MyMedR

Displaying publications 61 - 80 of 417 in total

Abstract:

Sort:

The effects of honey compared to silver sulfadiazine for the treatment of burns: A systematic review of randomized controlled trials

Aziz Z, Abdul Rasool Hassan B

Burns, 2017 Feb;43(1):50-57.
PMID: 27576926 DOI: 10.1016/j.burns.2016.07.004

Evidence from animal studies and trials suggests that honey may accelerate wound healing. The objective of this review was to assess the effects of honey compared with silver dressings on the healing of burn wounds. Relevant databases for randomized controlled trials (RCTs) of honey compared with silver sulfadiazine (SSD) were searched. The quality of the selected trials was assessed using the Cochrane Risk of Bias Assessment Tool. The primary endpoints considered were wound healing time and the number of infected wounds rendered sterile. Nine RCTs met the inclusion criteria. Based on moderate quality evidence there was a statistically significant difference between the two groups, favoring honey in healing time (MD -5.76days, 95% CI -8.14 to -3.39) and the proportions of infected wounds rendered sterile (RR 2.59; 95% CI 1.58-2.88). The available evidence suggests that honey dressings promote better wound healing than silver sulfadiazine for burns.

Matched MeSH terms: Wound Healing
The effects of age on monolayer culture of human keratinocytes for future use in skin engineering

Muhd Fakhruddin BH, Aminuddin BS, Mazlyzam AL, Ruszymah BH

Med J Malaysia, 2004 May;59 Suppl B:182-3.
PMID: 15468878

Skin is the largest organ in human system and plays a vital role as a barrier against environment and pathogens. Skin regeneration is important in tissue engineering especially in cases of chronic wounds. With the tissue engineering technology, these skins equivalent have been use clinically to repair burns and wounds. Consented redundant skin samples were obtained from patients aged 9 to 65 years old. Skin samples were digested with dispase, thus separating the epidermis and the dermis layer. The epidermis layer was trypsinized and cultured in DKSFM in 6-well plate at 37 degrees C and 5% CO2. Once confluent, the culture were trypsinized and the cells were pooled. Cells were counted using haemacytometer. Doubling time and viability were calculated and analysed. From the result, we conclude that doubling time and viability of in vitro keratinocytes cultured in DKSFM media is not age dependant.

Matched MeSH terms: Wound Healing/physiology
Fulltext The effects of acacia honey on in vitro corneal abrasion wound healing model

Ker-Woon C, Abd Ghafar N, Hui CK, Mohd Yusof YA, Wan Ngah WZ

BMC Cell Biol., 2015;16:2.
PMID: 25887200 DOI: 10.1186/s12860-015-0053-9

Acacia honey (AH) has been proven to improve skin wound healing, but its therapeutic effects on corneal epithelium has not been elucidated to date. This study aimed to investigate the effects of AH on cultured corneal epithelial cells (CEC) on in vitro corneal abrasion wound healing model. Six New Zealand white rabbits' CEC were isolated and cultured until passage 1. Circular wound area was created onto a confluent monolayer CEC using a corneal trephine which mimicked corneal abrasion and treated with 0.025% AH supplemented in basal medium (BM) and complete cornea medium (CCM). Wound healing was measured as the percentage of wound closure by the migration of CEC on day 0, day 3 and day 6, post wound creation. The morphological changes of CEC were assessed via phase contrast microscopy. Gene and protein expressions of cytokeratin (CK3), fibronectin and cluster of differentiation 44 (CD44) in AH treated groups and control groups were determined by real-time PCR and immunocytochemistry, respectively.

Matched MeSH terms: Wound Healing*
Fulltext The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process

Jacob A, Parolia A, Pau A, Davamani Amalraj F

BMC Complement Altern Med, 2015;15:294.
PMID: 26303848 DOI: 10.1186/s12906-015-0814-1

To evaluate and compare the effects of ethanolic extracts of Malaysian propolis and Brazilian red propolis at different concentrations on the migration and proliferation of fibroblast cells.

Matched MeSH terms: Wound Healing/drug effects*
Fulltext The effects of Carica papaya Linn. latex on the healing of burn wounds in rats

Ahmad Nazrun Shuid, Mohd Syukri Anwar, Ahmad Asmadi Yusof

Jurnal Sains Kesihatan Malaysia, 2005;3(2):39-47.
MyJurnal

This study was carried out to compare the rate of burn wound healing with the applications of the latex of Carica papaya Linn. (papaya) or of silver sulfadiazine cream (SSD). Partial and full thickness burn wound (2 cm x 2 cm) was induced on the dorsal part of anaesthetized rats by using heated metal plates. The rats were divided into three groups, i.e. untreated group and groups treated daily with SSD and papaya latex, respectively. A digital camera was used to take photographs of the burn wounds daily to monitor their healing. It was found that there was no significant difference in the healing time of papaya latex treated group compared to the SSD treated group. Papaya latex contained digestive enzymes which might clean burn wounds but might also cause wound bleeding in a few rats of the papaya latex group.

Matched MeSH terms: Wound Healing
The effect of topical extract of Momordica charantia (bitter gourd) on wound healing in nondiabetic rats and in rats with diabetes induced by streptozotocin

Teoh SL, Latiff AA, Das S

Clin Exp Dermatol, 2009 Oct;34(7):815-22.
PMID: 19508570 DOI: 10.1111/j.1365-2230.2008.03117.x

Momordica charantia (MC; bitter gourd) is a traditional herb commonly used for its antidiabetic, antioxidant, contraceptive and antibacterial properties. It is also used for the rapid healing of wounds.

Matched MeSH terms: Wound Healing/drug effects*; Wound Healing/physiology
Fulltext The effect of piper sarmentosum aqueous extract on buccal ulcer healing

Md Ismail, N.H., Nik Mohd Alwi N.A.

JUMMEC, 2019;22(1):13-19.
MyJurnal

Oral ulcer is a lesion with multifactorial causes and occurs worldwide. The lesion usually resolved within 14
days, but the pain may have an impact on the quality of patient’s life. Therefore, having a natural derived
remedy that can reduce healing time would be a great advantage. This study aims to investigate histological
sections of buccal ulcer on rats treated with aqueous extract of Piper sarmentosum (AEPS). Glacial acetic acid
was used to induce buccal ulcer on male Sprague Dawley rats. Control group received normal saline while
the experimental group received AEPS for treatment. On certain days of post-ulcer induction, buccal ulcer
tissue samples were harvested, sectioned and stained with Hematoxylin and Eosin (H&E). Histological slides
were examined for inflammation and scored. The inflammation severity reduced from day 2 to day 12. In the
experimental group there was a statistically significant differences of inflammation score, particularly on day
2 with a score of (2.8 + 0.2). Neutrophils were less in the experimental group and the tissue debris clearance
was faster compared to control group. Full reepithelization was observed on both treated tissue sections on
day 12 with less severe inflammation. Topical application of AEPS is proven to have anti-inflammatory effect
by reducing the number of neutrophils during inflammation phase of oral ulcer healing.

Matched MeSH terms: Wound Healing
The effect of Tualang honey in enhancing post tonsillectomy healing process. An open labelled prospective clinical trial

Mat Lazim N, Abdullah B, Salim R

Int J Pediatr Otorhinolaryngol, 2013 Apr;77(4):457-61.
PMID: 23273638 DOI: 10.1016/j.ijporl.2012.11.036

Tonsillectomy is a common operative procedure performed for tonsillar hypertrophy complicates with recurrent tonsillitis. Among the post tonsillectomy morbidities, post operative wound healing is of utmost importance to be effectively managed as it will interfere with patient recuperation from surgery. Tualang honey has been shown to accelerate wound healing in postoperative patients.

Matched MeSH terms: Wound Healing/drug effects*
Fulltext The effect of Piper betle on wound healing in male Sprague Dawley rats

Nur Ain, J., Ainaa Diyana, S., Nur Hazirah, R., Nur Fathiah, A.S., Fairus, A., Teoh, S.l., et al.

Medicine & Health, 2018;13(1):165-174.
MyJurnal

Piper betle (PB) leaves have been traditionally used in many Asian countries for the healing of wounds and other ailments. The aim of this study was to examine the wound healing effect of PB on skin injury-inflicted Sprague-Dawley rats. Eighteen male Sprague-Dawley rats were inflicted with wounds and then divided into three groups consisting of a control (normal wound healing without dressing), saline (wound healing aided by gauze soaked in saline) and PB (gauze impregnated with PB paste) dressings. Wounds were created on the back of rats with 6-mm sterilized punch biopsy needle. Wounds were examined on days 3, 5, 7, 9, 11 and 13 for dryness, exudation, and scar formation. Rats were sacrificed on day 14 and the granulation tissue formed on the wound was then excised for histological examination using Hematoxylin and Eosin staining. The formation of granulation tissue in rats treated with PB showed higher progress to wound closure with shorter days (on day 3) compared to the control and saline group (on day 5). PB dressing minimized the formation of scar tissue significantly (p

Matched MeSH terms: Wound Healing
The effect of Piper betel extract on the wound healing process in experimentally induced diabetic rats

Keat EC, Razak SS, Fadil NM, Yusof FM, Chan LH, Chyi FK, et al.

Clin Ter, 2010;161(2):117-20.
PMID: 20499023

Piper betel (PB) possesses antimicrobial, antifungal, antioxidant and wound healing properties due to its powerful antioxidant effect. Diabetes mellitus (DM) is a metabolic disorder which is associated with complications like impaired wound healing, nephropathy and neuropathy. The main aim of the study was to study the wound healing properties of PB.

Matched MeSH terms: Wound Healing/drug effects*
The Use of Engineered Bilayered Skin (MyDermTM) in the Management of Massive Skin Defect in Grade III Gustilo-Anderson Open Fracture

Mohamed Haflah NH, Ng MH, Mohd Yunus MH, Naicker AS, Htwe O, Fahmi M, et al.

Int J Low Extrem Wounds, 2017 Sep;16(3):212-216.
PMID: 28862056 DOI: 10.1177/1534734617724974

Open fracture Gustilo-Anderson grade IIIC is associated with higher risk of infection and problems with soft tissue coverage. Various methods have been used for soft tissue coverage in open fractures with large skin defect. We report a case of a patient who had grade IIIC open fracture of the tibia with posterior tibial artery injury. The patient underwent external fixation and reduction. Because of potential compartment syndrome after vascular repair, fasciotomy of the posterior compartment was performed. This wound, however, became infected and because of further debridement, gave rise to a large skin defect. A tissue engineered skin construct, MyDermTM was employed to cover this large defect. Complete wound closure was achieved 35 days postimplantation. The patient then underwent plating of the tibia for nonunion with no adverse effect to the grafted site. The tibia eventually healed 5 months postplating, and the cosmetic appearance of the newly formed skin was satisfactory.

Matched MeSH terms: Wound Healing/physiology
Fulltext The UV spectroscopic and chromatographic methods of hydroalcoholic extracts of Aloe vera

Kathleen J. Jalani, Razuan Hilmi Md Sulji, Hannis Fadzillah Mohsin, Ibtisam Abdul Wahab

ESTEEM Academic Journal, 2019;15(1):18-24.
MyJurnal

Aloe vera which is also known as Aloe barbadensis Miller,is a plant that is commonly used for medicinal purposes and as treatments for various health issues. It produces two substances; gel and latex, which are used for commercial household products, halal food and cosmetics. Aloe gel is the clear, jelly-like substance found in the inner part of the Aloe leaf while Aloe’s yellow latex comes from the peel. Aloe vera is able to provide therapeutic effects such as wound healing, anti-inflammatory, antioxidant, laxative and antimicrobial properties. The objective of this study was to
investigate the extracts via spectrophotometry (λ = 200 – 400 nm) and liquid chromatography. After 21 days, the ultraviolet spectra showed the evidence of the water molecules interactions and the hydroxyl groups in hydroalcoholic extracts. Significant peaks were also observed in the chromatograms. Further studies evaluating the stability of A. vera extracts should be carried out.

Matched MeSH terms: Wound Healing
Fulltext The Therapeutic Effect and In Vivo Assessment of Palmitoyl-GDPH on the Wound Healing Process

Fadilah NIM, Rahman MBA, Yusof LM, Mustapha NM, Ahmad H

Pharmaceutics, 2021 Feb 01;13(2).
PMID: 33535623 DOI: 10.3390/pharmaceutics13020193

The standard treatment of open wounds via the direct usage of therapeutic agents is not without limitations with respect to healing. Small peptides can create a favorable milieu for accelerating the healing of wounds. This study presents the potential of a novel fatty acid conjugated tetrapeptide (palmitic acid-glycine-aspartic acid-proline-histidine; Palmitoyl-GDPH) in alleviating wound healing. Tetracycline was employed as a standard control drug following its significance in wound healing including biologically active and antimicrobial effects. The peptide in liquid form was applied on to a 4 cm2 full thickness wound surgically induced at the dorsum of Sprague Dawley (SD) rats. The in vivo wound treatment with Palmitoyl-GDPH for eighteen days, histologically demonstrated an almost perfect healing exhibited by increased re-epithelialization, enhanced collagen deposition, and diminished scar formation compared to the controls. In addition, the well-developed epidermal-dermal junction and ultimate stimulation of hair follicle-growth in the Palmitoyl-GDPH treated group indicated the wound to have healed as functionally viable tissues. In general, the much lower hemogram values in the Palmitoyl-GDPH group indicated that the ongoing healing is en route to an earlier recovery. Additionally, the liver, kidney, and pancreas function biomarkers being within normal limits indicated the relatively non-toxic nature of Palmitoyl-GDPH at the used dosage. These results indisputably supported the great potential of this newly synthesized Palmitoyl-GDPH to be used as an effective therapeutic agent for wound healing (this actually means creating a new wound).

Matched MeSH terms: Wound Healing
Fulltext The Role of Calcium in Wound Healing

Subramaniam T, Fauzi MB, Lokanathan Y, Law JX

Int J Mol Sci, 2021 Jun 17;22(12).
PMID: 34204292 DOI: 10.3390/ijms22126486

Skin injury is quite common, and the wound healing is a complex process involving many types of cells, the extracellular matrix, and soluble mediators. Cell differentiation, migration, and proliferation are essential in restoring the integrity of the injured tissue. Despite the advances in science and technology, we have yet to find the ideal dressing that can support the healing of cutaneous wounds effectively, particularly for difficult-to-heal chronic wounds such as diabetic foot ulcers, bed sores, and venous ulcers. Hence, there is a need to identify and incorporate new ideas and methods to design a more effective dressing that not only can expedite wound healing but also can reduce scarring. Calcium has been identified to influence the wound healing process. This review explores the functions and roles of calcium in skin regeneration and reconstruction during would healing. Furthermore, this review also investigates the possibility of incorporating calcium into scaffolds and examines how it modulates cutaneous wound healing. In summary, the preliminary findings are promising. However, some challenges remain to be addressed before calcium can be used for cutaneous wound healing in clinical settings.

Matched MeSH terms: Wound Healing/drug effects; Wound Healing/physiology*
The Potential use of Honey as a Remedy for Allergic Diseases: A Mini Review

Aw Yong PY, Islam F, Harith HH, Israf DA, Tan JW, Tham CL

Front Pharmacol, 2020;11:599080.
PMID: 33574752 DOI: 10.3389/fphar.2020.599080

Honey has been conventionally consumed as food. However, its therapeutic properties have also gained much attention due to its application as a traditional medicine. Therapeutic properties of honey such as anti-microbial, anti-inflammatory, anti-cancer and wound healing have been widely reported. A number of interesting studies have reported the potential use of honey in the management of allergic diseases. Allergic diseases including anaphylaxis, asthma and atopic dermatitis (AD) are threatening around 20% of the world population. Although allergic reactions are somehow controllable with different drugs such as antihistamines, corticosteroids and mast cell stabilizers, modern dietary changes linked with allergic diseases have prompted studies to assess the preventive and therapeutic merits of dietary nutrients including honey. Many scientific evidences have shown that honey is able to relieve the pathological status and regulate the recruitment of inflammatory cells in cellular and animal models of allergic diseases. Clinically, a few studies demonstrated alleviation of allergic symptoms in patients after application or consumption of honey. Therefore, the objective of this mini review is to discuss the effectiveness of honey as a treatment or preventive approach for various allergic diseases. This mini review will provide insights into the potential use of honey in the management of allergic diseases in clinical settings.

Matched MeSH terms: Wound Healing
The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

Khangholi S, Majid FA, Berwary NJ, Ahmad F, Aziz RB

Planta Med, 2016 Jan;82(1-2):32-45.
PMID: 26550791 DOI: 10.1055/s-0035-1558086

Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

Matched MeSH terms: Wound Healing
The Efficacy of Immediate Implant Placement in Extraction Sockets for Alveolar Bone Preservation: A Clinical Evaluation Using Three-Dimensional Cone Beam Computerized Tomography and Resonance Frequency Analysis Value

Qabbani AA, Razak NHA, Kawas SA, Sheikh Abdul Hamid S, Wahbi S, Samsudin AR

J Craniofac Surg, 2017 Jun;28(4):e318-e325.
PMID: 28230596 DOI: 10.1097/SCS.0000000000003569

The aim of this study was to determine the efficacy of immediate implant placement with alveolar bone augmentation on socket preservation following atraumatic tooth extraction and comparing it with a tooth alveolar socket that was allowed to heal in a conventional way.Twenty medically fit patients (8 males and 12 females aged between 18 and 40 years) who needed noncomplicated tooth extraction of mandibular premolar teeth were divided randomly and equally into 2 groups. In Group I, the empty extraction socket was left untreated and allowed to heal in a conventional way. In Group II, the immediate implant was placed and the gap between the implant and the inner buccal plate surface of the socket wall was filled with lyophilized bovine bone granules and the wound was covered with pericardium membrane. The patients were followed up clinically and radiologically for regular reviews at 1 week, 3 months, and 9 months postoperative. Cone beam computerized tomography images of the alveolar ridge and socket were analyzed to determine the structural changes of the alveolar ridge. Resonance frequency analysis was measured at 9 months for Group II to assess the degree of secondary stability of the implants by using Osstell machine.A significant difference of bone resorption of 1.49 mm (confidence interval, CI 95%, 0.63-2.35) was observed within the control group at 3 months, and 1.84 mm (P ≤ 0.05) at 9 months intervals. No significant changes of bone resorption were observed in Group II. Comparison between groups showed a highly significant difference at 3 months; 2.56 mm (CI 95% 4.22-0.90) and at 9 months intervals; 3.2 mm (CI 95%, 4.70-1.62) P ≤ 0.001 between Group I and II. High resonance frequency analysis values were observed at 9 months postoperative in Group II.In conclusion, the insertion of immediate implants in fresh extraction sockets together with grafting the circumferential gap between the bony socket wall and the implant surface with bovine bone granules was able to preserve a greater amount of alveolar ridge volume when compared with an extraction socket that was left to heal in a conventional way.

Matched MeSH terms: Wound Healing
Fulltext The Efficacy of Gelam Honey Dressing towards Excisional Wound Healing

Tan MK, Hasan Adli DS, Tumiran MA, Abdulla MA, Yusoff KM

Evid Based Complement Alternat Med, 2012;2012:805932.
PMID: 22536292 DOI: 10.1155/2012/805932

Honey is one of the oldest substances used in wound management. Efficacy of Gelam honey in wound healing was evaluated in this paper. Sprague-Dawley rats were randomly divided into four groups of 24 rats each (untreated group, saline group, Intrasite Gel group, and Gelam honey group) with 2 cm by 2 cm full thickness, excisional wound created on neck area. Wounds were dressed topically according to groups. Rats were sacrificed on days 1, 5, 10, and 15 of treatments. Wounds were then processed for macroscopic and histological observations. Gelam-honey-dressed wounds healed earlier (day 13) than untreated and saline treated groups, as did wounds treated with Intrasite Gel. Honey-treated wounds exhibited less scab and only thin scar formations. Histological features demonstrated positive effects of Gelam honey on the wounds. This paper showed that Gelam honey dressing on excisional wound accelerated the process of wound healing.

Matched MeSH terms: Wound Healing
Fulltext The Effects Of CO2 Laser On Oral Lichen Planus And Lichenoid Lesions

Kok, T.C., Ong, S.T.

Ann Dent, 2001;8(1):-.
MyJurnal

The purpose of this study is to assess the effectiveness of C02 laser in relieving symptoms associated with Oral lichen planus (aLP) and lichenoid lesions (aLL) and the event of healing. Six patients were selected for this study with 13 sites treated. Each lesion was ablated with C02 laser and the wound allowed to heal undisturbed. Prior to treatment, 4 patients had both unprovoked and provoked pain and 2 patients rated for provoked pain only. After laser ablation, five out of six patients treated recorded no pain / 0 pain score. One month post-laser, the treated area was almost the same colour as the surrounding normal mucosa and soft in texture in all but one patient in which there was some fibrosis and residual plaque-like patch. Weconclude that the use of C02 laser in the treatment of aLP and aLL shows positive results in relieving symptoms associated with these lesions.

Matched MeSH terms: Wound Healing
Fulltext The Effect of Individualised Glycemic Intervention on Wound Healing Rate in Diabetic Foot Ulcer (The EIGIFU Study)

Lim KP, Nasruddi AB, Rani NM

J ASEAN Fed Endocr Soc, 2018;33(1):22-27.
PMID: 33442107 DOI: 10.15605/jafes.033.01.04

Objective: To evaluate the association of glycated haemoglobin (HbA1c) reduction and wound healing in patients with diabetic foot ulcer (DFU).
Methodology: A 12-week prospective, non-controlled, interventional study in suboptimal-controlled T2DM patients with DFU was conducted. Antidiabetic medications were adjusted with the aim of at least 1% in relation to patient's individualised HbA1c target. The wound area was determined by using specific wound tracing. The daily wound area healing rate in cm2 per day was calculated as the difference between wound area at first visit and the subsequent visit divided by the number of days between the two visits.
Results: 19 patients were included in the study. There was a significant HbA1c reduction from 10.33 %+1.83% to 6.89%+1.4% (p<0.001) with no severe hypoglycaemia. The median daily wound area healing rate was 0.234 (0.025,0.453) cm2/day. There was a strong positive correlation between these two variables (r=0.752, p=0.01). After dividing the patients into four quartiles based on final HbA1c and comparing the first quartile vs fourth quartile, there was a significant difference in daily wound area healing rates (0.597 vs 0.044 cm2/day, p=0.012).
Conclusion: There was a positive correlation between HbA1c reduction and wound healing rate in patients with DFU. Although this is an association study, the study postulated the benefits of achieving lower HbA1c on wound healing rate in DFU which require evidence from future randomised controlled studies.

Matched MeSH terms: Wound Healing

Filters

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links