Displaying publications 1961 - 1980 of 25053 in total

Abstract:
Sort:
  1. Ahmad Zamri Khairani, Nor Shafrin Ahmad, Aziah Ismail, Rahimi Che Aman
    MyJurnal
    Introduction: This study examines the psychometric characteristics of a translated version of the Beck Depression Inventory II (BDI – II) among Malaysian school students. Methods: The sample consisted of 257 boys and 302 girls. This study employed WINSTEPS 3.74 to provide statistics and other information from Rasch Model analysis, namely, the fit statistics, dimensionality analysis, rating scale analysis, reliability and separation indices, differential item func- tioning analysis, and distribution of items difficulty and students’ ability. Results: Rating scale analysis showed that category 2 and category 3 of the ratings were not different. Meanwhile, Item 19 did not fit the model’s expectations; and thus, it was omitted from further analyses. The scale demonstrated a high person reliability and a high person separation index. There were no items demonstrating gender DIF. The school students endorsed feeling guilty as the least severe symptom of depression, while committing suicide as the most serious symptom. Conclusion: In general, the BDI-II demonstrated acceptable properties in measuring depression symptoms among school students.
    Matched MeSH terms: Female
  2. S Maria Awaluddin, Nurhuda Ismail, Siti Munira Yasin, Yuslina Zakaria, Norzila Mohamed Zainudin, Faridah Kusnin, et al.
    MyJurnal
    Introduction: Parents play an essential role in their children’s tuberculosis (TB) treatment
    success despite many challenges from the beginning of their children’s symptoms until
    completion of the TB treatment. The challenges can be described as perceived barriers,
    according to the Health Belief Model, a theory of behaviour change. This study aims to explore
    parents’ experiences on the challenges in achieving a successful TB treatment for their child
    in two districts of Selangor state, Malaysia. Methods: The research was carried out using a
    phenomenology study design. In-depth interviews were conducted among purposively
    sampled parents of children with TB disease who have completed TB treatment or still
    undergoing treatment from MyTB version 2.1, a national TB surveillance database. The
    collected data was considered as achieving its saturation level if no new themes arise from
    the latest interviews’ session. The R-based Qualitative Data Analysis (RQDA) package
    version 0.2-8 was used for the thematic data analysis. Results: The total number of
    participants in this study was 15 mothers of children with TB disease; 12 (80%) of the children
    had completed TB treatment. There were six subthemes identified from this study focusing on
    the theme of multiple challenges, such as health symptoms challenges, TB investigation
    challenges, personal challenges, healthcare facilities challenges, administration medication
    challenges, and community challenges. Conclusions: Parents highlighted many challenges
    during the child’s illness phase, and they should be given adequate education and appropriate
    support to ensure TB treatment adherence. TB program managers should take action
    following the relevant parents’ feedback regarding the quality of TB care in a healthcare
    facility
    Matched MeSH terms: Female
  3. Ismaliza Ismail, Wan Salwina Wan Ismai, Norazirah Md. Nor, Lee Voon Yee, Ani Amelia Zainuddin
    MyJurnal
    Trichotillomania (TTM) or hair pulling disorder is characterized by repetitive pulling of hair on
    the body whereas Polycystic Ovarian Syndrome (PCOS) is a metabolic-endocrine disorder,
    manifested by irregular menstrual cycle and clinical hyperandrogenism. Both disorders
    commonly occur in young females. TTM and PCOS may be related and share the same
    pathophysiology. We reported a case of a teenager with TTM and PCOS, which were triggered
    by stress. Neurobiological mechanism may explain the co-occurrences between TTM and
    PCOS. Further research in the neurobiology of TTM and PCOS may better explain the cooccurrences between the two disorders.
    Matched MeSH terms: Female
  4. Yu L, Mei Q, Xiang L, Liu W, Mohamad NI, István B, et al.
    Front Bioeng Biotechnol, 2021;9:629809.
    PMID: 33842444 DOI: 10.3389/fbioe.2021.629809
    Ground reaction force (GRF) is a key metric in biomechanical research, including parameters of loading rate (LR), first impact peak, second impact peak, and transient between first and second impact peaks in heel strike runners. The GRFs vary over time during stance. This study was aimed to investigate the variances of GRFs in rearfoot striking runners across incremental speeds. Thirty female and male runners joined the running tests on the instrumented treadmill with speeds of 2.7, 3.0, 3.3, and 3.7 m/s. The discrete parameters of vertical average loading rate in the current study are consistent with the literature findings. The principal component analysis was modeled to investigate the main variances (95%) in the GRFs over stance. The females varied in the magnitude of braking and propulsive forces (PC1, 84.93%), whereas the male runners varied in the timing of propulsion (PC1, 53.38%). The female runners dominantly varied in the transient between the first and second peaks of vertical GRF (PC1, 36.52%) and LR (PC2, 33.76%), whereas the males variated in the LR and second peak of vertical GRF (PC1, 78.69%). Knowledge reported in the current study suggested the difference of the magnitude and patterns of GRF between male and female runners across different speeds. These findings may have implications for the prevention of sex-specific running-related injuries and could be integrated with wearable signals for the in-field prediction and estimation of impact loadings and GRFs.
    Matched MeSH terms: Female
  5. Akwiditya MA, Yong CY, Yusof MT, Mariatulqabtiah AR, Ho KL, Tan WS
    Int J Mol Sci, 2021 Feb 26;22(5).
    PMID: 33652577 DOI: 10.3390/ijms22052320
    Gene therapy research has advanced to clinical trials, but it is hampered by unstable nucleic acids packaged inside carriers and there is a lack of specificity towards targeted sites in the body. This study aims to address gene therapy limitations by encapsidating a plasmid synthesizing a short hairpin RNA (shRNA) that targets the anti-apoptotic Bcl-2 gene using truncated hepatitis B core antigen (tHBcAg) virus-like particle (VLP). A shRNA sequence targeting anti-apoptotic Bcl-2 was synthesized and cloned into the pSilencer 2.0-U6 vector. The recombinant plasmid, namely PshRNA, was encapsidated inside tHBcAg VLP and conjugated with folic acid (FA) to produce FA-tHBcAg-PshRNA VLP. Electron microscopy revealed that the FA-tHBcAg-PshRNA VLP has an icosahedral structure that is similar to the unmodified tHBcAg VLP. Delivery of FA-tHBcAg-PshRNA VLP into HeLa cells overexpressing the folate receptor significantly downregulated the expression of anti-apoptotic Bcl-2 at 48 and 72 h post-transfection. The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay demonstrated that the cells' viability was significantly reduced from 89.46% at 24 h to 64.52% and 60.63%, respectively, at 48 and 72 h post-transfection. As a conclusion, tHBcAg VLP can be used as a carrier for a receptor-mediated targeted delivery of a therapeutic plasmid encoding shRNA for gene silencing in cancer cells.
    Matched MeSH terms: Female
  6. Santhosh K, Manzoor S, Sushanth A, Seralathan S, Rajasekar V, Jacob A
    J Contemp Dent Pract, 2020 Nov 01;21(11):1258-1261.
    PMID: 33850072
    AIM AND OBJECTIVE: To evaluate the possible genotoxic effect of X-rays on buccal mucosa while exposing to dental panoramic radiography using micronucleus test.

    MATERIALS AND METHODS: The study group comprised of 30 healthy subjects, 15 males and 15 females, aged between 24 years and 65 years. Samples were obtained from the exfoliated oral mucosa cells of buccal mucosa before and 12 days after exposing the patients to panoramic radiography.

    RESULTS: The study reported that there was no significant increase in the number of micronuclei cells present before and after panoramic radiography. Positive correlation existed between age with pre- and postexposure micronuclei.

    CONCLUSION: Diagnostic dental panoramic radiograph does not induce micronuclei in the target buccal epithelium cells. A positive correlation between age and micronuclei frequency was established.

    CLINICAL SIGNIFICANCE: Panoramic radiographs does not induce cytotoxicity but increase frequency may be vulnerable to genotoxic effects in buccal mucosal cells. Hence, dental radiographs should be prescribed only when necessary.

    Matched MeSH terms: Female
  7. Ramasamy K, Saniasiaya J, Abdul Gani N
    Ann Otol Rhinol Laryngol, 2021 May;130(5):513-519.
    PMID: 33025798 DOI: 10.1177/0003489420963165
    OBJECTIVE: To investigate the prevalence of olfactory and gustatory dysfunction among patients with COVID-19 infection and the recovery rate.

    METHODS: Adult patients (≥18 years) tested positive for COVID-19 via reverse transcription-polymerase chain reaction (RT-PCR) and admitted in Hospital Tuanku Ja'afar Seremban, Malaysia, were recruited in this study. Patients completed a questionnaire via telephone interview comprising the following details: age, sex, ethnicity, comorbidities, general and otorhinolaryngological symptoms, onset and duration of olfactory and gustatory dysfunction. Patients with persistent olfactory and gustatory dysfunction at the time of the initial interview were followed-up every 3 to 5 days till resolution.

    RESULTS: A total of 145 patients were included in our study. The mean age of patients was 43.0 ± 17.7 (range: 18-86). Fever (44.1%) and cough (39.3%) were the most prevalent general symptoms. Thirty-one patients (21.4%) reported olfactory dysfunction and 34 (23.4%) reported dysgeusia. There was a significant association between both olfactory and gustatory dysfunction (P 

    Matched MeSH terms: Female
  8. Nurul Hidayah Hashim, Intan Nureslyna Samsudin, Ana Dalila Masiman, Subashini C. Thambiah
    MyJurnal
    Interpretation of thyroid function test (TFT) is often straightforward but in certain scenarios, discordance between the clinical impression and the laboratory results exists. A 50-year-old woman with a ten years history of hypothyroidism on levothyroxine presented with a recent notable change in TFT [elevated free thyroxine (FT4) and thyroid-stimulat- ing hormone (TSH)], in an otherwise clinically euthyroid and previously stable TFT, leading to levothyroxine being withheld. This case report highlights the possibility of assay interference as a cause of discordant TFT. It also draws the importance of close collaboration between clinicians and the laboratory to avoid unnecessary investigations and inappropriate management of such a case.
    Matched MeSH terms: Female
  9. Louis JP, Ortiz V, Barlas J, Lee JS, Lockwood G, Chong WF, et al.
    PLoS One, 2021;16(1):e0243508.
    PMID: 33481822 DOI: 10.1371/journal.pone.0243508
    BACKGROUND AND OBJECTIVES: Schema therapy (ST) has become a mainstream therapy for the treatment of psychopathology and has been validated through a series of large scale, international randomized control trials. Among other things, schema therapy emphasizes the meeting of core emotional needs in children by primary caregivers as these unmet needs continue to adversely affect their lives into adulthood. An early intervention parenting program has been developed to help parents meet these core emotional needs in order to prevent the development of psychopathology in the first place. The program, Good Enough Parenting, is equally focused on reducing problems and strengthening parenting practices, regardless of where the child is on the "disordered to well-being continuum". This study aims to explore "patient experience" by users of this program. Best clinical research guidelines advocate that participants should be used as collaborators rather than pure recipients; this process should predate large scale trials.

    DESIGN: An exploratory qualitative study with 55 parent-participants of Good Enough Parenting was conducted.

    METHODS: One-to-one interviews were conducted with participants, using critical incident technique and guided by semi-structured interview schedule, to explore their experiences with the program. Transcripts were then analyzed using thematic analysis.

    RESULTS: Coding showed a high degree of inter-rater reliability (kappa value of 0.78). The themes that emerged were Cultivating Awareness of Parents' Own Schemas, Cultivating Intentionality, Working through Developmental Issues, Responses to Challenges at Home, Performing Multiple Roles, and the Learning Process. Participants overwhelmingly reported satisfaction within these key themes.

    CONCLUSIONS: The results support the development of the program and the choice of "participant reported outcome measures" for use in subsequent randomized controlled trials.

    Matched MeSH terms: Female
  10. Muhammad Yusoff Mohd Ramdzan, Jamil Aiman Mohd Baharuddin, Nordiyana Azmi, Noraida Ramli, Nor Rosidah Ibrahim, Rostenberghe, Hans Van
    MyJurnal
    Neonatal mastitis and abscess are rare and most often unilateral. Neonatal breast massage for physiological breast hypertrophy is suspected to be a predisposing factor in the case reported here: a 14-day-old neonate with bilateral neonatal breast abscess, treated effectively with intravenous cloxacillin and surgical aspiration.
    Matched MeSH terms: Female
  11. Leong, J.F., Levin, K.B., Rajkumar V., Abdullah, S., Jamari, S.
    Medicine & Health, 2019;14(2):261-265.
    MyJurnal
    Cavernous lymphangioma is a congenital malformation of lymphatic system causing dilated lymphatic sinuses that involve the skin and subcutaneous tissues. This was an interesting case of dystrophic macrodactyly of the left ring and little finger in a 18-month-old girl who presented with swollen and sausage like fingers deformity which turned out to be an isolated cavernous lymphangioma. This tumor, although rare to occur in the extremeties, must be differentiated from other congenital vascular lesions of the hand that include arteriovenous malformations and hemangiomas. Diagnosis should be solely based on histopathological analysis of the excised tissue mass. Surgical excision is usually necessary for satisfactory functional and cosmetic outcome
    Matched MeSH terms: Female
  12. Iqbal MS, Kassab YW, Al-Saikhan FI, Almalki ZS, Haseeb A, Iqbal MZ, et al.
    Saudi Pharm J, 2020 Aug;28(8):936-942.
    PMID: 32792838 DOI: 10.1016/j.jsps.2020.06.014
    Background and aim: The effect of anticoagulation control on overall Health-Related Quality of Life (HRQoL) in patients taking warfarin in Malaysia has not been explored yet. Therefore, this study aimed to evaluate HRQoL among patients on warfarin in Malaysia.

    Methods: HRQoL among patients on warfarin was measured using WHOQOL-BREF (World Health Organization Quality of life Assessment: Brief Version). Descriptive and inferential statistical analysis was done using Statistical Package for the Social Sciences (SPSS) version 22.

    Results: Out of 319 patients, more female patients were observed than the males (n = 221, 69.3%, and n = 98, 30.7% respectively). Mean scores for the physical (61.14 ± 15.96), psychological (68.58 ± 16.11), social (63.55 ± 27.06) and environmental domains (62.78 ± 17.58) were observed. Statistically, a significant association was found between the comorbidities other than CVDs with health satisfaction (p = 0.002), physical (p = 0.001), psychological (p 

    Matched MeSH terms: Female
  13. Ng RL, Koay HS, Jamil MT
    Med J Malaysia, 2020 11;75(6):748-749.
    PMID: 33219191
    We describe here an infant girl with ductal dependent complex cyanotic heart disease, who required prostaglandin infusion for a total of five months prior to Blalock-Taussig shunt procedure. Her alkaline phosphatase activity was raised after seven weeks being on prostaglandin and only dropped to the normal range seven days after discontinuing prostaglandin infusion. During our review at five months old, her limbs were grossly swollen and radiographic examination showed dense periosteal reaction in the long bones. Based on the clinical findings and investigations, she was diagnosed to have cortical hyperostosis, which is an uncommon side effect of prostaglandin. She underwent right Blalock-Taussig Shunt procedure successfully with no major complications. Unfortunately, she succumbed to infection two months after surgery.
    Matched MeSH terms: Female
  14. Quah ESH, Wood PLJ, Anuar MSS, Muin MA
    Zootaxa, 2020 Apr 23;4767(1):zootaxa.4767.1.6.
    PMID: 33056576 DOI: 10.11646/zootaxa.4767.1.6
    A new, diminutive species of Rock Gecko Cnemaspis tubaensis sp. nov. of the C. kumpoli group, is described from Tuba Island, Langkawi Archipelago, Kedah, Peninsular Malaysia and is differentiated from all other species in the kumpoli group by having a unique combination of morphological and color pattern characteristics, including a maximum SVL of 37.0 mm; 10 or 11 supralabials; eight or nine infralabials; 15-18 semi-linearly arranged paravertebral tubercles; lateral caudal furrow present; lateral caudal tubercles on the anterior portion of the tail; caudal tubercles not encircling tail; five or six precloacal pores; 28 or 29 subdigital lamellae on the fourth toe; smooth ventrals; smooth subcaudals with an enlarged median row of scales; subcaudal region light-grey and speckled with yellow; absence of light-colored ocelli on the shoulder; no yellow postscapular band; dorsum light-brown with sage-green blotches and black spots; flanks with scattered yellow spots; absence of black gular markings in both sexes; and 13.0-22.0% uncorrected pairwise sequence divergences in the NADH dehydrogenase subunit 2 gene (ND2). Cnemaspis tubaensis sp. nov. is the fourth species of Cnemaspis to be described from the Langkawi Archipelago and underscores the underestimated biodiversity of the islands which is in need of more thorough herpetological inventories.
    Matched MeSH terms: Female
  15. Noor Hazfalinda Hamzah, Amalina Farhatul Farida Mohamad Seliman, Khairul Osman, Gabriel, Gina Francesca
    MyJurnal
    Cheiloscopy is recognized as a tool for personal identification due to its strength in criminalistics. In this study, the lip print of Malaysian Chinese population in Klang Valley was used for gender determination using lipstick-cellophane technique. 412 subjects (203 males and 209 females) were selected conveniently. Lipstick was first applied on the lips and the lip print was lifted using cellophane tape prior to pasting them onto a plain A4 paper and analysis using magnifying glass. Six topography areas of lip prints were classified using Suzuki and Tsuchihashi’s classification, including upper left, upper middle, upper right, lower right, lower middle and lower left. Chi-square test showed that all lip sections were significantly different from each other (p < 0.05). Type II was the dominant pattern in four lip sections for both genders: upper left (male 81.3%, female 57.4%), upper right (male 71.9%, female 42.9%), lower left (male 98.0%, female 90.0%) and lower right (male 96.1%, female 86.1%). Type IV was the dominant pattern for both middle part of the lips; upper middle (male 56.2%, female 50.7%) and lower middle (male 62.6%, female 50.2%). The results showed that gender can be differentiated based on lip print patterns. This finding suggested that cheiloscopy could be used in aiding personal identification for forensic investigation.
    Matched MeSH terms: Female
  16. Payus AO, Clarence C, Azman Ali R
    Int J Gen Med, 2020;13:861-864.
    PMID: 33116778 DOI: 10.2147/IJGM.S277394
    Group B streptococcus (GBS) is a rare cause of meningitis in adults that commonly affects patients with multiple underlying comorbidities. Although it is uncommon, it typically progresses very rapidly and has a high mortality rate as compared to other causes of bacterial meningitis. Here, we report a patient with GBS meningitis who had no underlying medical illness and presented with multiple episodes of seizure within hours of developing fever. Cerebrospinal fluid analysis results were consistent with bacterial meningitis, and blood cultures grew GBS. She was treated with intravenous ceftriaxone for 2 weeks and made a great recovery without any sequalae. In conclusion, although GBS meningitis is uncommon in adults, it is a serious medical disease and associated with a high mortality rate. To the best of our knowledge, this patient represents one of the few reported cases of GBS meningitis in a previously healthy young adult.
    Matched MeSH terms: Female
  17. Ng PKL
    Zookeys, 2020;994:1-34.
    PMID: 33273881 DOI: 10.3897/zookeys.994.56810
    The taxonomy of the potamid freshwater crabs of the Johora tahanensis (Bott, 1966) species group (Potamoidea) is revised. Seven species are recognised, all from Peninsular Malaysia and southern Thailand, three of which are described as new. The three new species were previously identified as J. tahanensis but can be distinguished by characters of the carapace, male first gonopod, and vulva. A revised key to the 18 recognised species of Johora Bott, 1966, is provided.
    Matched MeSH terms: Female
  18. Boo WH, Chan YC
    Malays Fam Physician, 2020;15(3):79-82.
    PMID: 33329866
    The discovery of a solitary pulmonary nodule (SPN) on chest imaging can be alarming for both the clinician and the patient. In the absence of a uniform guideline, managing SPN is nothing short of challenging for primary care physicians (PCPs). We present a case here of a patient presenting with prolonged cough who also displayed unilateral SPN on her chest radiograph. Through further examination, this presence was later shown to be a nipple shadow simulating SPN, and the patient was spared unnecessary testing and psychological distress.
    Matched MeSH terms: Female
  19. Mohd Nawi, N. S. A., Rahmad, A. A., Abdul Hamid, K., Rahman, S., Osman, S. S., Surat, S., et al.
    MyJurnal
    The connectivity patterns among the DMN nodes when the brain is resting are still in great debate. Among the unknowns is whether a dominant node exists in the network and if any, how does it influences the other nodes. Resting state functional magnetic resonance imaging (rsfMRI) was utilized in data acquisition on 25 healthy male and female participants. The DMN nodes selected were posterior cingulate cortex (PCC), bilateral inferior parietal cortex (IPL) and medial prefrontal cortex (mPFC). Fully connected causal models were constructed comprising four DMN nodes. The time invariant covariance of the random fluctuations between nodes was then estimated to obtain the effective connectivity (EC) between the DMN nodes. The EC values among the DMN nodes were averaged over the participants using Bayesian Parameter Averaging (BPA). All the DMN nodes have self-inhibitory dynamics. All connections between nodes were significant (P > 0.9) with a condition for any of the two nodes, one node inhibited the others. The PCC which exhibited the highest signal intensity was in fact inhibited by others. Inter-hemispheric RIPC to LIPC connections acted the same way, with excitatory LIPC to RIPC and inhibitory RIPC to LIPC connections. The results also showed a stronger mPFC to RIPC connection in the right hemisphere (as compared to mPFC to LIPC connection in the left hemisphere) and a weaker PCC to RIPC connection in the right hemisphere (as compared to PCC to LIPC connection in the left hemisphere). PCC can be regarded as a dominant node among the four nodes, being connected to all other nodes in different ways. All the four nodes were significantly activated and connected to each other even though the brain was in a state of resting.
    Matched MeSH terms: Female
  20. Pravin Sugunan, Netia Jeganathan, Philip Rajan Devesahayam
    MyJurnal
    Aspiration of a foreign body is rare in school-age children. This reports the 21-day journey of an 8-year-old girl who had a foreign body aspiration. She presented to our hospital after five days of respiratory distress. She subsequently required mechanical ventilation and was supported with triple inotropes. After 18 days, a foreign body was removed via rigid bronchoscopy, followed by a rapid recovery of the patient.
    Matched MeSH terms: Female
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links