Displaying publications 161 - 180 of 436 in total

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  1. Mokhsin A, Mokhtar SS, Mohd Ismail A, M Nor F, Shaari SA, Nawawi H, et al.
    BMJ Open, 2018 12 04;8(12):e021580.
    PMID: 30518581 DOI: 10.1136/bmjopen-2018-021580
    OBJECTIVES: To determine the prevalence of metabolic syndrome (MS), ascertain the status of coronary risk biomarkers and establish the independent predictors of these biomarkers among the Negritos.

    SETTINGS: Health screening programme conducted in three inland settlements in the east coast of Malaysia and Peninsular Malaysia.

    SUBJECTS: 150 Negritos who were still living in three inland settlements in the east coast of Malaysia and 1227 Malays in Peninsular Malaysia. These subjects were then categorised into MS and non-MS groups based on the International Diabetes Federation (IDF) consensus worldwide definition of MS and were recruited between 2010 and 2015. The subjects were randomly selected and on a voluntary basis.

    PRIMARY AND SECONDARY OUTCOME MEASURES: This study was a cross-sectional study. Serum samples were collected for analysis of inflammatory (hsCRP), endothelial activation (sICAM-1) and prothrombogenesis [lp(a)] biomarkers.

    RESULTS: MS was significantly higher among the Malays compared with Negritos (27.7%vs12.0%). Among the Malays, MS subjects had higher hsCRP (p=0.01) and sICAM-1 (p<0.05) than their non-MS counterpart. There were no significant differences in all the biomarkers between MS and the non-MS Negritos. However, when compared between ethnicity, all biomarkers were higher in Negritos compared with Malays (p<0.001). Binary logistic regression analysis affirmed that Negritos were an independent predictor for Lp(a) concentration (p<0.001).

    CONCLUSIONS: This study suggests that there may possibly be a genetic influence other than lifestyle, which could explain the lack of difference in biomarkers concentration between MS and non-MS Negritos and for Negritos predicting Lp(a).

    Matched MeSH terms: Life Style
  2. S.K. Norshafarina, M.S. Noor Ibrahim, S. Suzana, A. Mohamad Hasnan, M. Zahara, Y. Zaitun
    Sains Malaysiana, 2013;42:1345-1355.
    A cross sectional study was conducted to determine the prevalence of Sarcopenia and its association with health profiles and oxidative stress among multiethnic older adults in an urban area of Malaysia. Sarcopenia was assessed using Bioimpedance analysis (BIA) and the associations between demography, socioeconomic status, lifestyle practices, health risk factors and blood profile were examined on 388 apparently healthy subjects aged 60 years and above. Prevalence of sarcopenia was 89.0% in men and 40.3% in women with the overall prevalence of 59.8%. It was found that prevalence of severe sarcopenia was 13.9% and sarcopenia obese was 23.5%. Binary logistic regression showed that there was no predictor found in men or women. However, a decline in muscle mass was observed in sarcopenic as compared with normal subjects. Sarcopenia is prevalent and there is a need to implement interventional strategies to prevent sarcopenia and its associated comorbidities.
    Matched MeSH terms: Life Style
  3. Tan PY, Mitra SR, Amini F
    Public Health Genomics, 2018;21(5-6):169-185.
    PMID: 31117103 DOI: 10.1159/000499854
    BACKGROUND/AIMS: Excess weight gain is a result of the interaction between diet, environment, and genes. Evidence suggests that responses to lifestyle interventions to manage weight are partially modified by genetic factors. This review is aimed at summarizing the current evidence from studies done on gene variants - single nucleotide polymorphisms (SNPs) - and intervention outcomes on weight loss and obesity-related traits.

    METHODS: Intervention studies published in English between 2000 and August 2018 were retrieved from PubMed, Google Scholar, and Web of Science using various keywords.

    RESULTS: This article is a review of 36 studies conducted in 13 different countries which included a total of 15,931 participants between 19 and 70 years of age. The effect of 26 genes and 64 SNPs on the reduction of body weight and metabolic risk factors in response to diet, exercise, and lifestyle interventions was reviewed.

    CONCLUSION: Gene-lifestyle interaction studies on the same candidate gene in different populations have reported information which is challenging to interpret. Thus, it is difficult to arrive at a particular model for a strategy on weight management at this point in time. Most of the intervention studies focus on the effect of variants of a single candidate gene on weight loss. Further evidence from large-scale studies is necessary to assess the effect of multiple candidate genes to compute a gene score that could be used in a model intervention programme. Our review suggests that a healthy lifestyle with a balanced diet and regular physical activity will benefit individuals who carry the risk alleles of the obesity-related candidate genes. This message should be the mainstay of the recommendations and guidelines published by nutrition societies across the world.

    Matched MeSH terms: Life Style
  4. Norhayati Ibrahim, Rafidah Aini Pakri Mohamed, Sharlene Teo, Normah Che In, Abdul Halim Abdul Gafor, Rozmi Ismail, et al.
    Sains Malaysiana, 2016;45(5):753-759.
    The prevalence of chronic kidney disease (CKD) have increased and become one of the major public health concerns
    worldwide including Malaysia. Previous studies on CKD generally focused on patients who were already undergoing
    dialysis treatment; however, studies investigating the stresses experienced by pre-dialysis CKD patients were limited. This
    study aimed to examine the prevalence of psychological distress and their association with the Health Related Quality
    of Life (HRQoL) during the different stages of CKD. This cross-sectional study involved 200 pre-dialysis patients from
    stages 3 to 5, who were recruited from the Nephrology Clinic at the National University of Malaysia Medical Centre
    (UKMMC). The instruments used in this study were the Short Form 36 (measuring HRQoL) and Hospital Anxiety and
    Depression Scale (HADS) to measure the psychological distress. The results showed that the prevalence of depression
    and anxiety increased proportionally with the CKD stages. The HRQoL sub-component scores declined as the CKD stages
    increased except for social functioning. An impaired HRQoL was associated with depression and anxiety in the CKD
    patients. The results suggested that it is very important to manage kidney disease at an early stage and that a healthier
    lifestyle is adopted.
    Matched MeSH terms: Life Style
  5. Nam KD, Van NB, Hoang LV, Duc TP, Thi Ha TT, Tuan VT, et al.
    Heliyon, 2020 Feb;6(2):e03383.
    PMID: 32072063 DOI: 10.1016/j.heliyon.2020.e03383
    Background: Hypertension (HTN) significantly contributes to global disease burden, and its prevalence varies amongst different countries and regions. This work is aimed to characterize the hypertensive prevalence and identify risk factors for HTN among the residents in five locations (four communes and one town) of Moc Chau district (Son La province, Vietnam).

    Methods: A cross-sectional study with a cross-sectional methodology was done in selected places from August 2018 to December 2018. We interviewed 197 participants aged equal to or more than 18 years old and measured their blood pressure (BP). Univariate and multivariate logistic regression were applied.

    Results: The overall HTN prevalence of 30.0% was recorded. The differences of HTN prevalence rates were seen by several characters including age groups (p <0.001), accompanying disease (p <0.001) and alcohol drinking (p <0.05). Factors independently associated with hypertension were age (ORs: 3.1 [1.1-9.1]; 6.1 [1.7-22.3]), much salty consumption (OR: 2.6 [1.1-6.6]), alcohol use (OR: 3.1 [1.2-8.1]), HTN familial history (OR: 4.2 [1.3-13.3]) and at least one suffering disease (OR: 5.2 [2.1-12.7]).

    Conclusions: Thus, this study highlighted the high overall HTN prevalence in the Vietnam Northwestern region. Significant differences of HTN rate were observed among several characteristics such as age groups, accompanying disease and alcohol drinking. Age group, much salty consumption, alcohol use, hypertension familial history and at least one suffering disease were risk factors for HTN in study group.

    Matched MeSH terms: Life Style
  6. Muhammad, I. N., Saifullah, K., Hassan, B., Yasrul, I., Norizan, A./G., Ahmed Zubaidi, A. L., et al.
    MyJurnal
    A normal health status is highly depends on body weight. Many health problems may occur or impose risk for
    extremely obese individuals. Etiopathology of obesity includes interaction of several factors inclusive of
    genetic and non-genetic factors such as lifestyle changes. This study aimed to launch Malaysian Obesity
    DNA Bank and determine the prevalence of obesity along with anthropometric measurements of the subjects.
    The cross-sectional study was conducted on total of 340 subjects (obese = 95, overweight = 122 and normal =
    123), aged 19-60 years, in Terengganu. The BMI and well appropriate anthropometric measurements (waist
    circumference, hip circumference, waist to hip ratio, fat percentage and ASindex) were determined through
    standard protocols and formulae. The mean difference of anthropometrics was determined by independent ttest. Data was analysed using SPSS ver.16.0.0. The BMI was determined for all subjects and it was found that
    out of 340 subjects, a total of 95 (27.9%) subjects were obese , followed by a total of 122 (35.8%) subjects
    were overweight and normal individuals were 123 (36.1%). The mean of the BMI, WHR, Fat% and ASindex,
    in Malay obese were 32.83, 0.88, 33.5 and 13.21 respectively, while in normal healthy individuals were 22.1,
    0.78, 24.2 and 20.1 respectively. The difference of mean of BMI, WHR, Fat% and ASindex was calculated to
    be 10.73, 0.1, 9.3 and 6.89 respectively. To the best of our knowledge, this is the first report in Malaysia,
    reporting that this is very first Obesity DNA Bank in South East Asia region and prevalence of obesity in
    Terengganu, Malaysia to be 27.9%. In addition, it indicates a significant mean difference for anthropometric
    measurements among obese and normal individuals. For Asindex calculations suggest that the prevalence of
    genocide obesity is greater 89.9% of android obesity in Malay obese attributes
    .
    Matched MeSH terms: Life Style
  7. Wong YL
    JUMMEC, 2002;7:59-61.
    The majority of migrant workers studied in this survey were males Muslims from Bangladesh. The mean age was 30 and the majority were aged between 21-30 years. Although almost all of them had 7-13 years of schooling, the majority were working in the service industry. More than two thrids of the migrant workers were provided with various forms of housing by their employers. Majority of them stated that they had better amenities, such as piped drinking water and sanitary toilets, in Malaysia compared to those in their home countries. From their reports, it appears that the majority did not engage in risk behaviours such as, smoking, alcohol and drug abuse.
    Matched MeSH terms: Life Style
  8. Yuan Kei Ching, Mahenderan Appukutty, Wan Ying Gan, Yoke Mun Chan, Yit Siew Chin
    MyJurnal
    Introduction: Literatures suggest that insufficient physical activity as one of the contributors to non-communicable chronic diseases; nevertheless, data on the physical activity level is sparsely reported among individuals practising a vegetarian diet in Malaysia. The current study aims to determine the prevalence of insufficient physical activity and its association with socio-demographic factors, lifestyle factors and body weight status among 273 individuals prac- tising a vegetarian diet in Klang Valley, Malaysia. Methods: A set of self-administered questionnaire was distributed to all vegetarians and their data on physical activity was determined using the Global Physical Activity Questionnaire (GPAQ). Results: The average years of practising vegetarianism was 14.2±9.6 years, and most of the vegetarians were practised ovo-vegetarian diet (44.0%). A majority of them were Chinese (54.9%) and female (64.8%), with an aver- age age of 47.5 ± 13.1 years. The prevalence of overweight and obesity were 27.5% and 8.1%, respectively. Accord- ing to GPAQ, about two in five vegetarians (46.2%) were having insufficient physical activity. Being females, older age, Chinese, married individuals, and those with high total household income level were found to be significantly associated with low physical activity level among Malaysian vegetarians (p
    Matched MeSH terms: Life Style
  9. Dashti S, Latiff LA, Zulkefli NABM, Baharom AB, Minhat HS, Hamid HA, et al.
    J Family Reprod Health, 2017 Jun;11(2):56-66.
    PMID: 29282412
    Objective: Polycystic ovarian syndrome (PCOS) is a common condition amongst women of reproductive age that can result in increased mortality and morbidity in women due to increased risk of diabetes mellitus and cardiovascular diseases. The aim of this systematic review was to assess the effectiveness of common treatments of PCOS on the predictors of diabetes in non-diabetic PCOS women. Materials and methods: An extensive search was performed on the publications in three medical databases including pubmed, scopus and google scholar from 1995 till 2017. The articles were screened based on their quality and included in this systematic review. A total of 25 articles including cohort, randomised controlled trial, review and meta-analysis were included in the review. Results: This systematic review revealed that the effect of lifestyle modification might be low in PCOS subjects due to high drop-out rate while the benefits of this intervention including weight and fat reduction may not be achieved by medical interventions. Metformin treatment may result in improvements in insulin sensitivity while its weight reduction effect is still not documented in PCOS subjects. Thiazolidendiones might be tolerated by the PCOS subjects and may result in similar effects as metformin but this effect should be documented by further studies. Conclusion: Combination of lifestyle modification with metformin or thiazolidinedions might improve the outcome of the prevention strategies. On the other hand this study revealed a different response to treatments in non-obese compared with obese PCOS subjects.
    Matched MeSH terms: Life Style
  10. Cheng HP, Wong JSL, Selveindran NM, Hong JYH
    Endocrine, 2021 09;73(3):499-506.
    PMID: 34244903 DOI: 10.1007/s12020-021-02810-1
    AIMS: Malaysia implemented nationwide lockdown from 18th March till 3rd May 2020 to mitigate the spread of coronavirus disease (COVID-19). This study aimed to examine the impact of the lockdown on glycaemic control and lifestyle changes in children and adolescents with type 1 (T1DM) and 2 diabetes mellitus (T2DM) aged less than 18 years old.

    METHODS: In this cross-sectional study, interviews and a standardised questionnaire comparing lifestyle changes before and during the lockdown were performed in follow-up clinic visits after the lockdown. Anthropometry measurements and glycated haemoglobin (HbA1c) values were compared 3 months prior and after the lockdown.

    RESULTS: Participants were 93 patients with T1DM (11.08 ± 3.47 years) and 30 patients with T2DM (13.81 ± 2.03 years). Male gender, T2DM and pubertal adolescents were found to have a significant deterioration in glycaemic control. A significant increment of HbA1c was observed in patients with T2DM (8.5 ± 0.40 vs 9.9 ± 0.46%), but not in patients with T1DM (8.6 ± 0.28 vs 8.7 ± 0.33%). Contrarily, there was an improved glycaemic control in pre-pubertal T1DM children likely due to parental supervision during home confinement. Weight and BMI SDS increased in T1DM patients but surprisingly reduced in T2DM patients possibly due to worsening diabetes control. Reduced meal frequency mainly due to skipping breakfast, reduced physical activity level scores, increased screen time and sleep duration were observed in both groups.

    CONCLUSIONS: Adverse impact on glycaemic control and lifestyle were seen mostly in patients with T2DM and pubertal adolescent boys.

    Matched MeSH terms: Life Style
  11. Misliza A, Mas Ayu S
    JUMMEC, 2009;12(1):15-21.
    MyJurnal
    A case-control study was conducted between November 2005 and May 2007 in the University of Malaya Medical Centre (UMMC), University of Malaya, Kuala Lumpur, Malaysia. The objective of this study was to identify specific socio-demographic and lifestyle factors which were associated with foot ulcer in Type 1 and Type 2 diabetes patients. There were 125 cases and 250 controls by using universal sampling. Diabetic foot ulcer was defined as "the full thickness skin break at least to Grade 1 Wagner Stage, occurring distal to malleoli". The case was defined as the diabetic patient who was newly diagnosed or who has a known case of diabetic foot ulcer and the control was defined as the diabetic patient without active foot ulcer. Data was collected via face-to-face interview using a structured questionnaire. Results showed that diabetic patients at younger age group, 44 years old and less (OR 5.90 95% CI 2.31, 15.10), Indian (OR 3.24 95% CI 1.66, 6.30), and smoker (OR 3.85 95% CI 1.77, 8.35) were the independent risk factor for diabetic foot ulcer.
    Matched MeSH terms: Life Style
  12. Elumalai G, Hashim A, Sankaravel M, Chia RR
    MyJurnal
    This study is aimed to evaluate the obesity level and promote a healthy lifestyle among students at Universiti Pendidikan Sultan Idris, Perak. Fifteen male and fifteen female undergraduate students aged between 19 years to 24 years from each faculty of university Pendidikan Sultan Idris are randomly selected as samples (n=270). The Body Mass Index (BMI) and modified questionnaires by Burton (1999) are used as instruments for this study. Analysis showed that 15.9% of the respondents are overweight, 23.7% are in pre-obese level, 27.8% are in obese level one and 3.7% respondents are in obese level two. T-test analysis of independent samples was used to determine the level of knowledge and a healthy lifestyle among male and female students. The results showed that there is no significant difference between male and female students in the levels of healthy lifestyle practices with p = 0.089 (p> 0.05); the level of a healthy lifestyle practices among males (M = 71.57, SD = 8:42) have almost the same mean with females (M = 70.05, SD = 6:00). Furthermore, the findings indicate that the scores on the levels of knowledge on healthy lifestyle for male students is (M = 79.09, SD = 7:38), while the mean score for female students is (M = 76.95, SD = 8:59) with p = 0.028 (p <0.05). On comparing the means of the scores on the levels of knowledge on healthy lifestyle, the male students scored higher than the female students. It turns out there is a difference between male and female students in terms of the level of knowledge on healthy lifestyle. The study found that the respondents have a good knowledge on healthy lifestyle, but lack practice in daily life. This is an unpleasant indication because Universiti Pendidikan Sultan Idris students are facing the risk of cardiovascular-related diseases caused by obesity and a sedentary lifestyle.
    Study site: Universiti Pendidikan Sultan Idris (UPSI), Perak, Malaysia
    Matched MeSH terms: Life Style
  13. Najwa Haneem Mohamad, Zoharah Omar, Nor Aina Emran
    Int J Public Health Res, 2014;4(1):376-383.
    MyJurnal
    Introduction Breast cancer is ranked number one from the ten most frequent cancers in
    female, Peninsular Malaysia. Various studies provide negative evidence on
    malignancies and one of the end results is impaired quality of life (QOL).
    Studies show lifestyle approaches are key factors in enhancing the QOL
    among cancer survivors. The purpose of this study is to describe the lifestyle
    practices (LP) among breast cancer survivors (BCS) which consist of dietary
    intake, exercise habits, and stress management and to determine whether
    these practices have influence on the QOL among Malaysian BCS.

    Methods This study adopts a cross-sectional study design using a self-administered
    questionnaire. A total of 280 BCS from public and private hospitals
    throughout Peninsular Malaysia had participated. The questionnaire covers
    QOL and LP items which consist of dietary intake (consumption of high-fat
    food, high-fibre food, fruits and vegetables), exercise habits, and stress
    management. Descriptive statistics and one-way ANOVA were used to
    determine the relationship between LP and QOL.

    Results Mean age of the study sample was at 41 (SD=7.37). Majority of them were
    Malay (74%), 53% were diagnosed with breast cancer between 1 to 2 years
    whereas 54% were presented with stage 2 at diagnosis. There was a
    statistically significant difference (p
    Matched MeSH terms: Life Style
  14. Lean SS, Yeo CC
    Front Microbiol, 2017;8:1547.
    PMID: 28861061 DOI: 10.3389/fmicb.2017.01547
    Acinetobacter baumannii is a Gram-negative nosocomial pathogen that has become a serious healthcare concern within a span of two decades due to its ability to rapidly acquire resistance to all classes of antimicrobial compounds. One of the key features of the A. baumannii genome is an open pan genome with a plethora of plasmids, transposons, integrons, and genomic islands, all of which play important roles in the evolution and success of this clinical pathogen, particularly in the acquisition of multidrug resistance determinants. An interesting genetic feature seen in majority of A. baumannii genomes analyzed is the presence of small plasmids that usually ranged from 2 to 10 kb in size, some of which harbor antibiotic resistance genes and homologs of plasmid mobilization genes. These plasmids are often overlooked when compared to their larger, conjugative counterparts that harbor multiple antibiotic resistance genes and transposable elements. In this mini-review, we will examine our current knowledge of these small A. baumannii plasmids and look into their genetic diversity and phylogenetic relationships. Some of these plasmids, such as the Rep-3 superfamily group and the pRAY-type, which has no recognizable replicase genes, are quite widespread among diverse A. baumannii clinical isolates worldwide, hinting at their usefulness to the lifestyle of this pathogen. Other small plasmids especially those from the Rep-1 superfamily are truly enigmatic, encoding only hypothetical proteins of unknown function, leading to the question of whether these small plasmids are "good" or "bad" to their host A. baumannii.
    Matched MeSH terms: Life Style
  15. Megat Rusydi, M.R., Noraliza, C.W., Azrina, A., Zulkhairi, A.
    MyJurnal
    Proximate content and fatty acid composition of germinated and non-germinated legumes (kidney, mung, soy bean and peanut) and rice varieties (red, black, Barrio, brown and milled) were evaluated. In germinated samples, moisture content increased significantly while carbohydrate, protein and fat were decreased significantly. Total dietary fibre was increased in germinated samples except germinated kidney and mung bean. Germination also increased saturated fatty acids (SFA) in legumes, black, red and brown rice. Monounsaturated fatty acids (MUFA) decreased in all samples except germinated kidney, soy and Barrio rice. Polyunsaturated fatty acids (PUFA) increased in some germinated samples (mung bean, peanut, red, brown, Barrio and white rice) but decreased in other legume and rice samples. Generally, palmitic acid increased while stearic, oleic and linoleic acids decreased after germination. Overall, the proximate content and fatty acids of legume and rice varieties changed after germination and may be used as alternate resources for individuals with lifestyle diseases.
    Matched MeSH terms: Life Style
  16. Wei TM, Omar MS
    Malays Fam Physician, 2017;12(3):8-17.
    PMID: 29527274 MyJurnal
    Introduction: The prevalence of hypertension in Malaysia is increasing and an effective management of hypertension is important to reduce cardiovascular morbidity and mortality.

    Objective: To determine the knowledge, awareness and perception towards hypertension among residents in nursing homes as well as the roles of caregivers in hypertension management.

    Methods: A face-to-face survey with 200 hypertensive residents and 30 caregivers from 24 nursing homes in Kuala Lumpur and Selangor, Malaysia was conducted.

    Results: Of all the hypertensive residents, 90.5% (n= 181) knew that lowering their blood pressure could improve their health. Most residents strongly believed that taking antihypertensive drugs is important for keeping their high blood pressure under control (n= 162, 81%). Taking medication was perceived as the most important factor in controlling the high blood pressure (58%,n= 116) compared to lifestyle or diet modification. The majority of the caregivers reported that they played a major role in managing hypertension, especially with regards to medication-taking. task (66.7%,n= 20).

    Conclusion: The knowledge, attitude and perceptions of hypertension play a relatively major role in the self-management of hypertension. The role of caregivers also needed to be recognised in managing hypertension in nursing homes.

    Matched MeSH terms: Life Style
  17. Li Y, Babazono A, Jamal A, Liu N, Fujita T, Zhao R, et al.
    Soc Sci Med, 2022 Dec;314:115468.
    PMID: 36327638 DOI: 10.1016/j.socscimed.2022.115468
    Metabolic syndrome (MetS) prevalence has increased globally with considerable morbidity and economic burden at both individual and national levels. Japan is the first and only country that has introduced a nationwide lifestyle guidance intervention program to manage and control MetS. We conducted a quasi-experiment approach-regression discontinuity design-to evaluate the impact of this intervention on health outcomes at the population level. We retrospectively collected data of adults aged ≥35 years who participated in health checkups in 2015. Age in 2015 was used as the assignment variable, and an age of 40 years old was the threshold because those with MetS aged ≥40 were required to receive lifestyle guidance intervention. Among 26,772 MetS adults, those who received the intervention had significant reductions in obesity measurements (bodyweight, waist circumference, and body mass index [BMI]) after 1 year of this intervention. Blood pressure was also significantly reduced in men after 1 year of undertaking the intervention. The results were similar when including demographic, socioeconomic, and behavioral covariates and using alternative functional forms to estimate the impact, or when bandwidths around intervention thresholds were changed. Our results showed that lifestyle guidance intervention for MetS has an important impact on weight loss and blood pressure reduction at the population level. This intervention could address the high burden of obesity and cardiovascular diseases in Japan and other countries with an unmet need for MetS prevention and management.
    Matched MeSH terms: Life Style
  18. Seyedan A, Alshawsh MA, Alshagga MA, Koosha S, Mohamed Z
    PMID: 26640503 DOI: 10.1155/2015/973143
    Obesity is recognized as a major life style disorder especially in developing countries and it is prevailing at an alarming speed in new world countries due to fast food intake, industrialization, and reduction of physical activity. Furthermore, it is associated with a vast number of chronic diseases and disabilities. To date, relatively effective drugs, from either natural or synthetic sources, are generally associated with serious side effects, often leading to cessation of clinical trials or even withdrawal from the market. In order to find new compounds which are more effective or with less adverse effects compared to orlistat, the drug that has been approved for obesity, new compounds isolated from natural products are being identified and screened for antiobesity effects, in particular, for their pancreatic lipase inhibitory effect. Pancreatic lipase inhibitory activity has been extensively used for the determination of potential efficacy of natural products as antiobesity agents. In attempts to identify natural products for overcoming obesity, more researches have been focused on the identification of newer pancreatic lipase inhibitors with less unpleasant adverse effects. In this review, we consider the potential role of plants that have been investigated for their pancreatic lipase inhibitory activity.
    Matched MeSH terms: Life Style
  19. Cheng SH, Ismail A, Anthony J, Ng OC, Hamid AA, Barakatun-Nisak MY
    PMID: 26713097 DOI: 10.1155/2015/405615
    Objectives. Optimizing glycemic control is crucial to prevent type 2 diabetes related complications. Cosmos caudatus is reported to have promising effect in improving plasma blood glucose in an animal model. However, its impact on human remains ambiguous. This study was carried out to evaluate the effectiveness of C. caudatus on glycemic status in patients with type 2 diabetes. Materials and Methods. In this randomized controlled trial with two-arm parallel-group design, a total of 101 subjects with type 2 diabetes were randomly allocated to diabetic-ulam or diabetic controls for eight weeks. Subjects in diabetic-ulam group consumed 15 g of C. caudatus daily for eight weeks while diabetic controls abstained from taking C. caudatus. Both groups received the standard lifestyle advice. Results. After 8 weeks of supplementation, C. caudatus significantly reduced serum insulin (-1.16 versus +3.91), reduced HOMA-IR (-1.09 versus +1.34), and increased QUICKI (+0.05 versus -0.03) in diabetic-ulam group compared with the diabetic controls. HbA1C level was improved although it is not statistically significant (-0.76% versus -0.37%). C. caudatus was safe to consume. Conclusions. C. caudatus supplementation significantly improves insulin resistance and insulin sensitivity in patients with type 2 diabetes.
    Matched MeSH terms: Life Style
  20. Mohd Nani SZ, Majid FA, Jaafar AB, Mahdzir A, Musa MN
    PMID: 28105060 DOI: 10.1155/2016/6520475
    Deep sea water (DSW) commonly refers to a body of seawater that is pumped up from a depth of over 200 m. It is usually associated with the following characteristics: low temperature, high purity, and being rich with nutrients, namely, beneficial elements, which include magnesium, calcium, potassium, chromium, selenium, zinc, and vanadium. Less photosynthesis of plant planktons, consumption of nutrients, and organic decomposition have caused lots of nutrients to remain there. Due to this, DSW has potential to become a good source for health. Research has proven that DSW can help overcome health problems especially related to lifestyle-associated diseases such as cardiovascular disease, diabetes, obesity, cancer, and skin problems. This paper reviews the potential health benefits of DSW by referring to the findings from previous researches.
    Matched MeSH terms: Life Style
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