Blood gene signature for early hepatocellular carcinoma detection in patients with chronic hepatitis B

Omar H 1 , Lim CR , Chao S , Lee MM , Bong CW , Ooi EJ Show all authors , Yu CG , Tan SS , Abu Hassan MR , Menon J , Muthukaruppan R , Singh M , Nik Abdullah NA , Ooi BP , Ding RP , Low EJ , Tan F , Novak D , Harris DF , Yang H , Merican I , Liew CC

Affiliations 

  • 1 *Selayang Hospital, Lebuhraya Selayang-Kepong, Batu Caves, Selangor Darul Ehsan †GeneNews (Malaysia) Sdn. Bhd., Mount Miriam Cancer Hospital, Tanjung Bungah **Island Hospital, Penang §Sultanah Bahiyah Hospital, Jalan Langgar, Alor Setar, Kedah ∥Queen Elizabeth Hospital, Kota Kinabalu, Sabah ¶Umum Kuching Sarawak Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak #Penang Hospital, Jalan Residensi ††Lam Wah Ee Hospital, Pulau Pinang ‡‡GeneNews Diagnostics, Office/Lab 9, Biotechnology Incubation Centre, Technology Park Malaysia, Kuala Lumpur, Malaysia ‡GeneNews Ltd., Richmond Hill, ON, Canada §§Brigham and Women's Hospital, Harvard Medical School, Boston, MA
J Clin Gastroenterol, 2015 Feb;49(2):150-7.
PMID: 25569223 DOI: 10.1097/MCG.0000000000000112

Abstract

Up to 25% of chronic hepatitis B (CHB) patients eventually develop hepatocellular carcinoma (HCC), a disease with poor prognosis unless detected early. This study identifies a blood-based RNA biomarker panel for early HCC detection in CHB.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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