Affiliations 

  • 1 Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Bertam, 13200, Kepala Batas, Pulau Pinang, Malaysia. norashikin.zakaria@yahoo.com
  • 2 Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Bertam, 13200, Kepala Batas, Pulau Pinang, Malaysia. narazah@amdi.usm.edu.my
  • 3 Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), Kuala Lumpur, Malaysia. zubaidah@imr.gov.my
  • 4 Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), Kuala Lumpur, Malaysia. lisa@imr.gov.my
  • 5 Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), Kuala Lumpur, Malaysia. puteri@imr.gov.my
  • 6 Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), Kuala Lumpur, Malaysia. kamal@imr.gov.my
  • 7 Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Bertam, 13200, Kepala Batas, Pulau Pinang, Malaysia. badrul@amdi.usm.edu.my
BMC Cancer, 2015;15:84.
PMID: 25881239 DOI: 10.1186/s12885-015-1086-3

Abstract

Despite significant advances in staging and therapies, lung cancer remains a major cause of cancer-related lethality due to its high incidence and recurrence. Clearly, a novel approach is required to develop new therapies to treat this devastating disease. Recent evidence indicates that tumours contain a small population of cells known as cancer stem cells (CSCs) that are responsible for tumour maintenance, spreading and resistant to chemotherapy. The genetic composition of CSCs so far is not fully understood, but manipulation of the specific genes that maintain their integrity would be beneficial for developing strategies to combat cancer. Therefore, the goal of this study isto identify the transcriptomic composition and biological functions of CSCs from non-small cell lung cancer (NSCLC).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.