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Fulltext Sociodemographic, Lifestyle, and Health Factors Associated With Depression and Generalized Anxiety Disorder Among Malaysian Adults

Cheah YK, Azahadi M, Phang SN, Abd Manaf NH

J Prim Care Community Health, 2020 5 27;11:2150132720921738.
PMID: 32450747 DOI: 10.1177/2150132720921738

Objectives: Lowering the prevalence of mental health illness is one of the main public health concerns. The objective of the present study was to examine factors associated with depression and generalized anxiety disorder (GAD) among adults in Malaysia. Methods: Data were extracted from the National Health and Morbidity Survey 2011 (NHMS 2011), which is a nationally representative sample collected using a 2-stage stratified sampling method. A bivariate probit model was utilized to examine the influences of sociodemographic, lifestyle, and health factors on the likelihood of suffering from depression and GAD. Results: Age, gender, ethnicity, education, marital status, and self-rated health were significantly associated with depression and GAD. In particular, there were positive relationships between depression and GAD, and younger adults, females, Indian ethnic group, lower level of education, being unmarried, and self-rated poor health. Conclusions: Sociodemographic and health factors were associated with determining the risks of depression and GAD in Malaysia. With this information, future policies (eg, screening and treatment) could be targeted at those at most risk to develop depression and GAD.

Matched MeSH terms: Life Style
APOE Genotype and Alzheimer's Disease: The Influence of Lifestyle and Environmental Factors

Angelopoulou E, Paudel YN, Papageorgiou SG, Piperi C

ACS Chem Neurosci, 2021 08 04;12(15):2749-2764.
PMID: 34275270 DOI: 10.1021/acschemneuro.1c00295

Alzheimer's disease (AD) is the most common neurodegenerative disorder with obscure pathogenesis and no disease-modifying therapy to date. AD is multifactorial disease that develops from the complex interplay of genetic factors and environmental exposures. The E4 allele of the gene encoding apolipoprotein E (APOE) is the most common genetic risk factor for AD, whereas the E2 allele acts in a protective manner. A growing amount of epidemiological evidence suggests that several lifestyle habits and environmental factors may interact with APOE alleles to synergistically affect the risk of AD development. Among them, physical exercise, dietary habits including fat intake and ketogenic diet, higher education, traumatic brain injury, cigarette smoking, coffee consumption, alcohol intake, and exposure to pesticides and sunlight have gained increasing attention. Although the current evidence is inconsistent, it seems that younger APOE4 carriers in preclinical stages may benefit mostly from preventive lifestyle interventions, whereas older APOE4 noncarriers with dementia may show the most pronounced effects. The large discrepancies between the epidemiological studies may be attributed to differences in the sample sizes, the demographic characteristics of the participants, including age and sex, the methodological design, and potential related exposures and comorbidities as possible cofounding factors. In this Review, we aim to discuss available evidence of the prominent APOE genotype-environment interactions in regard to cognitive decline with a focus on AD, providing an overview of the current landscape in this field and suggesting future directions.

Matched MeSH terms: Life Style
Fulltext Coronary heart disease risk assessment among the security staff in a public university

Lua, G.W., Moy, F.M., Atiya, A.S.

Malaysian Journal of Public Health Medicine, 2004;4(1):29-34.
MyJurnal

A cross sectional survey on the assessment of coronary heart disease risks was conducted on a group of security guards in a public university. The objectives were to assess the risk of coronary heart disease (CHD) among the security staff and to provide advice on CHD prevention and practice of a healthy lifestyle. A face»t0»face questionnaire was used to conduct the survey. The main outcome measure was the coronary heart disease (CHD) risk score estimates. The handings showed that 61 participants ( 5 3 .0%) have very high CHD risk factors, while the rest, 38.3% and 8.7% have moderate and low CHD risk factors respectively. With increasing age, there is an increase in total risk score among the target groups. The percentage increases almost 2-fold between the 21-30 and the 31-40 age groups. Majority of the security staff had high CHD risk factors and more efforts and preventive measures must be taken to overcome this situation. Personalised advice was given to participants based on their CHD risks estimates.

Matched MeSH terms: Life Style
Fulltext Cultural beliefs and caffeine-induced sleep disorder: the kopitiam man

Leow M.Y., Russell V., Bharathy A.

Malaysian Journal of Psychiatry, 2015;24(1):86-90.
MyJurnal

Objective: A case of caffeine-induced sleep disorder is reported to illustrate the clinical benefits of assessing culturally determined health beliefs in such presentations. Method: A middle-aged Malaysian Chinese male presented with caffeine-induced sleep disturbance arising from dietary modifications. Result: Assessing the contribution of cultural beliefs regarding hot and cold drinks led to successful management of the patient’s sleep disturbance. Conclusion: It is important for clinicians to explore health beliefs and associated dietary and lifestyle behaviours in caffeine-related sleep disorders.

Matched MeSH terms: Life Style
Fulltext Dietary and lifestyle changes of Malaysian breast cancer survivors: a qualitative study

Redhwan, A.A., Md Idris, M.N., Robert, C.

Malaysian Journal of Community Health, 2008;14(1):24-31.
MyJurnal

Objective :This study was performed to determine changes in diet and lifestyle among breast cancer survivors in Malaysia.
Methods :This was a qualitative study done on fifteen survivors (8 Malays and 7 non-Malays) obtained from the Oncology and Surgery Department, National University of Malaysia Hospital. The study was conducted using a semi-structured interview format. The data obtained were sorted into various categories via content analysis.
Results :Majority of breast cancer survivors increased their fruit and vegetable intake following diagnosis. Some non-Malays changed to vegetarian whereas all the Malays remained on the same dietary pattern. As far as exercise was concerned, all Malays did not exercise before diagnosis, but did so after diagnosis, whereas most of non- Malays did not exercise either before or after diagnosis.
Conclusion : Some changes were noticed in dietary and lifestyle behaviors after diagnosis among some survivors. The differences were due to their different cultural and religious backgrounds.

Matched MeSH terms: Life Style
Fulltext Do elderly women in Malaysia go for mammogram screening?

Rahmah, M.A., Aniza, I., Che Engku Nor Bahiyah, C.E.M.

Malaysian Journal of Public Health Medicine, 2013;13(2):20-26.
MyJurnal

Despite the debates of the benefits of continuing mammography screening among elderly women, studies in Malaysia have shown that the prevalence of breast examination declines after age 45 years and for mammogram per se, the prevalence of examination increases until age of 64. This study aims to determine the prevalence of mammogram screening among elderly women in Hulu Langat, Selangor and its relationship with factors such as demographic factors, family history of breast cancer, perceived health status, perceived general psychological factor and lifestyle factors. Data used were from a cross sectional study of health status among community in Hulu Langat area by the Department of Community Health, Universiti Kebangsaan Malaysia carried out from the year 1998 till 2002. However this paper focused on the database involving elderly women age 60 and above. The sample population was 652. The mean (standard deviation) age was 67.17 (5.995). Only 8.3% of the elderly women claimed to ever had mammogram screening done. Hence, the prevalence of mammogram screening is still low among elderly women in Hulu Langat. Having family history of breast cancer (p < 0.001) and perceived positive psychological status (p=0.003) had shown significant associations with mammogram screening among them. It is therefore important for researcher to further look into the reasons behind this and qualitative exploration is highly recommended.

Matched MeSH terms: Life Style
Fulltext Review of elderly driver visual perception simulation system for vehicle design

Ghazilla, R. A. R., Yap, H. J.

Malaysian Journal of Public Health Medicine, 2016;16(20):113-120.
MyJurnal

The number of people above 60 years of age will increases due to the growth of the population in the first half of the 21st century, particularly in Malaysia. This has led to the growing number of older drivers which is often unavoidable as driving is a necessary task that not only achieves mobility but also shows a sign of independence and improves self-esteem, which are essential towards effecting the lifestyle. This paper briefly looks at common elderly related visual impairment, reviews design approaches and tools that tackle or include these issues in the design process and further outlines new research needs. It is the intention of this paper to steer the research direction of the development of future design approach and tools that would enhance the capabilities of designers to be well prepared to cater for inclusive design for the elderly, more specifically for visual impairments issues.

Matched MeSH terms: Life Style
Fulltext Dietary fatty acids and edible fruit oil: Potential therapy for heart

Noor Atiqah Aizan Abd Kadir, Azrina Azlan

The Pertanika Journal of Scholarly Research Reviews, 2017;3(2):45-55.
MyJurnal

Cardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. This disease is commonly experienced by people with unhealthy lifestyle, stress and physical inactivity. Cholesterol has received the most attention as single risk factor of CVD. Reducing the intake of cholesterol, saturated fat, and trans faty acids may be beneficial, yet controversy is still lingering to what constituents more beneficial dietary fats. The purpose of this article is to give an overview on the impact of major dietary fatty acids on cardiovascular morbidity and mortality and to give an insightful information regarding fatty acids composition in selected fruits oils in search for novel oils as potential therapy against CVD.

Matched MeSH terms: Life Style
Fulltext Factors associated with awareness, knowledge and attitude towards prostate cancer among Malay men in traditional Malay Villages, Negeri Sembilan, Malaysia

Suriani Ismail, Huda Zainuddin, Titi Rahmawati Hamedon, Muhammad Hanafiah Juni, Nor Afiah Mohd. Zulkefli, Suhainizam bin Muhamad Saliluddin

Malaysian Journal of Medicine and Health Sciences, 2018;14(2):31-38.
MyJurnal

Background: Lack of awareness, poor knowledge and attitude regarding cancer have been identified as possible reasons accounting for the late presentation which lead to the poor survival of cancer patients in Malaysia. Method: A cross sectional study was conducted in three traditional Malay villages in Negeri Sembilan among adult males. Those who were already diagnosed with prostate cancer or Non malaysians were excluded from the study. Data was collected using self-administered questionnaires which consist of several sections namely socio-demographic, awareness about prostate cancer, sources of information, family history of prostate cancer, lifestyle associated with risk of cancer, knowledge and attitude towards prostate cancer. Data was analysed using SPSS version 22.0. Chisquare test was used to determine associations. Level of significance was set at p

Matched MeSH terms: Life Style
Fulltext Non-ionizing radiation: exposure level at UMT and UniSZA campus

Syafiqah, H.N., Umar, R., Kamarudin, M.K.A., Hazmin, S.N., Dianah, A.R.S.N., Jaafar, H., et al.

ASM Science Journal, 2018;11(101):183-194.
MyJurnal

Nowadays, the wireless technology has become a lifestyle; even the children have their own
mobile phones, although they are categorized as high risk susceptible to health problems
due to radiation. Thus, the public exposure that stemmed from electromagnetic radiations
become public concern since studies have been done and the finding showed that the repetitive
and long term exposure may have adverse health effect. This study was conducted to
evaluate the exposure level at UMT and UniSZA campuses by measuring the electric field
strength. This measurement was conducted using omni-directional antenna below 4 GHz,
connected to spectrum analyzer. In this paper, the measured values are compared with
the previous study from several locations and then the spatial maps of exposure level are
developed. The result shows that high exposure level was recorded at UMT and UniSZA.
From this study, the findings may assist the Ministry of Health to monitor the public health
due to non-ionizing radiation (NIR) exposure. This is crucial to make sure the international
commission of non-ionizing radiation protection (ICNIRP) limit is complied. Moreover, the
development of public NIR exposure policy can be initiated to the Malaysia government for
health concern. For future study, the investigation of the suitable material used as antenna
and casing or exposure reduction tool can be done to reduce NIR exposure rate on human
body.

Matched MeSH terms: Life Style
Fulltext Online shopping practices and factors influencing

Farhan Mat Arisah, Shamsul Azahari Zainal Badari, Ahmad Hariza Hashim

Malaysian Journal of Social Sciences and Humanities, 2016;1(3):111-123.
MyJurnal

Online shopping has been preferred over the conventional shopping methods as the results of hectic
lifestyles nowadays. It is a convenient way to get groceries without having to queue at the counters.
The objective of this research is to study the online shopping practices and the factors that affect it.
Apart from that, it is also to identify the difference in online shopping behaviour among selected
background factors (sex, social status, generation, ethnic, household income, education level and zone).
The populations of this research include consumers of 17 years old and above whose chosen by
convenience through mall intercept method. T-test result shows there is significant difference (t=-
3.156, p=0.001) for online shopping practice between men and women. Meanwhile, based on ANOVA result, it shows that there is significant difference between mean scores of different generation [F(3,
1298)= 3.475, p = 0.016], ethnics [F(4, 1291)= 3.678, p = 0.006] and household income [F (4, 1227)=
6.935, p = 0.000]. However, there is no significant difference among mean scores for education level,
zones and stratum (p>0.05). Apart from that, the result also indicates that only five factors taken into
consideration before a particular customer does the online shopping which are safety, products offered,
risk, trustworthy and customers experience. Thus, the sellers should approach their customers in
different ways in order to meet the demand, hence expanding their bussiness.

Matched MeSH terms: Life Style
Planning Accessibility Strategies and Connectivity for Malaysian Urban Built Environment

Abd Samad NA, Said I, Abdul Rahim A

Stud Health Technol Inform, 2018;256:367-377.
PMID: 30371497

Access to our buildings relies to the accessibility of its external environment and the route taken. Developments and planning in urban areas has many several requirements and restrictions. Planning accessibility for Malaysian built environment is achievable by designing in compliance to the requirements enforced by authorities. Accessible design is commonly associated with providing facilities for Persons with Disabilities (PwDs), the issue that is often brought up is the inaccessibility of the external environment and lacking of seamless connectivity between buildings and the outdoor. The intention is to formulate accessibility strategies and work out planning process on how accessibility can be achieved. Universal Design will be the basis for the design and planning concept to accommodate all users to enjoy our urban built environment. It is notable that developed countries advances more in terms of implementing and enforcing accessibility measures via legislative and regulatory documents, government strategies and initiatives within its planning approach than the developing nations. The methodology will be looking into the establishment of strategies and measures of international and local planning policy, local and action plans of City of London as selected Local Authority to be analyzed its inclusive policy has been successfully implemented in their jurisdiction. The findings, discussions and result will be an outcome of generating a framework of accessibility strategies that is derived from interviews and government documents accordingly to targeted Malaysian urban areas focusing the City of Petaling Jaya and Putrajaya and how it can be improvised. Therefore, an interpretation of adopting accessibility planning strategies of developed country, to be adapted locally according to Malaysian legislation, culture and lifestyles.

Matched MeSH terms: Life Style
Violent crime datasets: Incidence and patterns in Malaysia from 2006 to 2017

Hakim HM, Khan HO, Hamzah HH, Othman MF, Nelson BR, Chambers GK, et al.

Data Brief, 2019 Oct;26:104449.
PMID: 31667222 DOI: 10.1016/j.dib.2019.104449

This article provides violent crime data in Malaysia from 2006 to 2017. The violent crimes include murder, rape, gang robbery, robbery and voluntarily causing hurt cases. A total of 330,395 violent crime cases were reported in this 12 year period and the data were tabulated state by state for all thirteen states of Malaysia, including two states in Borneo (Sabah and Sarawak) and one federal territory (Kuala Lumpur). In general, violent crimes show a decreasing trend from 2006 to 2017 in Malaysia. However, armed gang robbery and armed robbery show a fluctuating pattern from 2008 to 2011. A similar pattern was also recorded for unarmed gang robbery from 2008 to 2010. The violent crime data deposited here are available for further analysis, e.g., for identifying risk factors such as demography, lifestyle, socio-economic status, government policies etc. which may be associated with violent crime incidence and pattern across the country.

Matched MeSH terms: Life Style
Fulltext Development and evaluation of acceptance of a web based education module for reducing risk of mild cognitive impairment among older adults

Suzana Shahar, Divya Vanoh, Intan Hafizah Mohd Ishak, Zahara Abdul Manaf, Rosdinom Razali, Nazlena Mohd Ali, et al.

Jurnal Sains Kesihatan Malaysia, 2018;16(101):233-234.
MyJurnal

Relatively less comprehensive web based programme has been developed for detecting risk of mild cognitive impairment (MCI) and further impart preventive strategies and lifestyle education. Thus, this study has developed a comprehensive web based programme for early screening of risk of MCI together with education package for preventing MCI known as WESIHAT 2.0. WESIHAT 2.0 is a senior friendly website which has appropriate design interface facilitating access of older people especially with the use of touch-screen technology. WESIHAT 2.0 has incorporated four major components namely TUA WELLNESS screening tool, which is a comprehensive, online based, 10-item screening tool for detecting risk of MCI, 10-guides for preventing MCI, health diary and healthy food. Evaluation of acceptance of WESIHAT 2.0 was done among 71 people which comprised of 30 older people and 30 caregivers, chosen equally based on ethnic composition and 11 health care professionals who has experience working in the field of geriatric and 2 freelance website developer. All older people and caregivers stated that the content of website was very useful for preventing MCI, however, about 36.4% of health professionals stated several improvements needed to be done before releasing the end-product to the users. Comments given were smaller font size (27.3), addition of more pictures (27.3%), using simpler terms (36.4%) and changing certain design for better view of older people (18.2%). Amendments were made based on each comment given and the finalized website were used for a 6-month intervention programme for neuroprotection among older people who failed to achieve successful aging. It is timely for an online based approach for prevention of MCI. WESIHAT 2.0 is the first website in Malaysia which has been accepted by all older people and caregiver and more than half of healthcare professionals to prevent memory decline.

Matched MeSH terms: Life Style
Fulltext Sequence polymorphism and haplogroup data of the hypervariable regions on mtDNA in Semoq Beri population

Zahidin MA, Omar WBW, Taib WRW, Japning JRR, Abdullah MT

Data Brief, 2018 Dec;21:2609-2615.
PMID: 30761343 DOI: 10.1016/j.dib.2018.10.158

Orang Asli is the aboriginal people in Peninsular Malaysia who have been recognized as indigenous to the country and still practicing traditional lifestyle. The molecular interest on the Orang Asli started when the earliest prehistoric migration occurred approximately 200 kya and entering Peninsular Malaysia 50 kya in stages. A total of three groups of Orang Asli present in Peninsular Malaysia, namely, Negrito also known as Semang, Senoi and Proto Malays. Through records, there is no research has been conducted on mtDNA variations in the Semoq Beri population, one of the tribes in Senoi group. In this report, variations of mtDNA were analysed in the population in Hulu Terengganu as an initial effort to establish the genetic characterisation and elucidating the history of Orang Asli expansion in Peninsular Malaysia. An array of mtDNA parameters was estimated and the observed polymorphisms with their respective haplogroups in comparison to rCRS were inferred respectively. The DNA sequences are registered in the NCBI with accession numbers KY853670-KY853753.

Matched MeSH terms: Life Style
Fulltext Infection of army ant pupae by two new parasitoid mites (Mesostigmata: Uropodina)

Brückner A, Klompen H, Bruce AI, Hashim R, von Beeren C

PeerJ, 2017;5:e3870.
PMID: 29038753 DOI: 10.7717/peerj.3870

A great variety of parasites and parasitoids exploit ant societies. Among them are the Mesostigmata mites, a particularly common and diverse group of ant-associated arthropods. While parasitism is ubiquitous in Mesostigmata, parasitoidism has only been described in the genus Macrodinychus. Yet information about the basic biology of most Macrodinychus species is lacking. Out of 24 formally described species, information about basic life-history traits is only available for three species. Here we formally describe two new Macrodinychus species, i.e. Macrodinychus hilpertae and Macrodinychus derbyensis. In both species, immature stages developed as ecto-parasitoids on ant pupae of the South-East Asian army ant Leptogenys distinguenda. By piercing the developing ant with their chelicera, the mites apparently suck ant hemolymph, ultimately killing host individuals. We compare infection rates among all studied Macrodinychus species and discuss possible host countermeasures against parasitoidism. The cryptic lifestyle of living inside ant nests has certainly hampered the scientific discovery of Macrodinychus mites and we expect that many more macrodinychid species await scientific discovery and description.

Matched MeSH terms: Life Style
Fulltext The usage of computers and internet web 2.0 in generation Y among university students (Penggunaan komputer dan internet Web 2.0 dalam kalangan generasi Y pelajar universiti)

Abdul Manaf, S.Z., Din, R., Hamdan, A., Mat Salleh, N.S., Kamsin, I.F., Abdul Aziz, J.

Journal of Advanced Research Design, 2015;7(1):10-18.
MyJurnal

At present, the learning activities carried out is in line with the rapid growth of development of technology and lifestyle. ICT literacy is categorised as those who can operate a computer and Internet. This study is conducted to determine the level of computer and Internet literacy in generation Y. A total of ten respondents among university students were interviewed. The level of the skill is measured in terms of the use of information processing systems and the Internet. The new knowledge addresses the themes in information communication technology literacy namely; defining, accessing, assessing, managing, integrating, creating and passing data. As such, the model of computer technology in education can also be produced. A more robust method of learning can be heightened by seeing the level of skills possessed by university students. The findings of this study is expected to determine the level of competence of the students and university can provide the necessary equipment to ensure effective teaching and learning.

Matched MeSH terms: Life Style
Fulltext Assessment of mental wellbeing of undergraduate pharmacy students from 14 countries: The role of gender, lifestyle, health-related, and academic-related factors

Elnaem MH, Mubarak N, K T MS, Barakat M, Abdelaziz DH, Mansour NO, et al.

Front Public Health, 2022;10:1011376.
PMID: 36388263 DOI: 10.3389/fpubh.2022.1011376

BACKGROUND: Pharmacy students will assume future roles as frontline healthcare providers. Therefore, evaluating their current state of mental wellbeing and its associated factors is essential for better planning students' support initiatives. This study aimed to assess mental wellbeing and its associated factors among undergraduate pharmacy students from 14 countries during the pandemic.
METHODS: A cross-sectional study was conducted among undergraduate pharmacy students in 14 countries in Asia and the Middle East. The validated Warwick-Edinburgh Mental Wellbeing Scale (the 14-item WEMWBS) was adopted to assess mental wellbeing. Data collection was performed online between February and April 2022. Descriptive and inferential statistics were used as appropriate.
RESULTS: A total of 2,665 responses were received, mainly from females (68.7%) with a higher presence of private universities (59.1%). About 34.9% had low mental wellbeing levels, while 57 and 8.1% had medium, and high levels, respectively. Binary logistic regression showed that males (AOR: 1.34; CI 95%: 1.11-1.61; p < 0.01) and students with no chronic illnesses (AOR: 2.01; CI 95%: 1.45-2.80; p < 0.001) were more likely to have higher mental wellbeing. Also, participants who did not engage in any exercise (AOR: 0.71; CI 95%: 0.52-0.98; p = 0.04) and those in public universities (AOR: 0.82; CI 95%: 0.69-0.97; p = 0.02) were less likely to have higher mental wellbeing. Additionally, students who had interest/passion for pharmacy (AOR: 1.69; CI 95%: 1.07-2.68; p = 0.02), and those who known pharmacists inspired (AOR: 1.81; CI 95%: 1.06-3.12; p = 0.03), were more likely to have higher mental wellbeing compared with those who had no specific reason for their choice to study pharmacy. The participants with excellent (AOR: 1.87; CI 95%: 1.29-2.70; p = 0.001) or very good self-reported academic performance (AOR: 1.57; CI 95%: 1.12-2.22; p = 0.01) were more likely to have higher mental wellbeing compared to those with fair academic performance.
CONCLUSION: More than a third of the participants had low mental wellbeing. Various demographic, lifestyle, medical and academic factors appeared to affect students' mental wellbeing. Careful consideration of these factors and their integration into the pharmacy schools' plans for student support services and academic advising would be essential to improve students' mental wellbeing.

Matched MeSH terms: Life Style
Fulltext Effect of the national lifestyle guidance intervention for metabolic syndrome among middle-aged people in Japan

Li Y, Babazono A, Jamal A, Liu N, Liang L, Yamao R, et al.

J Glob Health, 2024 Feb 09;14:04007.
PMID: 38334270 DOI: 10.7189/jogh.14.04007

BACKGROUND: Japan has implemented a national lifestyle guidance intervention programme for potential metabolic syndrome among adults aged 40-74 years; however, there is limited evidence regarding the causal impact of this intervention. The study aims to determine the causal effect of this intervention on health outcomes and health care utilisation.
METHODS: We performed a regression discontinuity design study. A total of 46 975 adults with ≥1 cardiovascular risk factor in 2015 were included in the study. A two-stage evaluation process (stage 1: waist circumference ≥85 cm for men or ≥90 cm for women and ≥1 cardiovascular risk factor; stage 2: body mass index (BMI)≥25 kg/m2 and ≥2 cardiovascular risk factors) was applied. Changes in obesity, cardiovascular outcomes, and health care utilisation were evaluated in a one-year follow-up in the fiscal year 2016.
RESULTS: Participants who received lifestyle guidance intervention based on the waist circumference had a statistically significant reduction in obesity outcomes (Δ weight: -0.30 kg, 95% CI = -0.46 to -0.11; Δ waist circumference: -0.26 cm, 95% CI = -0.53 to -0.02; Δ BMI = -0.09 kg/m2, 95% CI = -0.17 to -0.04) but not in other cardiovascular risk factors and health care utilisation. Analyses based on BMI and results according to demographic subgroups did not reveal significant findings.
CONCLUSIONS: The provision of this intervention had a limited effect on health improvement and a decrease in health care costs, health care visits, and length of stay. A more intensive intervention delivery could potentially improve the efficacy of this intervention programme.

Matched MeSH terms: Life Style
Fulltext Diet, lifestyle and gut microbiota composition among Malaysian women with gestational diabetes mellitus: a prospective cohort study

Kunasegaran T, Balasubramaniam VRMT, Thirunavuk Arasoo VJ, Palanisamy UD, Tan YK, Ramadas A

Sci Rep, 2024 Mar 22;14(1):6891.
PMID: 38519592 DOI: 10.1038/s41598-024-57627-5

The study addressed a significant gap in the profiling and understanding of the gut microbiota's influence on Malaysian Malay women with gestational diabetes mellitus (GDM). This prospective cohort study aimed to explore the intricate relationship between gut microbiota, dietary choices, and lifestyle factors among Malay women, both with and without GDM. The research specifically focused on participants during the second (T0) and third (T1) trimesters of pregnancy in Johor Bahru, Malaysia. In Part 1 of the study, a diverse pool of pregnant women at T0 was categorized into two groups: those diagnosed with GDM and those without GDM, with a total sample size of 105 individuals. The assessments encompassed demographic, clinical, lifestyle, and dietary factors at the T0 and T1 trimesters. Part 2 of the study delved into microbiome analysis, targeting a better understanding of the gut microbiota among the participants. Stool samples were randomly collected from 50% of the individuals in each group (GDM and non-GDM) at T0 and T1. The collected samples underwent processing, and 16s rRNA metagenomic analysis was employed to study the microbial composition. The results suggested an association between elevated body weight and glucose levels, poor sleep quality, lack of physical activity, greater intake of iron and meat, and reduced fruit consumption among women with GDM compared to non-GDM groups. The microbiome analysis revealed changes in microbial composition over time, with reduced diversity observed in the GDM group during the third trimester. The genera Lactiplantibacillus, Parvibacter, Prevotellaceae UCG001, and Vagococcus positively correlated with physical activity levels in GDM women in the second trimester. Similarly, the genus Victivallis exhibited a strong positive correlation with gravida and parity. On the contrary, the genus Bacteroides and Roseburia showed a negative correlation with omega-3 polyunsaturated fatty acids (PUFAs) in women without GDM in the third trimester. The study highlighted the multifaceted nature of GDM, involving a combination of lifestyle factors, dietary choices, and changes in gut microbiota composition. The findings emphasized the importance of considering these interconnected elements in understanding and managing gestational diabetes among Malaysian Malay women. Further exploration is essential to comprehend the mechanisms underlying this relationship and develop targeted interventions for effective GDM management.

Matched MeSH terms: Life Style

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