Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in South East Asia

Phanuphak P; Sirivichayakul S; Jiamsakul A; Sungkanuparph S; Kumarasamy N; Lee MP; Sirisanthana T; Kantipong P; Lee C; Kamarulzaman A; Mustafa M; Ditangco R; Merati T; Ratanasuwan W; Singtoroj T; Kantor R

doi:10.1097/QAI.0000000000000108

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Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in South East Asia

Phanuphak P ¹ , Sirivichayakul S , Jiamsakul A , Sungkanuparph S , Kumarasamy N , Lee MP Show all authors , Sirisanthana T , Kantipong P , Lee C , Kamarulzaman A , Mustafa M , Ditangco R , Merati T , Ratanasuwan W , Singtoroj T , Kantor R

Affiliations

¹ *HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; †Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; ‡The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; §Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ‖YRG Centre for AIDS Research and Education, Chennai, India; ¶Queen Elizabeth Hospital, Hong Kong, China; #Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; **Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; ††Hospital Sungai Buloh, Kuala Lumpur, Malaysia; ‡‡University of Malaya, Kuala Lumpur, Malaysia; §§Hospital Raja Perempuan Zainab II, Kota Bharu, Malaysia; ‖‖Research Institute for Tropical Medicine, Manila, Philippines; ¶¶Faculty of Medicine, Udayana University and Sanglah Hospital, Bali, Indonesia; ##Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; ***TREAT Asia, amfAR-The Foundation for AIDS Research, Bangkok, Thailand; and †††Brown University Alpert Medical School, Providence, RI

J Acquir Immune Defic Syndr, 2014 May 01;66(1):74-9.

PMID: 24413039 DOI: 10.1097/QAI.0000000000000108

Abstract

BACKGROUND: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens.

METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models.

RESULTS: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR.

CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.