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  1. Abu Zarin M, Tan JS, Murugan P, Ahmad R
    BMC Complement Med Ther, 2020 Oct 19;20(1):317.
    PMID: 33076892 DOI: 10.1186/s12906-020-03113-0
    BACKGROUND: The banana or scientifically referred to as Musa sp., is one of the most popular fruits all over the world. Almost all parts of a banana tree, including the fruits, stem juice, and flowers are commonly used as traditional medicine for treating diarrhoea (unripe), menorrhagia, diabetes, dysentery, and antiulcerogenic, hypoglycemic, antilithic, hypolipidemic conditions, plus antioxidant actions, inflammation, pains and even snakebites. The study carried out was to evaluate in vitro anti-urolithiatic activity from different types of Musa pseudo-stems.

    METHODS: Observing anti-urolithiathic activity via in vitro nucleation and aggregation assay using a spectrophotometer followed by microscopic observation. A total of 12 methanolic extracts were tested to determine the potential extracts in anti-urolithiasis activities. Cystone was used as a positive control.

    RESULTS: The results manifested an inhibition of nucleation activity (0.11 ± 2.32% to 55.39 ± 1.01%) and an aggregation activity (4.34 ± 0.68% to 58.78 ± 1.81%) at 360 min of incubation time. The highest inhibition percentage in nucleation assay was obtained by the Musa acuminate x balbiciana Colla cv "Awak Legor" methanolic pseudo-stem extract (2D) which was 55.39 ± 1.01%at 60 min of incubation time compared to the cystone at 30.87 ± 0.74%. On the other hand,the Musa acuminate x balbiciana Colla cv "Awak Legor" methanolic bagasse extract (3D) had the highest inhibition percentage in the aggregation assay incubated at 360 min which was obtained at 58.78 ± 1.8%; 5.53% higher than the cystone (53.25%).The microscopic image showed a great reduction in the calcium oxalate (CaOx) crystals formation and the size of crystals in 2D and 3D extracts, respectively, as compared to negative control.

    CONCLUSIONS: The results obtained from this study suggest that the extracts are potential sources of alternative medicine for kidney stones disease.

    Matched MeSH terms: Plant Extracts/chemistry*; Musa/chemistry*
  2. Lee KM, Lai CW, Ngai KS, Juan JC
    Water Res, 2016 Jan 01;88:428-448.
    PMID: 26519627 DOI: 10.1016/j.watres.2015.09.045
    Today, a major issue about water pollution is the residual dyes from different sources (e.g., textile industries, paper and pulp industries, dye and dye intermediates industries, pharmaceutical industries, tannery and craft bleaching industries, etc.), and a wide variety of persistent organic pollutants have been introduced into our natural water resources or wastewater treatment systems. In fact, it is highly toxic and hazardous to the living organism; thus, the removal of these organic contaminants prior to discharge into the environment is essential. Varieties of techniques have been employed to degrade those organic contaminants and advanced heterogeneous photocatalysis involving zinc oxide (ZnO) photocatalyst appears to be one of the most promising technology. In recent years, ZnO photocatalyst have attracted much attention due to their extraordinary characteristics. The high efficiency of ZnO photocatalyst in heterogeneous photocatalysis reaction requires a suitable architecture that minimizes electron loss during excitation state and maximizes photon absorption. In order to further improve the immigration of photo-induced charge carriers during excitation state, considerable effort has to be exerted to further improve the heterogeneous photocatalysis under UV/visible/solar illumination. Lately, interesting and unique features of metal doping or binary oxide photocatalyst system have gained much attention and became favourite research matter among various groups of scientists. It was noted that the properties of this metal doping or binary oxide photocatalyst system primarily depend on the nature of the preparation method and the role of optimum dopants content incorporated into the ZnO photocatalyst. Therefore, this paper presents a critical review of recent achievements in the modification of ZnO photocatalyst for organic contaminants degradation.
    Matched MeSH terms: Water Pollutants, Chemical/chemistry; Zinc Oxide/chemistry*
  3. Ahmad Loti NN, Mohd Noor MR, Chang SW
    J Sci Food Agric, 2021 Jul;101(9):3582-3594.
    PMID: 33275806 DOI: 10.1002/jsfa.10987
    BACKGROUND: Chili is one of the most important and high-value vegetable crops worldwide. However, pest and disease infections are among the main limiting factors in chili cultivation. These diseases cannot be eradicated but can be handled and monitored to mitigate the damage. Hence, the use of an automated identification system based on images will promote quick identification of chili disease. The features extracted from the images are of utmost importance to develop such an accurate identification system.

    RESULTS: In this research, chili pest and disease features extracted using the traditional approach were compared with features extracted using a deep-learning-based approach. A total of 974 chili leaf images were collected, which consisted of five types of diseases, two types of pest infestations, and a healthy type. Six traditional feature-based approaches and six deep-learning feature-based approaches were used to extract significant pests and disease features from the chili leaf images. The extracted features were fed into three machine learning classifiers, namely a support vector machine (SVM), a random forest (RF), and an artificial neural network (ANN) for the identification task. The results showed that deep learning feature-based approaches performed better than the traditional feature-based approaches. The best accuracy of 92.10% was obtained with the SVM classifier.

    CONCLUSION: A deep-learning feature-based approach could capture the details and characteristics between different types of chili pests and diseases even though they possessed similar visual patterns and symptoms. © 2020 Society of Chemical Industry.

    Matched MeSH terms: Capsicum/chemistry*; Plant Leaves/chemistry*
  4. Kumar SR, Mohd Ramli ES, Abdul Nasir NA, Mohd Ismail N, Mohd Fahami NA
    Molecules, 2021 Jun 29;26(13).
    PMID: 34210097 DOI: 10.3390/molecules26133985
    Obesity and hyperlipidemia are metabolic dysregulations that arise from poor lifestyle and unhealthy dietary intakes. These co-morbidity conditions are risk factors for vascular diseases. Piper sarmentosum (PS) is a nutritious plant that has been shown to pose various phytochemicals and pharmacological actions. This study aimed to investigate the effect of PS on obesity and hyperlipidemia in an animal model. Forty male Wistar rats were randomly divided into five experimental groups. The groups were as follows: UG-Untreated group; CTRL-control; FDW-olive oil + 20% fructose; FDW-PS-PS (125 mg/kg) + 20% fructose; FDW-NGN-naringin (100 mg/kg) + 20% fructose. Fructose drinking water was administered daily for 12 weeks ad libitum to induce metabolic abnormality. Treatment was administered at week 8 for four weeks via oral gavage. The rats were sacrificed with anesthesia at the end of the experimental period. Blood, liver, and visceral fat were collected for further analysis. The consumption of 20% fructose water by Wistar rats for eight weeks displayed a tremendous increment in body weight, fat mass, percentage fat, LDL, TG, TC, HMG-CoA reductase, leptin, and reduced the levels of HDL and adiponectin as well as adipocyte hypertrophy. Following the treatment period, FDW-PS and FDW-NGN showed a significant reduction in body weight, fat mass, percentage fat, LDL, TG, TC, HMG-CoA reductase, and leptin with an increment in the levels of HDL and adiponectin compared to the FDW group. FDW-PS and FDW-NGN also showed adipocyte hypotrophy compared to the FDW group. In conclusion, oral administration of 125 mg/kg PS methanolic extract to fructose-induced obese rats led to significant amelioration of obesity and hyperlipidemia through suppressing the adipocytes and inhibiting HMG-CoA reductase. PS has the potential to be used as an alternative or adjunct therapy for obesity and hyperlipidemia.
    Matched MeSH terms: Methanol/chemistry*; Piper/chemistry*
  5. Her Choong F, Keat Yap B
    Chemphyschem, 2021 03 03;22(5):493-498.
    PMID: 33377300 DOI: 10.1002/cphc.202000873
    Cell-penetrating peptides are used in the delivery of peptides and biologics, with some cell-penetrating peptides found to be more efficient than others. The exact mechanism of how they interact with the cell membrane and penetrate it, however, remains unclear. This study attempts to investigate the difference in free energy profiles of three cell-penetrating peptides (TAT, CPP1 and CPP9) with a model lipid bilayer (DOPC) using molecular dynamics pulling simulations with umbrella sampling. Potential mean force (PMF) and free energy barrier between the peptides and DOPC are determined using WHAM analysis and MM-PBSA analysis, respectively. CPP9 is found to have the smallest PMF value, followed by CPP1 and TAT, consistent with the experimental data. YDEGE peptide, however, does not give the highest PMF value, although it is a non-cell-permeable peptide. YDEGE is also found to form water pores, alongside with TAT and CPP9, suggesting that it is difficult to distinguish true water pore formation from artefacts arising from pulling simulations. On the contrary, free energy analysis of the peptide-DOPC complex at the lipid-water interface with MM-PBSA provides results consistent with experimental data with CPP9 having the least interaction with DOPC and lowest free energy barrier, followed by CPP1, TAT and YDEGE. These findings suggest that peptide-lipid interaction at the lipid-water interface has a direct correlation with the penetration efficiency of peptides across the lipid bilayer.
    Matched MeSH terms: Lipids/chemistry; Water/chemistry
  6. Dyary HO, Arifah AK, Sharma RS, Rasedee A, Mohd-Aspollah MS, Zakaria ZA, et al.
    Trop Biomed, 2014 Mar;31(1):89-96.
    PMID: 24862048 MyJurnal
    Trypanosoma evansi, the causative agent of "surra", infects many species of wild and domestic animals worldwide. In the current study, the aqueous and ethanolic extracts of six medicinal plants, namely, Aquilaria malaccensis, Derris elliptica, Garcinia hombroniana, Goniothalamus umbrosus, Nigella sativa, and Strobilanthes crispus were screened in vitro for activity against T. evansi. The cytotoxic activity of the extracts was evaluated on green monkey kidney (Vero) cells using MTT-cell proliferation assay. The median inhibitory concentrations (IC50) of the extracts ranged between 2.30 and 800.97 μg/ml and the median cytotoxic concentrations (CC50) ranged between 29.10 μg/ml and 14.53 mg/ml. The aqueous extract of G. hombroniana exhibited the highest selectivity index (SI) value of 616.36, followed by A. malaccensis aqueous extract (47.38). Phytochemical screening of the G. hombroniana aqueous extract revealed the presence of flavonoids, phenols, tannins, and saponins. It is demonstrated here that the aqueous extract of G. hombroniana has potential antitrypanosomal activity with a high SI, and may be considered as a potential source for the development of new antitrypanosomal compounds.
    Matched MeSH terms: Flavonoids/chemistry; Plant Extracts/chemistry; Seeds/chemistry; Trypanocidal Agents/chemistry; Plant Leaves/chemistry; Angiosperms/chemistry*; Acanthaceae/chemistry; Thymelaeaceae/chemistry; Garcinia/chemistry; Derris/chemistry; Goniothalamus/chemistry
  7. Zaizuhana S, Puteri J Noor MB, Noral'ashikin Y, Muhammad H, Rohana AB, Zakiah I
    Trop Biomed, 2006 Dec;23(2):214-9.
    PMID: 17322824 MyJurnal
    Kacip Fatimah also known as Labisia pumila (Myrsinaceae), is a traditional herbal medicine with a long history in the Malay community. It has been used by many generations of Malay women to induce and facilitate childbirth as well as a post-partum medicine. We tested the genotoxic potential of Kacip Fatimah in bone marrow cells obtained from Sprague-Dawley rats using micronuclei formation as the toxicological endpoints. Five groups of five male rats each were administered orally for two consecutive days with doses of 100, 700 and 2000 mg/kg body weight of Kacip Fatimah extract dissolved in distilled water. Micronucleus preparation was obtained from bone marrow cells of the animals following standard protocols. No statistically significant increase in micronucleated polychromatic erythrocytes (MNPCEs) was observed at any dose level and sacrifice/harvest time point (24, 48 and 72h). However, a significant decrease in polychromatic erythrocytes/normochromatic erythrocytes (PCE:NCE) ratio was observed from the highest dose level (2000 mg/kg of body weight) at 48h harvest time point. In this study, we investigated the effect of Kacip Fatimah on mammalian bone marrow cells using micronuclei formation to assess the genotoxicity of the herb.
    Matched MeSH terms: Plant Extracts/chemistry*; Myrsinaceae/chemistry*
  8. Sengupta P, Chatterjee B
    Int J Pharm, 2017 Jun 30;526(1-2):353-365.
    PMID: 28461261 DOI: 10.1016/j.ijpharm.2017.04.068
    The Nanoemulgel drug delivery system is a formulation related intervention to improve the systemic delivery and therapeutic profile of lipophilic drugs. Nanoemulgel is an amalgamated formulation of two different systems in which nanoemulsion containing drug is incorporated into a gel base. The fusion of the two systems makes this formulation advantageous in several ways. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in several folds due to the finely distributed droplets of nanoemulsion phase. As a result, the pharmacokinetic and pharmacodynamic profiles of the lipophilic drugs are improved significantly. An increasing trend in topical nanoemulgel use in recent years has been noticed because of the better acceptability of the preparation to the patients due to their noninvasive delivery, avoidance of gastrointestinal side effects, easier applicability and good therapeutic and safety profile. Despite of having few limitations, nanoemulgel formulation can be considered as a potential and promising candidates for topical delivery of lipophilic drugs in the future. The aim of this review is to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming an effective delivery system for poorly water soluble drugs. In this review, we have summarized and discussed the outcome of different studies on permeability, pharmacokinetic, pharmacodynamic and safety profile of the drugs delivered topically through nanoemulgel. Rationality of use along with the major challenges to overcome for nanoemulgel formulation has been discussed.
    Matched MeSH terms: Chemistry, Pharmaceutical; Lipids/chemistry
  9. Chan SY, Goh CF, Lau JY, Tiew YC, Balakrishnan T
    Int J Pharm, 2019 May 01;562:203-211.
    PMID: 30904726 DOI: 10.1016/j.ijpharm.2019.03.044
    Rice starch is known to have an excellent film-forming behaviour in the packaging industry but inadequate attention was given to this biopolymer to be developed into thin films for drug delivery. Accordingly, rice starch thin films containing a model drug, paracetamol and plasticisers (glycerol or sorbitol) were developed using film casting technique. This study focuses on investigating the impact of plasticiser and drug loading on drug release pattern of rice starch films which has not been explored to date. The obtained rice films were characterised for their physicochemical properties including swelling and dissolution study. The highest drug dissolution rate was achieved in the rice films with a low drug loading due to drug amorphicity in nature. When drug loading increases, the swelling behaviour of rice films plays a dominant role in releasing drug in the crystalline form. The role of plasticiser was indicated by the plasticiser-starch interaction where a strong interaction allows drug solubilisation more readily in the dissolution medium. It is envisaged that rice films could be tailored to achieve desired drug release pattern with different plasticiser.
    Matched MeSH terms: Acetaminophen/chemistry; Plasticizers/chemistry
  10. Hassan EM, El Gendy AEG, Abd-ElGawad AM, Elshamy AI, Farag MA, Alamery SF, et al.
    Molecules, 2020 Dec 29;26(1).
    PMID: 33383905 DOI: 10.3390/molecules26010119
    Guava (Psidium guajava) leaves are commonly used in the treatment of diseases. They are considered a waste product resulting from guava cultivation. The leaves are very rich in essential oils (EOs) and volatiles. This work represents the detailed comparative chemical profiles of EOs derived from the leaves of six guava varieties cultivated in Egypt, including Red Malaysian (RM), El-Qanater (EQ), White Indian (WI), Early (E), El-Sabahya El-Gedida (ESEG), and Red Indian (RI), cultivated on the same farm in Egypt. The EOs from the leaves of guava varieties were extracted by hydro-distillation and analyzed with GC-MS. The EOs were categorized in a holistic manner using chemometric tools. The hydro-distillation of the samples yielded 0.11-0.48% of the EO (v/w). The GC-MS analysis of the extracted EOs showed the presence of 38 identified compounds from the six varieties. The sesquiterpene compounds were recorded as main compounds of E, EQ, ESEG, RI, and WI varieties, while the RM variety attained the highest content of monoterpenes (56.87%). The sesquiterpenes, β-caryophyllene (11.21-43.20%), and globulol (76.17-26.42%) were detected as the major compounds of all studied guava varieties, while trans-nerolidol (0.53-10.14) was reported as a plentiful compound in all of the varieties except for the RM variety. A high concentration of D-limonene was detected in the EOs of the RM (33.96%), WI (27.04%), and ESEG (9.10%) varieties. These major compounds were consistent with those reported for other genotypes from different countries. Overall, the EOs' composition and the chemometric analysis revealed substantial variations among the studied varieties that might be ascribed to genetic variability, considering the stability of the cultivation and climate conditions. Therefore, this chemical polymorphism of the studied varieties supports that these varieties could be considered as genotypes of P. guajava. It is worth mentioning here that the EOs, derived from leaves considered to be agricultural waste, of the studied varieties showed that they are rich in biologically active compounds, particularly β-caryophyllene, trans-nerolidol, globulol, and D-limonene. These could be considered as added value for pharmacological and industrial applications. Further study is recommended to confirm the chemical variations of the studied varieties at a molecular level, as well as their possible medicinal and industrial uses.
    Matched MeSH terms: Plant Leaves/chemistry; Psidium/chemistry*
  11. Adam FA, Mohd N, Rani H, Baharin B, Mohd Yusof MYP
    J Ethnopharmacol, 2021 Jun 28;274:113882.
    PMID: 33513418 DOI: 10.1016/j.jep.2021.113882
    ETHNOPHARMACOLOGICAL RELEVANCE: Salvadora persica L. chewing stick, commonly known as miswak is still being used as an oral hygiene tool for plaque control and prevention against gingivitis. Various studies have reported on the therapeutics and prophylactic effects particularly on periodontal disease. This review aimed to evaluate the effectiveness of S. persica chewing stick compared to the standard toothbrush for anti-plaque and anti-gingivitis.

    MATERIAL AND METHODS: A PRISMA-compliant systematic search of literature was done from the MEDLINE, CENTRAL, Science Direct, PubMed and Google Scholar. Literature that fulfilled eligibility criteria was identified. Data measuring plaque score and bleeding score were extracted. Qualitative and random-effects meta-analyses were conducted.

    RESULTS: From 1736 titles and abstracts screened, eight articles were utilized for qualitative analysis, while five were selected for meta-analysis. The pooled effect estimates of SMD and 95% CI were -0.07 [-0.60 to 0.45] with an χ2 statistic of 0.32 (p = 0.0001), I2 = 80% as anti-plaque function and 95% CI were -2.07 [-4.05 to -0.10] with an χ2 statistic of 1.67 (p = 0.02), I2 = 82%.

    CONCLUSION: S. persica chewing stick is a tool that could control plaque, comparable to a standard toothbrush. Further, it has a better anti-gingivitis effect and can be used as an alternative.

    Matched MeSH terms: Plant Stems/chemistry; Salvadoraceae/chemistry*
  12. Periasamy V, Rizan N, Al-Ta'ii HM, Tan YS, Tajuddin HA, Iwamoto M
    Sci Rep, 2016 07 20;6:29879.
    PMID: 27435636 DOI: 10.1038/srep29879
    The discovery of semiconducting behavior of deoxyribonucleic acid (DNA) has resulted in a large number of literatures in the study of DNA electronics. Sequence-specific electronic response provides a platform towards understanding charge transfer mechanism and therefore the electronic properties of DNA. It is possible to utilize these characteristic properties to identify/detect DNA. In this current work, we demonstrate a novel method of DNA-based identification of basidiomycetes using current-voltage (I-V) profiles obtained from DNA-specific Schottky barrier diodes. Electronic properties such as ideality factor, barrier height, shunt resistance, series resistance, turn-on voltage, knee-voltage, breakdown voltage and breakdown current were calculated and used to quantify the identification process as compared to morphological and molecular characterization techniques. The use of these techniques is necessary in order to study biodiversity, but sometimes it can be misleading and unreliable and is not sufficiently useful for the identification of fungi genera. Many of these methods have failed when it comes to identification of closely related species of certain genus like Pleurotus. Our electronics profiles, both in the negative and positive bias regions were however found to be highly characteristic according to the base-pair sequences. We believe that this simple, low-cost and practical method could be useful towards identifying and detecting DNA in biotechnology and pathology.
    Matched MeSH terms: Basidiomycota/chemistry*; DNA/chemistry*
  13. Rehman FU, Shah KU, Shah SU, Khan IU, Khan GM, Khan A
    Expert Opin Drug Deliv, 2017 Nov;14(11):1325-1340.
    PMID: 27485144 DOI: 10.1080/17425247.2016.1218462
    INTRODUCTION: Lipid-based drug delivery systems (LBDDS) are the most promising technique to formulate the poorly water soluble drugs. Nanotechnology strongly influences the therapeutic performance of hydrophobic drugs and has become an essential approach in drug delivery research. Self-nanoemulsifying drug delivery systems (SNEDDS) are a vital strategy that combines benefits of LBDDS and nanotechnology. SNEDDS are now preferred to improve the formulation of drugs with poor aqueous solubility. Areas covered: The review in its first part shortly describes the LBDDS, nanoemulsions and clarifies the ambiguity between nanoemulsions and microemulsions. In the second part, the review discusses SNEDDS and elaborates on the current developments and modifications in this area without discussing their associated preparation techniques and excipient properties. Expert opinion: SNEDDS have exhibit the potential to increase the bioavailability of poorly water soluble drugs. The stability of SNEDDS is further increased by solidification. Controlled release and supersaturation can be achieved, and are associated with increased patient compliance and improved drug loads, respectively. Presence of biodegradable ingredients and ease of large-scale manufacturing combined with a lot of 'drug-targeting opportunities' give SNEDDS a clear distinction and prominence over other solubility enhancement techniques.
    Matched MeSH terms: Pharmaceutical Preparations/chemistry; Emulsions/chemistry
  14. Lee KC, Tong WY, Ibrahim D, Arai T, Murata Y, Mori Y, et al.
    Appl Biochem Biotechnol, 2017 Jan;181(1):451-463.
    PMID: 27596245 DOI: 10.1007/s12010-016-2223-4
    Application of microbial enzymes for paper deinking is getting tremendous attention due to the rapidly increasing of waste paper every year. This study reports the deinking efficiency of laser-printed paper by the lignocellulolytic enzyme from Penicillium rolfsii c3-2(1) IBRL strain compared to other enzyme sources as well as commercial available enzymes. High enzymatic deinking efficiency of approximately 82 % on laser-printed paper was obtained by pulp treatment with crude enzyme from P. rolfsii c3-2(1) IBRL. However, this crude enzyme was found to reduce the paper strength properties of the pulp based on the results of tensile, tear and burst indices, most probably due to the cellulose degradation. This was further proven by the low viscosity of paper pulp obtained after enzymatic treatment and increasing of sugar production during the treatment. Balancing to this detrimental effect on paper pulp, high deinking efficiency was achieved within a short period of time, in which the enzymatic treatment was conducted for 30 min that enabled contribution to higher brightness index obtained, thus promoting savings of time and energy consumption, therefore environmental sustainability. Extensive research should be conducted to understand the nature and mechanism of enzymatic deinking process by the crude enzyme from P. rolfsii c3-2(1) IBRL in order to improve paper strength properties.
    Matched MeSH terms: Cellulase/chemistry; Penicillium/chemistry
  15. Najib MZM, Salmiati, Ujang Z, Salim MR, Ibrahim Z, Muda K
    Bioresour Technol, 2016 Dec;221:157-164.
    PMID: 27639234 DOI: 10.1016/j.biortech.2016.08.119
    The developed microbial granules containing photosynthetic pigments had successfully achieved approximately 18-21% of carbon dioxide (CO2) removal in POME for one complete SBR cycle. Also, the granules had reached CO2 removal at 15-29% within 24h and removal of 25% after 5 days. Both results were inconsistent possibly due to the slow mass transfer rate of CO2 from gas to liquid as well as the simultaneous effect of CO2 production and respiration among the microbes. Furthermore, results showed the removal of CO2 from air increases proportionally with the CO2 removed in liquid. The CO2 biofixation of granules attained was approximately 0.23g/L/day for a week. Using the regression model, the removal of CO2 between liquid and gas, CO2 biofixation rate were highly correlated with the treatment time. A statistically significant relationship was obtained between CO2 concentration in liquid, biomass productivity and treatment time for the CO2 biofixation rate of the granules.
    Matched MeSH terms: Carbon Dioxide/chemistry*; Plant Oils/chemistry*
  16. Behkami S, Zain SM, Gholami M, Bakirdere S
    Food Chem, 2017 Feb 15;217:438-444.
    PMID: 27664656 DOI: 10.1016/j.foodchem.2016.08.130
    The potential for the isotopic ratio analysis of cattle tail hair in determining the geographical origin of raw cow milk in Peninsular Malaysia had been investigated in this research using exploratory visualization. A significant positive correlation (p<0.0001) (n=54) was noticed between δ(13)C and δ(15)N in milk with that of hair which indicated that these matrices could be used in tracing the geographical origin of animal produce and tissues, and there is a possibility that hair could be used as a substitute in building the database for the geographical traceability of milk. It was also observed that both hair and milk isotopic ratio correlations exhibited separation between the northern and southern regions. The accuracy of using isotopic ratio in determining geographical discrimination had been clearly demonstrated when several commercial milk samples from the same regions under the study were correctly assigned to the appropriate geographical clusters.
    Matched MeSH terms: Hair/chemistry*; Milk/chemistry*
  17. Nge CE, Sim KS, Lim SH, Thomas NF, Low YY, Kam TS
    J Nat Prod, 2016 10 28;79(10):2709-2717.
    PMID: 27759387
    Examination of the EtOH extract of the Malayan Tabernaemontana corymbosa resulted in the isolation of three new alkaloids, viz., cononuridine (1), an unusual hexacyclic, iboga-derived, monoterpenoid indole characterized by contraction of the tetrahydroazepine C-ring and incorporation of an additional isoxazolidine ring, taberisidine (2), a seco-corynanthean alkaloid, and conofolidine (3), an Aspidosperma-Aspidosperma bisindole that showed pronounced in vitro growth inhibitory activity against an array of human cancer cell lines, including KB, vincristine-resistant KB, PC-3, LNCaP, MCF7, MDA-MB-231, HT-29, and HCT 116 cells. The structures and absolute configurations of 1 and 3 and the absolute configuration of the novel pyridopyrimidine indole alkaloid vernavosine (4) were confirmed by X-ray diffraction analysis. A reasonable biosynthesis route to cononuridine starting from an iboga precursor is presented.
    Matched MeSH terms: Aspidosperma/chemistry; Tabernaemontana/chemistry
  18. Maznah Z, Halimah M, Shitan M, Kumar Karmokar P, Najwa S
    PLoS One, 2017;12(1):e0166203.
    PMID: 28060816 DOI: 10.1371/journal.pone.0166203
    Ganoderma boninense is a fungus that can affect oil palm trees and cause a serious disease called the basal stem root (BSR). This disease causes the death of more than 80% of oil palm trees midway through their economic life and hexaconazole is one of the particular fungicides that can control this fungus. Hexaconazole can be applied by the soil drenching method and it will be of interest to know the concentration of the residue in the soil after treatment with respect to time. Hence, a field study was conducted in order to determine the actual concentration of hexaconazole in soil. In the present paper, a new approach that can be used to predict the concentration of pesticides in the soil is proposed. The statistical analysis revealed that the Exploratory Data Analysis (EDA) techniques would be appropriate in this study. The EDA techniques were used to fit a robust resistant model and predict the concentration of the residue in the topmost layer of the soil.
    Matched MeSH terms: Soil/chemistry*; Triazoles/chemistry*
  19. Subramonian W, Wu TY, Chai SP
    J Environ Manage, 2017 Feb 01;187:298-310.
    PMID: 27914351 DOI: 10.1016/j.jenvman.2016.10.024
    In this work, heterogeneous photocatalysis was used to treat pulp and paper mill effluent (PPME). Magnetically retrievable Fe2O3-TiO2 was fabricated by employing a solvent-free mechanochemical process under ambient conditions. Findings elucidated the successful incorporation of Fe2O3 into the TiO2 lattice. Fe2O3-TiO2 was found to be an irregular and slightly agglomerated surface morphology. In comparison to commercial P25, Fe2O3-TiO2 exhibited higher ferromagnetism and better catalyst properties with improvements in surface area (58.40 m2/g), pore volume (0.29 cm3/g), pore size (18.52 nm), and band gap (2.95 eV). Besides, reusability study revealed that Fe2O3-TiO2 was chemically stable and could be reused successively (five cycles) without significant changes in its photoactivity and intrinsic properties. Additionally, this study demonstrated the potential recovery of Fe2O3-TiO2 from an aqueous suspension by using an applied magnetic field or sedimentation. Interactive effects of photocatalytic conditions (initial effluent pH, Fe2O3-TiO2 dosage, and air flow-rate), reaction mechanism, and the presence of chemical oxidants (H2O2, BrO3-, and HOCl) during the treatment process of PPME were also investigated. Under optimal conditions (initial effluent pH = 3.88, [Fe2O3-TiO2] = 1.3 g/L, and air flow-rate = 2.28 L/min), the treatment efficiency of Fe2O3-TiO2 was 98.5% higher than the P25. Based on Langmuir-Hinshelwood kinetic model, apparent rate constants of Fe2O3-TiO2 and P25 were 9.2 × 10-3 and 2.7 × 10-3 min-1, respectively. The present study revealed not only the potential of using magnetic Fe2O3-TiO2 in PPME treatment but also demonstrated high reusability and easy separation of Fe2O3-TiO2 from the wastewater.
    Matched MeSH terms: Ferric Compounds/chemistry; Photochemistry; Titanium/chemistry
  20. Kunasundari B, Arai T, Sudesh K, Hashim R, Sulaiman O, Stalin NJ, et al.
    Appl Biochem Biotechnol, 2017 Sep;183(1):412-425.
    PMID: 28361245 DOI: 10.1007/s12010-017-2454-z
    The availability of fermentable sugars in high concentrations in the sap of felled oil palm trunks and the thermophilic nature of the recently isolated Bacillus coagulans strain 191 were exploited for lactic acid production under non-sterile conditions. Screening indicated that strain 191 was active toward most sugars including sucrose, which is a major component of sap. Strain 191 catalyzed a moderate conversion of sap sugars to lactic acid (53%) with a productivity of 1.56 g/L/h. Pretreatment of oil palm sap (OPS) using alkaline precipitation improved the sugar fermentability, providing a lactic acid yield of 92% and productivity of 2.64 g/L/h. To better characterize potential inhibitors in the sap, phenolic, organic, and mineral compounds were analyzed using non-treated sap and saps treated with activated charcoal and alkaline precipitation. Phthalic acid, 3,4-dimethoxybenzoic acid, aconitic acid, syringic acid, and ferulic acid were reduced in the sap after treatment. High concentrations of Mg, P, K, and Ca were also precipitated by the alkaline treatment. These results suggest that elimination of excess phenolic and mineral compounds in OPS can improve the fermentation yield. OPS, a non-food resource that is readily available in bulk quantities from plantation sites, is a promising source for lactic acid production.
    Matched MeSH terms: Sucrose/chemistry*; Arecaceae/chemistry*
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