Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

Dey YN 1 , Sharma G 2 , Wanjari MM 1 , Kumar D 3 , Lomash V 4 , Jadhav AD 1

Affiliations 

  • 1 a National Research Institute for Ayurveda-Siddha Human Resource Development , Gwalior , Madhya Pradesh , India , (Under Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, New Delhi, India)
  • 2 b School of Studies in Biomedical Technology, Jiwaji University , Gwalior , Madhya Pradesh , India
  • 3 c Centre for Advanced Research in Pharmaceutical Sciences, Shobhit University , Meerut , Uttar Pradesh , India
  • 4 d Shriram Institute for Industrial Research , New Delhi , India
Pharm Biol, 2017 Dec;55(1):53-62.
PMID: 27600166

Abstract

CONTEXT: The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment of different gastrointestinal and inflammatory disorders.

OBJECTIVE: The present study evaluated the effects of extracts of Amorphophallus paeoniifolius tubers on acetic acid-induced ulcerative colitis (UC) in rats.

MATERIALS AND METHODS: Wistar rats were orally administered methanol extract (APME) or aqueous extract (APAE) (250 and 500 mg/kg) or standard drug, prednisolone (PRDS) (4 mg/kg) for 7 days. On 6th day of treatment, UC was induced by transrectal instillation of 4% acetic acid (AA) and after 48 h colitis was assessed by measuring colitis parameters, biochemical estimations and histology of colon.

RESULTS: APME or APAE pretreatment significantly (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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