Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4

Ma RC; Hu C; Tam CH; Zhang R; Kwan P; Leung TF; Thomas GN; Go MJ; Hara K; Sim X; Ho JS; Wang C; Li H; Lu L; Wang Y; Li JW; Wang Y; Lam VK; Wang J; Yu W; Kim YJ; Ng DP; Fujita H; Panoutsopoulou K; Day-Williams AG; Lee HM; Ng AC; Fang YJ; Kong AP; Jiang F; Ma X; Hou X; Tang S; Lu J; Yamauchi T; Tsui SK; Woo J; Leung PC; Zhang X; Tang NL; Sy HY; Liu J; Wong TY; Lee JY; Maeda S; Xu G; Cherny SS; Chan TF; Ng MC; Xiang K; Morris AP; DIAGRAM Consortium; Keildson S; MuTHER Consortium; Hu R; Ji L; Lin X; Cho YS; Kadowaki T; Tai ES; Zeggini E; McCarthy MI; Hon KL; Baum L; Tomlinson B; So WY; Bao Y; Chan JC; Jia W

doi:10.1007/s00125-013-2874-4

Fulltext

Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4

Ma RC , Hu C , Tam CH , Zhang R , Kwan P , Leung TF Show all authors , Thomas GN , Go MJ , Hara K , Sim X , Ho JS , Wang C , Li H , Lu L , Wang Y , Li JW , Wang Y , Lam VK , Wang J , Yu W , Kim YJ , Ng DP , Fujita H , Panoutsopoulou K , Day-Williams AG , Lee HM , Ng AC , Fang YJ , Kong AP , Jiang F , Ma X , Hou X , Tang S , Lu J , Yamauchi T , Tsui SK , Woo J , Leung PC , Zhang X , Tang NL , Sy HY , Liu J , Wong TY , Lee JY , Maeda S , Xu G , Cherny SS , Chan TF , Ng MC , Xiang K , Morris AP , DIAGRAM Consortium , Keildson S , MuTHER Consortium , Hu R , Ji L , Lin X , Cho YS , Kadowaki T , Tai ES , Zeggini E , McCarthy MI , Hon KL , Baum L , Tomlinson B , So WY , Bao Y , Chan JC , Jia W

Diabetologia, 2013 Jun;56(6):1291-305.

PMID: 23532257 DOI: 10.1007/s00125-013-2874-4

Abstract

AIMS/HYPOTHESIS: Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians.

METHODS: We performed a meta-analysis of three GWAS comprising 684 patients with type 2 diabetes and 955 controls of Southern Han Chinese descent. We followed up the top signals in two independent Southern Han Chinese cohorts (totalling 10,383 cases and 6,974 controls), and performed in silico replication in multiple populations.

RESULTS: We identified CDKN2A/B and four novel type 2 diabetes association signals with p

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.