, antibacterial, antifungal, anti-inflammatory, hepatoprotective, cardiovascular, antidepressant, antidiarrheal, hypolipidemic, diuretic, and hypoglycemic have been ascribed to various parts of C. oblonga. The polysaccharide mucilage, glucuronoxylan extruded from seeds of C. oblonga is used in dermal patches to heal wounds. This review focuses on detailed investigations of high-valued phytochemicals as well as pharmacological and phytomedicinal attributes of the plant.
Fulltext A CMIP6 multi-model based analysis of potential climate change effects on watershed runoff using SWAT model: A case study of kunhar river basin, Pakistan

Waheed A, Jamal MH, Javed MF, Idlan Muhammad K

Heliyon, 2024 Apr 30;10(8):e28951.
PMID: 38655367 DOI: 10.1016/j.heliyon.2024.e28951

The hydrological regimes of watersheds might be drastically altered by climate change, a majority of Pakistan's watersheds are experiencing problems with water quality and quantity as a result precipitation changes and temperature, necessitating evaluation and alterations to management strategies. In this study, the regional water security in northern Pakistan is examined about anthropogenic climate change on runoff in the Kunhar River Basin (KRB), a typical river in northern Pakistan using Soil and Water Assessment tool (SWAT) and flow durarion curve (FDC). Nine general circulation models (GCMs) were successfully utilized following bias correction under two latest IPCC shared socioeconomic pathways (SSPs) emission scenarios. Correlation coefficients (R2), Nash-Sutcliffe efficiency coefficients (NSE), and the Percent Bias (PBIAS) are all above 0.75. The conclusions demonstrate that the SWAT model precisely simulates the runoff process in the KRB on monthly and daily timescales. For the two emission scenarios of SSP2-4.5 and SSP5-8.5, the mean annual precipitation is predicted to rise by 3.08 % and 5.86 %, respectively, compared to the 1980-2015 baseline. The forecasted rise in mean daily high temperatures is expected to range from 2.08 °C to 3.07 °C, while the anticipated increase in mean daily low temperatures is projected to fall within the range of 2.09 °C-3.39 °C, spanning the years 2020-2099. Under the two SSPs scenarios, annual runoff is estimated to increase by 5.47 % and 7.60 % due to climate change during the same period. Future socioeconomic growth will be supported by a sufficient water supply made possible by the rise in runoff. However, because of climate change, there is a greater possibility of flooding because of increases in both rainfall and runoff. As a result, flood control and development plans for KRB must consider the climate change's possible effects. There is a chance that the peak flow will move backwards relative to the baseline.
Simvastatin nanoparticles loaded polymeric film as a potential strategy for diabetic wound healing: in vitro and in vivo evaluation

Tufail S, Siddique MI, Sarfraz M, Sohail MF, Shahid MN, Omer MO, et al.

Curr Drug Deliv, 2021 Jul 20.
PMID: 34288836 DOI: 10.2174/1567201818666210720150929

INTRODUCTION: The pleiotropic effects of statins are recently explored for wound healing through angiogenesis and lymph-angiogenesis that could be of great importance in diabetic wounds.
AIM: Aim of the present study is to fabricate nanofilm embedded with simvastatin loaded chitosan nanoparticles (CS-SIM-NPs) has been reported herein to explore the efficacy of SIM in diabetic wound healing.
METHODS: The NPs, prepared via ionic gelation, were 173nm ± 2.645 in size with a zeta potential -0.299 ± 0.009 and PDI 0.051 ± 0.088 with excellent encapsulation efficiency (99.97%). The optimized formulation (CS: TPP, 1:1) that exhibited the highest drug release (91.64%) was incorporated into polymeric nanofilm (HPMC, Sodium alginate, PVA), followed by in vitro characterization. The optimized nanofilm was applied to the wound created on the back of diabetes-induced (with alloxan injection 120 mg/kg) albino rats.
RESULTS: The results showed significant (p < 0.05) improvement in the wound healing process compared to the diabetes-induced non-treated group. The results highlighted the importance of nanofilms loaded with SIM-NPs in diabetic wound healing through angiogenesis promotion at the wound site.
CONCLUSION: Thus, CS-SIM-NPs loaded polymeric nanofilms could be an emerging diabetic wound healing agent in the industry of nanomedicines.
Fulltext The non-Newtonian maxwell nanofluid flow between two parallel rotating disks under the effects of magnetic field

Ahmadian A, Bilal M, Khan MA, Asjad MI

Sci Rep, 2020 Oct 13;10(1):17088.
PMID: 33051520 DOI: 10.1038/s41598-020-74096-8

The main feature of the present numerical model is to explore the behavior of Maxwell nanoliquid moving within two horizontal rotating disks. The disks are stretchable and subjected to a magnetic field in axial direction. The time dependent characteristics of thermal conductivity have been considered to scrutinize the heat transfer phenomena. The thermophoresis and Brownian motion features of nanoliquid are studied with Buongiorno model. The lower and upper disk's rotation for both the cases, same direction as well as opposite direction of rotation is investigated. The subsequent arrangement of the three dimensional Navier Stoke's equations along with energy, mass and Maxwell equations are diminished to a dimensionless system of equations through the Von Karman's similarity framework. The comparative numerical arrangement of modeled equations is further set up by built-in numerical scheme "boundary value solver" (Bvp4c) and Runge Kutta fourth order method (RK4). The various physical constraints, such as Prandtl number, thermal conductivity, magnetic field, thermal radiation, time relaxation, Brownian motion and thermophoresis parameters and their impact are presented and discussed briefly for velocity, temperature, concentration and magnetic strength profiles. In the present analysis, some vital characteristics such as Nusselt and Sherwood numbers are considered for physical and numerical investigation. The outcomes concluded that the disk stretching action opposing the flow behavior. With the increases of magnetic field parameter [Formula: see text] the fluid velocity decreases, while improving its temperature. We show a good agreement of the present work by comparing with those published in literature.
Fulltext Impact of religiosity on purchase intentions towards counterfeit products: investigating the mediating role of attitude and moderating role of hedonic benefits

Yaakop AY, Hafeez HM, Faisal MM, Munir M, Ali M

Heliyon, 2021 Feb;7(2):e06026.
PMID: 33644436 DOI: 10.1016/j.heliyon.2021.e06026

This study was aimed at exploring the impact of religiosity on purchase intention towards counterfeit products by investigating the mediating role of consumer attitude. This study investigated religiosity as an independent variable, attitude towards counterfeit as a mediator while predicting the purchase intentions of the consumers. A self-administered questionnaire using a five-point Likert scale was used to collect data from the sample of 420 respondents who were from twin cities (Rawalpindi and Islamabad) of Pakistan. Structural equation modeling technique was used to achieve the set objectives. The results reveal a statistically significant effect of religiosity along with the significant mediating role of consumer attitude and the significant moderating role of hedonic benefits while predicting the purchase intentions of the consumers. This study also provides important insights for the researchers and the practitioners.
Fulltext Numerical analysis of thermal conductive hybrid nanofluid flow over the surface of a wavy spinning disk

Ahmadian A, Bilal M, Khan MA, Asjad MI

Sci Rep, 2020 Nov 02;10(1):18776.
PMID: 33139760 DOI: 10.1038/s41598-020-75905-w

A three dimensional (3D) numerical solution of unsteady, Ag-MgO hybrid nanoliquid flow with heat and mass transmission caused by upward/downward moving of wavy spinning disk has been scrutinized. The magnetic field has been also considered. The hybrid nanoliquid has been synthesized in the presence of Ag-MgO nanoparticles. The purpose of the study is to improve the rate of thermal energy transmission for several industrial purposes. The wavy rotating surface increases the heat transmission rate up to 15%, comparatively to the flat surface. The subsequent arrangement of modeled equations is diminished into dimensionless differential equation. The obtained system of equations is further analytically expounded via Homotopy analysis method HAM and the numerical Parametric continuation method (PCM) method has been used for the comparison of the outcomes. The results are graphically presented and discussed. It has been presumed that the geometry of spinning disk positively affects the velocity and thermal energy transmission. The addition of hybrid nanoparticles (silver and magnesium-oxide) significantly improved thermal property of carrier fluid. It uses is more efficacious to overcome low energy transmission. Such as, it provides improvement in thermal performance of carrier fluid, which play important role in power generation, hyperthermia, micro fabrication, air conditioning and metallurgical field.
Fulltext AI inspired EEG-based spatial feature selection method using multivariate empirical mode decomposition for emotion classification

Asghar MA, Khan MJ, Rizwan M, Shorfuzzaman M, Mehmood RM

Multimed Syst, 2021 Apr 21.
PMID: 33897112 DOI: 10.1007/s00530-021-00782-w

Classification of human emotions based on electroencephalography (EEG) is a very popular topic nowadays in the provision of human health care and well-being. Fast and effective emotion recognition can play an important role in understanding a patient's emotions and in monitoring stress levels in real-time. Due to the noisy and non-linear nature of the EEG signal, it is still difficult to understand emotions and can generate large feature vectors. In this article, we have proposed an efficient spatial feature extraction and feature selection method with a short processing time. The raw EEG signal is first divided into a smaller set of eigenmode functions called (IMF) using the empirical model-based decomposition proposed in our work, known as intensive multivariate empirical mode decomposition (iMEMD). The Spatio-temporal analysis is performed with Complex Continuous Wavelet Transform (CCWT) to collect all the information in the time and frequency domains. The multiple model extraction method uses three deep neural networks (DNNs) to extract features and dissect them together to have a combined feature vector. To overcome the computational curse, we propose a method of differential entropy and mutual information, which further reduces feature size by selecting high-quality features and pooling the k-means results to produce less dimensional qualitative feature vectors. The system seems complex, but once the network is trained with this model, real-time application testing and validation with good classification performance is fast. The proposed method for selecting attributes for benchmarking is validated with two publicly available data sets, SEED, and DEAP. This method is less expensive to calculate than more modern sentiment recognition methods, provides real-time sentiment analysis, and offers good classification accuracy.
Fulltext Evaluation of clinical manifestations, health risks, and quality of life among women with polycystic ovary syndrome

Sidra S, Tariq MH, Farrukh MJ, Mohsin M

PLoS One, 2019;14(10):e0223329.
PMID: 31603907 DOI: 10.1371/journal.pone.0223329

This study aimed to evaluate the clinical manifestations and health risks associated with polycystic ovary syndrome (PCOS) and its impact on quality of life (QOL) in Pakistan. A detailed cross-sectional study was conducted on PCOS among women of reproductive age visiting the gynecology and obstetrics and endocrinology departments at primary and tertiary care hospitals located in Abbottabad, Kohat, and Islamabad. In total, 440 patients meeting the inclusion criteria were included. A checklist was specifically designed to identify symptoms and health risks, including adverse drug reactions, complications, irrational prescription or underprescription, and drug-drug interactions. The Short Form-12 questionnaire was used to evaluate the QOL of patients with PCOS. Data collected were analyzed for descriptive and inferential statistics using chi-square test, analysis of variance, and post hoc analysis. All patients exhibited the cardinal symptoms of PCOS, including obesity (n = 352, 80%), acne (n = 296, 67.3), hirsutism (n = 299, 68%), hyperglycemia (n = 278, 63.2%), and irregular menstruation (n = 316, 71.8%). Ultrasonography confirmed that 268 (61%) patients had multiple cysts of >10 mm in diameter. Patients with untreated PCOS exhibited a high prevalence of health risks including hypertension (n = 87, 19.8%), diabetes (n = 268, 60.9%), sleep apnea (n = 11, 2.5%), infertility (n = 146, 33.2%), increased endometrial thickness (n = 21, 4.8%), miscarriages (n = 68, 15.5%), high cholesterol level (n = 85, 19.3%), and hyperandrogenism (n = 342, 77.7%). Most patients exhibited low QOL scores (n = 374, 85%), with depression being the largest contributor to low QOL. Apart from novel results, this study found an association between depression and low QOL in patients with PCOS, suggesting the need for reviewing the management guidelines and psychological health assessment of women with PCOS.

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